JP7059372B2 - デュアルモードの放射性トレーサーおよび療法剤 - Google Patents

デュアルモードの放射性トレーサーおよび療法剤 Download PDF

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JP7059372B2
JP7059372B2 JP2020526688A JP2020526688A JP7059372B2 JP 7059372 B2 JP7059372 B2 JP 7059372B2 JP 2020526688 A JP2020526688 A JP 2020526688A JP 2020526688 A JP2020526688 A JP 2020526688A JP 7059372 B2 JP7059372 B2 JP 7059372B2
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oligo
bond
acid
bonds
amide
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JP2020528461A (ja
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ワーザー，アレクサンデル・ヨーゼフ
ウェスター，ハンス－ユルゲン
アイバー，マティアス・ヨハネス
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Technische Universitaet Muenchen
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0402—Organic compounds carboxylic acid carriers, fatty acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Nuclear Medicine (AREA)
JP2020526688A 2017-07-28 2018-07-30 デュアルモードの放射性トレーサーおよび療法剤 Active JP7059372B2 (ja)

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JP2022065524A JP2022101601A (ja) 2017-07-28 2022-04-12 デュアルモードの放射性トレーサーおよび療法剤

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EP17183795.8 2017-07-28
EP17183795 2017-07-28
PCT/EP2018/070533 WO2019020831A1 (en) 2017-07-28 2018-07-30 AGENTS WITH TWO RADIOTRATIVE AND THERAPEUTIC MODES

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JP2020528461A JP2020528461A (ja) 2020-09-24
JP2020528461A5 JP2020528461A5 (https=) 2021-04-01
JP7059372B2 true JP7059372B2 (ja) 2022-04-25

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JP2022065524A Pending JP2022101601A (ja) 2017-07-28 2022-04-12 デュアルモードの放射性トレーサーおよび療法剤

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US (4) US11413360B2 (https=)
EP (3) EP4000640A1 (https=)
JP (2) JP7059372B2 (https=)
KR (2) KR102752620B1 (https=)
CN (1) CN111132700B (https=)
AU (2) AU2018308699B2 (https=)
BR (1) BR112020001785A2 (https=)
CA (1) CA3071315A1 (https=)
DK (1) DK3658194T3 (https=)
EA (1) EA202090370A1 (https=)
ES (1) ES3011272T3 (https=)
FI (1) FI3658194T3 (https=)
HU (1) HUE070098T2 (https=)
IL (2) IL318092A (https=)
MX (2) MX2020000352A (https=)
NZ (1) NZ760537A (https=)
PL (1) PL3658194T3 (https=)
PT (1) PT3658194T (https=)
SG (1) SG11202000725WA (https=)
WO (1) WO2019020831A1 (https=)
ZA (1) ZA202000467B (https=)

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CN113677375B (zh) * 2019-01-30 2024-07-23 慕尼黑工业大学 氟化硅受体取代的放射性药物及其前体
EP3917626B1 (en) * 2019-01-30 2023-05-31 Technische Universität München Psma binding dual mode radiotracer and therapeutic
CN112168978B (zh) * 2019-07-03 2022-01-11 北京大学 一种抗体偶联药物及其药物组合物与应用
WO2021086917A1 (en) * 2019-10-29 2021-05-06 The Cleveland Clinic Foundation Psma-targeting imaging agents
CN113350531A (zh) * 2020-03-02 2021-09-07 上海核力星医药科技有限公司 前列腺特异性膜抗原结合配体偶联物及其应用
GB202005282D0 (en) * 2020-04-09 2020-05-27 Blue Earth Diagnostics Ltd Pharmaceutical Formulations
WO2022018264A1 (en) 2020-07-23 2022-01-27 Technische Universität München Silicon-containing ligand compounds
CN116583527A (zh) 2020-09-03 2023-08-11 库瑞姆美国有限责任公司 用于64Cu-DOTATATE放大规模的放射性标记和制剂
EP4023250A1 (en) * 2021-01-04 2022-07-06 Technische Universität München Dual mode radiotracer and -therapeutics
US20240165281A1 (en) 2021-02-15 2024-05-23 Technische Universität München Dual mode radiotracer and therapeutics
US20240181092A1 (en) * 2021-04-02 2024-06-06 Novartis Ag Diagnostic methods of prostate cancer
KR20240008341A (ko) * 2021-05-14 2024-01-18 테크니쉐 유니베르시테트 뮌헨 방사성약제학적 소마토스타틴 수용체 리간드 및 그의 전구체
GB202108779D0 (en) 2021-06-18 2021-08-04 Blue Earth Diagnostics Ltd Si-at therapeutic/diagnostic compounds
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IL310066A (en) * 2021-08-05 2024-03-01 Technische Universit?T M?Nchen Ligand compounds comprising a chelating group as a bridging group
GB202113646D0 (en) 2021-09-24 2021-11-10 Blue Earth Diagnostics Ltd Method of preparation of 18F labelled silyl-fluoride compounds
CN114671806B (zh) * 2022-04-08 2024-03-01 上海如絮生物科技有限公司 一种亲水性吡啶衍生物、中间体、其制备方法及应用
GB202207372D0 (en) 2022-05-19 2022-07-06 Blue Earth Diagnostics Ltd Synthesis of fluorosilyl compounds
CA3257852A1 (en) 2022-07-29 2024-02-01 Technische Universitat Munchen Silicon Fluoride Accepting Groups for Radiopharmaceutical Products
WO2024054226A1 (en) * 2022-09-06 2024-03-14 Hoang Ba Xuan Gallium nitrate and dimethyl sulfoxide composition for respiratory treatment
JP2025532619A (ja) * 2022-09-20 2025-10-01 テクニシェ ユニバーシタット ミュンヘン イメージングおよび標的化放射線治療のための新規ミニガストリン由来コレシストキニン２受容体結合分子
AU2023347470A1 (en) 2022-09-23 2025-04-10 Nuclidium Ag High-purity copper radiopharmaceutical compositions and diagnostic and therapeutic uses thereof
TW202426433A (zh) 2022-09-23 2024-07-01 瑞士商紐利迪姆股份公司 成纖維細胞活化蛋白（ｆａｐ）抑制劑、ｆａｐ結合物及其診斷與治療用途
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NZ760537A (en) 2026-01-30
KR20240027896A (ko) 2024-03-04
US11413360B2 (en) 2022-08-16
JP2022101601A (ja) 2022-07-06
CA3071315A1 (en) 2019-01-31
EP3658194B1 (en) 2024-11-27
EP4424378A2 (en) 2024-09-04
AU2018308699A1 (en) 2020-01-23
EP3658194A1 (en) 2020-06-03
US12453787B2 (en) 2025-10-28
MX2020000352A (es) 2020-08-17
FI3658194T3 (fi) 2025-02-28
JP2020528461A (ja) 2020-09-24
US20260021211A1 (en) 2026-01-22
KR102752620B1 (ko) 2025-01-10
PL3658194T3 (pl) 2025-09-15
DK3658194T3 (da) 2025-02-17
WO2019020831A1 (en) 2019-01-31
IL318092A (en) 2025-02-01
ES3011272T3 (en) 2025-04-07
IL272291B1 (en) 2025-02-01
US12390540B2 (en) 2025-08-19
US20200197545A1 (en) 2020-06-25
AU2018308699B2 (en) 2023-11-30
MX2023007914A (es) 2023-07-13
IL272291A (en) 2020-03-31
CN111132700B (zh) 2022-12-13
US20220370649A1 (en) 2022-11-24
HUE070098T2 (hu) 2025-05-28
KR20200064057A (ko) 2020-06-05
BR112020001785A2 (pt) 2020-09-29
ZA202000467B (en) 2022-06-29
EA202090370A1 (ru) 2020-05-25
AU2024200440B2 (en) 2025-04-24
PT3658194T (pt) 2025-02-13
IL272291B2 (en) 2025-06-01
SG11202000725WA (en) 2020-02-27
CN111132700A (zh) 2020-05-08
EP4424378A3 (en) 2024-12-11
EP4000640A1 (en) 2022-05-25
US20250121102A1 (en) 2025-04-17
AU2024200440A1 (en) 2024-02-08

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