CN111132700B - 双模放射性示踪剂与治疗剂 - Google Patents

双模放射性示踪剂与治疗剂 Download PDF

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Publication number
CN111132700B
CN111132700B CN201880062949.0A CN201880062949A CN111132700B CN 111132700 B CN111132700 B CN 111132700B CN 201880062949 A CN201880062949 A CN 201880062949A CN 111132700 B CN111132700 B CN 111132700B
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bond
oligomeric
acid
sifa
amide
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CN111132700A (zh
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A·J·乌泽尔
H-J·韦斯特
M·J·艾贝尔
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Technische Universitaet Muenchen
Klinikum Rechts der Isar der Technischen Universitaet Muenchen
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Technische Universitaet Muenchen
Klinikum Rechts der Isar der Technischen Universitaet Muenchen
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0402—Organic compounds carboxylic acid carriers, fatty acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Nuclear Medicine (AREA)
CN201880062949.0A 2017-07-28 2018-07-30 双模放射性示踪剂与治疗剂 Active CN111132700B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP17183795.8 2017-07-28
EP17183795 2017-07-28
PCT/EP2018/070533 WO2019020831A1 (en) 2017-07-28 2018-07-30 AGENTS WITH TWO RADIOTRATIVE AND THERAPEUTIC MODES

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CN111132700A CN111132700A (zh) 2020-05-08
CN111132700B true CN111132700B (zh) 2022-12-13

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US (4) US11413360B2 (https=)
EP (3) EP4000640A1 (https=)
JP (2) JP7059372B2 (https=)
KR (2) KR102752620B1 (https=)
CN (1) CN111132700B (https=)
AU (2) AU2018308699B2 (https=)
BR (1) BR112020001785A2 (https=)
CA (1) CA3071315A1 (https=)
DK (1) DK3658194T3 (https=)
EA (1) EA202090370A1 (https=)
ES (1) ES3011272T3 (https=)
FI (1) FI3658194T3 (https=)
HU (1) HUE070098T2 (https=)
IL (2) IL318092A (https=)
MX (2) MX2020000352A (https=)
NZ (1) NZ760537A (https=)
PL (1) PL3658194T3 (https=)
PT (1) PT3658194T (https=)
SG (1) SG11202000725WA (https=)
WO (1) WO2019020831A1 (https=)
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Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA202090370A1 (ru) 2017-07-28 2020-05-25 Технише Универзитет Мюнхен Двухрежимная радиоактивная метка и радиотерапевтическое средство
IL303420A (en) * 2019-01-30 2023-08-01 Univ Muenchen Tech Diagnostic imaging materials for cancer
CN113677375B (zh) * 2019-01-30 2024-07-23 慕尼黑工业大学 氟化硅受体取代的放射性药物及其前体
EP3917626B1 (en) * 2019-01-30 2023-05-31 Technische Universität München Psma binding dual mode radiotracer and therapeutic
CN112168978B (zh) * 2019-07-03 2022-01-11 北京大学 一种抗体偶联药物及其药物组合物与应用
WO2021086917A1 (en) * 2019-10-29 2021-05-06 The Cleveland Clinic Foundation Psma-targeting imaging agents
CN113350531A (zh) * 2020-03-02 2021-09-07 上海核力星医药科技有限公司 前列腺特异性膜抗原结合配体偶联物及其应用
GB202005282D0 (en) * 2020-04-09 2020-05-27 Blue Earth Diagnostics Ltd Pharmaceutical Formulations
WO2022018264A1 (en) 2020-07-23 2022-01-27 Technische Universität München Silicon-containing ligand compounds
CN116583527A (zh) 2020-09-03 2023-08-11 库瑞姆美国有限责任公司 用于64Cu-DOTATATE放大规模的放射性标记和制剂
EP4023250A1 (en) * 2021-01-04 2022-07-06 Technische Universität München Dual mode radiotracer and -therapeutics
US20240165281A1 (en) 2021-02-15 2024-05-23 Technische Universität München Dual mode radiotracer and therapeutics
US20240181092A1 (en) * 2021-04-02 2024-06-06 Novartis Ag Diagnostic methods of prostate cancer
KR20240008341A (ko) * 2021-05-14 2024-01-18 테크니쉐 유니베르시테트 뮌헨 방사성약제학적 소마토스타틴 수용체 리간드 및 그의 전구체
GB202108779D0 (en) 2021-06-18 2021-08-04 Blue Earth Diagnostics Ltd Si-at therapeutic/diagnostic compounds
GB202109922D0 (en) 2021-07-09 2021-08-25 Blue Earth Diagnostics Ltd Radiotracers and therapeutics binding to fibroblast activation protein (fap)
IL310066A (en) * 2021-08-05 2024-03-01 Technische Universit?T M?Nchen Ligand compounds comprising a chelating group as a bridging group
GB202113646D0 (en) 2021-09-24 2021-11-10 Blue Earth Diagnostics Ltd Method of preparation of 18F labelled silyl-fluoride compounds
CN114671806B (zh) * 2022-04-08 2024-03-01 上海如絮生物科技有限公司 一种亲水性吡啶衍生物、中间体、其制备方法及应用
GB202207372D0 (en) 2022-05-19 2022-07-06 Blue Earth Diagnostics Ltd Synthesis of fluorosilyl compounds
CA3257852A1 (en) 2022-07-29 2024-02-01 Technische Universitat Munchen Silicon Fluoride Accepting Groups for Radiopharmaceutical Products
WO2024054226A1 (en) * 2022-09-06 2024-03-14 Hoang Ba Xuan Gallium nitrate and dimethyl sulfoxide composition for respiratory treatment
JP2025532619A (ja) * 2022-09-20 2025-10-01 テクニシェ ユニバーシタット ミュンヘン イメージングおよび標的化放射線治療のための新規ミニガストリン由来コレシストキニン２受容体結合分子
AU2023347470A1 (en) 2022-09-23 2025-04-10 Nuclidium Ag High-purity copper radiopharmaceutical compositions and diagnostic and therapeutic uses thereof
TW202426433A (zh) 2022-09-23 2024-07-01 瑞士商紐利迪姆股份公司 成纖維細胞活化蛋白（ｆａｐ）抑制劑、ｆａｐ結合物及其診斷與治療用途
AU2023379454A1 (en) * 2022-11-14 2025-05-29 Aktis Oncology, Inc. Decreased retention of miniproteins in kidney
TW202530249A (zh) 2023-09-29 2025-08-01 美商雅克提斯腫瘤學公司 小蛋白、結合物及其用途
GB202316239D0 (en) 2023-10-24 2023-12-06 Blue Earth Diagnostics Ltd Therapeutic combination
WO2025250644A1 (en) * 2024-05-28 2025-12-04 Case Western Reserve University Fluorescent nuclide-containing agents for detecting and treating cancer

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016191424A2 (en) * 2015-05-26 2016-12-01 The Regents Of The University Of California Novel heteroaromatic silicon-fluoride-acceptors useful for 18f labeling of molecules and biomolecules, and methods of preparing same

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU7384394A (en) * 1993-06-30 1995-01-24 Akzo Nobel N.V. Chelating compounds
WO2003011345A1 (en) 2001-07-27 2003-02-13 Targesome, Inc. Lipid constructs as therapeutic and imaging agents
CN102626522B (zh) * 2012-04-12 2014-09-10 韩彦江 基于趋化因子受体cxcr4多肽类拮抗剂的多肽放射性诊断与治疗药物
CN106794264B (zh) * 2014-06-10 2021-03-23 3B制药有限公司 包含神经降压肽受体配体的缀合物及其用途
EP3209336B1 (en) 2014-10-20 2019-12-11 Deutsches Krebsforschungszentrum 18f-tagged inhibitors of prostate specific membrane antigen (psma), their use as imaging agents and pharmaceutical agents for the treatment of prostate cancer
US20160287730A1 (en) * 2015-03-31 2016-10-06 The United States Of America, As Represented By The Secretary, Department Of Health And Human Serv Labeled evans blue dye derivative for in vivo serum albumin labeling
EA202090370A1 (ru) 2017-07-28 2020-05-25 Технише Универзитет Мюнхен Двухрежимная радиоактивная метка и радиотерапевтическое средство
BR112020011727A2 (pt) * 2017-12-11 2020-11-17 Technische Universität München ligantes de psma para imageamento e endorradioterapia
IL303420A (en) 2019-01-30 2023-08-01 Univ Muenchen Tech Diagnostic imaging materials for cancer
EP3917626B1 (en) 2019-01-30 2023-05-31 Technische Universität München Psma binding dual mode radiotracer and therapeutic

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016191424A2 (en) * 2015-05-26 2016-12-01 The Regents Of The University Of California Novel heteroaromatic silicon-fluoride-acceptors useful for 18f labeling of molecules and biomolecules, and methods of preparing same
CA2982269A1 (en) * 2015-05-26 2016-12-01 The Regents Of The University Of California Heteroaromatic silicon-fluoride-acceptors useful for 18f labeling of molecules and biomolecules, and methods of preparing same

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
HER2 affibody分子探针在放射免疫显像中的应用;柏志成等;《放射学实践》;20170620(第06期);全文 *

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KR20240027896A (ko) 2024-03-04
US11413360B2 (en) 2022-08-16
JP2022101601A (ja) 2022-07-06
JP7059372B2 (ja) 2022-04-25
CA3071315A1 (en) 2019-01-31
EP3658194B1 (en) 2024-11-27
EP4424378A2 (en) 2024-09-04
AU2018308699A1 (en) 2020-01-23
EP3658194A1 (en) 2020-06-03
US12453787B2 (en) 2025-10-28
MX2020000352A (es) 2020-08-17
FI3658194T3 (fi) 2025-02-28
JP2020528461A (ja) 2020-09-24
US20260021211A1 (en) 2026-01-22
KR102752620B1 (ko) 2025-01-10
PL3658194T3 (pl) 2025-09-15
DK3658194T3 (da) 2025-02-17
WO2019020831A1 (en) 2019-01-31
IL318092A (en) 2025-02-01
ES3011272T3 (en) 2025-04-07
IL272291B1 (en) 2025-02-01
US12390540B2 (en) 2025-08-19
US20200197545A1 (en) 2020-06-25
AU2018308699B2 (en) 2023-11-30
MX2023007914A (es) 2023-07-13
IL272291A (en) 2020-03-31
US20220370649A1 (en) 2022-11-24
HUE070098T2 (hu) 2025-05-28
KR20200064057A (ko) 2020-06-05
BR112020001785A2 (pt) 2020-09-29
ZA202000467B (en) 2022-06-29
EA202090370A1 (ru) 2020-05-25
AU2024200440B2 (en) 2025-04-24
PT3658194T (pt) 2025-02-13
IL272291B2 (en) 2025-06-01
SG11202000725WA (en) 2020-02-27
CN111132700A (zh) 2020-05-08
EP4424378A3 (en) 2024-12-11
EP4000640A1 (en) 2022-05-25
US20250121102A1 (en) 2025-04-17
AU2024200440A1 (en) 2024-02-08

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