MX2020000352A - Marcador radioactivo de modo dual y terapeuticos. - Google Patents

Marcador radioactivo de modo dual y terapeuticos.

Info

Publication number
MX2020000352A
MX2020000352A MX2020000352A MX2020000352A MX2020000352A MX 2020000352 A MX2020000352 A MX 2020000352A MX 2020000352 A MX2020000352 A MX 2020000352A MX 2020000352 A MX2020000352 A MX 2020000352A MX 2020000352 A MX2020000352 A MX 2020000352A
Authority
MX
Mexico
Prior art keywords
radiotracer
therapeutics
dual mode
sifa
silicon
Prior art date
Application number
MX2020000352A
Other languages
English (en)
Inventor
Alexander Josef Wurzer
Hans-Jürgen Wester
Matthias Johannes Eiber
Original Assignee
Univ Muenchen Tech
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Muenchen Tech filed Critical Univ Muenchen Tech
Publication of MX2020000352A publication Critical patent/MX2020000352A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0402—Organic compounds carboxylic acid carriers, fatty acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Abstract

La presente invención se refiere a un conjugado de ligando-SIFA-quelador, que comprende, dentro de una molécula única tres porciones separadas: (a) uno o más ligandos los cuales son capaces de unirse a una molécula dirigida a la enfermedad relevante, (b) una porción aceptora de fluoruro de silicio (SIFA) la cual comprende un enlace covalente entre un átomo de silicio y un átomo de flúor, y (c) uno o más grupos quelantes, que contienen opcionalmente un catión radioactivo o no radioactivo quelado.
MX2020000352A 2017-07-28 2018-07-30 Marcador radioactivo de modo dual y terapeuticos. MX2020000352A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP17183795 2017-07-28
PCT/EP2018/070533 WO2019020831A1 (en) 2017-07-28 2018-07-30 AGENTS WITH TWO RADIOTRATIVE AND THERAPEUTIC MODES

Publications (1)

Publication Number Publication Date
MX2020000352A true MX2020000352A (es) 2020-08-17

Family

ID=59501286

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2020000352A MX2020000352A (es) 2017-07-28 2018-07-30 Marcador radioactivo de modo dual y terapeuticos.
MX2023007914A MX2023007914A (es) 2017-07-28 2020-01-10 Marcador radioactivo de modo dual y terapeuticos.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2023007914A MX2023007914A (es) 2017-07-28 2020-01-10 Marcador radioactivo de modo dual y terapeuticos.

Country Status (14)

Country Link
US (2) US11413360B2 (es)
EP (2) EP3658194A1 (es)
JP (2) JP7059372B2 (es)
KR (2) KR20240027896A (es)
CN (1) CN111132700B (es)
AU (2) AU2018308699B2 (es)
BR (1) BR112020001785A2 (es)
CA (1) CA3071315A1 (es)
EA (1) EA202090370A1 (es)
IL (1) IL272291A (es)
MX (2) MX2020000352A (es)
SG (1) SG11202000725WA (es)
WO (1) WO2019020831A1 (es)
ZA (1) ZA202000467B (es)

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* Cited by examiner, † Cited by third party
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EP3917582A1 (en) * 2019-01-30 2021-12-08 Technische Universität München Cancer diagnostic imaging agents
WO2020157128A1 (en) * 2019-01-30 2020-08-06 Technische Universität München Silicon-fluoride acceptor substituted radiopharmaceuticals and precursors thereof
EP4249456A3 (en) * 2019-01-30 2023-10-11 Technische Universität München Psma binding dual mode radiotracer and therapeutic
CN112168978B (zh) * 2019-07-03 2022-01-11 北京大学 一种抗体偶联药物及其药物组合物与应用
WO2021086917A1 (en) * 2019-10-29 2021-05-06 The Cleveland Clinic Foundation Psma-targeting imaging agents
CN113350531A (zh) * 2020-03-02 2021-09-07 上海核力星医药科技有限公司 前列腺特异性膜抗原结合配体偶联物及其应用
GB202005282D0 (en) 2020-04-09 2020-05-27 Blue Earth Diagnostics Ltd Pharmaceutical Formulations
US20230277698A1 (en) 2020-07-23 2023-09-07 Technische Universität München Silicon-containing ligand compounds
EP4023250A1 (en) 2021-01-04 2022-07-06 Technische Universität München Dual mode radiotracer and -therapeutics
CA3211030A1 (en) 2021-02-15 2022-08-18 Technische Universitat Munchen Dual mode radiotracer and therapeutics
AU2022273184A1 (en) * 2021-05-14 2023-10-12 Technische Universität München Radiopharmaceutical somatostatin receptor ligands and precursors thereof
GB202108779D0 (en) 2021-06-18 2021-08-04 Blue Earth Diagnostics Ltd Si-at therapeutic/diagnostic compounds
GB202109922D0 (en) 2021-07-09 2021-08-25 Blue Earth Diagnostics Ltd Radiotracers and therapeutics binding to fibroblast activation protein (fap)
CA3224462A1 (en) * 2021-08-05 2023-02-09 Mara PARZINGER Ligand compounds comprising a chelating group as a bridging group
GB202113646D0 (en) 2021-09-24 2021-11-10 Blue Earth Diagnostics Ltd Method of preparation of 18F labelled silyl-fluoride compounds
CN114671806B (zh) * 2022-04-08 2024-03-01 上海如絮生物科技有限公司 一种亲水性吡啶衍生物、中间体、其制备方法及应用
GB202207372D0 (en) 2022-05-19 2022-07-06 Blue Earth Diagnostics Ltd Synthesis of fluorosilyl compounds
WO2024023332A1 (en) 2022-07-29 2024-02-01 Technische Universität München Silicon-based fluoride acceptor groups for radiopharmaceuticals
WO2024054226A1 (en) * 2022-09-06 2024-03-14 Hoang Ba Xuan Gallium nitrate and dimethyl sulfoxide composition for respiratory treatment
WO2024061483A1 (en) * 2022-09-20 2024-03-28 Technische Universität München Novel minigastrin-derived cholecystokinin 2 receptor binding molecules for imaging and targeted radiotherapy

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU7384394A (en) * 1993-06-30 1995-01-24 Akzo Nobel N.V. Chelating compounds
CN102626522B (zh) * 2012-04-12 2014-09-10 韩彦江 基于趋化因子受体cxcr4多肽类拮抗剂的多肽放射性诊断与治疗药物
JP7065567B2 (ja) * 2014-06-10 2022-05-12 スリービー・ファーマシューティカルズ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング ニューロテンシン受容体リガンドを含むコンジュゲートおよびそれらの使用
US20160287730A1 (en) * 2015-03-31 2016-10-06 The United States Of America, As Represented By The Secretary, Department Of Health And Human Serv Labeled evans blue dye derivative for in vivo serum albumin labeling
CA2982269C (en) * 2015-05-26 2023-12-05 The Regents Of The University Of California Heteroaromatic silicon-fluoride-acceptors useful for 18f labeling of molecules and biomolecules, and methods of preparing same

Also Published As

Publication number Publication date
WO2019020831A1 (en) 2019-01-31
US20200197545A1 (en) 2020-06-25
AU2018308699B2 (en) 2023-11-30
US20220370649A1 (en) 2022-11-24
IL272291A (en) 2020-03-31
CN111132700B (zh) 2022-12-13
AU2018308699A1 (en) 2020-01-23
CA3071315A1 (en) 2019-01-31
AU2024200440A1 (en) 2024-02-08
CN111132700A (zh) 2020-05-08
EA202090370A1 (ru) 2020-05-25
EP3658194A1 (en) 2020-06-03
JP7059372B2 (ja) 2022-04-25
EP4000640A1 (en) 2022-05-25
JP2020528461A (ja) 2020-09-24
BR112020001785A2 (pt) 2020-09-29
SG11202000725WA (en) 2020-02-27
KR20240027896A (ko) 2024-03-04
KR20200064057A (ko) 2020-06-05
MX2023007914A (es) 2023-07-13
ZA202000467B (en) 2022-06-29
US11413360B2 (en) 2022-08-16
JP2022101601A (ja) 2022-07-06

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