JP7041166B2 - トリアリールポリアミンを含む組成物および方法 - Google Patents

トリアリールポリアミンを含む組成物および方法 Download PDF

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Publication number
JP7041166B2
JP7041166B2 JP2019554606A JP2019554606A JP7041166B2 JP 7041166 B2 JP7041166 B2 JP 7041166B2 JP 2019554606 A JP2019554606 A JP 2019554606A JP 2019554606 A JP2019554606 A JP 2019554606A JP 7041166 B2 JP7041166 B2 JP 7041166B2
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group
biofilm
composition
compound
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Japanese (ja)
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JP2020520893A5 (enExample
JP2020520893A (ja
Inventor
イー．ルーパー ライアン
ウィリアムズ ダスティン
アール．セバハー ポール
ジェイ．ホーセナー トラビス
アール．カンナ レディ ハリプラサダ
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UNIVERSITY OF UTHA RESEARCHFOUNDATION
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UNIVERSITY OF UTHA RESEARCHFOUNDATION
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C07C211/27—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring having amino groups linked to the six-membered aromatic ring by saturated carbon chains
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
    • A01N33/02—Amines; Quaternary ammonium compounds
    • A01N33/04—Nitrogen directly attached to aliphatic or cycloaliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/54—1,3-Diazines; Hydrogenated 1,3-diazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pest Control & Pesticides (AREA)
  • Agronomy & Crop Science (AREA)
  • Plant Pathology (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
JP2019554606A 2017-04-05 2018-04-05 トリアリールポリアミンを含む組成物および方法 Active JP7041166B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762482106P 2017-04-05 2017-04-05
US62/482,106 2017-04-05
PCT/US2018/026320 WO2018187615A1 (en) 2017-04-05 2018-04-05 Compositions and methods comprising a triaryl polyamine

Publications (3)

Publication Number Publication Date
JP2020520893A JP2020520893A (ja) 2020-07-16
JP2020520893A5 JP2020520893A5 (enExample) 2021-05-20
JP7041166B2 true JP7041166B2 (ja) 2022-03-23

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JP2019554606A Active JP7041166B2 (ja) 2017-04-05 2018-04-05 トリアリールポリアミンを含む組成物および方法

Country Status (7)

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US (1) US11352315B2 (enExample)
EP (1) EP3606344B1 (enExample)
JP (1) JP7041166B2 (enExample)
CN (1) CN110785082B (enExample)
AU (1) AU2018249550B2 (enExample)
CA (1) CA3058813A1 (enExample)
WO (1) WO2018187615A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0811530B1 (pt) 2007-05-14 2019-01-02 Research Foundation Of State Univ Of New York composição compreendendo indutor(es) de resposta fisiológica à dispersão ácido decanóico, superfície, solução, método ex vivo de tratamento ou inibição da formação de um biofilme sobre uma superfície
US11274144B2 (en) 2013-06-13 2022-03-15 Research Institute At Nationwide Children's Hospital Compositions and methods for the removal of biofilms
HK1255383A1 (zh) 2015-07-31 2019-08-16 The Research Institute At Nationwide Children's Hospital 去除生物膜的肽及抗體
EP3365027B1 (en) 2015-10-14 2022-03-30 Research Institute at Nationwide Children's Hospital Hu specific antibodies and their use in inhibiting biofilm
AU2018249550B2 (en) 2017-04-05 2023-11-30 Curza, Inc. Compositions and methods comprising a triaryl polyamine
US11541105B2 (en) 2018-06-01 2023-01-03 The Research Foundation For The State University Of New York Compositions and methods for disrupting biofilm formation and maintenance
WO2020006528A2 (en) * 2018-06-29 2020-01-02 Research Institute At Nationwide Children's Hospital Compositions and methods for mediating eps
MX2021003838A (es) 2018-10-05 2021-05-27 Res Inst Nationwide Childrens Hospital Derivados de proteina hmgb1 para la eliminacion de biopeliculas.
WO2021207247A1 (en) * 2020-04-07 2021-10-14 Kalin Health Llc Spermidine-supplemented food products

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005520821A (ja) 2002-03-15 2005-07-14 チバ　スペシャルティ　ケミカルズ　ホールディング　インコーポレーテッド ４−アミノピリミジン及び表面の抗菌処理のためのその使用
WO2012151554A1 (en) 2011-05-04 2012-11-08 President And Fellows Of Harvard College Polyamines for treating biofilms
JP2016526038A (ja) 2013-05-22 2016-09-01 カーザ グローバル エルエルシーＣｕｒｚａ Ｇｌｏｂａｌ， Ｌｌｃ ポリアミンを含む組成物及び方法
WO2017147335A1 (en) 2016-02-24 2017-08-31 Rutgers, The State University Of New Jersey Bacterial efflux pump inhibitors

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4038312A (en) 1975-08-22 1977-07-26 E. I. Du Pont De Nemours And Company Tricyclic phosphorous triamides
US4340756A (en) 1981-02-04 1982-07-20 Merck & Co., Inc. Polyamine compounds as antibacterial agents
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
US4505861A (en) 1982-07-23 1985-03-19 University Of Florida Methods and intermediates for the preparation of spermidine, homospermidine and norspermidine
US5316757A (en) 1984-10-18 1994-05-31 Board Of Regents, The University Of Texas System Synthesis of polyazamacrocycles with more than one type of side-chain chelating groups
HUT74005A (en) 1993-02-23 1996-10-28 Merrell Pharma Inc Polyamine derivatives as radioprotective agents and pharmaceutical compositions containing them
US5583239A (en) 1995-05-30 1996-12-10 Lehigh University Antimicrobial sterol conjugates
EP0955044B1 (en) 1995-06-26 2005-11-16 Chelator LLC Method of inhibiting bacterial or fungal growth using a complexing agent
US6077954A (en) 1996-08-01 2000-06-20 Isis Pharmaceuticals, Inc. Substituted heterocyclic compounds
US7425579B2 (en) 1998-04-21 2008-09-16 Universite Laval Methods for inhibiting activity of polyamine transporters
US6149822A (en) 1999-03-01 2000-11-21 Polymer Ventures, Inc. Bio-film control
US6395189B1 (en) 1999-03-01 2002-05-28 Polymer Ventures, Inc. Method for the control of biofilms
PL354994A1 (en) 1999-10-26 2004-03-22 Dennis A. Guritza Bio-supportive matrices, methods of making and using the same
US6555228B2 (en) 2000-10-16 2003-04-29 Dennis A. Guritza Bio-supportive medium, and methods of making and using the same
US9056048B2 (en) 2001-08-16 2015-06-16 The Trustees Of The University Of Pennsylvania Synthesis and use of cationic steroids for anti-inflammatory drug therapy
JP2005511734A (ja) 2001-12-07 2005-04-28 スリル バイオメディカル コーポレイション 癌治療用のシクロアルキル置換ポリアミンおよびそれらの合成方法
US7144920B2 (en) 2002-09-23 2006-12-05 Mediquest Therapeutics, Inc. Polyamine analogs that activate antizyme frameshifting
AU2003255482A1 (en) * 2002-10-02 2004-04-23 Merck Patent Gmbh Use of 4 amino-quinazolines as anti cancer agents
FR2860129A1 (fr) 2003-09-30 2005-04-01 Antoine Vanlaer Combinaison biocide a base de h202 et d'amine, procede et utilisation desinfectante et antimicrobienne notamment vis-a-vis du biofilm bacterien
WO2005105729A1 (en) 2004-02-13 2005-11-10 Mediquest Therapeutics, Inc. Polyamine analogs that activate antizyme frameshifting
BRPI0614805A2 (pt) 2005-08-10 2011-04-12 Univ Johns Hopkins poliaminas úteis como produtos terapêuticos antiparasìticos e anticáncer e como inibidores de demetilase lisina-especìficos
GB0526240D0 (en) 2005-12-22 2006-02-01 Novartis Ag Organic compounds
WO2008101084A2 (en) 2007-02-15 2008-08-21 National Jewish Medical And Research Center Methods and compositions for the disruption of biofilms
WO2008105441A1 (ja) 2007-02-27 2008-09-04 Ajinomoto Co., Inc. リン吸収抑制活性を有するポリアミノ酸化合物及びリン吸収抑制剤
US20080274929A1 (en) 2007-05-01 2008-11-06 Whitekettle Wilson K Method for removing microbes from surfaces
FR2925491B1 (fr) 2007-12-19 2010-09-03 Oz Biosciences Sas Nouvelle classe de lipides cationiques pour le transport d'agents actifs dans les cellules
US20110117032A1 (en) 2008-07-22 2011-05-19 Donna Gilding Santising compositions and methods
US9212131B2 (en) 2009-06-19 2015-12-15 University Of Central Florida Research Foundation, Inc. Polyamine transport inhibitors as novel therapeutics
FR2982611B1 (fr) 2011-11-16 2014-01-03 Univ Bretagne Occidentale Procedes de preparation de composes tetraazacycloalcanes fonctionnels a l'aide d'un compose cyclique bisaminal particulier.
US9346741B2 (en) 2012-03-28 2016-05-24 University Of Central Florida Research Foundation, Inc. Polyamine transport selective therapeutic agents with enhanced stability
WO2014078801A1 (en) 2012-11-16 2014-05-22 President And Fellows Of Harvard College Methods and compositions comprising guanidines for treating biofilms
US8853278B1 (en) 2013-05-22 2014-10-07 Curza Global, Llc Compositions comprising a biocidal polyamine
US9439433B2 (en) 2013-05-22 2016-09-13 Curza Global, Llc Compositions and methods comprising a biocidal polyamine
WO2017218922A2 (en) * 2016-06-17 2017-12-21 Cidara Therapeutics, Inc. Compositions and methods for the treatment of bacterial infections
AU2018249550B2 (en) 2017-04-05 2023-11-30 Curza, Inc. Compositions and methods comprising a triaryl polyamine

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005520821A (ja) 2002-03-15 2005-07-14 チバ　スペシャルティ　ケミカルズ　ホールディング　インコーポレーテッド ４−アミノピリミジン及び表面の抗菌処理のためのその使用
WO2012151554A1 (en) 2011-05-04 2012-11-08 President And Fellows Of Harvard College Polyamines for treating biofilms
JP2016526038A (ja) 2013-05-22 2016-09-01 カーザ グローバル エルエルシーＣｕｒｚａ Ｇｌｏｂａｌ， Ｌｌｃ ポリアミンを含む組成物及び方法
WO2017147335A1 (en) 2016-02-24 2017-08-31 Rutgers, The State University Of New Jersey Bacterial efflux pump inhibitors

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
MICHELA ROSINI; ET AL，STRUCTUREACTIVITY RELATIONSHIPS OF METHOCTRAMINE-RELATED POLYAMINES AS MUSCULAR 以下備考，JOURNAL OF MEDICINAL CHEMISTRY，2002年04月，VOL:45, NR:9，PAGE(S):1860 - 1878，http://dx.doi.org/10.1021/jm011067f，NICOTINIC RECEPTOR NONCOMPETITIVE ANTAGONISTS. 2. 1 ROLE OF POLYMETHYLENE CHAIN 以下省略

Also Published As

Publication number Publication date
WO2018187615A1 (en) 2018-10-11
CN110785082A (zh) 2020-02-11
EP3606344A1 (en) 2020-02-12
EP3606344B1 (en) 2022-08-17
US11352315B2 (en) 2022-06-07
AU2018249550B2 (en) 2023-11-30
US20200031757A1 (en) 2020-01-30
CA3058813A1 (en) 2018-10-11
NZ757876A (en) 2024-05-31
AU2018249550A1 (en) 2019-10-31
CN110785082B (zh) 2021-12-28
JP2020520893A (ja) 2020-07-16

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