CA3058813A1 - Compositions and methods comprising a triaryl polyamine - Google Patents

Compositions and methods comprising a triaryl polyamine Download PDF

Info

Publication number
CA3058813A1
CA3058813A1 CA3058813A CA3058813A CA3058813A1 CA 3058813 A1 CA3058813 A1 CA 3058813A1 CA 3058813 A CA3058813 A CA 3058813A CA 3058813 A CA3058813 A CA 3058813A CA 3058813 A1 CA3058813 A1 CA 3058813A1
Authority
CA
Canada
Prior art keywords
independently selected
group
compound
alkyl
aspects
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3058813A
Other languages
English (en)
French (fr)
Inventor
Ryan E. LOOPER
Dustin Williams
Paul R. Sebahar
Travis J. HAUSSENER
Hariprasada R. Kanna REDDY
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CURZA GLOBAL LLC
University of Utah Research Foundation Inc
Original Assignee
CURZA GLOBAL LLC
University of Utah Research Foundation Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CURZA GLOBAL LLC, University of Utah Research Foundation Inc filed Critical CURZA GLOBAL LLC
Publication of CA3058813A1 publication Critical patent/CA3058813A1/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C07C211/27—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring having amino groups linked to the six-membered aromatic ring by saturated carbon chains
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
    • A01N33/02—Amines; Quaternary ammonium compounds
    • A01N33/04—Nitrogen directly attached to aliphatic or cycloaliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/54—1,3-Diazines; Hydrogenated 1,3-diazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pest Control & Pesticides (AREA)
  • Agronomy & Crop Science (AREA)
  • Plant Pathology (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
CA3058813A 2017-04-05 2018-04-05 Compositions and methods comprising a triaryl polyamine Pending CA3058813A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762482106P 2017-04-05 2017-04-05
US62/482,106 2017-04-05
PCT/US2018/026320 WO2018187615A1 (en) 2017-04-05 2018-04-05 Compositions and methods comprising a triaryl polyamine

Publications (1)

Publication Number Publication Date
CA3058813A1 true CA3058813A1 (en) 2018-10-11

Family

ID=62067821

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3058813A Pending CA3058813A1 (en) 2017-04-05 2018-04-05 Compositions and methods comprising a triaryl polyamine

Country Status (7)

Country Link
US (1) US11352315B2 (enExample)
EP (1) EP3606344B1 (enExample)
JP (1) JP7041166B2 (enExample)
CN (1) CN110785082B (enExample)
AU (1) AU2018249550B2 (enExample)
CA (1) CA3058813A1 (enExample)
WO (1) WO2018187615A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101801521B (zh) 2007-05-14 2015-06-17 纽约州立大学研究基金会 生物膜中细菌细胞内的生理学分散响应诱导
US11274144B2 (en) 2013-06-13 2022-03-15 Research Institute At Nationwide Children's Hospital Compositions and methods for the removal of biofilms
EP3328429B1 (en) 2015-07-31 2025-07-16 The Research Institute at Nationwide Children's Hospital Peptides and antibodies for the removal of biofilms
WO2017066719A2 (en) 2015-10-14 2017-04-20 Research Institute At Nationwide Children's Hospital Hu specific interfering agents
AU2018249550B2 (en) 2017-04-05 2023-11-30 Curza, Inc. Compositions and methods comprising a triaryl polyamine
US11541105B2 (en) 2018-06-01 2023-01-03 The Research Foundation For The State University Of New York Compositions and methods for disrupting biofilm formation and maintenance
CN112672736A (zh) * 2018-06-29 2021-04-16 国家儿童医院研究所 用于介导eps的组合物和方法
WO2020072993A1 (en) 2018-10-05 2020-04-09 Research Institute At Nationwide Children's Hospital Hmgb1 protein derivatives for the removal of biofilms cross-reference to related application
EP4132492A4 (en) * 2020-04-07 2024-08-14 Kalin Health LLC FOOD PRODUCTS CONTAINING SPERMIDINE SUPPLEMENT

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4038312A (en) 1975-08-22 1977-07-26 E. I. Du Pont De Nemours And Company Tricyclic phosphorous triamides
US4340756A (en) 1981-02-04 1982-07-20 Merck & Co., Inc. Polyamine compounds as antibacterial agents
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
US4505861A (en) 1982-07-23 1985-03-19 University Of Florida Methods and intermediates for the preparation of spermidine, homospermidine and norspermidine
US5316757A (en) 1984-10-18 1994-05-31 Board Of Regents, The University Of Texas System Synthesis of polyazamacrocycles with more than one type of side-chain chelating groups
FI953935A7 (fi) 1993-02-23 1995-09-13 Merrell Dow Pharma Polyamiinijohdannaisia radiosuojaavina aineina
US5583239A (en) 1995-05-30 1996-12-10 Lehigh University Antimicrobial sterol conjugates
EP0841951A2 (en) 1995-06-26 1998-05-20 Concat Ltd. Compounds with chelation affinity and selectivity for first transition series elements, and their use in medical therapy and diagnosis
US6077954A (en) 1996-08-01 2000-06-20 Isis Pharmaceuticals, Inc. Substituted heterocyclic compounds
US7425579B2 (en) 1998-04-21 2008-09-16 Universite Laval Methods for inhibiting activity of polyamine transporters
US6395189B1 (en) 1999-03-01 2002-05-28 Polymer Ventures, Inc. Method for the control of biofilms
US6149822A (en) 1999-03-01 2000-11-21 Polymer Ventures, Inc. Bio-film control
PL354994A1 (en) 1999-10-26 2004-03-22 Dennis A. Guritza Bio-supportive matrices, methods of making and using the same
US6555228B2 (en) 2000-10-16 2003-04-29 Dennis A. Guritza Bio-supportive medium, and methods of making and using the same
US9056048B2 (en) 2001-08-16 2015-06-16 The Trustees Of The University Of Pennsylvania Synthesis and use of cationic steroids for anti-inflammatory drug therapy
WO2003050072A1 (en) 2001-12-07 2003-06-19 Slil Biomedical Corporation Cycloalkyl substituted polyamines for cancer therapy and methods of synthesis therefor
WO2003077656A1 (en) * 2002-03-15 2003-09-25 Ciba Specialty Chemicals Holding Inc. 4-aminopyrimidines and their use for the antimicrobial treatment of surfaces
US7144920B2 (en) 2002-09-23 2006-12-05 Mediquest Therapeutics, Inc. Polyamine analogs that activate antizyme frameshifting
AU2003255482A1 (en) * 2002-10-02 2004-04-23 Merck Patent Gmbh Use of 4 amino-quinazolines as anti cancer agents
FR2860129A1 (fr) 2003-09-30 2005-04-01 Antoine Vanlaer Combinaison biocide a base de h202 et d'amine, procede et utilisation desinfectante et antimicrobienne notamment vis-a-vis du biofilm bacterien
AU2004319105A1 (en) 2004-03-29 2005-11-10 Mediquest Therapeutics, Inc. Polyamine analogs that activate antizyme frameshifting
BRPI0614805A2 (pt) 2005-08-10 2011-04-12 Univ Johns Hopkins poliaminas úteis como produtos terapêuticos antiparasìticos e anticáncer e como inibidores de demetilase lisina-especìficos
GB0526240D0 (en) 2005-12-22 2006-02-01 Novartis Ag Organic compounds
EP2114460B1 (en) 2007-02-15 2014-07-16 National Jewish Health Compositions for the disruption of biofilms
WO2008105441A1 (ja) 2007-02-27 2008-09-04 Ajinomoto Co., Inc. リン吸収抑制活性を有するポリアミノ酸化合物及びリン吸収抑制剤
US20080274929A1 (en) 2007-05-01 2008-11-06 Whitekettle Wilson K Method for removing microbes from surfaces
FR2925491B1 (fr) 2007-12-19 2010-09-03 Oz Biosciences Sas Nouvelle classe de lipides cationiques pour le transport d'agents actifs dans les cellules
US20110117032A1 (en) 2008-07-22 2011-05-19 Donna Gilding Santising compositions and methods
US9212131B2 (en) 2009-06-19 2015-12-15 University Of Central Florida Research Foundation, Inc. Polyamine transport inhibitors as novel therapeutics
WO2012151555A1 (en) 2011-05-04 2012-11-08 President And Fellows Of Harvard College Methods and coatings for treating biofilms
FR2982611B1 (fr) 2011-11-16 2014-01-03 Univ Bretagne Occidentale Procedes de preparation de composes tetraazacycloalcanes fonctionnels a l'aide d'un compose cyclique bisaminal particulier.
WO2013148230A1 (en) 2012-03-28 2013-10-03 University Of Central Florida Research Foundation, Inc. Polyamine transport selective therapeutic agents with enhanced stability
WO2014078801A1 (en) 2012-11-16 2014-05-22 President And Fellows Of Harvard College Methods and compositions comprising guanidines for treating biofilms
JP6417404B2 (ja) * 2013-05-22 2018-11-07 カーザ グローバル エルエルシーＣｕｒｚａ Ｇｌｏｂａｌ， Ｌｌｃ ポリアミンを含む組成物及び方法
US9439433B2 (en) 2013-05-22 2016-09-13 Curza Global, Llc Compositions and methods comprising a biocidal polyamine
US8853278B1 (en) 2013-05-22 2014-10-07 Curza Global, Llc Compositions comprising a biocidal polyamine
US10836706B2 (en) * 2016-02-24 2020-11-17 Rutgers, The State University Of New Jersey Bacterial efflux pump inhibitors
WO2017218922A2 (en) * 2016-06-17 2017-12-21 Cidara Therapeutics, Inc. Compositions and methods for the treatment of bacterial infections
AU2018249550B2 (en) 2017-04-05 2023-11-30 Curza, Inc. Compositions and methods comprising a triaryl polyamine

Also Published As

Publication number Publication date
NZ757876A (en) 2024-05-31
AU2018249550A1 (en) 2019-10-31
JP7041166B2 (ja) 2022-03-23
US11352315B2 (en) 2022-06-07
US20200031757A1 (en) 2020-01-30
WO2018187615A1 (en) 2018-10-11
CN110785082B (zh) 2021-12-28
JP2020520893A (ja) 2020-07-16
CN110785082A (zh) 2020-02-11
EP3606344A1 (en) 2020-02-12
EP3606344B1 (en) 2022-08-17
AU2018249550B2 (en) 2023-11-30

Similar Documents

Publication Publication Date Title
US11352315B2 (en) Compositions and methods comprising a triaryl polyamine
US9220267B2 (en) Methods of use comprising a biocidal polyamine
CA2913162C (en) Compositions and methods comprising a polyamine
US10440955B2 (en) Methods comprising a biocidal polyamine
US20130071439A1 (en) Methods and compositions for treating biofilms
US20140056951A1 (en) Methods and compositions for treating biofilms
EP3334439A1 (en) Antimicrobial preparation and uses thereof
RU2741764C2 (ru) Лизобактин для применения для лечения коровьего мастита
US20030216361A1 (en) Therapeutic compositions effective against gram positive bacteria
NZ715457B2 (en) Compositions and methods comprising a polyamine

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20230331

EEER Examination request

Effective date: 20230331

EEER Examination request

Effective date: 20230331