JP7030109B2 - Ｃｄ３結合抗体 - Google Patents

Ｃｄ３結合抗体 Download PDF

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JP7030109B2
JP7030109B2 JP2019514099A JP2019514099A JP7030109B2 JP 7030109 B2 JP7030109 B2 JP 7030109B2 JP 2019514099 A JP2019514099 A JP 2019514099A JP 2019514099 A JP2019514099 A JP 2019514099A JP 7030109 B2 JP7030109 B2 JP 7030109B2
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heavy chain
multispecific antibody
domain
antibody
sequence
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JP2019536430A (ja
JP2019536430A5 (enExample
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ネイサン トリンクライン，
ショーテン， ウィム ヴァン
シェリー フォース オルドレッド，
キャサリン ハリス，
デュイ ファム，
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テネオバイオ， インコーポレイテッド
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Publication of JP2019536430A5 publication Critical patent/JP2019536430A5/ja
Priority to JP2022000116A priority Critical patent/JP7321303B2/ja
Priority to JP2022000115A priority patent/JP7431868B2/ja
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Priority to JP2023120345A priority patent/JP2023156342A/ja
Priority to JP2023190748A priority patent/JP7521728B2/ja
Priority to JP2023190749A priority patent/JP7521729B2/ja
Priority to JP2024110717A priority patent/JP2024153676A/ja
Priority to JP2025167195A priority patent/JP2026021330A/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/515—Complete light chain, i.e. VL + CL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2019514099A 2016-09-14 2017-06-20 Ｃｄ３結合抗体 Active JP7030109B2 (ja)

Priority Applications (7)

Application Number Priority Date Filing Date Title
JP2022000115A JP7431868B2 (ja) 2016-09-14 2022-01-04 Ｃｄ３結合抗体
JP2022000116A JP7321303B2 (ja) 2016-09-14 2022-01-04 Ｃｄ３結合抗体
JP2023120345A JP2023156342A (ja) 2016-09-14 2023-07-25 Ｃｄ３結合抗体
JP2023190748A JP7521728B2 (ja) 2016-09-14 2023-11-08 Ｃｄ３結合抗体
JP2023190749A JP7521729B2 (ja) 2016-09-14 2023-11-08 Ｃｄ３結合抗体
JP2024110717A JP2024153676A (ja) 2016-09-14 2024-07-10 Ｃｄ３結合抗体
JP2025167195A JP2026021330A (ja) 2016-09-14 2025-10-03 Ｃｄ３結合抗体

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662394360P 2016-09-14 2016-09-14
US62/394,360 2016-09-14
US201762491908P 2017-04-28 2017-04-28
US62/491,908 2017-04-28
PCT/US2017/038377 WO2018052503A1 (en) 2016-09-14 2017-06-20 Cd3 binding antibodies

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JP2022000116A Division JP7321303B2 (ja) 2016-09-14 2022-01-04 Ｃｄ３結合抗体
JP2022000115A Division JP7431868B2 (ja) 2016-09-14 2022-01-04 Ｃｄ３結合抗体

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JP2019536430A JP2019536430A (ja) 2019-12-19
JP2019536430A5 JP2019536430A5 (enExample) 2020-08-06
JP7030109B2 true JP7030109B2 (ja) 2022-03-04

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JP2019514099A Active JP7030109B2 (ja) 2016-09-14 2017-06-20 Ｃｄ３結合抗体
JP2022000115A Active JP7431868B2 (ja) 2016-09-14 2022-01-04 Ｃｄ３結合抗体
JP2022000116A Active JP7321303B2 (ja) 2016-09-14 2022-01-04 Ｃｄ３結合抗体
JP2023120345A Pending JP2023156342A (ja) 2016-09-14 2023-07-25 Ｃｄ３結合抗体
JP2023190748A Active JP7521728B2 (ja) 2016-09-14 2023-11-08 Ｃｄ３結合抗体
JP2023190749A Active JP7521729B2 (ja) 2016-09-14 2023-11-08 Ｃｄ３結合抗体
JP2024110717A Pending JP2024153676A (ja) 2016-09-14 2024-07-10 Ｃｄ３結合抗体
JP2025167195A Pending JP2026021330A (ja) 2016-09-14 2025-10-03 Ｃｄ３結合抗体

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JP2022000115A Active JP7431868B2 (ja) 2016-09-14 2022-01-04 Ｃｄ３結合抗体
JP2022000116A Active JP7321303B2 (ja) 2016-09-14 2022-01-04 Ｃｄ３結合抗体
JP2023120345A Pending JP2023156342A (ja) 2016-09-14 2023-07-25 Ｃｄ３結合抗体
JP2023190748A Active JP7521728B2 (ja) 2016-09-14 2023-11-08 Ｃｄ３結合抗体
JP2023190749A Active JP7521729B2 (ja) 2016-09-14 2023-11-08 Ｃｄ３結合抗体
JP2024110717A Pending JP2024153676A (ja) 2016-09-14 2024-07-10 Ｃｄ３結合抗体
JP2025167195A Pending JP2026021330A (ja) 2016-09-14 2025-10-03 Ｃｄ３結合抗体

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US (6) US11505606B2 (enExample)
EP (3) EP4050034B1 (enExample)
JP (8) JP7030109B2 (enExample)
KR (5) KR102507537B1 (enExample)
CN (3) CN109843325B (enExample)
AU (2) AU2017327723B2 (enExample)
BR (2) BR122022002481A8 (enExample)
CA (1) CA3036550A1 (enExample)
CL (4) CL2019000643A1 (enExample)
CO (1) CO2019003706A2 (enExample)
CR (3) CR20220408A (enExample)
DK (1) DK4050034T3 (enExample)
DO (3) DOP2019000059A (enExample)
EC (1) ECSP19026304A (enExample)
ES (1) ES2980623T3 (enExample)
FI (1) FI4050034T3 (enExample)
HR (1) HRP20240767T1 (enExample)
HU (1) HUE066651T2 (enExample)
IL (3) IL290517B2 (enExample)
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MX (4) MX2019002967A (enExample)
MY (1) MY200988A (enExample)
PE (2) PE20190976A1 (enExample)
PH (1) PH12019500545A1 (enExample)
PL (1) PL4050034T3 (enExample)
PT (1) PT4050034T (enExample)
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SA (2) SA523442262B1 (enExample)
SI (1) SI4050034T1 (enExample)
UA (1) UA126384C2 (enExample)
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Cited By (2)

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JP2021508479A (ja) * 2017-12-27 2021-03-11 テネオバイオ， インコーポレイテッド ヘテロ二量体特異的抗体上のｃｄ３デルタ及びｃｄ３イプシロン
US12371505B2 (en) 2016-12-21 2025-07-29 Teneobio, Inc. Anti-BCMA heavy chain-only antibodies

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CN109641049B (zh) * 2016-06-21 2023-07-07 特尼奥生物股份有限公司 Cd3结合抗体
RU2762835C2 (ru) 2016-08-24 2021-12-23 Тенеобио, Инк. Трансгенные животные, отличные от человека, продуцирующие модифицированные антитела, содержащие только тяжелые цепи
MY200988A (en) * 2016-09-14 2024-01-27 Teneobio Inc CD3 Binding Antibodies
IL312322B2 (en) * 2017-06-20 2026-05-01 Teneobio Inc Antibodies against BCMA containing only heavy chains
WO2018237006A1 (en) 2017-06-20 2018-12-27 Teneoone, Inc. Anti-bcma heavy chain-only antibodies
WO2019126756A1 (en) 2017-12-22 2019-06-27 Teneobio, Inc. Heavy chain antibodies binding to cd22
CN112912397B (zh) 2018-05-24 2025-03-14 詹森生物科技公司 抗cd3抗体及其用途
MX2021000532A (es) 2018-07-19 2021-04-12 Regeneron Pharma Receptores antigénicos quiméricos con especificidad para bcma y usos de estos.
TWI838389B (zh) 2018-07-19 2024-04-11 美商再生元醫藥公司 雙特異性抗-BCMAｘ抗-CD3抗體及其用途
BR112020024074A2 (pt) 2018-07-20 2021-02-17 Teneobio, Inc. anticorpos de cadeia pesada com ligação a cd19
US10867104B2 (en) * 2018-08-31 2020-12-15 Taiwan Semiconductor Manufacturing Company Ltd. Isolation circuit between power domains
CN112955467A (zh) 2018-10-26 2021-06-11 特尼奥生物股份有限公司 与cd38结合的重链抗体
CR20210500A (es) * 2019-04-05 2021-11-05 Teneobio Inc Anticuerpos de cadena pesada que se unen al psma
JP7665538B2 (ja) * 2019-06-14 2025-04-21 テネオバイオ， インコーポレイテッド Ｃｄ２２及びｃｄ３に結合する多重特異性重鎖抗体
AU2020298104A1 (en) * 2019-06-21 2022-02-24 Università Degli Studi Magna Graecia Catanzaro Monoclonal antibody targeting a unique cancer-associated epitope of CD43
EP4004050A2 (en) * 2019-07-30 2022-06-01 QLSF Biotherapeutics Inc. Multispecific binding compound that bind to lfrrc15 and cd3
CN112574308A (zh) * 2019-09-30 2021-03-30 和铂医药(苏州)有限公司 靶向bcma的抗体、双特异性抗体及其用途
CN115023441A (zh) 2019-12-18 2022-09-06 特诺福尔股份有限公司 与cd38结合的重链抗体
WO2021222578A1 (en) 2020-04-29 2021-11-04 Teneobio, Inc. Multispecific heavy chain antibodies with modified heavy chain constant regions
WO2021222616A1 (en) 2020-04-29 2021-11-04 Teneobio, Inc. Methods of treating multiple myeloma
IL297601A (en) 2020-04-29 2022-12-01 Teneobio Inc Multispecific heavy chain antibodies with modified heavy chain constant regions
CA3184189A1 (en) 2020-05-27 2021-12-02 Janssen Biotech, Inc. Proteins comprising cd3 antigen binding domains and uses thereof
PE20230464A1 (es) 2020-06-30 2023-03-14 Teneobio Inc Union de anticuerpos multiespecificos a bcma
WO2022060901A1 (en) 2020-09-16 2022-03-24 Amgen Inc. Methods for administering therapeutic doses of bispecific t-cell engaging molecules for the treatment of cancer
EP3991796A1 (en) * 2020-10-27 2022-05-04 Lindis Blood Care GmbH An ex vivo method for removal of tumor cells from intra-operatively salvaged blood
TW202233684A (zh) 2020-11-18 2022-09-01 美商泰尼歐生物公司 結合於葉酸受體α之重鏈抗體
JP2024507540A (ja) 2021-02-25 2024-02-20 テネオバイオ， インコーポレイテッド 抗ｐｓｍａ抗体及びｃａｒ－ｔ構造
CA3211142A1 (en) 2021-02-26 2022-09-01 Teneobio, Inc. Anti-muc1-c antibodies and car-t structures
TW202304994A (zh) 2021-04-02 2023-02-01 美商泰尼歐生物公司 促效性抗ｉｌ－２ｒ抗體及使用方法
KR20230166090A (ko) 2021-04-06 2023-12-06 테네오바이오, 인코포레이티드 항-cd19 항체 및 car-t 구조체
KR20230171952A (ko) 2021-04-16 2023-12-21 테네오바이오, 인코포레이티드 항-cd20 항체 및 car-t 구조
WO2022271987A1 (en) 2021-06-23 2022-12-29 TeneoFour, Inc. Anti-cd38 antibodies and epitopes of same
CN119569887A (zh) * 2021-06-24 2025-03-07 益科思特(北京)医药科技发展有限公司 结合bcma和cd3的双特异性抗体及其制备方法与应用
WO2023288191A1 (en) * 2021-07-13 2023-01-19 University Of Washington Multiple de novo designed protein binding proteins
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