JP7025432B2 - Ｃｙｐ１１ａ１（チトクロムｐ４５０モノオキシゲナーゼ１１ａ１）阻害剤としてのピラン誘導体 - Google Patents
Ｃｙｐ１１ａ１（チトクロムｐ４５０モノオキシゲナーゼ１１ａ１）阻害剤としてのピラン誘導体 Download PDFInfo
- Publication number
- JP7025432B2 JP7025432B2 JP2019534192A JP2019534192A JP7025432B2 JP 7025432 B2 JP7025432 B2 JP 7025432B2 JP 2019534192 A JP2019534192 A JP 2019534192A JP 2019534192 A JP2019534192 A JP 2019534192A JP 7025432 B2 JP7025432 B2 JP 7025432B2
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- pyran
- compound
- methyl
- isoindoline
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 0 *CC(C1)=CCc2c1cccc2 Chemical compound *CC(C1)=CCc2c1cccc2 0.000 description 17
- UHEVNPHRPRHQGH-UHFFFAOYSA-N BrCC1CCNCC1 Chemical compound BrCC1CCNCC1 UHEVNPHRPRHQGH-UHFFFAOYSA-N 0.000 description 1
- GOCGWQXAPGQXGA-UHFFFAOYSA-N C#CCNC(c1ccc(CCl)cc1)=O Chemical compound C#CCNC(c1ccc(CCl)cc1)=O GOCGWQXAPGQXGA-UHFFFAOYSA-N 0.000 description 1
- HTAJKFUPEFNKQD-UHFFFAOYSA-N C/C=S(\c1ccc(COC2=COC(CN3Cc4ccccc4C3)=CC2=O)cc1)/N(C)C(C)=O Chemical compound C/C=S(\c1ccc(COC2=COC(CN3Cc4ccccc4C3)=CC2=O)cc1)/N(C)C(C)=O HTAJKFUPEFNKQD-UHFFFAOYSA-N 0.000 description 1
- XDTMQSROBMDMFD-UHFFFAOYSA-N C1CCCCC1 Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 description 1
- WLNQPBMEFYCTOG-UHFFFAOYSA-N C1S[N]1(C1)Cc2c1cccc2 Chemical compound C1S[N]1(C1)Cc2c1cccc2 WLNQPBMEFYCTOG-UHFFFAOYSA-N 0.000 description 1
- JTOCXIOOHUCNJB-UHFFFAOYSA-N C=[Br]c1c[n](-c2ccc(CBr)cc2)nc1 Chemical compound C=[Br]c1c[n](-c2ccc(CBr)cc2)nc1 JTOCXIOOHUCNJB-UHFFFAOYSA-N 0.000 description 1
- KCZCJKYDDRQUKC-UHFFFAOYSA-N CC(C)C(N1CCC(COC2=COC(CN3Cc4ccccc4C3)=CC2=O)CC1)O Chemical compound CC(C)C(N1CCC(COC2=COC(CN3Cc4ccccc4C3)=CC2=O)CC1)O KCZCJKYDDRQUKC-UHFFFAOYSA-N 0.000 description 1
- FJATZRCLBFVHER-UHFFFAOYSA-N CC(CC1)=CC1S Chemical compound CC(CC1)=CC1S FJATZRCLBFVHER-UHFFFAOYSA-N 0.000 description 1
- QBLSEYFSECQFHK-UHFFFAOYSA-N CCCCCCNC(c1ccc(CCl)cc1)=O Chemical compound CCCCCCNC(c1ccc(CCl)cc1)=O QBLSEYFSECQFHK-UHFFFAOYSA-N 0.000 description 1
- VZIKCNLKNWDJSA-UHFFFAOYSA-N CCCCNC(c1ccc(CCl)cc1)=O Chemical compound CCCCNC(c1ccc(CCl)cc1)=O VZIKCNLKNWDJSA-UHFFFAOYSA-N 0.000 description 1
- KZBDMXFIDCWCOU-UHFFFAOYSA-N CCN(CC)C(c1ccc(CCl)cc1)=O Chemical compound CCN(CC)C(c1ccc(CCl)cc1)=O KZBDMXFIDCWCOU-UHFFFAOYSA-N 0.000 description 1
- IACYGTPEKZKTBS-UHFFFAOYSA-N CCN=S(C)(c1ccc(CCl)cc1)=O Chemical compound CCN=S(C)(c1ccc(CCl)cc1)=O IACYGTPEKZKTBS-UHFFFAOYSA-N 0.000 description 1
- MXQKRJBRKTTYMU-UHFFFAOYSA-N CN(C)C(C(CC1)CCC1C(OC)=O)=O Chemical compound CN(C)C(C(CC1)CCC1C(OC)=O)=O MXQKRJBRKTTYMU-UHFFFAOYSA-N 0.000 description 1
- CMXBYINWLGVYBA-BUSXIPJBSA-N CN(C1C[C@@H](COC2=COC(CN3Cc4ccccc4C3)=CC2=O)CC1)S=O Chemical compound CN(C1C[C@@H](COC2=COC(CN3Cc4ccccc4C3)=CC2=O)CC1)S=O CMXBYINWLGVYBA-BUSXIPJBSA-N 0.000 description 1
- AZWJQOPYJHSPRA-UHFFFAOYSA-N CN(Cc1c2ccc(CO)c1)C2=O Chemical compound CN(Cc1c2ccc(CO)c1)C2=O AZWJQOPYJHSPRA-UHFFFAOYSA-N 0.000 description 1
- DTEXILGOBOJCQG-UHFFFAOYSA-N CNC(C1CCC(CO)CC1)=O Chemical compound CNC(C1CCC(CO)CC1)=O DTEXILGOBOJCQG-UHFFFAOYSA-N 0.000 description 1
- SLHBCCWDHOSOHN-UHFFFAOYSA-N CNS(C1=CCC(CBr)C=C1)(=O)=O Chemical compound CNS(C1=CCC(CBr)C=C1)(=O)=O SLHBCCWDHOSOHN-UHFFFAOYSA-N 0.000 description 1
- ZQJNPHCQABYENK-UHFFFAOYSA-N COC(C(CC1)CCC1C(O)=O)=O Chemical compound COC(C(CC1)CCC1C(O)=O)=O ZQJNPHCQABYENK-UHFFFAOYSA-N 0.000 description 1
- LOIAOYYTUMKKCK-UHFFFAOYSA-N CS(N1CCC(COC2=COC(CCl)=CC2=O)CC1)(=O)=O Chemical compound CS(N1CCC(COC2=COC(CCl)=CC2=O)CC1)(=O)=O LOIAOYYTUMKKCK-UHFFFAOYSA-N 0.000 description 1
- DFBVGWUMJXPNCG-UHFFFAOYSA-N CS(N1CCC(COC2=COC(CN(Cc3ccc4F)Cc3c4F)=CC2=O)CC1)(=O)=O Chemical compound CS(N1CCC(COC2=COC(CN(Cc3ccc4F)Cc3c4F)=CC2=O)CC1)(=O)=O DFBVGWUMJXPNCG-UHFFFAOYSA-N 0.000 description 1
- OXJSFIXGFSSETB-UHFFFAOYSA-N CS(c1ccc(CCl)cc1)(=N)=O Chemical compound CS(c1ccc(CCl)cc1)(=N)=O OXJSFIXGFSSETB-UHFFFAOYSA-N 0.000 description 1
- FEIVTHCUCOBCNA-UHFFFAOYSA-N CSc1ccc(CN(CC(OC=C2O)=CC2=O)C2)c2c1 Chemical compound CSc1ccc(CN(CC(OC=C2O)=CC2=O)C2)c2c1 FEIVTHCUCOBCNA-UHFFFAOYSA-N 0.000 description 1
- QHNOFICCGDHAGY-UHFFFAOYSA-N Cc(cc1)ccc1S(N=S(C)(c1ccc(CCl)cc1)=O)(=O)=O Chemical compound Cc(cc1)ccc1S(N=S(C)(c1ccc(CCl)cc1)=O)(=O)=O QHNOFICCGDHAGY-UHFFFAOYSA-N 0.000 description 1
- WNWYEAGEJSMPJW-UHFFFAOYSA-N Cc(cc1)ccc1S(OCC(CC1)CCN1C(C1CC1)=O)(=O)=O Chemical compound Cc(cc1)ccc1S(OCC(CC1)CCN1C(C1CC1)=O)(=O)=O WNWYEAGEJSMPJW-UHFFFAOYSA-N 0.000 description 1
- GEIUZTVZSHDJOO-UHFFFAOYSA-N Cc(cc1)ccc1S(OCC(CC1)CCN1C(CS(C)(=O)=O)=O)(=O)=O Chemical compound Cc(cc1)ccc1S(OCC(CC1)CCN1C(CS(C)(=O)=O)=O)(=O)=O GEIUZTVZSHDJOO-UHFFFAOYSA-N 0.000 description 1
- KFNQAYDGVQSDFT-UHFFFAOYSA-N ClCc(cc1)ccc1-[n]1nncc1 Chemical compound ClCc(cc1)ccc1-[n]1nncc1 KFNQAYDGVQSDFT-UHFFFAOYSA-N 0.000 description 1
- FOMQOEHZFJEHAP-UHFFFAOYSA-N Fc1ccc(CNC2)c2c1F Chemical compound Fc1ccc(CNC2)c2c1F FOMQOEHZFJEHAP-UHFFFAOYSA-N 0.000 description 1
- XCVZLKJBFRDHMR-UHFFFAOYSA-N NC(c1cc(F)c(CBr)cc1)=O Chemical compound NC(c1cc(F)c(CBr)cc1)=O XCVZLKJBFRDHMR-UHFFFAOYSA-N 0.000 description 1
- WGXYNHYXVDRNCU-MBIQTGHCSA-N NC1C[C@@H](COC2=COC(CN(C3)Cc4c3cccc4)=CC2=O)CC1 Chemical compound NC1C[C@@H](COC2=COC(CN(C3)Cc4c3cccc4)=CC2=O)CC1 WGXYNHYXVDRNCU-MBIQTGHCSA-N 0.000 description 1
- BMOCIRHCNKTQGC-UHFFFAOYSA-N O=C(C(F)(F)F)N1CCC(COC2=COC(CN3Cc4ccccc4C3)CC2=O)CC1 Chemical compound O=C(C(F)(F)F)N1CCC(COC2=COC(CN3Cc4ccccc4C3)CC2=O)CC1 BMOCIRHCNKTQGC-UHFFFAOYSA-N 0.000 description 1
- ARMMDQIVPBFNLH-UHFFFAOYSA-N OC(c1c2cc(C(F)(F)F)cc1)N(CC(OC=C1O)=CC1=O)C2=O Chemical compound OC(c1c2cc(C(F)(F)F)cc1)N(CC(OC=C1O)=CC1=O)C2=O ARMMDQIVPBFNLH-UHFFFAOYSA-N 0.000 description 1
- GYISJBANZFFZCW-UHFFFAOYSA-N OC(c1cc(C(F)(F)F)ccc11)N(CC(OC=C2O)=CC2=O)C1=O Chemical compound OC(c1cc(C(F)(F)F)ccc11)N(CC(OC=C2O)=CC2=O)C1=O GYISJBANZFFZCW-UHFFFAOYSA-N 0.000 description 1
- LFMGJNUSGPWNMW-UHFFFAOYSA-N OC1(COC1)c1ccc(CCl)cc1 Chemical compound OC1(COC1)c1ccc(CCl)cc1 LFMGJNUSGPWNMW-UHFFFAOYSA-N 0.000 description 1
- MZSBKRMQLAGNEK-UHFFFAOYSA-N OC1=COC(CN(C2)Cc3c2ccc(OC(F)(F)F)c3)=CC1=O Chemical compound OC1=COC(CN(C2)Cc3c2ccc(OC(F)(F)F)c3)=CC1=O MZSBKRMQLAGNEK-UHFFFAOYSA-N 0.000 description 1
- RZYWTDLWXFNYNS-UHFFFAOYSA-N OC1=COC(CN(C2)Cc3c2cccc3)=CC1=O Chemical compound OC1=COC(CN(C2)Cc3c2cccc3)=CC1=O RZYWTDLWXFNYNS-UHFFFAOYSA-N 0.000 description 1
- MHSHKYQGEAQPMA-UHFFFAOYSA-N OC1=COC(CN(CC2)Cc3c2cccc3)=CC1=O Chemical compound OC1=COC(CN(CC2)Cc3c2cccc3)=CC1=O MHSHKYQGEAQPMA-UHFFFAOYSA-N 0.000 description 1
- JILNWDWVBOWNCJ-UHFFFAOYSA-N OC1=COC(CN(Cc2c3ccc(C(F)(F)F)c2)C3=O)=CC1=O Chemical compound OC1=COC(CN(Cc2c3ccc(C(F)(F)F)c2)C3=O)=CC1=O JILNWDWVBOWNCJ-UHFFFAOYSA-N 0.000 description 1
- JMAIKCGJGUXCKD-UHFFFAOYSA-N OC1=COC(CN(Cc2ccc(C(F)(F)I)cc22)C2=O)=CC1=O Chemical compound OC1=COC(CN(Cc2ccc(C(F)(F)I)cc22)C2=O)=CC1=O JMAIKCGJGUXCKD-UHFFFAOYSA-N 0.000 description 1
- JPHFBBBHVANQIH-UHFFFAOYSA-N OC1=COC(CN(Cc2ccc3)Cc2c3I)=CC1=O Chemical compound OC1=COC(CN(Cc2ccc3)Cc2c3I)=CC1=O JPHFBBBHVANQIH-UHFFFAOYSA-N 0.000 description 1
- UGKPDUFAKNBONO-UHFFFAOYSA-N OCC1CCC(CN(CCC2)S2(=O)=O)CC1 Chemical compound OCC1CCC(CN(CCC2)S2(=O)=O)CC1 UGKPDUFAKNBONO-UHFFFAOYSA-N 0.000 description 1
- ZCTWNRBXLSRJCL-UHFFFAOYSA-N OCCCNC(c1ccc(CCl)cc1)=O Chemical compound OCCCNC(c1ccc(CCl)cc1)=O ZCTWNRBXLSRJCL-UHFFFAOYSA-N 0.000 description 1
- OPLCYGTZYZLOKI-UHFFFAOYSA-N ON(C1)Cc2c1cccc2 Chemical compound ON(C1)Cc2c1cccc2 OPLCYGTZYZLOKI-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/056—Ortho-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Steroid Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyrane Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022019891A JP7286825B2 (ja) | 2016-12-22 | 2022-02-10 | Ｃｙｐ１１ａ１（チトクロムｐ４５０モノオキシゲナーゼ１１ａ１）阻害剤としてのピラン誘導体 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI20166024 | 2016-12-22 | ||
| FI20166024 | 2016-12-22 | ||
| PCT/FI2017/050926 WO2018115591A1 (en) | 2016-12-22 | 2017-12-21 | Pyran dervatives as cyp11a1 (cytochrome p450 monooxygenase 11a1) inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022019891A Division JP7286825B2 (ja) | 2016-12-22 | 2022-02-10 | Ｃｙｐ１１ａ１（チトクロムｐ４５０モノオキシゲナーゼ１１ａ１）阻害剤としてのピラン誘導体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020502229A JP2020502229A (ja) | 2020-01-23 |
| JP2020502229A5 JP2020502229A5 (enExample) | 2021-09-30 |
| JP7025432B2 true JP7025432B2 (ja) | 2022-02-24 |
Family
ID=61005837
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019534192A Active JP7025432B2 (ja) | 2016-12-22 | 2017-12-21 | Ｃｙｐ１１ａ１（チトクロムｐ４５０モノオキシゲナーゼ１１ａ１）阻害剤としてのピラン誘導体 |
| JP2022019891A Active JP7286825B2 (ja) | 2016-12-22 | 2022-02-10 | Ｃｙｐ１１ａ１（チトクロムｐ４５０モノオキシゲナーゼ１１ａ１）阻害剤としてのピラン誘導体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022019891A Active JP7286825B2 (ja) | 2016-12-22 | 2022-02-10 | Ｃｙｐ１１ａ１（チトクロムｐ４５０モノオキシゲナーゼ１１ａ１）阻害剤としてのピラン誘導体 |
Country Status (31)
| Country | Link |
|---|---|
| US (4) | US10717726B2 (enExample) |
| EP (2) | EP3558981B1 (enExample) |
| JP (2) | JP7025432B2 (enExample) |
| KR (3) | KR102491308B1 (enExample) |
| CN (1) | CN110139861B (enExample) |
| AR (1) | AR110412A1 (enExample) |
| AU (2) | AU2017380282B2 (enExample) |
| CA (1) | CA3047370A1 (enExample) |
| CL (1) | CL2019001728A1 (enExample) |
| CO (1) | CO2019007321A2 (enExample) |
| CY (1) | CY1124461T1 (enExample) |
| DK (1) | DK3558981T3 (enExample) |
| EA (1) | EA039309B1 (enExample) |
| ES (1) | ES2880151T3 (enExample) |
| HR (1) | HRP20211255T1 (enExample) |
| HU (1) | HUE056540T2 (enExample) |
| IL (2) | IL267484B (enExample) |
| LT (1) | LT3558981T (enExample) |
| MA (2) | MA55983A (enExample) |
| MX (1) | MX388538B (enExample) |
| NZ (1) | NZ755395A (enExample) |
| PE (1) | PE20191137A1 (enExample) |
| PH (1) | PH12019550111A1 (enExample) |
| PL (1) | PL3558981T3 (enExample) |
| PT (1) | PT3558981T (enExample) |
| RS (1) | RS62198B1 (enExample) |
| SI (1) | SI3558981T1 (enExample) |
| TN (1) | TN2019000189A1 (enExample) |
| TW (2) | TWI762544B (enExample) |
| UA (1) | UA124640C2 (enExample) |
| WO (1) | WO2018115591A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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| CN121002012A (zh) * | 2023-03-29 | 2025-11-21 | 西藏海思科制药有限公司 | Cyp11a1抑制剂及其用途 |
| CN121039123A (zh) * | 2023-04-21 | 2025-11-28 | 西藏海思科制药有限公司 | Cyp11a1抑制剂及其用途 |
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| JP2022078068A (ja) * | 2016-12-22 | 2022-05-24 | オリオン コーポレーション | Ｃｙｐ１１ａ１（チトクロムｐ４５０モノオキシゲナーゼ１１ａ１）阻害剤としてのピラン誘導体 |
| JP7286825B2 (ja) | 2016-12-22 | 2023-06-05 | オリオン コーポレーション | Ｃｙｐ１１ａ１（チトクロムｐ４５０モノオキシゲナーゼ１１ａ１）阻害剤としてのピラン誘導体 |
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