JP7025414B2 - Ｔｒｐｖ４拮抗薬 - Google Patents

Ｔｒｐｖ４拮抗薬 Download PDF

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JP7025414B2
JP7025414B2 JP2019515462A JP2019515462A JP7025414B2 JP 7025414 B2 JP7025414 B2 JP 7025414B2 JP 2019515462 A JP2019515462 A JP 2019515462A JP 2019515462 A JP2019515462 A JP 2019515462A JP 7025414 B2 JP7025414 B2 JP 7025414B2
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Japan
Prior art keywords
sulfonyl
hydroxy
pyrrolidine
hydroxymethyl
oxy
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JP2019515462A
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Japanese (ja)
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JP2019529443A5 (enExample
JP2019529443A (ja
Inventor
エドワード、ジェイ．ブルナルディク
カール、エイ．ブルックス
ブライアン、グリフィン、ロウホーン
イェ、グゥオセン
リンダ、エス．バートン
ブライアン、ダブリュ．ブドゥジック
ジェイ、エム．マシューズ
ジョン、ジェフリー、マカティー
ジャクリン、アール．パターソン
ジョセフ、イー．ペロ
ロバート、サンチェス
マシュー、ロバート、センダー
ラモント、ロスコー、テレル
デイビッド、ジェイ．ベーム
ジェームズ、ブイ．トーマス
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GlaxoSmithKline Intellectual Property No 2 Ltd
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GlaxoSmithKline Intellectual Property No 2 Ltd
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109790116B (zh) 2016-09-20 2022-10-28 葛兰素史密斯克莱知识产权（第2 号）有限公司 Trpv4拮抗剂
EP3515889A1 (en) 2016-09-20 2019-07-31 GlaxoSmithKline Intellectual Property (No. 2) Limited Trpv4 antagonists
TW201825458A (zh) * 2016-09-20 2018-07-16 英商葛蘭素史克智慧財產（第二）有限公司 Ｔｒｐｖ４拮抗劑
CN108836972A (zh) * 2018-08-16 2018-11-20 青岛大学 Ws6对trp通道的作用
TWI878266B (zh) 2019-02-15 2025-04-01 愛爾蘭商博士倫愛爾蘭有限公司 治療眼表痛之方法
JP6994061B2 (ja) 2019-02-15 2022-01-14 ノバルティス アーゲー ４－（７－ヒドロキシ－２－イソプロピル－４－オキソ－４ｈ－キナゾリン－３－イル）－ベンゾニトリルの製剤
JP7624745B2 (ja) * 2019-11-21 2025-01-31 ユニバーシティ オブ ユタ リサーチ ファウンデーション Ｔｒｐｖ４受容体リガンド
TWI899220B (zh) 2020-04-30 2025-10-01 日商拉夸里亞創藥股份有限公司 作為trpv4拮抗劑之嘧啶-4(3h)-酮衍生物
WO2021233752A1 (en) 2020-05-19 2021-11-25 Bayer Aktiengesellschaft Trpa1 antagonists for the treatment of diseases associated with pain and inflammation
WO2022013225A1 (en) 2020-07-13 2022-01-20 Precirix N.V. Antibody fragment against folr1
EP4183415A4 (en) 2020-07-16 2024-07-17 RaQualia Pharma Inc. Trpv4 inhibitor as therapeutic drug for eye disease
CN112574090B (zh) * 2020-11-23 2022-04-29 浙大城市学院 一种含硫的多取代吡咯类化合物及其制备方法
WO2023203135A1 (en) 2022-04-22 2023-10-26 Precirix N.V. Improved radiolabelled antibody
WO2023213801A1 (en) 2022-05-02 2023-11-09 Precirix N.V. Pre-targeting

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009523176A (ja) 2006-01-11 2009-06-18 スミスクライン・ビーチャム・コーポレイション 新規化合物
CN103896946A (zh) 2012-12-28 2014-07-02 浙江导明医药科技有限公司 用于预防及治疗多种自身免疫疾病的新化合物

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CY1308A (en) 1979-12-06 1985-12-06 Glaxo Group Ltd Device for dispensing medicaments
ATE23272T1 (de) 1981-07-08 1986-11-15 Draco Ab Pulverinhalator.
US4778054A (en) 1982-10-08 1988-10-18 Glaxo Group Limited Pack for administering medicaments to patients
GR79615B (enExample) 1982-10-08 1984-10-31 Glaxo Group Ltd
GB2169265B (en) 1982-10-08 1987-08-12 Glaxo Group Ltd Pack for medicament
DK163640C (da) 1985-07-30 1992-08-17 Glaxo Group Ltd Apparat til administrering af medikamenter
GB9004781D0 (en) 1990-03-02 1990-04-25 Glaxo Group Ltd Device
US6536427B2 (en) 1990-03-02 2003-03-25 Glaxo Group Limited Inhalation device
SK280967B6 (sk) 1990-03-02 2000-10-09 Glaxo Group Limited Inhalačný prístroj
WO1998008815A1 (en) 1996-08-28 1998-03-05 The Procter & Gamble Company Substituted cyclic amine metalloprotease inhibitors
GB9700226D0 (en) 1997-01-08 1997-02-26 Glaxo Group Ltd Inhalation device
DK1461315T3 (da) 2001-12-06 2009-11-16 Cornell Res Foundation Inc Katalytisk carbonylering af tre- og fireleddede heterocykler
GB0201677D0 (en) 2002-01-25 2002-03-13 Glaxo Group Ltd Medicament dispenser
EP1605752B1 (en) 2003-03-27 2011-09-14 Cytokinetics, Inc. Sulfonamides for the treatment of congestive heart failure, their compositions and uses.
GB0317374D0 (en) 2003-07-24 2003-08-27 Glaxo Group Ltd Medicament dispenser
SG150524A1 (en) 2004-02-16 2009-03-30 Glaxo Group Ltd Counter for use with a medicament dispenser
AR048523A1 (es) 2004-04-07 2006-05-03 Kalypsys Inc Compuestos con estructura de aril sulfonamida y sulfonilo como moduladores de ppar y metodos para tratar trastornos metabolicos
JP2007534755A (ja) 2004-04-28 2007-11-29 メルク　エンド　カムパニー　インコーポレーテッド ケモカイン受容体活性のモジュレーターとなる３，３−ジ置換テトラヒドロピラニルシクロペンチルアミド
JP2007538106A (ja) 2004-05-20 2007-12-27 イーラン ファーマスーティカルズ、インコーポレイテッド γセクレターゼのＮ−環式スルホンアミド阻害剤
CN1329374C (zh) 2004-06-09 2007-08-01 上海靶点药物有限公司 作为ccr5拮抗剂的化合物
BRPI0513262A (pt) 2004-07-12 2008-04-29 Bayer Cropscience Ag heterociclos substituìdos
GB0418278D0 (en) 2004-08-16 2004-09-15 Glaxo Group Ltd Medicament dispenser
DOP2006000010A (es) 2005-01-10 2006-07-31 Arena Pharm Inc Procedimiento para preparar eteres aromáticos
GB0515584D0 (en) 2005-07-28 2005-09-07 Glaxo Group Ltd Medicament dispenser
AR058289A1 (es) 2005-12-12 2008-01-30 Glaxo Group Ltd Colector para ser usado en dispensador de medicamento
AR058558A1 (es) 2005-12-21 2008-02-13 Schering Corp Derivados de anilina sustituida utiles como antagonistas de la histamina h3
CN101595107A (zh) 2006-06-30 2009-12-02 先灵公司 能提高p53活性的有取代哌啶及其用途
WO2008091863A1 (en) 2007-01-23 2008-07-31 Kalypsys, Inc. Sulfonyl-substituted bicyclic compounds as ppar modulators for the treatment of non-alcoholic steatohepatitis
EP2244571A4 (en) 2008-01-17 2014-02-19 Purdue Research Foundation SMALL MOLECULAR INHIBITORS OF HIV PROTEASES
DE102008008838A1 (de) * 2008-02-13 2009-08-20 Bayer Healthcare Ag Cycloalkoxy-substituierte 4-Phenyl-3,5-dicyanopyridine und ihre Verwendung
KR20110026481A (ko) 2008-06-20 2011-03-15 메타볼렉스, 인코포레이티드 아릴 ｇｐｒ１１９ 작동약 및 이의 용도
EA201590951A1 (ru) 2012-11-16 2015-08-31 Бристол-Майерс Сквибб Компани Дигидропиразольные модуляторы gpr40
TW201524952A (zh) 2013-03-15 2015-07-01 Araxes Pharma Llc Ｋｒａｓ ｇ１２ｃ之共價抑制劑
EP2970215B1 (en) 2013-03-15 2019-04-17 AbbVie Deutschland GmbH & Co. KG Pyrrolidine derivatives, pharmaceutical compositions containing them, and their use in therapy
JP6272832B2 (ja) 2013-04-04 2018-01-31 武田薬品工業株式会社 複素環化合物
RU2710928C2 (ru) 2014-07-31 2020-01-14 Инсерм (Институт Насьональ Де Ла Сант Эт Де Ла Решерш Медикаль) Антагонисты рецептора flt3
CN109790116B (zh) 2016-09-20 2022-10-28 葛兰素史密斯克莱知识产权（第2 号）有限公司 Trpv4拮抗剂
EP3515889A1 (en) 2016-09-20 2019-07-31 GlaxoSmithKline Intellectual Property (No. 2) Limited Trpv4 antagonists
TW201825458A (zh) * 2016-09-20 2018-07-16 英商葛蘭素史克智慧財產（第二）有限公司 Ｔｒｐｖ４拮抗劑

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009523176A (ja) 2006-01-11 2009-06-18 スミスクライン・ビーチャム・コーポレイション 新規化合物
CN103896946A (zh) 2012-12-28 2014-07-02 浙江导明医药科技有限公司 用于预防及治疗多种自身免疫疾病的新化合物

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