JP7016853B2 - ｓＧＣ刺激剤のリンプロドラッグ - Google Patents

ｓＧＣ刺激剤のリンプロドラッグ Download PDF

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JP7016853B2
JP7016853B2 JP2019500509A JP2019500509A JP7016853B2 JP 7016853 B2 JP7016853 B2 JP 7016853B2 JP 2019500509 A JP2019500509 A JP 2019500509A JP 2019500509 A JP2019500509 A JP 2019500509A JP 7016853 B2 JP7016853 B2 JP 7016853B2
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disease
pulmonary
disorders
hypertension
compound
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JP2019525915A (ja
JP2019525915A5 (https=
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シェペック，ジェームズ・エドワード
レンハウ，ポール・アラン
マーメリアン，アラ
バーデン，ティモシー・クロード
レニー，グレン・ロバート
アイアンガー，ラジェシュ・アール
崇 中井
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サイクレリオン・セラピューティクス，インコーポレーテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
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    • A61K31/66—Phosphorus compounds
    • A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom

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  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
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  • Pharmacology & Pharmacy (AREA)
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  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Pulmonology (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Reproductive Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Gynecology & Obstetrics (AREA)
  • Vascular Medicine (AREA)
  • Pregnancy & Childbirth (AREA)
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JP2019500509A 2016-07-07 2017-07-06 ｓＧＣ刺激剤のリンプロドラッグ Active JP7016853B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2022010212A JP7368516B2 (ja) 2016-07-07 2022-01-26 ｓＧＣ刺激剤のリンプロドラッグ

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662359419P 2016-07-07 2016-07-07
US62/359,419 2016-07-07
PCT/US2017/040809 WO2018009596A1 (en) 2016-07-07 2017-07-06 Phosphorus prodrugs of sgc stimulators

Related Child Applications (1)

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JP2022010212A Division JP7368516B2 (ja) 2016-07-07 2022-01-26 ｓＧＣ刺激剤のリンプロドラッグ

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JP2019525915A JP2019525915A (ja) 2019-09-12
JP2019525915A5 JP2019525915A5 (https=) 2020-08-13
JP7016853B2 true JP7016853B2 (ja) 2022-02-07

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JP2022010212A Active JP7368516B2 (ja) 2016-07-07 2022-01-26 ｓＧＣ刺激剤のリンプロドラッグ

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Country Status (13)

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US (4) US10927136B2 (https=)
EP (1) EP3481837B1 (https=)
JP (2) JP7016853B2 (https=)
KR (1) KR102513343B1 (https=)
CN (2) CN109476686B (https=)
AU (2) AU2017291826B2 (https=)
BR (1) BR112019000290B1 (https=)
CA (1) CA3029374A1 (https=)
EA (1) EA039683B1 (https=)
IL (1) IL263993B2 (https=)
MA (1) MA45592A (https=)
MX (2) MX391896B (https=)
WO (1) WO2018009596A1 (https=)

Families Citing this family (5)

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Publication number Priority date Publication date Assignee Title
CN109476686B (zh) * 2016-07-07 2022-01-18 赛克里翁治疗有限公司 sGC刺激剂的磷前药
KR20210031931A (ko) 2018-07-11 2021-03-23 사이클리온 테라퓨틱스, 인크. 미토콘드리아 장애의 치료를 위한 sGC 자극제의 용도
CN114377149B (zh) * 2021-12-14 2023-11-10 西北工业大学 一种Mn基可降解MOF纳米反应器及其制备方法和应用
WO2024102304A1 (en) * 2022-11-07 2024-05-16 Virginia Commonwealth University Benzaldehyde compounds with direct polymer destabilizing effects to treat sickle cell disease
CN116478309B (zh) * 2023-05-19 2024-05-17 青海大学 锁阳精多糖、锁阳多糖化合物及制备方法和应用

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009521397A (ja) 2005-12-27 2009-06-04 大塚製薬株式会社 水溶性ベンゾアゼピン化合物及び医薬組成物
JP2010534695A (ja) 2007-08-01 2010-11-11 バイエル・シェーリング・ファルマ・アクチェンゲゼルシャフト ２−アミノ−６−（｛［２−（４−クロロフェニル）−１，３−チアゾール−４−イル］メチル｝チオ）−４−［４−（２−ヒドロキシエトキシ）フェニル］ピリジン−３，５−ジカルボニトリルのプロドラッグ
JP2014503557A (ja) 2011-01-14 2014-02-13 バーテックス ファーマシューティカルズ インコーポレイテッド ピリミジンジャイレースおよびトポイソメラーゼｉｖ阻害剤
JP2016516736A (ja) 2013-03-29 2016-06-09 シュエンジュウ・ファーマ・カンパニー・リミテッド 二環式置換ピリミジン型ｐｄｅ−５阻害剤のプロドラッグ
JP2016517432A (ja) 2013-03-15 2016-06-16 アイアンウッド ファーマシューティカルズ インコーポレイテッド ｓＧＣ刺激薬

Family Cites Families (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5721365A (en) 1989-09-15 1998-02-24 Us Health N-substituted piperazine NONOates
US5155137A (en) 1990-09-20 1992-10-13 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Complexes of nitric oxide with polyamines
AU668107B2 (en) 1991-09-24 1996-04-26 United States Of America, Represented By The Secretary, Department Of Health And Human Services, The Oxygen substituted derivatives of nucleophile-nitric oxide adducts as nitric oxide donor prodrugs
US5814666A (en) 1992-04-13 1998-09-29 The United States As Represented By The Department Of Health And Human Services Encapsulated and non-encapsulated nitric oxide generators used as antimicrobial agents
US5632981A (en) 1992-08-24 1997-05-27 The United States Of America As Represented By The Department Of Health And Human Services Biopolymer-bound nitric oxide-releasing compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same
US5405919A (en) 1992-08-24 1995-04-11 The United States Of America As Represented By The Secretary Of Health And Human Services Polymer-bound nitric oxide/nucleophile adduct compositions, pharmaceutical compositions and methods of treating biological disorders
US5910316A (en) 1992-08-24 1999-06-08 The United States Of America, As Represented By The Department Of Health And Human Services Use of nitric oxide-releasing agents to treat impotency
US5691423A (en) 1992-08-24 1997-11-25 The United States Of America As Represented By The Department Of Health And Human Services Polysaccharide-bound nitric oxide-nucleophile adducts
AU685178B2 (en) 1993-10-08 1998-01-15 United States Of America, Represented By The Secretary, Department Of Health And Human Services, The Use of nitric oxide-releasing compounds as hypoxic cell radiation sensitizers
JP2928079B2 (ja) 1994-02-14 1999-07-28 永信薬品工業股▲ふん▼有限公司 １−（置換ベンジル）−３−（置換アリール）縮合ピラゾール類、その製造法及びその用途
US5700830A (en) 1994-11-22 1997-12-23 The United States Of America As Represented By The Department Of Health And Human Services Use of nitric oxide-releasing agents for reducing metastasis risk
EP0837052B1 (en) 1995-06-21 2006-08-23 Shionogi & Co., Ltd. Bicyclic amino derivatives and pgd 2 antagonist containing the same
US5714511A (en) 1995-07-31 1998-02-03 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Selective prevention of organ injury in sepsis and shock using selection release of nitric oxide in vulnerable organs
EP0945450B1 (en) 1996-12-12 2005-05-11 Shionogi & Co., Ltd. Fused heterocyclic benzenecarboxylic acid amide derivatives and pgd2 antagonists containing the same
CZ297324B6 (cs) 1996-12-13 2006-11-15 Shionogi & Co., Ltd. Benzothiofenkarboxamidové deriváty a antagonisty PGD2, které je obsahují
DE19744026A1 (de) 1997-10-06 1999-04-08 Hoechst Marion Roussel De Gmbh Pyrazol-Derivate, ihre Herstellung und ihre Verwendung in Arzneimitteln
DE19830430A1 (de) 1998-07-08 2000-01-13 Hoechst Marion Roussel De Gmbh Schwefelsubstituierte Sulfonylamino-carbonsäure-N-arylamide, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
CN1332943C (zh) 1998-07-08 2007-08-22 萨诺费－阿文蒂斯德国有限公司 硫取代的磺酰基氨基羧酸n－芳基酰胺,其制备方法、用途以及含有该化合物的药物制剂
DE19834047A1 (de) 1998-07-29 2000-02-03 Bayer Ag Substituierte Pyrazolderivate
DE19834044A1 (de) 1998-07-29 2000-02-03 Bayer Ag Neue substituierte Pyrazolderivate
GB9824310D0 (en) 1998-11-05 1998-12-30 Univ London Activators of soluble guanylate cyclase
DE19942809A1 (de) 1999-09-08 2001-03-15 Bayer Ag Verfahren zur Herstellung substituierter Pyrimidinderivate
DE19943635A1 (de) 1999-09-13 2001-03-15 Bayer Ag Neuartige Aminodicarbonsäurederivate mit pharmazeutischen Eigenschaften
DE60115411D1 (de) 2000-04-12 2006-01-05 Merck Frosst Canada & Co Kirkl Verfahren und zusammensetzungen zur behandlung von allergischen zuständen mit pgd2 rezeptor antagonisten
US20010051624A1 (en) 2000-04-12 2001-12-13 Jones Thomas R. Method and compositions for the treatment of allergic conditions using PGD2 receptor antagonists
US6878522B2 (en) 2000-07-07 2005-04-12 Baiyong Li Methods for the identification of compounds useful for the treatment of disease states mediated by prostaglandin D2
PE20020856A1 (es) 2001-02-13 2002-11-11 Aventis Pharma Gmbh 1,2,3,4-tetrahidronaftil aminas aciladas
PE20020870A1 (es) 2001-02-13 2002-11-18 Aventis Pharma Gmbh 6,7,8,9-tetrahidro-5h-benzocicloheptenil aminas aciladas
TWI243164B (en) 2001-02-13 2005-11-11 Aventis Pharma Gmbh Acylated indanyl amines and their use as pharmaceuticals
TWI241190B (en) 2001-02-13 2005-10-11 Aventis Pharma Gmbh 4-Fluoro-N-indan-2-yl benzamide and its use as pharmaceutical
US6511911B1 (en) 2001-04-03 2003-01-28 Advanced Micro Devices, Inc. Metal gate stack with etch stop layer
KR20040044856A (ko) 2001-09-07 2004-05-31 오노 야꾸힝 고교 가부시키가이샤 인돌 유도체 화합물
EP1424325A4 (en) 2001-09-07 2005-12-21 Ono Pharmaceutical Co INDOLE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND MEDICAMENTS CONTAINING THEM AS AN ACTIVE AGENT
SE0200411D0 (sv) 2002-02-05 2002-02-05 Astrazeneca Ab Novel use
SE0200356D0 (sv) 2002-02-05 2002-02-05 Astrazeneca Ab Novel use
DE10216145A1 (de) 2002-04-12 2003-10-23 Bayer Ag Verwendung von Stimulatoren der löslichen Guanylatcyclase zur Behandlung von Glaukom
DE10220570A1 (de) 2002-05-08 2003-11-20 Bayer Ag Carbamat-substituierte Pyrazolopyridine
AU2003231513A1 (en) 2002-05-16 2003-12-02 Shionogi And Co., Ltd. Pgd2 receptor antagonist
EP2423190A1 (en) 2002-05-16 2012-02-29 Shionogi&Co., Ltd. Compounds Exhibiting PGD 2 Receptor Antagonism
TW200307542A (en) 2002-05-30 2003-12-16 Astrazeneca Ab Novel compounds
SE0201635D0 (sv) 2002-05-30 2002-05-30 Astrazeneca Ab Novel compounds
SE0202241D0 (sv) 2002-07-17 2002-07-17 Astrazeneca Ab Novel Compounds
AU2003277285B2 (en) 2002-10-04 2007-12-13 Millennium Pharmaceuticals, Inc. PGD2 receptor antagonists for the treatment of inflammatory diseases
ZA200505523B (en) 2002-12-20 2006-09-27 Amgen Inc Asthma and allergic inflammation modulators
US8309608B2 (en) 2003-11-06 2012-11-13 Sanofi-Aventis Deutschland Gmbh Use of eNOS transcription enhancers in the cell therapy of ischemic heart diseases
KR20100059952A (ko) 2007-09-06 2010-06-04 머크 샤프 앤드 돔 코포레이션 가용성 구아닐레이트 사이클라제 활성제
WO2009094242A1 (en) 2008-01-24 2009-07-30 Merck & Co., Inc. Angiotensin ii receptor antagonists
CN101735267A (zh) * 2008-11-17 2010-06-16 上海阳帆医药科技有限公司 水溶性(r)-(-)-比卡鲁胺前药、其制备方法及用途
AU2009322836B2 (en) 2008-11-25 2013-04-04 Merck Sharp & Dohme Corp. Soluble guanylate cyclase activators
CN102414194A (zh) 2009-02-26 2012-04-11 默沙东公司 可溶性鸟苷酸环化酶激活剂
US9284301B2 (en) 2010-03-25 2016-03-15 Merck Sharp & Dohme Corp. Soluble guanylate cyclase activators
UA107112C2 (uk) 2010-05-27 2014-11-25 Мерк Шарп Енд Доме Корп. Активатори розчинної гуанілатциклази
EP2632551B1 (en) 2010-10-28 2016-07-06 Merck Sharp & Dohme Corp. Soluble guanylate cyclase activators
CN103288809B (zh) * 2012-02-24 2015-09-23 深圳市健元医药科技有限公司 葛根素单磷酸盐或单磺酸盐衍生物及其制备方法
WO2015106268A1 (en) 2014-01-13 2015-07-16 Ironwood Pharmaceuticals, Inc. USE OF sGC STIMULATORS FOR THE TREATMENT OF NEUROMUSCULAR DISORDERS
CN109476686B (zh) * 2016-07-07 2022-01-18 赛克里翁治疗有限公司 sGC刺激剂的磷前药

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009521397A (ja) 2005-12-27 2009-06-04 大塚製薬株式会社 水溶性ベンゾアゼピン化合物及び医薬組成物
JP2010534695A (ja) 2007-08-01 2010-11-11 バイエル・シェーリング・ファルマ・アクチェンゲゼルシャフト ２−アミノ−６−（｛［２−（４−クロロフェニル）−１，３−チアゾール−４−イル］メチル｝チオ）−４−［４−（２−ヒドロキシエトキシ）フェニル］ピリジン−３，５−ジカルボニトリルのプロドラッグ
JP2014503557A (ja) 2011-01-14 2014-02-13 バーテックス ファーマシューティカルズ インコーポレイテッド ピリミジンジャイレースおよびトポイソメラーゼｉｖ阻害剤
JP2016517432A (ja) 2013-03-15 2016-06-16 アイアンウッド ファーマシューティカルズ インコーポレイテッド ｓＧＣ刺激薬
JP2016516736A (ja) 2013-03-29 2016-06-09 シュエンジュウ・ファーマ・カンパニー・リミテッド 二環式置換ピリミジン型ｐｄｅ−５阻害剤のプロドラッグ

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
HUTTUNEN K M，PRODRUGS―FROM SERENDIPITY TO RATIONAL DESIGN，PHARMACOLOGICAL REVIEWS，2011年09月，VOL:63, NR:3，PAGE(S):750 - 771，http://dx.doi.org/10.1124/pr.110.003459

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