JP7009504B2 - ヤヌスキナーゼ阻害剤としての新規アミノイミダゾピリジン誘導体及びそれらの医薬としての使用 - Google Patents

ヤヌスキナーゼ阻害剤としての新規アミノイミダゾピリジン誘導体及びそれらの医薬としての使用 Download PDF

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JP7009504B2
JP7009504B2 JP2019557681A JP2019557681A JP7009504B2 JP 7009504 B2 JP7009504 B2 JP 7009504B2 JP 2019557681 A JP2019557681 A JP 2019557681A JP 2019557681 A JP2019557681 A JP 2019557681A JP 7009504 B2 JP7009504 B2 JP 7009504B2
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acetonitrile
cyclohexyl
imidazole
trans
pyridin
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JP2020504186A (ja
JP2020504186A5 (https=
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イェンス・ラーセン
モーエンス・ラーセン
ラース・キューン・ラスムッセン
アンドレアス・リッツェン
ティーネ・マリアネ・ドゥース
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Leo Pharma AS
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2019557681A 2017-01-11 2018-01-10 ヤヌスキナーゼ阻害剤としての新規アミノイミダゾピリジン誘導体及びそれらの医薬としての使用 Active JP7009504B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP17151020.9 2017-01-11
EP17151020 2017-01-11
PCT/EP2018/050548 WO2018130563A1 (en) 2017-01-11 2018-01-10 Novel amino-imidazopyridine derivatives as janus kinase inhibitors and pharmaceutical use thereof

Publications (3)

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JP2020504186A JP2020504186A (ja) 2020-02-06
JP2020504186A5 JP2020504186A5 (https=) 2021-02-12
JP7009504B2 true JP7009504B2 (ja) 2022-01-25

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JP2019557681A Active JP7009504B2 (ja) 2017-01-11 2018-01-10 ヤヌスキナーゼ阻害剤としての新規アミノイミダゾピリジン誘導体及びそれらの医薬としての使用

Country Status (26)

Country Link
US (1) US10703751B2 (https=)
EP (1) EP3568396B1 (https=)
JP (1) JP7009504B2 (https=)
KR (1) KR102548543B1 (https=)
CN (1) CN110167938B (https=)
AU (1) AU2018208516B2 (https=)
CA (1) CA3045567A1 (https=)
CY (1) CY1123864T1 (https=)
DK (1) DK3568396T3 (https=)
ES (1) ES2846741T3 (https=)
HR (1) HRP20210095T1 (https=)
HU (1) HUE052720T2 (https=)
IL (1) IL267829B (https=)
LT (1) LT3568396T (https=)
MX (1) MX389378B (https=)
MY (1) MY195576A (https=)
NZ (1) NZ754922A (https=)
PL (1) PL3568396T3 (https=)
PT (1) PT3568396T (https=)
RS (1) RS61317B1 (https=)
RU (1) RU2019125177A (https=)
SI (1) SI3568396T1 (https=)
TW (1) TWI760419B (https=)
UA (1) UA123972C2 (https=)
WO (1) WO2018130563A1 (https=)
ZA (1) ZA201904190B (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JOP20190144A1 (ar) 2016-12-16 2019-06-16 Janssen Pharmaceutica Nv إيميدازو بيرولو بيريدين كمثبطات لعائلة jak الخاصة بإنزيمات الكيناز
JP7291077B2 (ja) 2016-12-16 2023-06-14 ヤンセン ファーマシューティカ エヌ．ベー． Ｊａｋファミリーのキナーゼの低分子阻害物質
TW202016110A (zh) 2018-06-15 2020-05-01 比利時商健生藥品公司 Ｊａｋ激酶家族之小分子抑制劑
CN112384514A (zh) * 2018-07-06 2021-02-19 利奥制药有限公司 作为janus激酶抑制剂的新的氨基-咪唑并嘧啶衍生物及其药物用途
KR102459614B1 (ko) * 2019-08-30 2022-10-31 주식회사 티에스디라이프사이언스 이미다조피리딘 유도체 및 이를 유효성분으로 함유하는 약학적 조성물
MX2023010642A (es) 2021-03-11 2023-11-28 Janssen Pharmaceutica Nv Lorpucitinib para uso en el tratamiento de trastornos mediados por jak.
CN119569971B (zh) * 2025-02-07 2025-05-27 吉林大学 一种用于蛋白质磷酸化和棕榈酰化修饰同时筛选的Janus材料的制备方法

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2518071A1 (en) 2011-04-29 2012-10-31 Almirall, S.A. Imidazopyridine derivatives as PI3K inhibitors
WO2013007768A1 (en) 2011-07-13 2013-01-17 F. Hoffmann-La Roche Ag Tricyclic heterocyclic compounds, compositions and methods of use thereof as jak inhibitors
JP2013517220A (ja) 2010-01-12 2013-05-16 エフ．ホフマン−ラ ロシュ アーゲー 三環式複素環式化合物、その組成物、及び使用の方法
WO2013117645A1 (en) 2012-02-10 2013-08-15 Galapagos Nv Imidazo [4, 5 -c] pyridine derivatives useful for the treatment of degenerative and inflammatory diseases
JP2014515362A (ja) 2011-05-25 2014-06-30 アルミラル・ソシエダッド・アノニマ 骨髄増殖性疾患、移植拒絶、免疫介在性疾患および炎症性疾患の処置のための医薬の製造に有用な、ピリジン−２（１ｈ）−オン誘導体
CN104098563A (zh) 2013-04-02 2014-10-15 山东亨利医药科技有限责任公司 Jnk抑制剂化合物
WO2015168246A1 (en) 2014-04-30 2015-11-05 Incyte Corporation Processes of preparing a jak1 inhibitor and new forms thereto

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009100375A1 (en) * 2008-02-06 2009-08-13 Bristol-Myers Squibb Company Substituted imidazopyridazines useful as kinase inhibitors
SG10201505997TA (en) * 2010-08-05 2015-09-29 Amgen Inc Benzimidazole And Azabenzimidazole Compounds That Inhibit Anaplastic Lymphoma Kinase
WO2013007765A1 (en) 2011-07-13 2013-01-17 F. Hoffmann-La Roche Ag Fused tricyclic compounds for use as inhibitors of janus kinases
TWI646099B (zh) 2012-11-01 2019-01-01 英塞特控股公司 作爲ｊａｋ抑制劑之三環稠合噻吩衍生物
WO2014081718A1 (en) * 2012-11-20 2014-05-30 Genentech, Inc. Aminopyrimidine compounds as inhibitors of t790m containing egfr mutants
MX390005B (es) 2016-10-03 2025-03-20 Hangzhou Highlightll Pharmaceutical Co Ltd Inhibidores selectivos de jak1 novedosos y usos de los mismos.
JOP20190144A1 (ar) * 2016-12-16 2019-06-16 Janssen Pharmaceutica Nv إيميدازو بيرولو بيريدين كمثبطات لعائلة jak الخاصة بإنزيمات الكيناز

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013517220A (ja) 2010-01-12 2013-05-16 エフ．ホフマン−ラ ロシュ アーゲー 三環式複素環式化合物、その組成物、及び使用の方法
EP2518071A1 (en) 2011-04-29 2012-10-31 Almirall, S.A. Imidazopyridine derivatives as PI3K inhibitors
JP2014515362A (ja) 2011-05-25 2014-06-30 アルミラル・ソシエダッド・アノニマ 骨髄増殖性疾患、移植拒絶、免疫介在性疾患および炎症性疾患の処置のための医薬の製造に有用な、ピリジン−２（１ｈ）−オン誘導体
WO2013007768A1 (en) 2011-07-13 2013-01-17 F. Hoffmann-La Roche Ag Tricyclic heterocyclic compounds, compositions and methods of use thereof as jak inhibitors
WO2013117645A1 (en) 2012-02-10 2013-08-15 Galapagos Nv Imidazo [4, 5 -c] pyridine derivatives useful for the treatment of degenerative and inflammatory diseases
CN104098563A (zh) 2013-04-02 2014-10-15 山东亨利医药科技有限责任公司 Jnk抑制剂化合物
WO2015168246A1 (en) 2014-04-30 2015-11-05 Incyte Corporation Processes of preparing a jak1 inhibitor and new forms thereto

Also Published As

Publication number Publication date
EP3568396A1 (en) 2019-11-20
US10703751B2 (en) 2020-07-07
IL267829B (en) 2022-02-01
CN110167938A (zh) 2019-08-23
KR102548543B1 (ko) 2023-06-29
CN110167938B (zh) 2024-06-14
PT3568396T (pt) 2021-02-09
HUE052720T2 (hu) 2021-05-28
JP2020504186A (ja) 2020-02-06
RU2019125177A (ru) 2021-02-15
AU2018208516A1 (en) 2019-07-11
SI3568396T1 (sl) 2021-04-30
KR20190103231A (ko) 2019-09-04
MX389378B (es) 2025-03-20
MX2019008331A (es) 2020-01-14
CY1123864T1 (el) 2022-05-27
TW201829407A (zh) 2018-08-16
ES2846741T3 (es) 2021-07-29
IL267829A (en) 2019-09-26
AU2018208516B2 (en) 2021-07-08
EP3568396B1 (en) 2020-11-11
PL3568396T3 (pl) 2021-05-31
WO2018130563A1 (en) 2018-07-19
UA123972C2 (uk) 2021-06-30
TWI760419B (zh) 2022-04-11
RS61317B1 (sr) 2021-02-26
NZ754922A (en) 2025-11-28
CA3045567A1 (en) 2018-07-19
ZA201904190B (en) 2020-10-28
HRP20210095T1 (hr) 2021-03-05
DK3568396T3 (da) 2021-01-18
MY195576A (en) 2023-02-02
LT3568396T (lt) 2021-02-10
US20190367512A1 (en) 2019-12-05
BR112019014191A2 (pt) 2020-02-11
RU2019125177A3 (https=) 2021-05-11

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