ZA201904190B - Novel amino-imidazopyridine derivatives as janus kinase inhibitors and pharmaceutical use thereof - Google Patents
Novel amino-imidazopyridine derivatives as janus kinase inhibitors and pharmaceutical use thereofInfo
- Publication number
- ZA201904190B ZA201904190B ZA2019/04190A ZA201904190A ZA201904190B ZA 201904190 B ZA201904190 B ZA 201904190B ZA 2019/04190 A ZA2019/04190 A ZA 2019/04190A ZA 201904190 A ZA201904190 A ZA 201904190A ZA 201904190 B ZA201904190 B ZA 201904190B
- Authority
- ZA
- South Africa
- Prior art keywords
- kinase inhibitors
- pharmaceutical use
- janus kinase
- novel amino
- imidazopyridine derivatives
- Prior art date
Links
- KXQPVJRJUJJWQJ-UHFFFAOYSA-N 1h-imidazo[4,5-b]pyridin-2-amine Chemical class C1=CN=C2NC(N)=NC2=C1 KXQPVJRJUJJWQJ-UHFFFAOYSA-N 0.000 title 1
- 229940122245 Janus kinase inhibitor Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17151020 | 2017-01-11 | ||
| PCT/EP2018/050548 WO2018130563A1 (en) | 2017-01-11 | 2018-01-10 | Novel amino-imidazopyridine derivatives as janus kinase inhibitors and pharmaceutical use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA201904190B true ZA201904190B (en) | 2020-10-28 |
Family
ID=57777557
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA2019/04190A ZA201904190B (en) | 2017-01-11 | 2019-06-26 | Novel amino-imidazopyridine derivatives as janus kinase inhibitors and pharmaceutical use thereof |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US10703751B2 (https=) |
| EP (1) | EP3568396B1 (https=) |
| JP (1) | JP7009504B2 (https=) |
| KR (1) | KR102548543B1 (https=) |
| CN (1) | CN110167938B (https=) |
| AU (1) | AU2018208516B2 (https=) |
| CA (1) | CA3045567A1 (https=) |
| CY (1) | CY1123864T1 (https=) |
| DK (1) | DK3568396T3 (https=) |
| ES (1) | ES2846741T3 (https=) |
| HR (1) | HRP20210095T1 (https=) |
| HU (1) | HUE052720T2 (https=) |
| IL (1) | IL267829B (https=) |
| LT (1) | LT3568396T (https=) |
| MX (1) | MX389378B (https=) |
| MY (1) | MY195576A (https=) |
| NZ (1) | NZ754922A (https=) |
| PL (1) | PL3568396T3 (https=) |
| PT (1) | PT3568396T (https=) |
| RS (1) | RS61317B1 (https=) |
| RU (1) | RU2019125177A (https=) |
| SI (1) | SI3568396T1 (https=) |
| TW (1) | TWI760419B (https=) |
| UA (1) | UA123972C2 (https=) |
| WO (1) | WO2018130563A1 (https=) |
| ZA (1) | ZA201904190B (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LT3555097T (lt) | 2016-12-16 | 2022-08-25 | Janssen Pharmaceutica Nv | Imidazo[4,5-d]pirolo[2,3-b]piridino junginiai kaip janus kinazės inhibitoriai |
| JOP20190144A1 (ar) | 2016-12-16 | 2019-06-16 | Janssen Pharmaceutica Nv | إيميدازو بيرولو بيريدين كمثبطات لعائلة jak الخاصة بإنزيمات الكيناز |
| TW202016110A (zh) | 2018-06-15 | 2020-05-01 | 比利時商健生藥品公司 | Ｊａｋ激酶家族之小分子抑制劑 |
| JP2021528479A (ja) * | 2018-07-06 | 2021-10-21 | レオ ファーマ アクティーゼルスカブ | ヤヌスキナーゼ阻害剤としての新規アミノ−イミダゾピリミジン誘導体およびその製薬学的用途 |
| AU2020337720B2 (en) * | 2019-08-30 | 2024-02-15 | Tsd Life Sciences Co., Ltd. | Imidazopyridine derivative and pharmaceutical composition comprising same as active ingredient |
| BR112023018286A2 (pt) | 2021-03-11 | 2023-10-31 | Janssen Pharmaceutica Nv | Lorpucitinib para uso no tratamento de distúrbios mediados por jak |
| CN119569971B (zh) * | 2025-02-07 | 2025-05-27 | 吉林大学 | 一种用于蛋白质磷酸化和棕榈酰化修饰同时筛选的Janus材料的制备方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009100375A1 (en) * | 2008-02-06 | 2009-08-13 | Bristol-Myers Squibb Company | Substituted imidazopyridazines useful as kinase inhibitors |
| EP2523957A1 (en) | 2010-01-12 | 2012-11-21 | F. Hoffmann-La Roche AG | Tricyclic heterocyclic compounds, compositions and methods of use thereof |
| CN103168032A (zh) * | 2010-08-05 | 2013-06-19 | 安美基公司 | 抑制间变性淋巴瘤激酶的苯并咪唑和氮杂苯并咪唑化合物 |
| EP2518071A1 (en) * | 2011-04-29 | 2012-10-31 | Almirall, S.A. | Imidazopyridine derivatives as PI3K inhibitors |
| EP2527344A1 (en) | 2011-05-25 | 2012-11-28 | Almirall, S.A. | Pyridin-2(1H)-one derivatives useful as medicaments for the treatment of myeloproliferative disorders, transplant rejection, immune-mediated and inflammatory diseases |
| WO2013007765A1 (en) | 2011-07-13 | 2013-01-17 | F. Hoffmann-La Roche Ag | Fused tricyclic compounds for use as inhibitors of janus kinases |
| WO2013007768A1 (en) | 2011-07-13 | 2013-01-17 | F. Hoffmann-La Roche Ag | Tricyclic heterocyclic compounds, compositions and methods of use thereof as jak inhibitors |
| UY34616A (es) | 2012-02-10 | 2013-09-30 | Galapagos Nv | Nuevo compuesto útil para el tratamiento de enfermedades degenerativas e inflamatorias. |
| CN104918945B (zh) | 2012-11-01 | 2018-01-05 | 因赛特公司 | 作为jak抑制剂的三环稠合噻吩衍生物 |
| RU2015118647A (ru) * | 2012-11-20 | 2017-01-10 | Дженентек, Инк. | Аминопиримидиновые соединения в качестве ингибиторов содержащих т790м мутантных egfr |
| CN104098563A (zh) | 2013-04-02 | 2014-10-15 | 山东亨利医药科技有限责任公司 | Jnk抑制剂化合物 |
| CN106687462A (zh) | 2014-04-30 | 2017-05-17 | 因赛特公司 | Jak1抑制剂的制备方法以及其新形式 |
| KR102399848B1 (ko) | 2016-10-03 | 2022-05-19 | 하이라이트ll 파머슈티컬 (하이난) 컴퍼니, 리미티드 | 신규한 jak1 선택적 억제제 및 그 용도 |
| JOP20190144A1 (ar) | 2016-12-16 | 2019-06-16 | Janssen Pharmaceutica Nv | إيميدازو بيرولو بيريدين كمثبطات لعائلة jak الخاصة بإنزيمات الكيناز |
-
2018
- 2018-01-10 PL PL18702412T patent/PL3568396T3/pl unknown
- 2018-01-10 AU AU2018208516A patent/AU2018208516B2/en active Active
- 2018-01-10 PT PT187024120T patent/PT3568396T/pt unknown
- 2018-01-10 HU HUE18702412A patent/HUE052720T2/hu unknown
- 2018-01-10 CN CN201880006261.0A patent/CN110167938B/zh active Active
- 2018-01-10 HR HRP20210095TT patent/HRP20210095T1/hr unknown
- 2018-01-10 NZ NZ754922A patent/NZ754922A/en unknown
- 2018-01-10 ES ES18702412T patent/ES2846741T3/es active Active
- 2018-01-10 JP JP2019557681A patent/JP7009504B2/ja active Active
- 2018-01-10 US US16/477,249 patent/US10703751B2/en active Active
- 2018-01-10 WO PCT/EP2018/050548 patent/WO2018130563A1/en not_active Ceased
- 2018-01-10 LT LTEP18702412.0T patent/LT3568396T/lt unknown
- 2018-01-10 RS RS20210044A patent/RS61317B1/sr unknown
- 2018-01-10 DK DK18702412.0T patent/DK3568396T3/da active
- 2018-01-10 EP EP18702412.0A patent/EP3568396B1/en active Active
- 2018-01-10 CA CA3045567A patent/CA3045567A1/en active Pending
- 2018-01-10 SI SI201830191T patent/SI3568396T1/sl unknown
- 2018-01-10 MY MYPI2019003964A patent/MY195576A/en unknown
- 2018-01-10 MX MX2019008331A patent/MX389378B/es unknown
- 2018-01-10 UA UAA201908568A patent/UA123972C2/uk unknown
- 2018-01-10 KR KR1020197021697A patent/KR102548543B1/ko active Active
- 2018-01-10 RU RU2019125177A patent/RU2019125177A/ru unknown
- 2018-01-11 TW TW107101035A patent/TWI760419B/zh active
-
2019
- 2019-06-26 ZA ZA2019/04190A patent/ZA201904190B/en unknown
- 2019-07-03 IL IL267829A patent/IL267829B/en unknown
-
2021
- 2021-02-01 CY CY20211100085T patent/CY1123864T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ZA201700652B (en) | 2-h-indazole derivatives as cyclin-dependent kinase (cdk) inhibitors and therapeutic uses thereof | |
| EP3293177A4 (en) | Tyrosine kinase inhibitor and pharmaceutical composition comprising same | |
| IL267829B (en) | History of new amino-imidazopyridines as Janus kinase inhibitors and their pharmaceutical use | |
| SG10201913927VA (en) | Kinase inhibitors and uses thereof | |
| PT3786160T (pt) | Derivados de piridina e suas utilizações terapêuticas como inibidores de trpc6 | |
| IL304547A (en) | 3-substituted benzamide derivatives as kinase inhibitors | |
| PL3496722T3 (pl) | Kompozycje farmaceutyczne zawierające inhibitory kinazy białkowej Akt | |
| ZA201900421B (en) | Novel quinazolinone derivatives inhibiting pi3k and pharmaceutical composition containing same | |
| IL281357A (en) | Cd73 inhibitors and their pharmacological uses | |
| IL262662B (en) | History of pyridinyl, pharmaceutical preparations and their uses as aoc3 inhibitors | |
| IL258690A (en) | Pyridone derivatives and their use as kinase inhibitors | |
| EP3327021A4 (en) | Janus kinase 1 selective inhibitor and pharmaceutical use thereof | |
| IL254152B (en) | Pyrimidine derivatives as kinase inhibitors and their medicinal uses | |
| ZA202000959B (en) | Adamantylmethylamine derivative and use thereof as pharmaceutical | |
| ZA201908372B (en) | Pyridoquinazoline derivatives useful as protein kinase inhibitors | |
| GB201705201D0 (en) | Novel compounds and their use as kinase inhibitors | |
| HK40026701A (en) | Kinase inhibitors and uses thereof | |
| GB201609580D0 (en) | Novel compounds and their use as kinase inhibitors | |
| HK1240918A1 (en) | 2-h-indazole derivatives as cyclin-dependent kinase (cdk) inhibitors and therapeutic uses thereof | |
| GB201505460D0 (en) | Novel compounds and their use as kinase inhibitors |