JP7005071B1 - メトホルミン塩の調製方法 - Google Patents

メトホルミン塩の調製方法 Download PDF

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JP7005071B1
JP7005071B1 JP2021139963A JP2021139963A JP7005071B1 JP 7005071 B1 JP7005071 B1 JP 7005071B1 JP 2021139963 A JP2021139963 A JP 2021139963A JP 2021139963 A JP2021139963 A JP 2021139963A JP 7005071 B1 JP7005071 B1 JP 7005071B1
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metformin
hydroxy
naphthoate
acid
salt
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JP2022155436A (ja
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子舟 王
依▲リン▼ 鐘
雅欣 李
玉萍 呉
梓淳 周
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▲広▼州大学
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C277/00—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42—Separation; Purification; Stabilisation; Use of additives
    • C07C51/43—Separation; Purification; Stabilisation; Use of additives by change of the physical state, e.g. crystallisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Biochemistry (AREA)
  • Reproductive Health (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2021139963A 2021-03-30 2021-08-30 メトホルミン塩の調製方法 Active JP7005071B1 (ja)

Applications Claiming Priority (2)

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CN202110341539.3 2021-03-30
CN202110341539.3A CN113105367B (zh) 2021-03-30 2021-03-30 一类二甲双胍盐及其制备方法和应用

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JP7005071B1 true JP7005071B1 (ja) 2022-01-21
JP2022155436A JP2022155436A (ja) 2022-10-13

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Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001525361A (ja) * 1997-12-08 2001-12-11 ブリストル−マイヤーズ スクイブ カンパニー メトホルミンの新規塩および方法
JP2009541220A (ja) * 2006-06-16 2009-11-26 インディジーン ファーマシューティカルズ インコーポレイテッド 糖尿病性高血糖および糖尿病合併症の制御のための抗糖尿病薬としてのメトホルミンｒ−（＋）リポエート
JP2010516759A (ja) * 2007-01-29 2010-05-20 ハナル ファーマシューティカル カンパニー リミテッド Ｎ，ｎ−ジメチルイミドジカルボンイミド酸ジアミドの酢酸塩、その製造方法、及びそれを含む薬剤学的組成物
JP2010539229A (ja) * 2007-09-21 2010-12-16 ハンオル バイオファーマ カンパニー，リミテッド Ｎ，ｎ−ジメチルイミドジカルボンイミド酸ジアミドのジカルボン酸塩、その製造方法、及びその薬剤学的組成物
JP2011525900A (ja) * 2008-06-26 2011-09-29 ラボラトリオス シラネス、エセ．ア．デ セ．べ． 血糖制御のための新規グリシン酸メトホルミン塩
JP2014512333A (ja) * 2011-01-12 2014-05-22 テティス・ファーマシューティカルズ・エルエルシー 脂質低下抗糖尿病薬
JP2015523382A (ja) * 2012-07-10 2015-08-13 テティス・ファーマシューティカルズ・エルエルシー メトホルミンの三塩形態

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2796940B1 (fr) * 1999-07-26 2005-04-08 Lipha Nouveaux sels de metformine, leur procede d'obtention et les compositions pharmaceutiques en renfermant
CN100497337C (zh) * 2006-11-20 2009-06-10 淮北辉克药业有限公司 叶酸二甲双胍及其制备方法
CN102093261A (zh) * 2009-12-14 2011-06-15 中国药科大学 水杨酸二甲双胍盐、其制备方法及医药用途
WO2012090225A2 (en) * 2010-12-29 2012-07-05 Nutracryst Therapeutics Private Limited Novel cocrystals / molecular salts of metformin with oleoylethanolamide as an effective anti-diabetic + anti- obesity agent
CN102391160A (zh) * 2011-11-23 2012-03-28 黎波 二甲双胍与2，5-二羟基苯磺酸盐以及二甲双胍与2，5-二羟基苯磺酸盐的复方组合物
CN107118130A (zh) * 2017-05-11 2017-09-01 杜剑平 一类治疗肿瘤的药物化合物及其应用

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001525361A (ja) * 1997-12-08 2001-12-11 ブリストル−マイヤーズ スクイブ カンパニー メトホルミンの新規塩および方法
JP2009541220A (ja) * 2006-06-16 2009-11-26 インディジーン ファーマシューティカルズ インコーポレイテッド 糖尿病性高血糖および糖尿病合併症の制御のための抗糖尿病薬としてのメトホルミンｒ−（＋）リポエート
JP2010516759A (ja) * 2007-01-29 2010-05-20 ハナル ファーマシューティカル カンパニー リミテッド Ｎ，ｎ−ジメチルイミドジカルボンイミド酸ジアミドの酢酸塩、その製造方法、及びそれを含む薬剤学的組成物
JP2010539229A (ja) * 2007-09-21 2010-12-16 ハンオル バイオファーマ カンパニー，リミテッド Ｎ，ｎ−ジメチルイミドジカルボンイミド酸ジアミドのジカルボン酸塩、その製造方法、及びその薬剤学的組成物
JP2011525900A (ja) * 2008-06-26 2011-09-29 ラボラトリオス シラネス、エセ．ア．デ セ．べ． 血糖制御のための新規グリシン酸メトホルミン塩
JP2014512333A (ja) * 2011-01-12 2014-05-22 テティス・ファーマシューティカルズ・エルエルシー 脂質低下抗糖尿病薬
JP2015523382A (ja) * 2012-07-10 2015-08-13 テティス・ファーマシューティカルズ・エルエルシー メトホルミンの三塩形態

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JP2022155436A (ja) 2022-10-13
CN113105367B (zh) 2022-08-02

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