JP6990182B2 - 蝸牛および前庭細胞に核酸を送達するための材料および方法 - Google Patents
蝸牛および前庭細胞に核酸を送達するための材料および方法 Download PDFInfo
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- JP6990182B2 JP6990182B2 JP2018529927A JP2018529927A JP6990182B2 JP 6990182 B2 JP6990182 B2 JP 6990182B2 JP 2018529927 A JP2018529927 A JP 2018529927A JP 2018529927 A JP2018529927 A JP 2018529927A JP 6990182 B2 JP6990182 B2 JP 6990182B2
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- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
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- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
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- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
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- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14145—Special targeting system for viral vectors
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Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021196596A JP7309827B2 (ja) | 2015-12-11 | 2021-12-03 | 蝸牛および前庭細胞に核酸を送達するための材料および方法 |
| JP2023110371A JP7745594B2 (ja) | 2015-12-11 | 2023-07-05 | 蝸牛および前庭細胞に核酸を送達するための材料および方法 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562266477P | 2015-12-11 | 2015-12-11 | |
| US201562266462P | 2015-12-11 | 2015-12-11 | |
| US62/266,462 | 2015-12-11 | ||
| US62/266,477 | 2015-12-11 | ||
| PCT/US2016/066225 WO2017100791A1 (en) | 2015-12-11 | 2016-12-12 | Materials and methods for delivering nucleic acids to cochlear and vestibular cells |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021196596A Division JP7309827B2 (ja) | 2015-12-11 | 2021-12-03 | 蝸牛および前庭細胞に核酸を送達するための材料および方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018536420A JP2018536420A (ja) | 2018-12-13 |
| JP2018536420A5 JP2018536420A5 (https=) | 2019-12-05 |
| JP6990182B2 true JP6990182B2 (ja) | 2022-02-15 |
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Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018529927A Active JP6990182B2 (ja) | 2015-12-11 | 2016-12-12 | 蝸牛および前庭細胞に核酸を送達するための材料および方法 |
| JP2021196596A Active JP7309827B2 (ja) | 2015-12-11 | 2021-12-03 | 蝸牛および前庭細胞に核酸を送達するための材料および方法 |
| JP2023110371A Active JP7745594B2 (ja) | 2015-12-11 | 2023-07-05 | 蝸牛および前庭細胞に核酸を送達するための材料および方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021196596A Active JP7309827B2 (ja) | 2015-12-11 | 2021-12-03 | 蝸牛および前庭細胞に核酸を送達するための材料および方法 |
| JP2023110371A Active JP7745594B2 (ja) | 2015-12-11 | 2023-07-05 | 蝸牛および前庭細胞に核酸を送達するための材料および方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US11167042B2 (https=) |
| EP (2) | EP3386537B1 (https=) |
| JP (3) | JP6990182B2 (https=) |
| KR (1) | KR102794870B1 (https=) |
| CN (2) | CN116236591B (https=) |
| AU (1) | AU2016366846B2 (https=) |
| CA (1) | CA3007476A1 (https=) |
| ES (1) | ES2903000T3 (https=) |
| SG (2) | SG11201804814YA (https=) |
| WO (1) | WO2017100791A1 (https=) |
Families Citing this family (73)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10834922B2 (en) * | 2014-11-26 | 2020-11-17 | Microban Products Company | Surface disinfectant with residual biocidal property |
| SG11201804814YA (en) | 2015-12-11 | 2018-07-30 | Massachusetts Eye & Ear Infirmary | Materials and methods for delivering nucleic acids to cochlear and vestibular cells |
| JP2019530737A (ja) | 2016-08-23 | 2019-10-24 | アコーオス インコーポレイテッド | ヒト対象において非加齢性聴力障害を治療するための組成物および方法 |
| WO2018145111A1 (en) * | 2017-02-06 | 2018-08-09 | Children's Medical Center Corporation | Materials and methods for delivering nucleic acids to cochlear and vestibular cells |
| US12391936B2 (en) | 2017-03-17 | 2025-08-19 | Rescue Hearing, Inc. | Gene therapy systems and related methods for treatment of hearing loss |
| US20200248203A1 (en) * | 2017-03-17 | 2020-08-06 | Rescue Hearing Inc | Gene Therapy Constructs and Methods for Treatment of Hearing Loss |
| AU2018261769B2 (en) | 2017-05-05 | 2024-03-14 | The Regents Of The University Of California | Compositions and methods for expressing Otoferlin |
| US20210154326A1 (en) * | 2017-06-26 | 2021-05-27 | Arizona Board Of Regents On Behalf Of Arizona State University | CRISPR-Based Synthetic Gene Circuits as Next Generation Gene Therapy of Inner Ear |
| EP3661523A4 (en) * | 2017-08-03 | 2021-08-04 | University of Iowa Research Foundation | TREATMENT METHODS FOR GENETIC HEARING LOSS |
| MX2020006435A (es) | 2017-12-19 | 2021-02-09 | Akouos Inc | Administracion de anticuerpos terapeuticos mediada por vector de virus adenoasociado (aav) en el oido interno. |
| DE102018100619A1 (de) | 2018-01-12 | 2019-07-18 | Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts, Universitätsmedizin | Gentherapeutische Behandlung von Schwerhörigkeit |
| KR20200122320A (ko) | 2018-01-16 | 2020-10-27 | 씨엘에스 테라퓨틱스 리미티드 | 데옥시리보뉴클레아제 (dnase) 활성을 갖는 효소의 간 발현에 의한 질환의 치료 |
| DE102018103924A1 (de) | 2018-02-21 | 2019-08-22 | Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts, Universitätsmedizin | Gentherapeutische Behandlung von Schwerhörigkeit |
| JP7430652B2 (ja) * | 2018-03-05 | 2024-02-13 | ザ チルドレンズ メディカル センター コーポレーション | 蝸牛および前庭細胞に核酸を送達するための組成物および方法 |
| CA3094828A1 (en) | 2018-03-23 | 2019-09-26 | Massachusetts Eye And Ear Infirmary | Crispr/cas9-mediated exon-skipping approach for ush2a-associated usher syndrome |
| US12054724B2 (en) | 2018-04-10 | 2024-08-06 | President And Fellows Of Harvard College | AAV vectors encoding clarin-1 or GJB2 and uses thereof |
| US11660353B2 (en) | 2018-04-27 | 2023-05-30 | Decibel Therapeutics, Inc. | Compositions and methods for treating sensorineural hearing loss using otoferlin dual vector systems |
| CN119410636A (zh) * | 2018-04-27 | 2025-02-11 | 分贝治疗公司 | 肌球蛋白15启动子及其用途 |
| IL278598B2 (en) | 2018-05-11 | 2025-11-01 | Massachusetts Eye & Ear Infirmary | Altering tissue tropism of adeno-associated viruses |
| SG11202012710WA (en) * | 2018-06-25 | 2021-01-28 | Akouos Inc | Methods of treating clrn1-associated hearing loss and/or vision loss |
| WO2020014625A1 (en) * | 2018-07-13 | 2020-01-16 | Akouos, Inc. | Methods of treating non-syndromic sensorineural hearing loss |
| WO2020028717A1 (en) * | 2018-08-01 | 2020-02-06 | University Of Maryland, Baltimore | MODULATION OF mTORC1 ACTIVITY AND AUTOPHAGY VIA CIB2-RHEB INTERACTION |
| WO2020069320A1 (en) | 2018-09-27 | 2020-04-02 | Akouos, Inc. | A method for treating an auditory neuropathy spectrum disorder |
| CA3115810A1 (en) * | 2018-10-11 | 2020-04-16 | Decibel Therapeutics, Inc. | Aav1 vectors and uses thereof for treatment of otic indications |
| CA3119059A1 (en) * | 2018-11-07 | 2020-05-14 | Akouos, Inc. | Compositions and methods of inducing differentiation of a hair cell |
| CN118497276A (zh) * | 2018-11-07 | 2024-08-16 | 阿库斯股份有限公司 | 腺相关病毒载体用于在内耳中的毛细胞和支持细胞中校正基因缺陷/表达蛋白质的用途 |
| WO2020148458A1 (en) * | 2019-01-18 | 2020-07-23 | Institut Pasteur | Aav-mediated gene therapy restoring the otoferlin gene |
| AU2020218547A1 (en) * | 2019-02-08 | 2021-08-26 | Decibel Therapeutics, Inc. | Myosin 15 promoters and uses thereof |
| EP3921032A4 (en) | 2019-02-08 | 2022-11-30 | Decibel Therapeutics, Inc. | COMPOSITIONS AND METHODS FOR TREATMENT OF SENSORINEURAL HEARING LOSS USING OTOFERLIN DOUBLE VECTOR SYSTEMS |
| US20220202957A1 (en) * | 2019-04-09 | 2022-06-30 | The Regents Of The University Of California | Long-lasting analgesia via targeted in vivo epigenetic repression |
| CN110129368B (zh) * | 2019-04-22 | 2021-03-09 | 中国科学院脑科学与智能技术卓越创新中心 | 一种感染支持细胞和毛细胞的aav载体 |
| US11278013B2 (en) | 2019-04-26 | 2022-03-22 | Usher 2020 Foundation | Large animal model for developing therapeutic agents to treat impaired ophthalmic function in usher syndrome |
| EP3967706A4 (en) * | 2019-05-08 | 2022-12-28 | Center For Excellence In Brain Science And Intelligence Technology, Chinese Academy Of Sciences | AAV MUTANT FOR EFFICIENT INFECTION OF SUPPORT CELLS |
| EP3999647A1 (en) * | 2019-07-18 | 2022-05-25 | Lysogene | Compositions and methods for the treatment of sanfilippo disease and other disorders |
| CN110423778B (zh) * | 2019-07-26 | 2023-04-21 | 上海科技大学 | 一种逆行性重组2型腺相关病毒在感染螺旋神经元中的应用 |
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| CA3153133A1 (en) * | 2019-09-30 | 2021-04-08 | Chris Bartolome | Adeno-associated virus (aav) systems for treatment of genetic hearing loss |
| EP4045092A1 (en) * | 2019-10-18 | 2022-08-24 | Research Institute at Nationwide Children's Hospital | Gene therapy targeting cochlear cells |
| CA3159549A1 (en) | 2019-10-30 | 2021-05-06 | Decibel Therapeutics, Inc. | Compositions and methods for treating sensorineural hearing loss using otoferlin dual vector systems |
| WO2021091950A1 (en) * | 2019-11-04 | 2021-05-14 | Decibel Therapeutics, Inc. | Vestibular supporting cell promoters and uses thereof |
| EP4055175A4 (en) | 2019-11-04 | 2023-11-29 | Decibel Therapeutics, Inc. | Cochlear inner hair cell promoters and uses thereof |
| WO2021108512A1 (en) * | 2019-11-27 | 2021-06-03 | Icahn School Of Medicine At Mount Sinai | Gene therapy for the regeneration of auditory hair cells |
| US20230047254A1 (en) * | 2019-12-29 | 2023-02-16 | Gloriana Therapeutics | Mammalian Cells Secreting GDNF and Their Therapeutic Use |
| JP7807380B2 (ja) | 2020-02-21 | 2026-01-27 | アコーオス インコーポレイテッド | ヒト対象において非加齢関連聴力障害を処置するための組成物および方法 |
| AU2021247172A1 (en) | 2020-04-01 | 2022-09-15 | University Of Florida Research Foundation, Incorporated | Dual AAV-MY07A vectors with improved safety for the treatment of USH1B |
| WO2021222682A1 (en) * | 2020-04-30 | 2021-11-04 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Application of aav44.9 vector in gene therapy for the inner ear |
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| KR102326582B1 (ko) * | 2020-05-15 | 2021-11-16 | 사회복지법인 삼성생명공익재단 | 청각장애의 진단용 마커 및 그의 용도 |
| WO2022032151A1 (en) * | 2020-08-07 | 2022-02-10 | University Of Miami | Treatment of sensorineural deafness |
| US12129287B2 (en) | 2020-09-14 | 2024-10-29 | President And Fellows Of Harvard College | Recombinant adeno associated virus encoding clarin-1 and uses thereof |
| IL303317A (en) | 2020-12-01 | 2023-07-01 | Akouos Inc | ANTI-NATURAL ANTIBODY STRUCTURES AND RELATED METHODS FOR THE TREATMENT OF SYMPTOMS ASSOCIATED WITH VESTIBULAR SWANNOMA |
| WO2022129543A1 (en) * | 2020-12-18 | 2022-06-23 | Institut Pasteur | Gene therapy for treating usher syndrome |
| JP2024515629A (ja) * | 2021-04-14 | 2024-04-10 | リサーチ インスティチュート アット ネイションワイド チルドレンズ ホスピタル | ニューロフィブロミン2/マーリン(nf2)遺伝子療法のための材料及び方法 |
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| US20220016262A1 (en) | 2022-01-20 |
| SG10201913266UA (en) | 2020-02-27 |
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| JP2023145460A (ja) | 2023-10-11 |
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| CN109310745B (zh) | 2022-12-06 |
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| EP3386537A4 (en) | 2019-05-15 |
| EP3984550A1 (en) | 2022-04-20 |
| CN116236591A (zh) | 2023-06-09 |
| JP2018536420A (ja) | 2018-12-13 |
| JP7309827B2 (ja) | 2023-07-18 |
| EP3386537B1 (en) | 2021-10-20 |
| CN116236591B (zh) | 2026-02-27 |
| KR20180097631A (ko) | 2018-08-31 |
| CN109310745A (zh) | 2019-02-05 |
| US11167042B2 (en) | 2021-11-09 |
| US20180369414A1 (en) | 2018-12-27 |
| KR102794870B1 (ko) | 2025-04-10 |
| JP7745594B2 (ja) | 2025-09-29 |
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