JP6989505B2 - Ｍａｌｔ１阻害剤およびその使用 - Google Patents

Ｍａｌｔ１阻害剤およびその使用 Download PDF

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JP6989505B2
JP6989505B2 JP2018529516A JP2018529516A JP6989505B2 JP 6989505 B2 JP6989505 B2 JP 6989505B2 JP 2018529516 A JP2018529516 A JP 2018529516A JP 2018529516 A JP2018529516 A JP 2018529516A JP 6989505 B2 JP6989505 B2 JP 6989505B2
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JP2018531987A (ja
JP2018531987A5 (enrdf_load_stackoverflow
Inventor
スコット，デイヴィッド，エー．
ハッチャー，ジョン
チェンナマダヴーニ，スパンダン
ギャバス，ロレナ，フォンタン
カオ，キ
ドゥ，グァンヤン
メルニク，アリ，エム．
グレイ，ナサニエル，エス．
ウー，ハオ
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Boston Childrens Hospital
Dana Farber Cancer Institute Inc
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Boston Childrens Hospital
Dana Farber Cancer Institute Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1019—Tetrapeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/07—Tetrapeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06052—Val-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/0606—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2018529516A 2015-08-28 2016-08-26 Ｍａｌｔ１阻害剤およびその使用 Active JP6989505B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2021135770A JP2021193093A (ja) 2015-08-28 2021-08-23 Ｍａｌｔ１阻害剤およびその使用

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562211629P 2015-08-28 2015-08-28
US62/211,629 2015-08-28
US201562256672P 2015-11-17 2015-11-17
US62/256,672 2015-11-17
PCT/US2016/049038 WO2017040304A1 (en) 2015-08-28 2016-08-26 Malt1 inhibitors and uses thereof

Related Child Applications (1)

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JP2021135770A Division JP2021193093A (ja) 2015-08-28 2021-08-23 Ｍａｌｔ１阻害剤およびその使用

Publications (3)

Publication Number Publication Date
JP2018531987A JP2018531987A (ja) 2018-11-01
JP2018531987A5 JP2018531987A5 (enrdf_load_stackoverflow) 2019-10-03
JP6989505B2 true JP6989505B2 (ja) 2022-01-05

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JP2018529516A Active JP6989505B2 (ja) 2015-08-28 2016-08-26 Ｍａｌｔ１阻害剤およびその使用
JP2021135770A Pending JP2021193093A (ja) 2015-08-28 2021-08-23 Ｍａｌｔ１阻害剤およびその使用

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US (1) US10711036B2 (enrdf_load_stackoverflow)
EP (1) EP3341007B1 (enrdf_load_stackoverflow)
JP (2) JP6989505B2 (enrdf_load_stackoverflow)
WO (1) WO2017040304A1 (enrdf_load_stackoverflow)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA53299A (fr) 2016-07-29 2022-02-23 Lupin Ltd Composés de thiazolo-pyridine substitués en tant qu'inhibiteurs de malt1
KR20190033607A (ko) 2016-07-29 2019-03-29 루핀 리미티드 Malt1 저해제로서의 치환 티아졸로-피리딘 화합물
CA3030949A1 (en) * 2016-07-29 2018-02-01 Toray Industries, Inc. Guanidine derivative and medical use thereof
CN111770759A (zh) * 2017-12-28 2020-10-13 通用医疗公司 靶向cbm信号体复合物诱导调节性t细胞使肿瘤微环境发炎
WO2019159097A1 (en) * 2018-02-14 2019-08-22 Sun Pharmaceutical Industries Limited Crystalline polymorphic forms of acalabrutinib
US11040031B2 (en) * 2018-06-18 2021-06-22 Janssen Pharmaceutica Nv Pyrazole derivatives as MALT1 inhibitors
BR112020025814A2 (pt) * 2018-06-18 2021-04-06 Janssen Pharmaceutica Nv Derivados de pirazol como inibidores de malt1
WO2020076889A1 (en) * 2018-10-09 2020-04-16 The Research Institute At Nationwide Children's Hospital Anticancer rocaglamide derivatives
CN111358959B (zh) * 2019-10-10 2021-03-26 鹿文葆 Roquin1蛋白及其编码基因在制备抑制肿瘤的药物中的应用
CN111686111B (zh) * 2020-06-09 2023-06-13 南方医科大学 Malt1蛋白酶抑制剂在制备非小细胞肺癌治疗药物中的应用
CN116916924A (zh) * 2020-10-16 2023-10-20 稀有生物科学股份有限公司 Malt1调节剂及其用途
CN113057957A (zh) * 2021-03-30 2021-07-02 福建中医药大学 葛杜宁及其衍生物在制备抗氧化药物和/或化妆品及治疗类风湿性关节炎药物中的用途
CN113024565B (zh) * 2021-03-31 2022-09-13 上海启甄环境科技有限公司 一种放射性同位素碳-14标记依鲁替尼及其合成方法
WO2023149945A1 (en) * 2022-02-03 2023-08-10 Purdue Research Foundation Peptidomimetic inhibitors of protein n-terminal methyltransferase 1, composition, and method of use

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5210272A (en) 1990-02-16 1993-05-11 Prototek, Inc. Process for forming a fluoromethyl ketone
EP0906296A1 (en) * 1996-06-18 1999-04-07 Warner-Lambert Company Llc Process for the preparation of chiral keto-heterocycles of basic amino acids
MXPA01012887A (es) 1999-07-07 2002-07-30 Astrazeneca Uk Ltd Derivados de quinazolina.
WO2009060835A1 (ja) 2007-11-05 2009-05-14 Kyoto University 新規ユビキリン結合性小分子
WO2012071414A2 (en) 2010-11-22 2012-05-31 Board Of Regents Of The University Of Nebraska Quinoxaline compounds and uses thereof
AU2013342267B2 (en) 2012-11-09 2017-01-12 Cornell University Small molecule inhibitors of MALT1
CN119591582A (zh) 2014-04-14 2025-03-11 阿尔维纳斯运营股份有限公司 基于酰亚胺的蛋白水解调节剂和相关使用方法
HUE044351T2 (hu) 2014-05-28 2019-10-28 Novartis Ag Új pirazolo-pirimidin származékok és azok alkalmazása MALT1 inhibitorként
WO2018085247A1 (en) 2016-11-01 2018-05-11 Cornell University Compounds for malt1 degradation

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Publication number Publication date
US20190389904A2 (en) 2019-12-26
WO2017040304A1 (en) 2017-03-09
US10711036B2 (en) 2020-07-14
EP3341007B1 (en) 2020-12-23
EP3341007A4 (en) 2019-05-01
JP2018531987A (ja) 2018-11-01
JP2021193093A (ja) 2021-12-23
EP3341007A1 (en) 2018-07-04
US20180251489A1 (en) 2018-09-06

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