JP6982392B2 - 染色体又は遺伝子コピーの計数のための一本鎖オリゴヌクレオチドプローブ - Google Patents

染色体又は遺伝子コピーの計数のための一本鎖オリゴヌクレオチドプローブ Download PDF

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JP6982392B2
JP6982392B2 JP2016553385A JP2016553385A JP6982392B2 JP 6982392 B2 JP6982392 B2 JP 6982392B2 JP 2016553385 A JP2016553385 A JP 2016553385A JP 2016553385 A JP2016553385 A JP 2016553385A JP 6982392 B2 JP6982392 B2 JP 6982392B2
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probe
her2
sequence
hybridization
chr17
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JP2017511698A5 (enExample
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マイケル ファレル，
アントニー ハバード，
ドナルド ジョンソン，
ブライアン ディー． ケリー，
テイラー シングラー，
レイ タン，
ウェンチュン チャン，
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ヴェンタナ メディカル システムズ， インク．
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6841—In situ hybridisation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
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  • Pathology (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP2016553385A 2014-02-21 2015-02-20 染色体又は遺伝子コピーの計数のための一本鎖オリゴヌクレオチドプローブ Active JP6982392B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201461943196P 2014-02-21 2014-02-21
US61/943,196 2014-02-21
US201462094543P 2014-12-19 2014-12-19
US62/094,543 2014-12-19
PCT/EP2015/053555 WO2015124702A1 (en) 2014-02-21 2015-02-20 Single-stranded oligonucleotide probes for chromosome or gene copy enumeration

Related Child Applications (1)

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JP2020002295A Division JP2020089374A (ja) 2014-02-21 2020-01-09 染色体又は遺伝子コピーの計数のための一本鎖オリゴヌクレオチドプローブ

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JP2017511698A JP2017511698A (ja) 2017-04-27
JP2017511698A5 JP2017511698A5 (enExample) 2018-03-29
JP6982392B2 true JP6982392B2 (ja) 2021-12-17

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JP2016553385A Active JP6982392B2 (ja) 2014-02-21 2015-02-20 染色体又は遺伝子コピーの計数のための一本鎖オリゴヌクレオチドプローブ
JP2020002295A Pending JP2020089374A (ja) 2014-02-21 2020-01-09 染色体又は遺伝子コピーの計数のための一本鎖オリゴヌクレオチドプローブ

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US (3) US10752955B2 (enExample)
EP (1) EP3108006B1 (enExample)
JP (2) JP6982392B2 (enExample)
AU (1) AU2015220749B2 (enExample)
CA (1) CA2940111C (enExample)
DK (1) DK3108006T3 (enExample)
ES (1) ES2689568T3 (enExample)
WO (1) WO2015124702A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2015326827B2 (en) * 2014-10-02 2019-11-07 Ventana Medical Systems, Inc. Polymers and conjugates comprising the same
JP7038209B2 (ja) 2017-11-13 2022-03-17 エフ．ホフマン－ラ ロシュ アーゲー エピタコ電気泳動を使用する試料分析のための装置
EP3864403A1 (en) 2018-10-12 2021-08-18 F. Hoffmann-La Roche AG Detection methods for epitachophoresis workflow automation
WO2020229437A1 (en) 2019-05-14 2020-11-19 F. Hoffmann-La Roche Ag Devices and methods for sample analysis
CN111411146B (zh) * 2020-03-31 2024-01-16 宜昌美光硅谷生命科技股份有限公司 一种检测和定量单拷贝染色体外dna或rna的方法
CN112795649A (zh) * 2021-01-05 2021-05-14 武汉友芝友医疗科技股份有限公司 一种用于检测her2基因扩增水平的探针组及其应用
CN114214318A (zh) * 2021-11-30 2022-03-22 广州康立明生物科技股份有限公司 一种染色体着丝粒探针
WO2024215528A1 (en) 2023-04-13 2024-10-17 Ventana Medical Systems, Inc. Proliferation assay for fixed solid tumors
WO2025193604A1 (en) 2024-03-11 2025-09-18 Ventana Medical Systems, Inc. Non-enzymatic dissociation of ffpe tissue and generation of single cells with intact cell surface markers

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5447841A (en) 1986-01-16 1995-09-05 The Regents Of The Univ. Of California Methods for chromosome-specific staining
JPH0686697A (ja) * 1991-04-09 1994-03-29 Univ California 反復配列染色体特異的核酸プローブ
US5750340A (en) * 1995-04-07 1998-05-12 University Of New Mexico In situ hybridization solution and process
US6046004A (en) * 1997-02-27 2000-04-04 Lorne Park Research, Inc. Solution hybridization of nucleic acids with antisense probes having modified backbones
US6573043B1 (en) * 1998-10-07 2003-06-03 Genentech, Inc. Tissue analysis and kits therefor
GB2373500B (en) * 2000-02-04 2004-12-15 Aeomica Inc Methods and apparatus for predicting, confirming, and displaying functional information derived from genomic sequence
US20030017491A1 (en) 2000-09-14 2003-01-23 Zuo-Rong Shi Chromogenic in situ hybridization methods, kits, and compositions
JP2002296279A (ja) * 2001-03-29 2002-10-09 Hitachi Software Eng Co Ltd バイオチップ及びプローブ設計方法
US20020160401A1 (en) 2001-03-29 2002-10-31 Yasuyuki Nozaki Biochip and method of designing probes
EP1989329A2 (en) * 2006-01-25 2008-11-12 Board of Regents, The University of Texas System Detection and diagnosis of smoking related cancers
US7807356B2 (en) 2006-03-09 2010-10-05 Agilent Technologies, Inc. Labeled nucleotide composition
JP5126644B2 (ja) * 2006-05-31 2013-01-23 独立行政法人産業技術総合研究所 遺伝子発現プロファイルを用いた漢方薬の評価法
US20080299555A1 (en) * 2007-05-30 2008-12-04 Hiroaki Nitta Multicolor chromogenic detection of biomarkers
EP2335221B8 (en) * 2008-09-16 2016-05-25 Novartis AG Reproducible quantification of biomarker expression
ES2645754T3 (es) 2009-07-30 2017-12-07 F. Hoffmann-La Roche Ag Conjunto de sondas de oligonucleótidos así como métodos y usos relacionados con el mismo
EP2627780B1 (en) * 2010-10-12 2018-02-21 Universite Libre De Bruxelles Bach2 repression in cells
CA2838736A1 (en) * 2011-06-07 2012-12-13 Caris Mpi, Inc. Molecular profiling for cancer
US10510435B2 (en) * 2013-04-30 2019-12-17 California Institute Of Technology Error correction of multiplex imaging analysis by sequential hybridization

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US11788149B2 (en) 2023-10-17
JP2020089374A (ja) 2020-06-11
AU2015220749A1 (en) 2016-07-07
CA2940111C (en) 2022-03-15
CA2940111A1 (en) 2015-08-27
ES2689568T3 (es) 2018-11-14
DK3108006T3 (en) 2018-10-15
US20170009305A1 (en) 2017-01-12
EP3108006B1 (en) 2018-08-01
US10752955B2 (en) 2020-08-25
JP2017511698A (ja) 2017-04-27
US20240084395A1 (en) 2024-03-14
EP3108006A1 (en) 2016-12-28
WO2015124702A1 (en) 2015-08-27
AU2015220749B2 (en) 2020-12-24
US20210002726A1 (en) 2021-01-07

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