JP6976581B2 - α−トルキシル酸誘導体およびその医薬組成物 - Google Patents

α−トルキシル酸誘導体およびその医薬組成物 Download PDF

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JP6976581B2
JP6976581B2 JP2018567019A JP2018567019A JP6976581B2 JP 6976581 B2 JP6976581 B2 JP 6976581B2 JP 2018567019 A JP2018567019 A JP 2018567019A JP 2018567019 A JP2018567019 A JP 2018567019A JP 6976581 B2 JP6976581 B2 JP 6976581B2
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alkyl
aryl
heteroaryl
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JP2019510086A (ja
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オジマ、イワオ
ドイチュ、デール
カッソチャ、マーティン
フ、コンジェン
トング、シモン
エルメス、マシュー
ヤン、ス
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ザ・リサーチ・ファウンデーション・フォア・ザ・ステイト・ユニバーシティー・オブ・ニューヨーク
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    • C07—ORGANIC CHEMISTRY
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    • C07C69/74—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C69/753—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring of polycyclic acids
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4192—1,2,3-Triazoles
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
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    • C07C205/55—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the carbon skeleton
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    • C07C233/24—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/25—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
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    • C07C69/757—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
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    • C07D215/04—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms
    • C07D215/06—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms having only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to the ring nitrogen atom
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    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • C07D249/06—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles with aryl radicals directly attached to ring atoms
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    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
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    • C07D309/04—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
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    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
    • C07C2603/18—Fluorenes; Hydrogenated fluorenes

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  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Pain & Pain Management (AREA)
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  • Emergency Medicine (AREA)
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  • Addiction (AREA)
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  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Quinoline Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2018567019A 2016-03-11 2017-03-10 α−トルキシル酸誘導体およびその医薬組成物 Active JP6976581B2 (ja)

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US201662307262P 2016-03-11 2016-03-11
US62/307,262 2016-03-11
PCT/US2017/021711 WO2017156354A1 (en) 2016-03-11 2017-03-10 α-TRUXILLIC ACID DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS THEREOF

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JP2019510086A JP2019510086A (ja) 2019-04-11
JP2019510086A5 JP2019510086A5 (https=) 2020-04-16
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US (3) US10968163B2 (https=)
EP (1) EP3452441B1 (https=)
JP (1) JP6976581B2 (https=)
KR (1) KR102365059B1 (https=)
CN (1) CN109415295B (https=)
AU (1) AU2017230790B2 (https=)
BR (1) BR112018068414B1 (https=)
CA (1) CA3017496A1 (https=)
EA (1) EA201892045A1 (https=)
ES (1) ES3055898T3 (https=)
MX (1) MX2018010801A (https=)
PL (1) PL3452441T3 (https=)
SG (2) SG10202008700VA (https=)
WO (1) WO2017156354A1 (https=)

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ES2802049T3 (es) 2012-07-20 2021-01-15 Univ New York State Res Found Derivados de ácido alfa- y gamma-truxílico y composiciones farmacéuticas de los mismos
BR112018068414B1 (pt) * 2016-03-11 2022-08-23 The Research Foundation For The State University Of New York Derivados de ácido a-truxílico e composições farmacêuticas dos mesmos
JP7798358B2 (ja) * 2019-11-25 2026-01-14 ザ・リサーチ・ファウンデーション・フォア・ザ・ステイト・ユニバーシティー・オブ・ニューヨーク 癌の処置のためにタキサンと共にｆａｂｐ５阻害剤を使用する併用療法
CA3194829A1 (en) * 2020-10-08 2022-04-14 Iwao Ojima Truxillic acid monoester-derivatives as selective fabp5 inhibitors and pharmaceutical compositions and uses thereof
CN117298091A (zh) * 2023-11-01 2023-12-29 张凯楠 Sbfi-26在制备用于预防肝纤维化药物中的用途
WO2025193881A1 (en) * 2024-03-12 2025-09-18 Artelo Biosciences Incorporated Enantiomers that inhibit fatty acid binding protein 5

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US3903297A (en) 1973-11-01 1975-09-02 Upjohn Co Method of treatment and prophylaxis of gastric hypersecretion and gastric and duodenal ulcers using prostaglandin analogs
JP2001199884A (ja) 2000-01-21 2001-07-24 Seiwa Yakuhin Kk 鎮痛作用剤
ES2189602B1 (es) * 2000-10-11 2004-08-01 Universidad De Murcia Procedimiento para la inmovilizacion de un ligando sobre un soporte.
JP2002154959A (ja) * 2000-11-15 2002-05-28 Seiwa Yakuhin Kk 鎮痛抗炎症作用剤
EP1443919A4 (en) 2001-11-16 2006-03-22 Bristol Myers Squibb Co DOUBLE INHIBITORS OF THE FATTY ACID BINDING PROTEIN OF THE ADIPOCYTES AND THE FATTY ACID BINDING PROTEIN OF KERATINOCYTES
CA2709784A1 (en) * 2007-12-21 2009-07-09 University Of Rochester Method for altering the lifespan of eukaryotic organisms
US8980820B2 (en) 2009-01-19 2015-03-17 The Research Foundation For The State University Of New York Fatty acid binding proteins as drug targets for endocannabinoids
CN101838239B (zh) 2010-02-02 2012-03-21 中国科学院广州生物医药与健康研究院 一种吡唑类化合物及其组合物和应用
ES2802049T3 (es) * 2012-07-20 2021-01-15 Univ New York State Res Found Derivados de ácido alfa- y gamma-truxílico y composiciones farmacéuticas de los mismos
CN104619705B (zh) * 2012-09-12 2018-01-02 霍夫曼-拉罗奇有限公司 作为脂肪酸结合蛋白(fabp)4和/或5的抑制剂的非成环噻吩基酰胺
BR112018068414B1 (pt) 2016-03-11 2022-08-23 The Research Foundation For The State University Of New York Derivados de ácido a-truxílico e composições farmacêuticas dos mesmos

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CN109415295A (zh) 2019-03-01
EP3452441A4 (en) 2019-10-23
EP3452441A1 (en) 2019-03-13
CA3017496A1 (en) 2017-09-14
PL3452441T3 (pl) 2026-02-23
SG10202008700VA (en) 2020-10-29
MX2018010801A (es) 2019-02-07
JP2019510086A (ja) 2019-04-11
AU2017230790A1 (en) 2018-11-01
US20190062261A1 (en) 2019-02-28
EP3452441B1 (en) 2025-08-27
US20210179535A1 (en) 2021-06-17
US11739047B2 (en) 2023-08-29
SG11201807365QA (en) 2018-09-27
CN109415295B (zh) 2022-05-17
NZ747067A (en) 2025-02-28
US20240092725A1 (en) 2024-03-21
KR20180120230A (ko) 2018-11-05
US10968163B2 (en) 2021-04-06
BR112018068414A2 (pt) 2019-01-22
ES3055898T3 (en) 2026-02-16
WO2017156354A1 (en) 2017-09-14
BR112018068414B1 (pt) 2022-08-23
KR102365059B1 (ko) 2022-02-18
EA201892045A1 (ru) 2019-04-30
AU2017230790B2 (en) 2021-07-08

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