JP2019510086A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2019510086A5 JP2019510086A5 JP2018567019A JP2018567019A JP2019510086A5 JP 2019510086 A5 JP2019510086 A5 JP 2019510086A5 JP 2018567019 A JP2018567019 A JP 2018567019A JP 2018567019 A JP2018567019 A JP 2018567019A JP 2019510086 A5 JP2019510086 A5 JP 2019510086A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- aryl
- heteroaryl
- naphthalene
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- UFWIBTONFRDIAS-UHFFFAOYSA-N Naphthalene Chemical compound C1=CC=CC2=CC=CC=C21 UFWIBTONFRDIAS-UHFFFAOYSA-N 0.000 claims 24
- 125000003118 aryl group Chemical group 0.000 claims 18
- 150000001875 compounds Chemical class 0.000 claims 18
- 125000001072 heteroaryl group Chemical group 0.000 claims 16
- 125000000217 alkyl group Chemical group 0.000 claims 13
- 125000000753 cycloalkyl group Chemical group 0.000 claims 9
- 102000030914 Fatty Acid-Binding Human genes 0.000 claims 8
- 108091022862 fatty acid binding Proteins 0.000 claims 8
- 125000000304 alkynyl group Chemical group 0.000 claims 7
- -1 and R 14 is CF 3 Chemical group 0.000 claims 7
- 229910052736 halogen Inorganic materials 0.000 claims 7
- 150000002367 halogens Chemical class 0.000 claims 7
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 6
- 125000006374 C2-C10 alkenyl group Chemical group 0.000 claims 5
- 239000000203 mixture Substances 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 2
- 229910052794 bromium Inorganic materials 0.000 claims 2
- 229910052801 chlorine Inorganic materials 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 229910052731 fluorine Inorganic materials 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 125000001425 triazolyl group Chemical group 0.000 claims 2
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- 125000005605 benzo group Chemical group 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 239000003446 ligand Substances 0.000 claims 1
- 125000003107 substituted aryl group Chemical group 0.000 claims 1
- 125000005346 substituted cycloalkyl group Chemical group 0.000 claims 1
- 125000003944 tolyl group Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662307262P | 2016-03-11 | 2016-03-11 | |
| US62/307,262 | 2016-03-11 | ||
| PCT/US2017/021711 WO2017156354A1 (en) | 2016-03-11 | 2017-03-10 | α-TRUXILLIC ACID DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS THEREOF |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019510086A JP2019510086A (ja) | 2019-04-11 |
| JP2019510086A5 true JP2019510086A5 (https=) | 2020-04-16 |
| JP6976581B2 JP6976581B2 (ja) | 2021-12-08 |
Family
ID=59789897
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018567019A Active JP6976581B2 (ja) | 2016-03-11 | 2017-03-10 | α−トルキシル酸誘導体およびその医薬組成物 |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US10968163B2 (https=) |
| EP (1) | EP3452441B1 (https=) |
| JP (1) | JP6976581B2 (https=) |
| KR (1) | KR102365059B1 (https=) |
| CN (1) | CN109415295B (https=) |
| AU (1) | AU2017230790B2 (https=) |
| BR (1) | BR112018068414B1 (https=) |
| CA (1) | CA3017496A1 (https=) |
| EA (1) | EA201892045A1 (https=) |
| ES (1) | ES3055898T3 (https=) |
| MX (1) | MX2018010801A (https=) |
| PL (1) | PL3452441T3 (https=) |
| SG (2) | SG10202008700VA (https=) |
| WO (1) | WO2017156354A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2802049T3 (es) | 2012-07-20 | 2021-01-15 | Univ New York State Res Found | Derivados de ácido alfa- y gamma-truxílico y composiciones farmacéuticas de los mismos |
| BR112018068414B1 (pt) * | 2016-03-11 | 2022-08-23 | The Research Foundation For The State University Of New York | Derivados de ácido a-truxílico e composições farmacêuticas dos mesmos |
| JP7798358B2 (ja) * | 2019-11-25 | 2026-01-14 | ザ・リサーチ・ファウンデーション・フォア・ザ・ステイト・ユニバーシティー・オブ・ニューヨーク | 癌の処置のためにタキサンと共にｆａｂｐ５阻害剤を使用する併用療法 |
| CA3194829A1 (en) * | 2020-10-08 | 2022-04-14 | Iwao Ojima | Truxillic acid monoester-derivatives as selective fabp5 inhibitors and pharmaceutical compositions and uses thereof |
| CN117298091A (zh) * | 2023-11-01 | 2023-12-29 | 张凯楠 | Sbfi-26在制备用于预防肝纤维化药物中的用途 |
| WO2025193881A1 (en) * | 2024-03-12 | 2025-09-18 | Artelo Biosciences Incorporated | Enantiomers that inhibit fatty acid binding protein 5 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3903297A (en) | 1973-11-01 | 1975-09-02 | Upjohn Co | Method of treatment and prophylaxis of gastric hypersecretion and gastric and duodenal ulcers using prostaglandin analogs |
| JP2001199884A (ja) | 2000-01-21 | 2001-07-24 | Seiwa Yakuhin Kk | 鎮痛作用剤 |
| ES2189602B1 (es) * | 2000-10-11 | 2004-08-01 | Universidad De Murcia | Procedimiento para la inmovilizacion de un ligando sobre un soporte. |
| JP2002154959A (ja) * | 2000-11-15 | 2002-05-28 | Seiwa Yakuhin Kk | 鎮痛抗炎症作用剤 |
| EP1443919A4 (en) | 2001-11-16 | 2006-03-22 | Bristol Myers Squibb Co | DOUBLE INHIBITORS OF THE FATTY ACID BINDING PROTEIN OF THE ADIPOCYTES AND THE FATTY ACID BINDING PROTEIN OF KERATINOCYTES |
| CA2709784A1 (en) * | 2007-12-21 | 2009-07-09 | University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
| US8980820B2 (en) | 2009-01-19 | 2015-03-17 | The Research Foundation For The State University Of New York | Fatty acid binding proteins as drug targets for endocannabinoids |
| CN101838239B (zh) | 2010-02-02 | 2012-03-21 | 中国科学院广州生物医药与健康研究院 | 一种吡唑类化合物及其组合物和应用 |
| ES2802049T3 (es) * | 2012-07-20 | 2021-01-15 | Univ New York State Res Found | Derivados de ácido alfa- y gamma-truxílico y composiciones farmacéuticas de los mismos |
| CN104619705B (zh) * | 2012-09-12 | 2018-01-02 | 霍夫曼-拉罗奇有限公司 | 作为脂肪酸结合蛋白(fabp)4和/或5的抑制剂的非成环噻吩基酰胺 |
| BR112018068414B1 (pt) | 2016-03-11 | 2022-08-23 | The Research Foundation For The State University Of New York | Derivados de ácido a-truxílico e composições farmacêuticas dos mesmos |
-
2017
- 2017-03-10 BR BR112018068414-7A patent/BR112018068414B1/pt active IP Right Grant
- 2017-03-10 US US16/080,493 patent/US10968163B2/en active Active
- 2017-03-10 SG SG10202008700VA patent/SG10202008700VA/en unknown
- 2017-03-10 ES ES17764162T patent/ES3055898T3/es active Active
- 2017-03-10 WO PCT/US2017/021711 patent/WO2017156354A1/en not_active Ceased
- 2017-03-10 JP JP2018567019A patent/JP6976581B2/ja active Active
- 2017-03-10 SG SG11201807365QA patent/SG11201807365QA/en unknown
- 2017-03-10 MX MX2018010801A patent/MX2018010801A/es unknown
- 2017-03-10 PL PL17764162.8T patent/PL3452441T3/pl unknown
- 2017-03-10 AU AU2017230790A patent/AU2017230790B2/en active Active
- 2017-03-10 CA CA3017496A patent/CA3017496A1/en active Pending
- 2017-03-10 KR KR1020187028746A patent/KR102365059B1/ko active Active
- 2017-03-10 CN CN201780016751.4A patent/CN109415295B/zh active Active
- 2017-03-10 EP EP17764162.8A patent/EP3452441B1/en active Active
- 2017-03-10 EA EA201892045A patent/EA201892045A1/ru unknown
-
2021
- 2021-02-11 US US17/174,030 patent/US11739047B2/en active Active
-
2023
- 2023-07-03 US US18/346,363 patent/US20240092725A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2019510086A5 (https=) | ||
| JP2016503793A5 (https=) | ||
| JP2020500916A5 (https=) | ||
| JP2013540755A5 (https=) | ||
| JP2016505614A5 (https=) | ||
| JP2018024670A5 (https=) | ||
| JP2012521994A5 (https=) | ||
| JP2015143283A5 (https=) | ||
| JP2013544860A5 (https=) | ||
| JP2016531126A5 (https=) | ||
| JP2014521688A5 (https=) | ||
| JP2017524025A5 (https=) | ||
| ME02861B (me) | Postupak za pripremu treprostinila i njegovih derivata | |
| JP2016525093A5 (https=) | ||
| JP2015512946A5 (https=) | ||
| JP2015527363A5 (https=) | ||
| JP2013147490A5 (ja) | イリジウム錯体 | |
| JP2014526533A5 (https=) | ||
| JP2017520540A5 (https=) | ||
| JP2015078201A5 (https=) | ||
| JP2016528273A5 (https=) | ||
| JP2014043437A5 (ja) | 有機化合物 | |
| JP2018530582A5 (https=) | ||
| JP2016503403A5 (https=) | ||
| RU2019131147A (ru) | Новые хиназолиноновые производные, ингибирующие pi3k, и содержащая их фармацевтическая композиция |