JP6975641B2 - アンギオポエチン様３（ＡＮＧＰＴＬ３）ｉＲＮＡ組成物およびそれらの使用方法 - Google Patents

アンギオポエチン様３（ＡＮＧＰＴＬ３）ｉＲＮＡ組成物およびそれらの使用方法 Download PDF

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JP6975641B2
JP6975641B2 JP2017553347A JP2017553347A JP6975641B2 JP 6975641 B2 JP6975641 B2 JP 6975641B2 JP 2017553347 A JP2017553347 A JP 2017553347A JP 2017553347 A JP2017553347 A JP 2017553347A JP 6975641 B2 JP6975641 B2 JP 6975641B2
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angptl3
dsrna
pat
irna
expression
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JP2018512155A (ja
JP2018512155A5 (cg-RX-API-DMAC7.html
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ウィリアム・クアーベス
ケビン・フィッツジェラルド
ジェイムズ・バトラー
ステファニー・ウィリアムズ
グレゴリー・ヒンクル
マルティン・マイアー
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Alnylam Pharmaceuticals Inc
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    • C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
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JP2017553347A 2015-04-13 2016-04-13 アンギオポエチン様３（ＡＮＧＰＴＬ３）ｉＲＮＡ組成物およびそれらの使用方法 Active JP6975641B2 (ja)

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JP2021147698A JP2022002518A (ja) 2015-04-13 2021-09-10 アンギオポエチン様３（ＡＮＧＰＴＬ３）ｉＲＮＡ組成物およびそれらの使用方法
JP2023169168A JP2024009838A (ja) 2015-04-13 2023-09-29 アンギオポエチン様３（ＡＮＧＰＴＬ３）ｉＲＮＡ組成物およびそれらの使用方法

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562146604P 2015-04-13 2015-04-13
US62/146,604 2015-04-13
US201562261361P 2015-12-01 2015-12-01
US62/261,361 2015-12-01
PCT/US2016/027271 WO2016168286A1 (en) 2015-04-13 2016-04-13 Angiopoietin-like 3 (angptl3) irna compositions and methods of use thereof

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JP2018512155A JP2018512155A (ja) 2018-05-17
JP2018512155A5 JP2018512155A5 (cg-RX-API-DMAC7.html) 2019-05-23
JP6975641B2 true JP6975641B2 (ja) 2021-12-01

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JP2021147698A Pending JP2022002518A (ja) 2015-04-13 2021-09-10 アンギオポエチン様３（ＡＮＧＰＴＬ３）ｉＲＮＡ組成物およびそれらの使用方法
JP2023169168A Pending JP2024009838A (ja) 2015-04-13 2023-09-29 アンギオポエチン様３（ＡＮＧＰＴＬ３）ｉＲＮＡ組成物およびそれらの使用方法

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JP2023169168A Pending JP2024009838A (ja) 2015-04-13 2023-09-29 アンギオポエチン様３（ＡＮＧＰＴＬ３）ｉＲＮＡ組成物およびそれらの使用方法

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US (4) US10570393B2 (cg-RX-API-DMAC7.html)
EP (1) EP3283631A1 (cg-RX-API-DMAC7.html)
JP (3) JP6975641B2 (cg-RX-API-DMAC7.html)
KR (2) KR102749152B1 (cg-RX-API-DMAC7.html)
CN (2) CN115927335A (cg-RX-API-DMAC7.html)
AU (2) AU2016247922B2 (cg-RX-API-DMAC7.html)
BR (1) BR112017021053A2 (cg-RX-API-DMAC7.html)
CA (1) CA2982450A1 (cg-RX-API-DMAC7.html)
EA (1) EA201792263A1 (cg-RX-API-DMAC7.html)
IL (2) IL254786B (cg-RX-API-DMAC7.html)
MX (2) MX392757B (cg-RX-API-DMAC7.html)
TW (3) TWI862799B (cg-RX-API-DMAC7.html)
WO (1) WO2016168286A1 (cg-RX-API-DMAC7.html)

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TWI862799B (zh) 2015-04-13 2024-11-21 美商阿尼拉製藥公司 類血管生成素３（ＡＮＧＰＴＬ３）ｉＲＮＡ組成物及其用途方法
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JP7273417B2 (ja) 2017-12-01 2023-05-15 スーチョウ リボ ライフ サイエンス カンパニー、リミテッド 核酸、当該核酸を含む組成物および複合体ならびに調製方法と使用
JP7727308B2 (ja) * 2017-12-01 2025-08-21 スーチョウ リボ ライフ サイエンス カンパニー、リミテッド 二本鎖オリゴヌクレオチド、二本鎖オリゴヌクレオチドを含む組成物および複合体ならびに調製方法と使用
US12083142B2 (en) 2017-12-01 2024-09-10 Suzhou Ribo Life Science Co., Ltd. Nucleic acid, composition and conjugate comprising the same, and preparation method and use thereof
US11414661B2 (en) 2017-12-01 2022-08-16 Suzhou Ribo Life Science Co., Ltd. Nucleic acid, composition and conjugate containing nucleic acid, preparation method therefor and use thereof
JP7365052B2 (ja) 2017-12-01 2023-10-19 スーチョウ リボ ライフ サイエンス カンパニー、リミテッド 核酸、当該核酸を含む組成物及び複合体ならびに調製方法と使用
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TWI851574B (zh) * 2018-05-14 2024-08-11 美商阿尼拉製藥公司 血管收縮素原（ＡＧＴ）ｉＲＮＡ組成物及其使用方法
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CN111655297A (zh) 2018-09-30 2020-09-11 苏州瑞博生物技术有限公司 一种siRNA缀合物及其制备方法和用途
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EP3903830A4 (en) 2018-12-28 2023-04-26 Suzhou Ribo Life Science Co., Ltd. NUCLEIC ACID, COMPOSITION AND CONJUGATE WITH NUCLEIC ACID, PROCESS FOR THEIR PREPARATION AND ITS USE
AU2020280438B2 (en) 2019-05-22 2025-03-06 Suzhou Ribo Life Science Co., Ltd. Nucleic acid, pharmaceutical composition, conjugate, preparation method, and use
WO2021119019A1 (en) * 2019-12-09 2021-06-17 Empirico Inc. Oligonucleotides for treatment of angiopoietin like 4 (angptl4) related diseases
KR20230011913A (ko) * 2020-03-04 2023-01-25 버브 테라퓨틱스, 인크. 표적화된 rna 전달을 위한 조성물 및 방법
WO2021204872A1 (en) * 2020-04-07 2021-10-14 Uniqure Ip B.V. Gene constructs for silencing angiopoietin-like 3 (angptl3) and uses thereof
EP4223875A1 (en) * 2020-09-30 2023-08-09 Nanopeptide (Qingdao) Biotechnology Ltd. Sirna of angiopoietin-like 3 (angptl3) and use thereof
EP4229200A1 (en) * 2020-10-16 2023-08-23 Sanofi Novel rna compositions and methods for inhibiting angptl3
CN114685585B (zh) * 2020-12-31 2024-06-04 苏州瑞博生物技术股份有限公司 核苷酸序列、双链寡核苷酸、药物组合物与缀合物及制备方法和用途
IL305414A (en) * 2021-03-04 2023-10-01 Alnylam Pharmaceuticals Inc Angiopoietin-like 3 (ANGPTL3) IRNA compositions and methods of using them
EP4313075A4 (en) * 2021-03-24 2025-06-18 Atalanta Therapeutics, Inc. DOUBLE-STRANDED SIRNA WITH PATTERNED CHEMICAL MODIFICATIONS
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