JP6968094B2 - ヘテロアリール置換されたピリジン類及び使用方法 - Google Patents

ヘテロアリール置換されたピリジン類及び使用方法 Download PDF

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Publication number
JP6968094B2
JP6968094B2 JP2018552704A JP2018552704A JP6968094B2 JP 6968094 B2 JP6968094 B2 JP 6968094B2 JP 2018552704 A JP2018552704 A JP 2018552704A JP 2018552704 A JP2018552704 A JP 2018552704A JP 6968094 B2 JP6968094 B2 JP 6968094B2
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formula
substituted
sulfonyl
amino
trifluoromethoxy
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JP2019517455A5 (en:Method
JP2019517455A (ja
Inventor
アルテンバック，ロバート・ジェイ
ボグダン，アンドリュー
コーチ，ジュバンニ・ペトル・ディウニス
コワート，マーロン・ディー
グレスツラー，スティーブン・エヌ
ケルグテルマンス，ハンス
キム，フィリップ・アール
ファン・デル・プラス，スティーブン・エミエル
ワン，シュエチン
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Galapagos NV
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Galapagos NV
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Priority to JP2021173679A priority Critical patent/JP7392211B2/ja
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Priority to JP2023049450A priority patent/JP7622122B2/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2018552704A 2016-06-03 2017-05-24 ヘテロアリール置換されたピリジン類及び使用方法 Active JP6968094B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2021173679A JP7392211B2 (ja) 2016-06-03 2021-10-25 ヘテロアリール置換されたピリジン類及び使用方法
JP2023049450A JP7622122B2 (ja) 2016-06-03 2023-03-27 ヘテロアリール置換されたピリジン類及び使用方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662345315P 2016-06-03 2016-06-03
US62/345,315 2016-06-03
PCT/IB2017/053068 WO2017208115A1 (en) 2016-06-03 2017-05-24 Heteroaryl substituted pyridines and methods of use

Related Child Applications (1)

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JP2021173679A Division JP7392211B2 (ja) 2016-06-03 2021-10-25 ヘテロアリール置換されたピリジン類及び使用方法

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JP2019517455A JP2019517455A (ja) 2019-06-24
JP2019517455A5 JP2019517455A5 (en:Method) 2020-06-25
JP6968094B2 true JP6968094B2 (ja) 2021-11-17

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JP2021173679A Active JP7392211B2 (ja) 2016-06-03 2021-10-25 ヘテロアリール置換されたピリジン類及び使用方法
JP2023049450A Active JP7622122B2 (ja) 2016-06-03 2023-03-27 ヘテロアリール置換されたピリジン類及び使用方法

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US (2) US10138227B2 (en:Method)
EP (1) EP3464282B1 (en:Method)
JP (3) JP6968094B2 (en:Method)
KR (2) KR102719916B1 (en:Method)
CN (2) CN114671864B (en:Method)
AR (2) AR108672A1 (en:Method)
AU (3) AU2017273215B2 (en:Method)
CA (1) CA3022216A1 (en:Method)
CL (1) CL2018003323A1 (en:Method)
CO (1) CO2018012171A2 (en:Method)
CR (1) CR20180547A (en:Method)
CY (1) CY1124031T1 (en:Method)
DK (1) DK3464282T3 (en:Method)
DO (1) DOP2018000257A (en:Method)
EC (1) ECSP18094790A (en:Method)
ES (1) ES2806873T3 (en:Method)
HR (1) HRP20201068T1 (en:Method)
HU (1) HUE050248T2 (en:Method)
IL (3) IL288243B2 (en:Method)
LT (1) LT3464282T (en:Method)
MX (2) MX385054B (en:Method)
MY (1) MY199604A (en:Method)
PE (1) PE20190511A1 (en:Method)
PH (1) PH12018502534B1 (en:Method)
PL (1) PL3464282T3 (en:Method)
PT (1) PT3464282T (en:Method)
RS (1) RS60574B1 (en:Method)
RU (2) RU2021127810A (en:Method)
SG (1) SG11201808842VA (en:Method)
SI (1) SI3464282T1 (en:Method)
SM (1) SMT202000394T1 (en:Method)
TW (4) TW202515560A (en:Method)
UY (2) UY37272A (en:Method)
WO (1) WO2017208115A1 (en:Method)
ZA (1) ZA201808423B (en:Method)

Cited By (1)

* Cited by examiner, † Cited by third party
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JP2022009448A (ja) * 2016-06-03 2022-01-14 アッヴィ・エス・ア・エール・エル ヘテロアリール置換されたピリジン類及び使用方法

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022009448A (ja) * 2016-06-03 2022-01-14 アッヴィ・エス・ア・エール・エル ヘテロアリール置換されたピリジン類及び使用方法
JP2023172889A (ja) * 2016-06-03 2023-12-06 アッヴィ・グローバル・エンタープライザズ・リミテッド ヘテロアリール置換されたピリジン類及び使用方法
JP7392211B2 (ja) 2016-06-03 2023-12-06 アッヴィ・グローバル・エンタープライザズ・リミテッド ヘテロアリール置換されたピリジン類及び使用方法
JP7622122B2 (ja) 2016-06-03 2025-01-27 アッヴィ・グローバル・エンタープライザズ・リミテッド ヘテロアリール置換されたピリジン類及び使用方法

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