JP6951592B2 - 皮膚感染の予防または治療用組成物 - Google Patents
皮膚感染の予防または治療用組成物 Download PDFInfo
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Description
1.実験方法:ディスク拡散法(modified clsi method)
2.指標菌および条件(表01)
本明細書による組成物の抗菌活性を判断するためにCandida albicans、Candida prapsilosis、Candida kruseiおよびAspergillus fumigatusを指標菌(indicator)として実験を行った。
図1〜図3は本明細書による組成物のCandida albicansに対する抗菌活性実験結果である抑制帯形成結果である。
図6〜図15は本明細書による組成物のCandida parapsilosisに対する抗菌活性実験結果である抑制帯形成結果である。
図18〜図27は本明細書による組成物のCandida kruseiに対する抗菌活性実験結果である抑制帯形成結果である。
図30〜図39は本明細書による組成物のAspergillus fumigatusに対する抗菌活性実験結果である抑制帯形成結果である。
前述したように、多くの液状医薬品の場合、塩化イオンを含む賦形剤が含まれ、塩酸テルビナフィンと複合剤形の本発明の組成物も沈殿が発生し得る。ただし、マレイン酸とホウ酸ナトリウムをさらに含み、塩酸テルビナフィンの沈殿物生成を防止することができる。以下では塩酸テルビナフィンの沈殿物生成実験について説明する。
Claims (19)
- 塩酸テルビナフィン;
クロルヘキシジングルコン酸塩;
シクロピロクスオラミン;
マレイン酸;および
ホウ酸ナトリウム;を含有し、
pH値の範囲が5.3〜5.7である、皮膚感染の予防または治療用薬学的組成物。 - 前記塩酸テルビナフィンが組成物に対して0.1〜10.0重量部で含まれる、請求項1に記載の皮膚感染の予防または治療用薬学的組成物。
- 前記クロルヘキシジングルコン酸塩が組成物に対して0.1〜20.0重量部で含まれる、請求項1に記載の皮膚感染の予防または治療用薬学的組成物。
- 前記シクロピロクスオラミンが組成物に対して0.1〜10.0重量部で含まれる、請求項1に記載の皮膚感染の予防または治療用薬学的組成物。
- ティーツリーオイル;をさらに含む、請求項1に記載の皮膚感染の予防または治療用薬学的組成物。
- 前記ティーツリーオイルが組成物に対して0.1〜10.0重量部で含まれる、請求項5に記載の皮膚感染の予防または治療用薬学的組成物。
- エンバク抽出物;をさらに含む、請求項5に記載の皮膚感染の予防または治療用薬学的組成物。
- 前記エンバク抽出物が組成物に対して0.1〜10.0重量部で含まれる、請求項7に記載の皮膚感染の予防または治療用薬学的組成物。
- フィトスフィンゴシン、およびフィトスフィンゴシンとセラミドの混合物からなる群より選ばれたいずれか一つをさらに含む、請求項7に記載の皮膚感染の予防または治療用薬学的組成物。
- 前記組成物が動物に使用される、請求項1に記載の皮膚感染の予防または治療用薬学的組成物。
- 塩酸テルビナフィン;
クロルヘキシジングルコン酸塩;
シクロピロクスオラミン;
ティーツリーオイル、ティーツリーオイルとエンバク抽出物の混合物、ティーツリーオイルとエンバク抽出物とフィトスフィンゴシンの混合物、およびティーツリーオイルとエンバク抽出物とフィトスフィンゴシンとセラミドの混合物からなる群より選ばれたいずれか一つ;
マレイン酸;および
ホウ酸ナトリウム;を含み、
pH値の範囲が5.3〜5.7である、皮膚感染の予防または治療用薬学的組成物。 - 塩酸テルビナフィン;
クロルヘキシジングルコン酸塩;
シクロピロクスオラミン;
マレイン酸;および
ホウ酸ナトリウム;を含み、
pH値の範囲が5.3〜5.7である、皮膚感染の予防または改善用化粧料組成物。 - ティーツリーオイル、ティーツリーオイルとエンバク抽出物の混合物、ティーツリーオイルとエンバク抽出物とフィトスフィンゴシンの混合物、およびティーツリーオイルとエンバク抽出物とフィトスフィンゴシンとセラミドの混合物からなる群より選ばれたいずれか一つをさらに含む、請求項12に記載の皮膚感染の予防または改善用化粧料組成物。
- 前記組成物の剤形がローション、クリーム、軟膏、シャンプー、スプレー、ゲルまたはシャンプーである、請求項12に記載の皮膚感染の予防または改善用化粧料組成物。
- 前記塩酸テルビナフィンが組成物に対して0.1〜10.0重量部で含まれる、請求項12に記載の皮膚感染の予防または改善用化粧料組成物。
- 前記クロルヘキシジングルコン酸塩が組成物に対して0.1〜20.0重量部で含まれる、請求項12に記載の皮膚感染の予防または改善用化粧料組成物。
- 前記シクロピロクスオラミンが組成物に対して0.1〜10.0重量部で含まれる、請求項12に記載の皮膚感染の予防または改善用化粧料組成物。
- 前記組成物に対して、
前記塩酸テルビナフィンが0.1〜2.0重量部;
前記クロルヘキシジングルコン酸塩が0.1〜4.0重量部;
前記シクロピロクスオラミンが0.1〜6.0重量部;
前記マレイン酸が0.5〜2.0重量部および
前記ホウ酸ナトリウムが0.3〜0.5重量部含まれる、請求項1に記載の皮膚感染の予防または治療用薬学的組成物。 - 前記組成物に対して、
前記塩酸テルビナフィンが0.1〜2.0重量部;
前記クロルヘキシジングルコン酸塩が0.1〜4.0重量部;
前記シクロピロクスオラミンが0.1〜6.0重量部;
前記マレイン酸が0.5〜2.0重量部および
前記ホウ酸ナトリウムが0.3〜0.5重量部含まれる、請求項12に記載の皮膚感染の予防または改善用化粧料組成物。
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KR1020180051150A KR101899413B1 (ko) | 2018-05-03 | 2018-05-03 | 피부 감염의 예방 또는 치료용 조성물 |
PCT/KR2018/013614 WO2019212110A1 (ko) | 2018-05-03 | 2018-11-09 | 피부 감염의 예방 또는 치료용 조성물 |
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BR102020021144A2 (pt) * | 2020-10-15 | 2021-03-02 | Rubia Fernanda De Oliveira Munhoz | formulação para produto antisséptico com propriedades hidratantes na forma de gel e na forma de solução para spray |
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JP3603924B2 (ja) * | 1997-03-25 | 2004-12-22 | ライオン株式会社 | 殺菌剤組成物 |
ES2207023T3 (es) * | 1997-12-05 | 2004-05-16 | Cosmoferm B.V. | Composiciones que comprenden una combinacion de una base esfingoide libre y una ceramida y utilizacion de las mismas. |
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CN1552314A (zh) * | 2003-05-27 | 2004-12-08 | 北京亚科希药物研究所 | 一种抗菌药物组合物 |
US20080207560A1 (en) * | 2005-01-07 | 2008-08-28 | Ayako Harada | Composition For External Use |
JP2007091661A (ja) * | 2005-09-29 | 2007-04-12 | Nippon Nohyaku Co Ltd | 外用抗真菌剤組成物 |
JP5559449B2 (ja) * | 2006-06-05 | 2014-07-23 | 小林製薬株式会社 | 抗真菌組成物 |
US20080113037A1 (en) * | 2006-11-10 | 2008-05-15 | Green Barbara A | Topical Compositions Comprising Polyhydroxy Acids and/or Lactones for Improved Cutaneous Effects of Oxidative Therapeutic Drugs |
KR101658361B1 (ko) | 2010-12-10 | 2016-09-21 | 유영국 | 피부 감염의 예방 및 치료용 조성물 |
JP6339940B2 (ja) * | 2011-12-20 | 2018-06-06 | ビョーメ バイオサイエンシズ ピーブイティー.リミテッド | 真菌感染症の治療用の局所用オイル組成物 |
FR3004353B1 (fr) * | 2013-04-10 | 2015-05-15 | Fabre Pierre Dermo Cosmetique | Association synergique de l'alanine-glutamine, l'acide hyaluronique et un extrait d'avoine, et son utilisation dans une composition destinee a la cicatrisation et la reparation des lesions cutanees |
CA2945692A1 (en) * | 2014-01-29 | 2015-08-06 | Vyome Biosciences Pvt. Ltd. | Treatments for resistant acne |
KR101658365B1 (ko) | 2015-06-10 | 2016-09-22 | 주식회사 케어사이드 | 피부 감염의 예방 및 치료용 조성물 |
US20170290778A1 (en) | 2016-04-12 | 2017-10-12 | Illustris Pharmaceuticals, Inc. | Compositions for topical application of compounds |
KR101899413B1 (ko) * | 2018-05-03 | 2018-09-18 | 주식회사 케어사이드 | 피부 감염의 예방 또는 치료용 조성물 |
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- 2018-11-09 JP JP2020561015A patent/JP6951592B2/ja active Active
- 2018-11-09 WO PCT/KR2018/013614 patent/WO2019212110A1/ko active Application Filing
- 2018-11-09 EP EP18917117.6A patent/EP3789019B1/en active Active
- 2018-11-09 US US17/043,036 patent/US20210045986A1/en not_active Abandoned
- 2018-11-09 CN CN201880092375.1A patent/CN112004532B/zh active Active
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KR101899413B1 (ko) | 2018-09-18 |
WO2019212110A1 (ko) | 2019-11-07 |
EP3789019B1 (en) | 2023-08-23 |
CN112004532A (zh) | 2020-11-27 |
CN112004532B (zh) | 2022-02-18 |
US20210045986A1 (en) | 2021-02-18 |
JP2021512145A (ja) | 2021-05-13 |
EP3789019A4 (en) | 2021-12-29 |
EP3789019A1 (en) | 2021-03-10 |
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