JP6945557B2 - 光学走査顕微鏡および検査方法 - Google Patents

光学走査顕微鏡および検査方法 Download PDF

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Publication number
JP6945557B2
JP6945557B2 JP2018559780A JP2018559780A JP6945557B2 JP 6945557 B2 JP6945557 B2 JP 6945557B2 JP 2018559780 A JP2018559780 A JP 2018559780A JP 2018559780 A JP2018559780 A JP 2018559780A JP 6945557 B2 JP6945557 B2 JP 6945557B2
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light
optical
beam splitter
polarization direction
channel
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JP2019517027A (ja
JP2019517027A5 (enExample
Inventor
シューマン クリスティアン
シューマン クリスティアン
ヴァイス アルブレヒト
ヴァイス アルブレヒト
バウアー トビアス
バウアー トビアス
ペーター ゴンシオア コーネル
ペーター ゴンシオア コーネル
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Leica Microsystems CMS GmbH
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Leica Microsystems CMS GmbH
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    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0032—Optical details of illumination, e.g. light-sources, pinholes, beam splitters, slits, fibers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F5/00—Orthopaedic methods or devices for non-surgical treatment of bones or joints; Nursing devices ; Anti-rape devices
    • A61F5/01—Orthopaedic devices, e.g. long-term immobilising or pressure directing devices for treating broken or deformed bones such as splints, casts or braces
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F5/00—Orthopaedic methods or devices for non-surgical treatment of bones or joints; Nursing devices ; Anti-rape devices
    • A61F5/01—Orthopaedic devices, e.g. long-term immobilising or pressure directing devices for treating broken or deformed bones such as splints, casts or braces
    • A61F5/0102—Orthopaedic devices, e.g. long-term immobilising or pressure directing devices for treating broken or deformed bones such as splints, casts or braces specially adapted for correcting deformities of the limbs or for supporting them; Ortheses, e.g. with articulations
    • A61F5/0123—Orthopaedic devices, e.g. long-term immobilising or pressure directing devices for treating broken or deformed bones such as splints, casts or braces specially adapted for correcting deformities of the limbs or for supporting them; Ortheses, e.g. with articulations for the knees
    • A61F5/0125—Orthopaedic devices, e.g. long-term immobilising or pressure directing devices for treating broken or deformed bones such as splints, casts or braces specially adapted for correcting deformities of the limbs or for supporting them; Ortheses, e.g. with articulations for the knees the device articulating around a single pivot-point
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0052—Optical details of the image generation
    • G02B21/0068—Optical details of the image generation arrangements using polarisation
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/0092—Polarisation microscopes
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/02—Objectives
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/16—Microscopes adapted for ultraviolet illumination ; Fluorescence microscopes
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B27/00—Optical systems or apparatus not provided for by any of the groups G02B1/00 - G02B26/00, G02B30/00
    • G02B27/28—Optical systems or apparatus not provided for by any of the groups G02B1/00 - G02B26/00, G02B30/00 for polarising
    • G02B27/283—Optical systems or apparatus not provided for by any of the groups G02B1/00 - G02B26/00, G02B30/00 for polarising used for beam splitting or combining
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F5/00—Orthopaedic methods or devices for non-surgical treatment of bones or joints; Nursing devices ; Anti-rape devices
    • A61F5/01—Orthopaedic devices, e.g. long-term immobilising or pressure directing devices for treating broken or deformed bones such as splints, casts or braces
    • A61F5/0102—Orthopaedic devices, e.g. long-term immobilising or pressure directing devices for treating broken or deformed bones such as splints, casts or braces specially adapted for correcting deformities of the limbs or for supporting them; Ortheses, e.g. with articulations
    • A61F2005/0132—Additional features of the articulation
    • A61F2005/0153—Additional features of the articulation combining rotational and stretching movements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F5/00—Orthopaedic methods or devices for non-surgical treatment of bones or joints; Nursing devices ; Anti-rape devices
    • A61F5/01—Orthopaedic devices, e.g. long-term immobilising or pressure directing devices for treating broken or deformed bones such as splints, casts or braces
    • A61F5/0102—Orthopaedic devices, e.g. long-term immobilising or pressure directing devices for treating broken or deformed bones such as splints, casts or braces specially adapted for correcting deformities of the limbs or for supporting them; Ortheses, e.g. with articulations
    • A61F2005/0132—Additional features of the articulation
    • A61F2005/0165—Additional features of the articulation with limits of movement
    • A61F2005/0167—Additional features of the articulation with limits of movement adjustable
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F5/00—Orthopaedic methods or devices for non-surgical treatment of bones or joints; Nursing devices ; Anti-rape devices
    • A61F5/01—Orthopaedic devices, e.g. long-term immobilising or pressure directing devices for treating broken or deformed bones such as splints, casts or braces
    • A61F5/0102—Orthopaedic devices, e.g. long-term immobilising or pressure directing devices for treating broken or deformed bones such as splints, casts or braces specially adapted for correcting deformities of the limbs or for supporting them; Ortheses, e.g. with articulations
    • A61F2005/0132—Additional features of the articulation
    • A61F2005/0172—Additional features of the articulation with cushions
    • A61F2005/0174—Additional features of the articulation with cushions laterally placed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F5/00—Orthopaedic methods or devices for non-surgical treatment of bones or joints; Nursing devices ; Anti-rape devices
    • A61F5/01—Orthopaedic devices, e.g. long-term immobilising or pressure directing devices for treating broken or deformed bones such as splints, casts or braces
    • A61F5/0102—Orthopaedic devices, e.g. long-term immobilising or pressure directing devices for treating broken or deformed bones such as splints, casts or braces specially adapted for correcting deformities of the limbs or for supporting them; Ortheses, e.g. with articulations
    • A61F2005/0132—Additional features of the articulation
    • A61F2005/0179—Additional features of the articulation with spring means
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0052—Optical details of the image generation
    • G02B21/0076—Optical details of the image generation arrangements using fluorescence or luminescence

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  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • General Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Nursing (AREA)
  • Microscoopes, Condenser (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
JP2018559780A 2016-05-13 2017-05-12 光学走査顕微鏡および検査方法 Expired - Fee Related JP6945557B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102016108987.7A DE102016108987A1 (de) 2016-05-13 2016-05-13 Optisches Rastermikroskop und Untersuchungsverfahren
DE102016108987.7 2016-05-13
PCT/EP2017/061470 WO2017194742A1 (de) 2016-05-13 2017-05-12 Optisches rastermikroskop und untersuchungsverfahren

Publications (3)

Publication Number Publication Date
JP2019517027A JP2019517027A (ja) 2019-06-20
JP2019517027A5 JP2019517027A5 (enExample) 2020-03-12
JP6945557B2 true JP6945557B2 (ja) 2021-10-06

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JP2018559780A Expired - Fee Related JP6945557B2 (ja) 2016-05-13 2017-05-12 光学走査顕微鏡および検査方法

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Country Link
US (1) US11630292B2 (enExample)
EP (1) EP3455663A1 (enExample)
JP (1) JP6945557B2 (enExample)
DE (2) DE202016008489U1 (enExample)
WO (1) WO2017194742A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102019135521A1 (de) * 2019-12-20 2021-06-24 Carl Zeiss Microscopy Gmbh Messanordnung, Lichtmikroskop und Messverfahren zur bildgebenden Tiefenmessung
US11921273B2 (en) 2020-10-30 2024-03-05 Electronics And Telecommunications Research Institute Two-photon excited fluorescence microscope for diagnosis of Alzheimer's disease (AD) and mild cognitive impairment (MCI), and pulse compressor including therein
KR102572214B1 (ko) * 2020-10-30 2023-08-30 한국전자통신연구원 치매, 및 경도인지장애 진단용 이광자 여기 형광 현미경 그리고 그에 포함되는 펄스 압축기
EP4300059B1 (en) * 2021-02-25 2025-05-21 Inter-University Research Institute Corporation National Institutes of Natural Sciences Circularly polarized light illuminator, analysis device, and microscope
DE102025100905B3 (de) * 2025-01-13 2026-01-29 Acal Bfi Germany Gmbh Xy-ablenkeinheit für laserlicht mit zwei betriebsmodi und deren verwendung

Family Cites Families (19)

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US6091523A (en) * 1989-02-07 2000-07-18 Northrop Grumman Corporation Multi-channel receiver
JP3942906B2 (ja) * 2002-02-01 2007-07-11 株式会社ニデック レーザ治療装置
JP4414722B2 (ja) 2003-10-15 2010-02-10 オリンパス株式会社 レーザー顕微鏡
DE102005020545A1 (de) 2005-05-03 2006-11-09 Carl Zeiss Jena Gmbh Vorrichtung zur Steuerung von Lichtstrahlung
DE102005037818A1 (de) 2005-08-08 2007-02-15 Leica Microsystems Cms Gmbh Mikroskop
DE102006028530A1 (de) 2005-11-11 2007-05-16 Till I D Gmbh Mikroskopvorrichtung
DE102006033306A1 (de) 2006-07-17 2008-01-31 Leica Microsystems Cms Gmbh Tirf Mikroskop
US7706069B2 (en) * 2007-05-14 2010-04-27 Coherent, Inc. Attenuator for high-power unpolarized laser beams
CN102597845B (zh) * 2009-11-02 2016-06-29 奥林巴斯株式会社 分束器装置、光源装置和扫描观测装置
JP5551477B2 (ja) * 2010-03-15 2014-07-16 オリンパス株式会社 光源装置およびレーザ走査型顕微鏡装置
US9411144B2 (en) * 2011-01-12 2016-08-09 Ge Healthcare Bio-Sciences Corp. Systems for fluorescence illumination using superimposed polarization states
JP5885673B2 (ja) * 2011-01-18 2016-03-15 オリンパス株式会社 光走査装置および走査型検査装置
WO2013067643A1 (en) * 2011-11-08 2013-05-16 UNIVERSITé LAVAL Method and system for improving resolution in laser imaging microscopy
DE102012010207B4 (de) * 2012-05-15 2024-02-29 Carl Zeiss Microscopy Gmbh Mikroskop und Mikroskopieverfahren
JP2014164097A (ja) * 2013-02-25 2014-09-08 Olympus Corp ビームスプリッタ装置、走査型観察装置、レーザ走査型顕微鏡およびレーザ走査型内視鏡
US9110294B2 (en) * 2013-03-15 2015-08-18 Christie Digital Systems Usa, Inc. Imaging with shaped highlight beam
DE102013222562B4 (de) 2013-11-06 2023-01-26 Leica Microsystems Cms Gmbh Mikroskop und Verfahren sowie Verwendung eines Mikroskops für evaneszente Beleuchtung und punktförmige Rasterbeleuchtung
US9606069B2 (en) * 2014-06-25 2017-03-28 Kla-Tencor Corporation Method, apparatus and system for generating multiple spatially separated inspection regions on a substrate
GB201508376D0 (en) 2015-05-15 2015-07-01 Univ St Andrews Light sheet imaging

Also Published As

Publication number Publication date
US11630292B2 (en) 2023-04-18
DE102016108987A1 (de) 2017-11-16
DE202016008489U1 (de) 2018-02-22
US20200319445A1 (en) 2020-10-08
WO2017194742A1 (de) 2017-11-16
JP2019517027A (ja) 2019-06-20
EP3455663A1 (de) 2019-03-20

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