DE202016008489U1 - Optisches Rastermikroskop - Google Patents
Optisches Rastermikroskop Download PDFInfo
- Publication number
- DE202016008489U1 DE202016008489U1 DE202016008489.6U DE202016008489U DE202016008489U1 DE 202016008489 U1 DE202016008489 U1 DE 202016008489U1 DE 202016008489 U DE202016008489 U DE 202016008489U DE 202016008489 U1 DE202016008489 U1 DE 202016008489U1
- Authority
- DE
- Germany
- Prior art keywords
- light
- channel
- beam splitter
- polarization direction
- scanning microscope
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 230000003287 optical effect Effects 0.000 title claims abstract description 87
- 230000010287 polarization Effects 0.000 claims abstract description 124
- 238000005286 illumination Methods 0.000 claims abstract description 61
- 230000001419 dependent effect Effects 0.000 claims abstract description 22
- 210000001747 pupil Anatomy 0.000 claims description 23
- 230000006978 adaptation Effects 0.000 claims description 2
- 238000000034 method Methods 0.000 description 9
- 230000008901 benefit Effects 0.000 description 4
- 238000000492 total internal reflection fluorescence microscopy Methods 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 2
- 238000002376 fluorescence recovery after photobleaching Methods 0.000 description 2
- 239000004973 liquid crystal related substance Substances 0.000 description 2
- BUHVIAUBTBOHAG-FOYDDCNASA-N (2r,3r,4s,5r)-2-[6-[[2-(3,5-dimethoxyphenyl)-2-(2-methylphenyl)ethyl]amino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol Chemical compound COC1=CC(OC)=CC(C(CNC=2C=3N=CN(C=3N=CN=2)[C@H]2[C@@H]([C@H](O)[C@@H](CO)O2)O)C=2C(=CC=CC=2)C)=C1 BUHVIAUBTBOHAG-FOYDDCNASA-N 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000006059 cover glass Substances 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- CNQCVBJFEGMYDW-UHFFFAOYSA-N lawrencium atom Chemical compound [Lr] CNQCVBJFEGMYDW-UHFFFAOYSA-N 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 238000000386 microscopy Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000013307 optical fiber Substances 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 230000002186 photoactivation Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000001360 synchronised effect Effects 0.000 description 1
- 230000009625 temporal interaction Effects 0.000 description 1
- 239000005341 toughened glass Substances 0.000 description 1
Images
Classifications
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/0004—Microscopes specially adapted for specific applications
- G02B21/002—Scanning microscopes
- G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
- G02B21/0032—Optical details of illumination, e.g. light-sources, pinholes, beam splitters, slits, fibers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F5/00—Orthopaedic methods or devices for non-surgical treatment of bones or joints; Nursing devices ; Anti-rape devices
- A61F5/01—Orthopaedic devices, e.g. long-term immobilising or pressure directing devices for treating broken or deformed bones such as splints, casts or braces
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F5/00—Orthopaedic methods or devices for non-surgical treatment of bones or joints; Nursing devices ; Anti-rape devices
- A61F5/01—Orthopaedic devices, e.g. long-term immobilising or pressure directing devices for treating broken or deformed bones such as splints, casts or braces
- A61F5/0102—Orthopaedic devices, e.g. long-term immobilising or pressure directing devices for treating broken or deformed bones such as splints, casts or braces specially adapted for correcting deformities of the limbs or for supporting them; Ortheses, e.g. with articulations
- A61F5/0123—Orthopaedic devices, e.g. long-term immobilising or pressure directing devices for treating broken or deformed bones such as splints, casts or braces specially adapted for correcting deformities of the limbs or for supporting them; Ortheses, e.g. with articulations for the knees
- A61F5/0125—Orthopaedic devices, e.g. long-term immobilising or pressure directing devices for treating broken or deformed bones such as splints, casts or braces specially adapted for correcting deformities of the limbs or for supporting them; Ortheses, e.g. with articulations for the knees the device articulating around a single pivot-point
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/0004—Microscopes specially adapted for specific applications
- G02B21/002—Scanning microscopes
- G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
- G02B21/0052—Optical details of the image generation
- G02B21/0068—Optical details of the image generation arrangements using polarisation
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/0004—Microscopes specially adapted for specific applications
- G02B21/002—Scanning microscopes
- G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
- G02B21/0052—Optical details of the image generation
- G02B21/0076—Optical details of the image generation arrangements using fluorescence or luminescence
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/0004—Microscopes specially adapted for specific applications
- G02B21/0092—Polarisation microscopes
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/02—Objectives
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/16—Microscopes adapted for ultraviolet illumination ; Fluorescence microscopes
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B27/00—Optical systems or apparatus not provided for by any of the groups G02B1/00 - G02B26/00, G02B30/00
- G02B27/28—Optical systems or apparatus not provided for by any of the groups G02B1/00 - G02B26/00, G02B30/00 for polarising
- G02B27/283—Optical systems or apparatus not provided for by any of the groups G02B1/00 - G02B26/00, G02B30/00 for polarising used for beam splitting or combining
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F5/00—Orthopaedic methods or devices for non-surgical treatment of bones or joints; Nursing devices ; Anti-rape devices
- A61F5/01—Orthopaedic devices, e.g. long-term immobilising or pressure directing devices for treating broken or deformed bones such as splints, casts or braces
- A61F5/0102—Orthopaedic devices, e.g. long-term immobilising or pressure directing devices for treating broken or deformed bones such as splints, casts or braces specially adapted for correcting deformities of the limbs or for supporting them; Ortheses, e.g. with articulations
- A61F2005/0132—Additional features of the articulation
- A61F2005/0153—Additional features of the articulation combining rotational and stretching movements
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F5/00—Orthopaedic methods or devices for non-surgical treatment of bones or joints; Nursing devices ; Anti-rape devices
- A61F5/01—Orthopaedic devices, e.g. long-term immobilising or pressure directing devices for treating broken or deformed bones such as splints, casts or braces
- A61F5/0102—Orthopaedic devices, e.g. long-term immobilising or pressure directing devices for treating broken or deformed bones such as splints, casts or braces specially adapted for correcting deformities of the limbs or for supporting them; Ortheses, e.g. with articulations
- A61F2005/0132—Additional features of the articulation
- A61F2005/0165—Additional features of the articulation with limits of movement
- A61F2005/0167—Additional features of the articulation with limits of movement adjustable
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F5/00—Orthopaedic methods or devices for non-surgical treatment of bones or joints; Nursing devices ; Anti-rape devices
- A61F5/01—Orthopaedic devices, e.g. long-term immobilising or pressure directing devices for treating broken or deformed bones such as splints, casts or braces
- A61F5/0102—Orthopaedic devices, e.g. long-term immobilising or pressure directing devices for treating broken or deformed bones such as splints, casts or braces specially adapted for correcting deformities of the limbs or for supporting them; Ortheses, e.g. with articulations
- A61F2005/0132—Additional features of the articulation
- A61F2005/0172—Additional features of the articulation with cushions
- A61F2005/0174—Additional features of the articulation with cushions laterally placed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F5/00—Orthopaedic methods or devices for non-surgical treatment of bones or joints; Nursing devices ; Anti-rape devices
- A61F5/01—Orthopaedic devices, e.g. long-term immobilising or pressure directing devices for treating broken or deformed bones such as splints, casts or braces
- A61F5/0102—Orthopaedic devices, e.g. long-term immobilising or pressure directing devices for treating broken or deformed bones such as splints, casts or braces specially adapted for correcting deformities of the limbs or for supporting them; Ortheses, e.g. with articulations
- A61F2005/0132—Additional features of the articulation
- A61F2005/0179—Additional features of the articulation with spring means
Landscapes
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nursing (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Microscoopes, Condenser (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE202016008489.6U DE202016008489U1 (de) | 2016-05-13 | 2016-05-13 | Optisches Rastermikroskop |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102016108987.7A DE102016108987A1 (de) | 2016-05-13 | 2016-05-13 | Optisches Rastermikroskop und Untersuchungsverfahren |
| DE202016008489.6U DE202016008489U1 (de) | 2016-05-13 | 2016-05-13 | Optisches Rastermikroskop |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE202016008489U1 true DE202016008489U1 (de) | 2018-02-22 |
Family
ID=58709942
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE202016008489.6U Expired - Lifetime DE202016008489U1 (de) | 2016-05-13 | 2016-05-13 | Optisches Rastermikroskop |
| DE102016108987.7A Withdrawn DE102016108987A1 (de) | 2016-05-13 | 2016-05-13 | Optisches Rastermikroskop und Untersuchungsverfahren |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE102016108987.7A Withdrawn DE102016108987A1 (de) | 2016-05-13 | 2016-05-13 | Optisches Rastermikroskop und Untersuchungsverfahren |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US11630292B2 (enExample) |
| EP (1) | EP3455663A1 (enExample) |
| JP (1) | JP6945557B2 (enExample) |
| DE (2) | DE202016008489U1 (enExample) |
| WO (1) | WO2017194742A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102019135521A1 (de) * | 2019-12-20 | 2021-06-24 | Carl Zeiss Microscopy Gmbh | Messanordnung, Lichtmikroskop und Messverfahren zur bildgebenden Tiefenmessung |
| KR102572214B1 (ko) * | 2020-10-30 | 2023-08-30 | 한국전자통신연구원 | 치매, 및 경도인지장애 진단용 이광자 여기 형광 현미경 그리고 그에 포함되는 펄스 압축기 |
| US11921273B2 (en) | 2020-10-30 | 2024-03-05 | Electronics And Telecommunications Research Institute | Two-photon excited fluorescence microscope for diagnosis of Alzheimer's disease (AD) and mild cognitive impairment (MCI), and pulse compressor including therein |
| CN116897279A (zh) * | 2021-02-25 | 2023-10-17 | 大学共同利用机关法人自然科学研究机构 | 圆偏振光照射器、分析装置以及显微镜 |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7187494B2 (en) | 2003-10-15 | 2007-03-06 | Olympus Corporation | Laser microscope |
| DE102006033306A1 (de) | 2006-07-17 | 2008-01-31 | Leica Microsystems Cms Gmbh | Tirf Mikroskop |
| US7573635B2 (en) | 2005-11-11 | 2009-08-11 | Till I.D. Gmbh | Microscope device |
| EP1752809B1 (de) | 2005-08-08 | 2011-12-14 | Leica Microsystems CMS GmbH | Mikroskop |
| DE102013222562A1 (de) | 2013-11-06 | 2015-05-07 | Leica Microsystems Cms Gmbh | Mikroskop für evaneszente Beleuchtung und punktförmige Rasterbeleuchtung |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6091523A (en) * | 1989-02-07 | 2000-07-18 | Northrop Grumman Corporation | Multi-channel receiver |
| JP3942906B2 (ja) * | 2002-02-01 | 2007-07-11 | 株式会社ニデック | レーザ治療装置 |
| DE102005020545A1 (de) * | 2005-05-03 | 2006-11-09 | Carl Zeiss Jena Gmbh | Vorrichtung zur Steuerung von Lichtstrahlung |
| US7706069B2 (en) * | 2007-05-14 | 2010-04-27 | Coherent, Inc. | Attenuator for high-power unpolarized laser beams |
| CN102597845B (zh) * | 2009-11-02 | 2016-06-29 | 奥林巴斯株式会社 | 分束器装置、光源装置和扫描观测装置 |
| JP5551477B2 (ja) * | 2010-03-15 | 2014-07-16 | オリンパス株式会社 | 光源装置およびレーザ走査型顕微鏡装置 |
| US9411144B2 (en) * | 2011-01-12 | 2016-08-09 | Ge Healthcare Bio-Sciences Corp. | Systems for fluorescence illumination using superimposed polarization states |
| WO2012099151A1 (ja) * | 2011-01-18 | 2012-07-26 | オリンパス株式会社 | 光走査装置および走査型検査装置 |
| US9721326B2 (en) * | 2011-11-08 | 2017-08-01 | UNIVERSITé LAVAL | Method and system for improving resolution in laser imaging microscopy |
| DE102012010207B4 (de) | 2012-05-15 | 2024-02-29 | Carl Zeiss Microscopy Gmbh | Mikroskop und Mikroskopieverfahren |
| JP2014164097A (ja) * | 2013-02-25 | 2014-09-08 | Olympus Corp | ビームスプリッタ装置、走査型観察装置、レーザ走査型顕微鏡およびレーザ走査型内視鏡 |
| US9110294B2 (en) * | 2013-03-15 | 2015-08-18 | Christie Digital Systems Usa, Inc. | Imaging with shaped highlight beam |
| US9606069B2 (en) * | 2014-06-25 | 2017-03-28 | Kla-Tencor Corporation | Method, apparatus and system for generating multiple spatially separated inspection regions on a substrate |
| GB201508376D0 (en) * | 2015-05-15 | 2015-07-01 | Univ St Andrews | Light sheet imaging |
-
2016
- 2016-05-13 DE DE202016008489.6U patent/DE202016008489U1/de not_active Expired - Lifetime
- 2016-05-13 DE DE102016108987.7A patent/DE102016108987A1/de not_active Withdrawn
-
2017
- 2017-05-12 WO PCT/EP2017/061470 patent/WO2017194742A1/de not_active Ceased
- 2017-05-12 US US16/300,966 patent/US11630292B2/en active Active
- 2017-05-12 EP EP17723981.1A patent/EP3455663A1/de not_active Withdrawn
- 2017-05-12 JP JP2018559780A patent/JP6945557B2/ja not_active Expired - Fee Related
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7187494B2 (en) | 2003-10-15 | 2007-03-06 | Olympus Corporation | Laser microscope |
| EP1752809B1 (de) | 2005-08-08 | 2011-12-14 | Leica Microsystems CMS GmbH | Mikroskop |
| US7573635B2 (en) | 2005-11-11 | 2009-08-11 | Till I.D. Gmbh | Microscope device |
| DE102006033306A1 (de) | 2006-07-17 | 2008-01-31 | Leica Microsystems Cms Gmbh | Tirf Mikroskop |
| DE102013222562A1 (de) | 2013-11-06 | 2015-05-07 | Leica Microsystems Cms Gmbh | Mikroskop für evaneszente Beleuchtung und punktförmige Rasterbeleuchtung |
Non-Patent Citations (3)
| Title |
|---|
| Bennett, J.M.: Polarizers, Kapitel 3 in: Bass, M.E. et al. (Hrsg.): Handbook of Optics. Fundamentals, Techniques & Design, Band 2, New York: McGraw-Hill, 2. Auflage 1995 |
| D. Axelrod, Traffic 2, 764–774 (2001) |
| E. A. J. Reits, Nat. Cell Biol. 3, E145–E147 (2001) |
Also Published As
| Publication number | Publication date |
|---|---|
| EP3455663A1 (de) | 2019-03-20 |
| US11630292B2 (en) | 2023-04-18 |
| US20200319445A1 (en) | 2020-10-08 |
| DE102016108987A1 (de) | 2017-11-16 |
| JP6945557B2 (ja) | 2021-10-06 |
| JP2019517027A (ja) | 2019-06-20 |
| WO2017194742A1 (de) | 2017-11-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| R207 | Utility model specification | ||
| R150 | Utility model maintained after payment of first maintenance fee after three years | ||
| R082 | Change of representative |
Representative=s name: DEHNS GERMANY PARTNERSCHAFT MBB, DE Representative=s name: DEHNSGERMANY PARTNERSCHAFT VON PATENTANWAELTEN, DE |
|
| R151 | Utility model maintained after payment of second maintenance fee after six years | ||
| R158 | Lapse of ip right after 8 years |