JP6944377B2 - グルタミナーゼの阻害剤を用いる肺がんの処置 - Google Patents

グルタミナーゼの阻害剤を用いる肺がんの処置 Download PDF

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JP6944377B2
JP6944377B2 JP2017552153A JP2017552153A JP6944377B2 JP 6944377 B2 JP6944377 B2 JP 6944377B2 JP 2017552153 A JP2017552153 A JP 2017552153A JP 2017552153 A JP2017552153 A JP 2017552153A JP 6944377 B2 JP6944377 B2 JP 6944377B2
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kras
mutation
certain embodiments
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lung cancer
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JP2018510884A5 (enExample
JP2018510884A (ja
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フランチェスコ パルラーティ，
フランチェスコ パルラーティ，
メリッサ ジー． ワークス，
メリッサ ジー． ワークス，
ミルナ エル．エム． ロドリゲス，
ミルナ エル．エム． ロドリゲス，
ドン ザン，
ドン ザン，
Original Assignee
キャリセラ バイオサイエンシーズ， インコーポレイテッド
キャリセラ バイオサイエンシーズ， インコーポレイテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
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    • A61K31/33—Heterocyclic compounds
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/433—Thidiazoles
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5355—Non-condensed oxazines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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    • C12Q2600/00—Oligonucleotides characterized by their use
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  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2017552153A 2015-04-06 2016-04-06 グルタミナーゼの阻害剤を用いる肺がんの処置 Expired - Fee Related JP6944377B2 (ja)

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JP2021069815A JP2021102662A (ja) 2015-04-06 2021-04-16 グルタミナーゼの阻害剤を用いる肺がんの処置

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US201562143494P 2015-04-06 2015-04-06
US62/143,494 2015-04-06
US201562149489P 2015-04-17 2015-04-17
US62/149,489 2015-04-17
PCT/US2016/026127 WO2016164401A1 (en) 2015-04-06 2016-04-06 Treatment of lung cancer with inhibitors of glutaminase

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US (1) US10441587B2 (enExample)
EP (1) EP3280415A4 (enExample)
JP (2) JP6944377B2 (enExample)
KR (1) KR20170132333A (enExample)
CN (1) CN107949387B (enExample)
AU (1) AU2016246521B2 (enExample)
BR (1) BR112017021312A2 (enExample)
CA (1) CA2981762A1 (enExample)
EA (1) EA035354B1 (enExample)
IL (1) IL254876A0 (enExample)
MX (1) MX383034B (enExample)
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US10316030B2 (en) 2014-08-07 2019-06-11 Calithera Biosciences, Inc. Crystal forms of glutaminase inhibitors
EP3359150A4 (en) 2015-10-05 2019-11-06 Calithera Biosciences, Inc. COMBINATION THERAPY WITH GLUTAMINASE INHIBITORS AND IMMUNO-ONCOLOGICAL AGENTS
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US20250275964A1 (en) * 2019-10-15 2025-09-04 Cornell University Methods of inhibiting liver-type glutaminase, gls2
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CN113956233B (zh) * 2021-10-22 2023-06-06 南方医科大学 一种酰胺类化合物或其药学上可接受的盐及其制备方法和应用
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AU2016246521A8 (en) 2019-08-15
AU2016246521B2 (en) 2020-07-09
MX2017012824A (es) 2018-05-15
MX383034B (es) 2025-03-13
EP3280415A4 (en) 2018-12-26
EA035354B1 (ru) 2020-06-01
BR112017021312A2 (pt) 2018-06-26
CA2981762A1 (en) 2016-10-13
EP3280415A1 (en) 2018-02-14
SG11201708153XA (en) 2017-11-29
WO2016164401A1 (en) 2016-10-13
AU2016246521A1 (en) 2017-11-02
HK1254349A1 (zh) 2019-07-19
CN107949387A (zh) 2018-04-20
EA201792227A1 (ru) 2018-11-30
CN107949387B (zh) 2021-08-13
WO2016164401A8 (en) 2017-11-23
US10441587B2 (en) 2019-10-15
JP2018510884A (ja) 2018-04-19
US20160287585A1 (en) 2016-10-06
KR20170132333A (ko) 2017-12-01
JP2021102662A (ja) 2021-07-15
IL254876A0 (en) 2017-12-31

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