JP6932304B2 - 発色団およびゲル化剤を含む、創傷を治療するための生体光組成物 - Google Patents
発色団およびゲル化剤を含む、創傷を治療するための生体光組成物 Download PDFInfo
- Publication number
- JP6932304B2 JP6932304B2 JP2016522147A JP2016522147A JP6932304B2 JP 6932304 B2 JP6932304 B2 JP 6932304B2 JP 2016522147 A JP2016522147 A JP 2016522147A JP 2016522147 A JP2016522147 A JP 2016522147A JP 6932304 B2 JP6932304 B2 JP 6932304B2
- Authority
- JP
- Japan
- Prior art keywords
- composition
- chromophore
- light
- wound
- biolight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000000203 mixture Substances 0.000 title claims description 552
- 239000003349 gelling agent Substances 0.000 title claims description 79
- 208000027418 Wounds and injury Diseases 0.000 title description 343
- 206010052428 Wound Diseases 0.000 title description 339
- 239000001301 oxygen Substances 0.000 claims description 47
- 229910052760 oxygen Inorganic materials 0.000 claims description 47
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 44
- 230000008439 repair process Effects 0.000 claims description 42
- 239000003795 chemical substances by application Substances 0.000 claims description 40
- 239000000463 material Substances 0.000 claims description 33
- 238000002386 leaching Methods 0.000 claims description 32
- 230000014509 gene expression Effects 0.000 claims description 31
- 208000025865 Ulcer Diseases 0.000 claims description 30
- 231100000397 ulcer Toxicity 0.000 claims description 28
- 208000004210 Pressure Ulcer Diseases 0.000 claims description 27
- 229920000642 polymer Polymers 0.000 claims description 27
- 108010035532 Collagen Proteins 0.000 claims description 26
- 102000008186 Collagen Human genes 0.000 claims description 26
- 229920001436 collagen Polymers 0.000 claims description 26
- 210000004027 cell Anatomy 0.000 claims description 25
- 239000003102 growth factor Substances 0.000 claims description 18
- 230000001965 increasing effect Effects 0.000 claims description 18
- 230000000638 stimulation Effects 0.000 claims description 18
- 206010011985 Decubitus ulcer Diseases 0.000 claims description 10
- 102000004127 Cytokines Human genes 0.000 claims description 7
- 108090000695 Cytokines Proteins 0.000 claims description 7
- 230000001939 inductive effect Effects 0.000 claims description 6
- 238000002399 angioplasty Methods 0.000 claims description 5
- 238000007634 remodeling Methods 0.000 claims description 5
- 230000004936 stimulating effect Effects 0.000 claims description 5
- 230000009471 action Effects 0.000 claims description 3
- 230000003287 optical effect Effects 0.000 claims description 3
- 210000000130 stem cell Anatomy 0.000 claims description 3
- 229920006037 cross link polymer Polymers 0.000 claims description 2
- 238000011282 treatment Methods 0.000 description 162
- 238000000034 method Methods 0.000 description 119
- 210000001519 tissue Anatomy 0.000 description 72
- 210000003491 skin Anatomy 0.000 description 65
- 239000000499 gel Substances 0.000 description 49
- -1 polyethylene Polymers 0.000 description 49
- 229920002125 Sokalan® Polymers 0.000 description 45
- SEACYXSIPDVVMV-UHFFFAOYSA-L eosin Y Chemical group [Na+].[Na+].[O-]C(=O)C1=CC=CC=C1C1=C2C=C(Br)C(=O)C(Br)=C2OC2=C(Br)C([O-])=C(Br)C=C21 SEACYXSIPDVVMV-UHFFFAOYSA-L 0.000 description 43
- 238000000862 absorption spectrum Methods 0.000 description 39
- 230000035876 healing Effects 0.000 description 38
- 239000012528 membrane Substances 0.000 description 32
- YQGOJNYOYNNSMM-UHFFFAOYSA-N eosin Chemical compound [Na+].OC(=O)C1=CC=CC=C1C1=C2C=C(Br)C(=O)C(Br)=C2OC2=C(Br)C(O)=C(Br)C=C21 YQGOJNYOYNNSMM-UHFFFAOYSA-N 0.000 description 30
- 210000004379 membrane Anatomy 0.000 description 30
- 230000029663 wound healing Effects 0.000 description 29
- 238000000295 emission spectrum Methods 0.000 description 28
- GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical group O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 description 28
- 238000012546 transfer Methods 0.000 description 26
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 25
- 230000015572 biosynthetic process Effects 0.000 description 25
- 229960002143 fluorescein Drugs 0.000 description 25
- 239000003242 anti bacterial agent Substances 0.000 description 24
- 102000005962 receptors Human genes 0.000 description 22
- 108020003175 receptors Proteins 0.000 description 22
- AZJPTIGZZTZIDR-UHFFFAOYSA-L rose bengal Chemical compound [K+].[K+].[O-]C(=O)C1=C(Cl)C(Cl)=C(Cl)C(Cl)=C1C1=C2C=C(I)C(=O)C(I)=C2OC2=C(I)C([O-])=C(I)C=C21 AZJPTIGZZTZIDR-UHFFFAOYSA-L 0.000 description 22
- 229930187593 rose bengal Natural products 0.000 description 21
- 229940081623 rose bengal Drugs 0.000 description 21
- STRXNPAVPKGJQR-UHFFFAOYSA-N rose bengal A Natural products O1C(=O)C(C(=CC=C2Cl)Cl)=C2C21C1=CC(I)=C(O)C(I)=C1OC1=C(I)C(O)=C(I)C=C21 STRXNPAVPKGJQR-UHFFFAOYSA-N 0.000 description 21
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 20
- 239000002609 medium Substances 0.000 description 20
- 230000001684 chronic effect Effects 0.000 description 19
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 18
- 230000000699 topical effect Effects 0.000 description 18
- AQLJVWUFPCUVLO-UHFFFAOYSA-N urea hydrogen peroxide Chemical compound OO.NC(N)=O AQLJVWUFPCUVLO-UHFFFAOYSA-N 0.000 description 17
- 239000007788 liquid Substances 0.000 description 16
- 230000001225 therapeutic effect Effects 0.000 description 16
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 14
- 239000000835 fiber Substances 0.000 description 14
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 13
- 238000010521 absorption reaction Methods 0.000 description 13
- 229960001631 carbomer Drugs 0.000 description 13
- 230000000694 effects Effects 0.000 description 13
- 229920002674 hyaluronan Polymers 0.000 description 13
- 230000008569 process Effects 0.000 description 12
- 231100000241 scar Toxicity 0.000 description 12
- 230000004913 activation Effects 0.000 description 11
- IINNWAYUJNWZRM-UHFFFAOYSA-L erythrosin B Chemical compound [Na+].[Na+].[O-]C(=O)C1=CC=CC=C1C1=C2C=C(I)C(=O)C(I)=C2OC2=C(I)C([O-])=C(I)C=C21 IINNWAYUJNWZRM-UHFFFAOYSA-L 0.000 description 11
- 208000014674 injury Diseases 0.000 description 11
- 239000010410 layer Substances 0.000 description 11
- 239000007787 solid Substances 0.000 description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 11
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 10
- 230000006378 damage Effects 0.000 description 10
- 239000000017 hydrogel Substances 0.000 description 10
- 230000001737 promoting effect Effects 0.000 description 10
- 108090000623 proteins and genes Proteins 0.000 description 10
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 9
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 9
- ATNHDLDRLWWWCB-AENOIHSZSA-M chlorophyll a Chemical compound C1([C@@H](C(=O)OC)C(=O)C2=C3C)=C2N2C3=CC(C(CC)=C3C)=[N+]4C3=CC3=C(C=C)C(C)=C5N3[Mg-2]42[N+]2=C1[C@@H](CCC(=O)OC\C=C(/C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)[C@H](C)C2=C5 ATNHDLDRLWWWCB-AENOIHSZSA-M 0.000 description 9
- 230000003111 delayed effect Effects 0.000 description 9
- 239000000975 dye Substances 0.000 description 9
- 229960003160 hyaluronic acid Drugs 0.000 description 9
- GVKCHTBDSMQENH-UHFFFAOYSA-L phloxine B Chemical compound [Na+].[Na+].[O-]C(=O)C1=C(Cl)C(Cl)=C(Cl)C(Cl)=C1C1=C2C=C(Br)C(=O)C(Br)=C2OC2=C(Br)C([O-])=C(Br)C=C21 GVKCHTBDSMQENH-UHFFFAOYSA-L 0.000 description 9
- 102000004169 proteins and genes Human genes 0.000 description 9
- 239000000758 substrate Substances 0.000 description 9
- 238000003786 synthesis reaction Methods 0.000 description 9
- 206010063560 Excessive granulation tissue Diseases 0.000 description 8
- 108010010803 Gelatin Proteins 0.000 description 8
- 239000007864 aqueous solution Substances 0.000 description 8
- 229940078916 carbamide peroxide Drugs 0.000 description 8
- 210000002950 fibroblast Anatomy 0.000 description 8
- 239000008273 gelatin Substances 0.000 description 8
- 229920000159 gelatin Polymers 0.000 description 8
- 235000019322 gelatine Nutrition 0.000 description 8
- 235000011852 gelatine desserts Nutrition 0.000 description 8
- 210000001126 granulation tissue Anatomy 0.000 description 8
- 230000001976 improved effect Effects 0.000 description 8
- 230000001678 irradiating effect Effects 0.000 description 8
- 238000004519 manufacturing process Methods 0.000 description 8
- CXKWCBBOMKCUKX-UHFFFAOYSA-M methylene blue Chemical compound [Cl-].C1=CC(N(C)C)=CC2=[S+]C3=CC(N(C)C)=CC=C3N=C21 CXKWCBBOMKCUKX-UHFFFAOYSA-M 0.000 description 8
- 239000004745 nonwoven fabric Substances 0.000 description 8
- 150000002978 peroxides Chemical class 0.000 description 8
- 238000001126 phototherapy Methods 0.000 description 8
- 238000001228 spectrum Methods 0.000 description 8
- 238000012360 testing method Methods 0.000 description 8
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 7
- 206010040943 Skin Ulcer Diseases 0.000 description 7
- 230000003115 biocidal effect Effects 0.000 description 7
- 239000004202 carbamide Substances 0.000 description 7
- 235000013877 carbamide Nutrition 0.000 description 7
- 229920002678 cellulose Polymers 0.000 description 7
- 239000000084 colloidal system Substances 0.000 description 7
- 150000001875 compounds Chemical class 0.000 description 7
- 230000002757 inflammatory effect Effects 0.000 description 7
- 239000004417 polycarbonate Substances 0.000 description 7
- 229920000515 polycarbonate Polymers 0.000 description 7
- 239000011148 porous material Substances 0.000 description 7
- 230000005855 radiation Effects 0.000 description 7
- 239000003642 reactive oxygen metabolite Substances 0.000 description 7
- 150000003839 salts Chemical class 0.000 description 7
- 230000002195 synergetic effect Effects 0.000 description 7
- 230000003442 weekly effect Effects 0.000 description 7
- 239000004342 Benzoyl peroxide Substances 0.000 description 6
- OMPJBNCRMGITSC-UHFFFAOYSA-N Benzoylperoxide Chemical compound C=1C=CC=CC=1C(=O)OOC(=O)C1=CC=CC=C1 OMPJBNCRMGITSC-UHFFFAOYSA-N 0.000 description 6
- 208000032544 Cicatrix Diseases 0.000 description 6
- WZUVPPKBWHMQCE-UHFFFAOYSA-N Haematoxylin Chemical compound C12=CC(O)=C(O)C=C2CC2(O)C1C1=CC=C(O)C(O)=C1OC2 WZUVPPKBWHMQCE-UHFFFAOYSA-N 0.000 description 6
- 206010067482 No adverse event Diseases 0.000 description 6
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 6
- 208000002847 Surgical Wound Diseases 0.000 description 6
- 244000172533 Viola sororia Species 0.000 description 6
- 230000001580 bacterial effect Effects 0.000 description 6
- 235000019400 benzoyl peroxide Nutrition 0.000 description 6
- 239000001913 cellulose Substances 0.000 description 6
- 235000010980 cellulose Nutrition 0.000 description 6
- 238000011156 evaluation Methods 0.000 description 6
- 238000005469 granulation Methods 0.000 description 6
- 230000003179 granulation Effects 0.000 description 6
- 150000002632 lipids Chemical class 0.000 description 6
- 230000017074 necrotic cell death Effects 0.000 description 6
- 230000001338 necrotic effect Effects 0.000 description 6
- 239000003504 photosensitizing agent Substances 0.000 description 6
- 229920000728 polyester Polymers 0.000 description 6
- 230000002829 reductive effect Effects 0.000 description 6
- 238000002271 resection Methods 0.000 description 6
- 230000037387 scars Effects 0.000 description 6
- 230000028327 secretion Effects 0.000 description 6
- 239000000243 solution Substances 0.000 description 6
- 238000002834 transmittance Methods 0.000 description 6
- 230000008733 trauma Effects 0.000 description 6
- MSWZFWKMSRAUBD-IVMDWMLBSA-N 2-amino-2-deoxy-D-glucopyranose Chemical compound N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O MSWZFWKMSRAUBD-IVMDWMLBSA-N 0.000 description 5
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 5
- GSDSWSVVBLHKDQ-UHFFFAOYSA-N 9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid Chemical compound FC1=CC(C(C(C(O)=O)=C2)=O)=C3N2C(C)COC3=C1N1CCN(C)CC1 GSDSWSVVBLHKDQ-UHFFFAOYSA-N 0.000 description 5
- 208000008960 Diabetic foot Diseases 0.000 description 5
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 5
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 5
- 108010076876 Keratins Proteins 0.000 description 5
- 102000011782 Keratins Human genes 0.000 description 5
- 206010033892 Paraplegia Diseases 0.000 description 5
- 229920002472 Starch Polymers 0.000 description 5
- 239000002253 acid Substances 0.000 description 5
- 230000003213 activating effect Effects 0.000 description 5
- 208000038016 acute inflammation Diseases 0.000 description 5
- 230000006022 acute inflammation Effects 0.000 description 5
- 229940072056 alginate Drugs 0.000 description 5
- 235000010443 alginic acid Nutrition 0.000 description 5
- 229920000615 alginic acid Polymers 0.000 description 5
- 230000000844 anti-bacterial effect Effects 0.000 description 5
- MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Natural products NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 description 5
- 229930002875 chlorophyll Natural products 0.000 description 5
- 235000019804 chlorophyll Nutrition 0.000 description 5
- 230000003247 decreasing effect Effects 0.000 description 5
- 210000004207 dermis Anatomy 0.000 description 5
- 230000005284 excitation Effects 0.000 description 5
- 210000002744 extracellular matrix Anatomy 0.000 description 5
- 210000000416 exudates and transudate Anatomy 0.000 description 5
- 229940072686 floxin Drugs 0.000 description 5
- 229960002442 glucosamine Drugs 0.000 description 5
- 230000012010 growth Effects 0.000 description 5
- KIUKXJAPPMFGSW-MNSSHETKSA-N hyaluronan Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)C1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H](C(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-MNSSHETKSA-N 0.000 description 5
- 238000000338 in vitro Methods 0.000 description 5
- 230000033001 locomotion Effects 0.000 description 5
- 229960000907 methylthioninium chloride Drugs 0.000 description 5
- 239000002953 phosphate buffered saline Substances 0.000 description 5
- 229920001223 polyethylene glycol Polymers 0.000 description 5
- 239000000047 product Substances 0.000 description 5
- INCIMLINXXICKS-UHFFFAOYSA-M pyronin Y Chemical compound [Cl-].C1=CC(=[N+](C)C)C=C2OC3=CC(N(C)C)=CC=C3C=C21 INCIMLINXXICKS-UHFFFAOYSA-M 0.000 description 5
- 238000006862 quantum yield reaction Methods 0.000 description 5
- 150000003254 radicals Chemical class 0.000 description 5
- 230000001105 regulatory effect Effects 0.000 description 5
- 239000000523 sample Substances 0.000 description 5
- 230000037390 scarring Effects 0.000 description 5
- 239000008107 starch Substances 0.000 description 5
- 235000019698 starch Nutrition 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 230000009885 systemic effect Effects 0.000 description 5
- 208000002874 Acne Vulgaris Diseases 0.000 description 4
- 229920001817 Agar Polymers 0.000 description 4
- 235000015655 Crocus sativus Nutrition 0.000 description 4
- 244000124209 Crocus sativus Species 0.000 description 4
- 206010056340 Diabetic ulcer Diseases 0.000 description 4
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 4
- 229920002907 Guar gum Polymers 0.000 description 4
- 101001034652 Homo sapiens Insulin-like growth factor 1 receptor Proteins 0.000 description 4
- 102100039688 Insulin-like growth factor 1 receptor Human genes 0.000 description 4
- 208000034693 Laceration Diseases 0.000 description 4
- 229920000161 Locust bean gum Polymers 0.000 description 4
- 239000004677 Nylon Substances 0.000 description 4
- KFSLWBXXFJQRDL-UHFFFAOYSA-N Peracetic acid Chemical compound CC(=O)OO KFSLWBXXFJQRDL-UHFFFAOYSA-N 0.000 description 4
- 239000004698 Polyethylene Substances 0.000 description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 4
- 206010000496 acne Diseases 0.000 description 4
- 239000008272 agar Substances 0.000 description 4
- 235000010419 agar Nutrition 0.000 description 4
- HFVAFDPGUJEFBQ-UHFFFAOYSA-M alizarin red S Chemical compound [Na+].O=C1C2=CC=CC=C2C(=O)C2=C1C=C(S([O-])(=O)=O)C(O)=C2O HFVAFDPGUJEFBQ-UHFFFAOYSA-M 0.000 description 4
- 229910052783 alkali metal Inorganic materials 0.000 description 4
- 229940088710 antibiotic agent Drugs 0.000 description 4
- 235000012733 azorubine Nutrition 0.000 description 4
- 230000004888 barrier function Effects 0.000 description 4
- 239000002585 base Substances 0.000 description 4
- 230000008901 benefit Effects 0.000 description 4
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 4
- 230000005540 biological transmission Effects 0.000 description 4
- LLEMOWNGBBNAJR-UHFFFAOYSA-N biphenyl-2-ol Chemical compound OC1=CC=CC=C1C1=CC=CC=C1 LLEMOWNGBBNAJR-UHFFFAOYSA-N 0.000 description 4
- 150000001732 carboxylic acid derivatives Chemical group 0.000 description 4
- 230000037319 collagen production Effects 0.000 description 4
- 229920001577 copolymer Polymers 0.000 description 4
- ZXJXZNDDNMQXFV-UHFFFAOYSA-M crystal violet Chemical compound [Cl-].C1=CC(N(C)C)=CC=C1[C+](C=1C=CC(=CC=1)N(C)C)C1=CC=C(N(C)C)C=C1 ZXJXZNDDNMQXFV-UHFFFAOYSA-M 0.000 description 4
- RAGZEDHHTPQLAI-UHFFFAOYSA-L disodium;2',4',5',7'-tetraiodo-3-oxospiro[2-benzofuran-1,9'-xanthene]-3',6'-diolate Chemical compound [Na+].[Na+].O1C(=O)C2=CC=CC=C2C21C1=CC(I)=C([O-])C(I)=C1OC1=C(I)C([O-])=C(I)C=C21 RAGZEDHHTPQLAI-UHFFFAOYSA-L 0.000 description 4
- ZBQZBWKNGDEDOA-UHFFFAOYSA-N eosin B Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC([N+]([O-])=O)=C(O)C(Br)=C1OC1=C2C=C([N+]([O-])=O)C(O)=C1Br ZBQZBWKNGDEDOA-UHFFFAOYSA-N 0.000 description 4
- 239000004744 fabric Substances 0.000 description 4
- 239000000945 filler Substances 0.000 description 4
- 239000007789 gas Substances 0.000 description 4
- 235000011187 glycerol Nutrition 0.000 description 4
- 235000010417 guar gum Nutrition 0.000 description 4
- 239000000665 guar gum Substances 0.000 description 4
- 229960002154 guar gum Drugs 0.000 description 4
- HLUCICHZHWJHLL-UHFFFAOYSA-N hematein Chemical compound C12=CC=C(O)C(O)=C2OCC2(O)C1=C1C=C(O)C(=O)C=C1C2 HLUCICHZHWJHLL-UHFFFAOYSA-N 0.000 description 4
- 229940099552 hyaluronan Drugs 0.000 description 4
- 238000012744 immunostaining Methods 0.000 description 4
- 229910052751 metal Inorganic materials 0.000 description 4
- 239000002184 metal Substances 0.000 description 4
- 210000004400 mucous membrane Anatomy 0.000 description 4
- SHXOKQKTZJXHHR-UHFFFAOYSA-N n,n-diethyl-5-iminobenzo[a]phenoxazin-9-amine;hydrochloride Chemical compound [Cl-].C1=CC=C2C3=NC4=CC=C(N(CC)CC)C=C4OC3=CC(=[NH2+])C2=C1 SHXOKQKTZJXHHR-UHFFFAOYSA-N 0.000 description 4
- 229920001778 nylon Polymers 0.000 description 4
- HSXUHWZMNJHFRV-QIKYXUGXSA-L orange G Chemical compound [Na+].[Na+].OC1=CC=C2C=C(S([O-])(=O)=O)C=C(S([O-])(=O)=O)C2=C1\N=N\C1=CC=CC=C1 HSXUHWZMNJHFRV-QIKYXUGXSA-L 0.000 description 4
- 208000033808 peripheral neuropathy Diseases 0.000 description 4
- 238000002428 photodynamic therapy Methods 0.000 description 4
- 239000004584 polyacrylic acid Substances 0.000 description 4
- 229920000573 polyethylene Polymers 0.000 description 4
- BBNQQADTFFCFGB-UHFFFAOYSA-N purpurin Chemical compound C1=CC=C2C(=O)C3=C(O)C(O)=CC(O)=C3C(=O)C2=C1 BBNQQADTFFCFGB-UHFFFAOYSA-N 0.000 description 4
- 230000009467 reduction Effects 0.000 description 4
- GHMLBKRAJCXXBS-UHFFFAOYSA-N resorcinol Chemical class OC1=CC=CC(O)=C1 GHMLBKRAJCXXBS-UHFFFAOYSA-N 0.000 description 4
- 235000013974 saffron Nutrition 0.000 description 4
- 239000004248 saffron Substances 0.000 description 4
- 208000017520 skin disease Diseases 0.000 description 4
- 230000003595 spectral effect Effects 0.000 description 4
- 229920002994 synthetic fiber Polymers 0.000 description 4
- 235000012756 tartrazine Nutrition 0.000 description 4
- 239000004149 tartrazine Substances 0.000 description 4
- 239000004753 textile Substances 0.000 description 4
- 231100000331 toxic Toxicity 0.000 description 4
- 230000002588 toxic effect Effects 0.000 description 4
- 230000002792 vascular Effects 0.000 description 4
- 229920002554 vinyl polymer Polymers 0.000 description 4
- 238000001429 visible spectrum Methods 0.000 description 4
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 3
- AXDJCCTWPBKUKL-UHFFFAOYSA-N 4-[(4-aminophenyl)-(4-imino-3-methylcyclohexa-2,5-dien-1-ylidene)methyl]aniline;hydron;chloride Chemical compound Cl.C1=CC(=N)C(C)=CC1=C(C=1C=CC(N)=CC=1)C1=CC=C(N)C=C1 AXDJCCTWPBKUKL-UHFFFAOYSA-N 0.000 description 3
- OSDLLIBGSJNGJE-UHFFFAOYSA-N 4-chloro-3,5-dimethylphenol Chemical compound CC1=CC(O)=CC(C)=C1Cl OSDLLIBGSJNGJE-UHFFFAOYSA-N 0.000 description 3
- CFKMVGJGLGKFKI-UHFFFAOYSA-N 4-chloro-m-cresol Chemical compound CC1=CC(O)=CC=C1Cl CFKMVGJGLGKFKI-UHFFFAOYSA-N 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 3
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 description 3
- MCZVRBLCRZWFJH-UHFFFAOYSA-N Bismark brown Y Chemical compound Cl.Cl.NC1=CC(N)=CC=C1N=NC1=CC=CC(N=NC=2C(=CC(N)=CC=2)N)=C1 MCZVRBLCRZWFJH-UHFFFAOYSA-N 0.000 description 3
- 229920002101 Chitin Polymers 0.000 description 3
- 229920001661 Chitosan Polymers 0.000 description 3
- 208000034656 Contusions Diseases 0.000 description 3
- 229920000742 Cotton Polymers 0.000 description 3
- 206010051814 Eschar Diseases 0.000 description 3
- 240000006927 Foeniculum vulgare Species 0.000 description 3
- 235000004204 Foeniculum vulgare Nutrition 0.000 description 3
- 208000004221 Multiple Trauma Diseases 0.000 description 3
- 208000002193 Pain Diseases 0.000 description 3
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 3
- 239000002202 Polyethylene glycol Substances 0.000 description 3
- 239000004743 Polypropylene Substances 0.000 description 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- 229920000297 Rayon Polymers 0.000 description 3
- 229920002385 Sodium hyaluronate Polymers 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 229920002334 Spandex Polymers 0.000 description 3
- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 description 3
- 229920002709 Ultraz Polymers 0.000 description 3
- 208000000558 Varicose Ulcer Diseases 0.000 description 3
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 description 3
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 description 3
- 238000002835 absorbance Methods 0.000 description 3
- RZUBARUFLYGOGC-MTHOTQAESA-L acid fuchsin Chemical compound [Na+].[Na+].[O-]S(=O)(=O)C1=C(N)C(C)=CC(C(=C\2C=C(C(=[NH2+])C=C/2)S([O-])(=O)=O)\C=2C=C(C(N)=CC=2)S([O-])(=O)=O)=C1 RZUBARUFLYGOGC-MTHOTQAESA-L 0.000 description 3
- ISAOCJYIOMOJEB-UHFFFAOYSA-N benzoin Chemical class C=1C=CC=CC=1C(O)C(=O)C1=CC=CC=C1 ISAOCJYIOMOJEB-UHFFFAOYSA-N 0.000 description 3
- 239000007853 buffer solution Substances 0.000 description 3
- 235000010418 carrageenan Nutrition 0.000 description 3
- 229920001525 carrageenan Polymers 0.000 description 3
- 239000000679 carrageenan Substances 0.000 description 3
- 229940113118 carrageenan Drugs 0.000 description 3
- 229930002868 chlorophyll a Natural products 0.000 description 3
- 229930002869 chlorophyll b Natural products 0.000 description 3
- NSMUHPMZFPKNMZ-VBYMZDBQSA-M chlorophyll b Chemical compound C1([C@@H](C(=O)OC)C(=O)C2=C3C)=C2N2C3=CC(C(CC)=C3C=O)=[N+]4C3=CC3=C(C=C)C(C)=C5N3[Mg-2]42[N+]2=C1[C@@H](CCC(=O)OC\C=C(/C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)[C@H](C)C2=C5 NSMUHPMZFPKNMZ-VBYMZDBQSA-M 0.000 description 3
- 239000002131 composite material Substances 0.000 description 3
- 230000008602 contraction Effects 0.000 description 3
- 230000009519 contusion Effects 0.000 description 3
- 230000007423 decrease Effects 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 210000002889 endothelial cell Anatomy 0.000 description 3
- 210000002919 epithelial cell Anatomy 0.000 description 3
- 235000012732 erythrosine Nutrition 0.000 description 3
- 229940011411 erythrosine Drugs 0.000 description 3
- 239000004174 erythrosine Substances 0.000 description 3
- 231100000333 eschar Toxicity 0.000 description 3
- UKZQEOHHLOYJLY-UHFFFAOYSA-M ethyl eosin Chemical compound [K+].CCOC(=O)C1=CC=CC=C1C1=C2C=C(Br)C(=O)C(Br)=C2OC2=C(Br)C([O-])=C(Br)C=C21 UKZQEOHHLOYJLY-UHFFFAOYSA-M 0.000 description 3
- 150000004676 glycans Chemical class 0.000 description 3
- 230000001969 hypertrophic effect Effects 0.000 description 3
- 208000015181 infectious disease Diseases 0.000 description 3
- CXORMDKZEUMQHX-UHFFFAOYSA-N kermesic acid Chemical compound O=C1C2=C(O)C(O)=CC(O)=C2C(=O)C2=C1C=C(O)C(C(O)=O)=C2C CXORMDKZEUMQHX-UHFFFAOYSA-N 0.000 description 3
- 230000003902 lesion Effects 0.000 description 3
- 235000010420 locust bean gum Nutrition 0.000 description 3
- 239000000711 locust bean gum Substances 0.000 description 3
- 210000002540 macrophage Anatomy 0.000 description 3
- FDZZZRQASAIRJF-UHFFFAOYSA-M malachite green Chemical compound [Cl-].C1=CC(N(C)C)=CC=C1C(C=1C=CC=CC=1)=C1C=CC(=[N+](C)C)C=C1 FDZZZRQASAIRJF-UHFFFAOYSA-M 0.000 description 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 3
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 description 3
- CTIQLGJVGNGFEW-UHFFFAOYSA-L naphthol yellow S Chemical compound [Na+].[Na+].C1=C(S([O-])(=O)=O)C=C2C([O-])=C([N+]([O-])=O)C=C([N+]([O-])=O)C2=C1 CTIQLGJVGNGFEW-UHFFFAOYSA-L 0.000 description 3
- 201000001119 neuropathy Diseases 0.000 description 3
- 230000007823 neuropathy Effects 0.000 description 3
- PGSADBUBUOPOJS-UHFFFAOYSA-N neutral red Chemical compound Cl.C1=C(C)C(N)=CC2=NC3=CC(N(C)C)=CC=C3N=C21 PGSADBUBUOPOJS-UHFFFAOYSA-N 0.000 description 3
- 238000006386 neutralization reaction Methods 0.000 description 3
- 229920001277 pectin Polymers 0.000 description 3
- 239000001814 pectin Substances 0.000 description 3
- 235000010987 pectin Nutrition 0.000 description 3
- 125000002081 peroxide group Chemical group 0.000 description 3
- 230000002186 photoactivation Effects 0.000 description 3
- 229920002401 polyacrylamide Polymers 0.000 description 3
- 229920000058 polyacrylate Polymers 0.000 description 3
- 229920001155 polypropylene Polymers 0.000 description 3
- 229920001282 polysaccharide Polymers 0.000 description 3
- 239000005017 polysaccharide Substances 0.000 description 3
- 229920002451 polyvinyl alcohol Polymers 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- YPFDHNVEDLHUCE-UHFFFAOYSA-N propane-1,3-diol Chemical group OCCCO YPFDHNVEDLHUCE-UHFFFAOYSA-N 0.000 description 3
- PYWVYCXTNDRMGF-UHFFFAOYSA-N rhodamine B Chemical compound [Cl-].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=CC=C1C(O)=O PYWVYCXTNDRMGF-UHFFFAOYSA-N 0.000 description 3
- 210000004927 skin cell Anatomy 0.000 description 3
- 230000036555 skin type Effects 0.000 description 3
- 229940010747 sodium hyaluronate Drugs 0.000 description 3
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 3
- 238000007920 subcutaneous administration Methods 0.000 description 3
- UJMBCXLDXJUMFB-GLCFPVLVSA-K tartrazine Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)C1=NN(C=2C=CC(=CC=2)S([O-])(=O)=O)C(=O)C1\N=N\C1=CC=C(S([O-])(=O)=O)C=C1 UJMBCXLDXJUMFB-GLCFPVLVSA-K 0.000 description 3
- 230000017423 tissue regeneration Effects 0.000 description 3
- 230000005641 tunneling Effects 0.000 description 3
- 230000036269 ulceration Effects 0.000 description 3
- 239000002759 woven fabric Substances 0.000 description 3
- 229920001285 xanthan gum Polymers 0.000 description 3
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 3
- AMLFJZRZIOZGPW-NSCUHMNNSA-N (e)-prop-1-en-1-amine Chemical compound C\C=C\N AMLFJZRZIOZGPW-NSCUHMNNSA-N 0.000 description 2
- NXXYKOUNUYWIHA-UHFFFAOYSA-N 2,6-Dimethylphenol Chemical compound CC1=CC=CC(C)=C1O NXXYKOUNUYWIHA-UHFFFAOYSA-N 0.000 description 2
- HCLJOFJIQIJXHS-UHFFFAOYSA-N 2-[2-[2-(2-prop-2-enoyloxyethoxy)ethoxy]ethoxy]ethyl prop-2-enoate Chemical compound C=CC(=O)OCCOCCOCCOCCOC(=O)C=C HCLJOFJIQIJXHS-UHFFFAOYSA-N 0.000 description 2
- NCKMMSIFQUPKCK-UHFFFAOYSA-N 2-benzyl-4-chlorophenol Chemical compound OC1=CC=C(Cl)C=C1CC1=CC=CC=C1 NCKMMSIFQUPKCK-UHFFFAOYSA-N 0.000 description 2
- DHVLDKHFGIVEIP-UHFFFAOYSA-N 2-bromo-2-(bromomethyl)pentanedinitrile Chemical compound BrCC(Br)(C#N)CCC#N DHVLDKHFGIVEIP-UHFFFAOYSA-N 0.000 description 2
- WRMNZCZEMHIOCP-UHFFFAOYSA-N 2-phenylethanol Chemical compound OCCC1=CC=CC=C1 WRMNZCZEMHIOCP-UHFFFAOYSA-N 0.000 description 2
- YCOXTKKNXUZSKD-UHFFFAOYSA-N 3,4-xylenol Chemical compound CC1=CC=C(O)C=C1C YCOXTKKNXUZSKD-UHFFFAOYSA-N 0.000 description 2
- BMUDPLZKKRQECS-UHFFFAOYSA-K 3-[18-(2-carboxyethyl)-8,13-bis(ethenyl)-3,7,12,17-tetramethylporphyrin-21,24-diid-2-yl]propanoic acid iron(3+) hydroxide Chemical compound [OH-].[Fe+3].[N-]1C2=C(C)C(CCC(O)=O)=C1C=C([N-]1)C(CCC(O)=O)=C(C)C1=CC(C(C)=C1C=C)=NC1=CC(C(C)=C1C=C)=NC1=C2 BMUDPLZKKRQECS-UHFFFAOYSA-K 0.000 description 2
- RHPUJHQBPORFGV-UHFFFAOYSA-N 4-chloro-2-methylphenol Chemical compound CC1=CC(Cl)=CC=C1O RHPUJHQBPORFGV-UHFFFAOYSA-N 0.000 description 2
- WXNZTHHGJRFXKQ-UHFFFAOYSA-N 4-chlorophenol Chemical compound OC1=CC=C(Cl)C=C1 WXNZTHHGJRFXKQ-UHFFFAOYSA-N 0.000 description 2
- HXDOZKJGKXYMEW-UHFFFAOYSA-N 4-ethylphenol Chemical compound CCC1=CC=C(O)C=C1 HXDOZKJGKXYMEW-UHFFFAOYSA-N 0.000 description 2
- QFIIYGZAUXVPSZ-UHFFFAOYSA-N 8-(2,4-dihydroxy-6-methylanilino)-2-(2,4-dihydroxy-6-methylphenyl)imino-7-hydroxy-1,9-dimethyldibenzofuran-3-one Chemical compound CC1=CC(=CC(=C1NC2=C(C3=C(C=C2O)OC4=CC(=O)C(=NC5=C(C=C(C=C5C)O)O)C(=C43)C)C)O)O QFIIYGZAUXVPSZ-UHFFFAOYSA-N 0.000 description 2
- GJCOSYZMQJWQCA-UHFFFAOYSA-N 9H-xanthene Chemical compound C1=CC=C2CC3=CC=CC=C3OC2=C1 GJCOSYZMQJWQCA-UHFFFAOYSA-N 0.000 description 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 2
- RGCKGOZRHPZPFP-UHFFFAOYSA-N Alizarin Natural products C1=CC=C2C(=O)C3=C(O)C(O)=CC=C3C(=O)C2=C1 RGCKGOZRHPZPFP-UHFFFAOYSA-N 0.000 description 2
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 2
- 239000005711 Benzoic acid Substances 0.000 description 2
- QFOHBWFCKVYLES-UHFFFAOYSA-N Butylparaben Chemical compound CCCCOC(=O)C1=CC=C(O)C=C1 QFOHBWFCKVYLES-UHFFFAOYSA-N 0.000 description 2
- JUQPZRLQQYSMEQ-UHFFFAOYSA-N CI Basic red 9 Chemical compound [Cl-].C1=CC(N)=CC=C1C(C=1C=CC(N)=CC=1)=C1C=CC(=[NH2+])C=C1 JUQPZRLQQYSMEQ-UHFFFAOYSA-N 0.000 description 2
- 229920000049 Carbon (fiber) Polymers 0.000 description 2
- 102000012422 Collagen Type I Human genes 0.000 description 2
- 108010022452 Collagen Type I Proteins 0.000 description 2
- 240000000491 Corchorus aestuans Species 0.000 description 2
- 235000011777 Corchorus aestuans Nutrition 0.000 description 2
- 235000010862 Corchorus capsularis Nutrition 0.000 description 2
- 229920000858 Cyclodextrin Polymers 0.000 description 2
- MDNWOSOZYLHTCG-UHFFFAOYSA-N Dichlorophen Chemical compound OC1=CC=C(Cl)C=C1CC1=CC(Cl)=CC=C1O MDNWOSOZYLHTCG-UHFFFAOYSA-N 0.000 description 2
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 2
- 229920002148 Gellan gum Polymers 0.000 description 2
- GLZPCOQZEFWAFX-UHFFFAOYSA-N Geraniol Chemical compound CC(C)=CCCC(C)=CCO GLZPCOQZEFWAFX-UHFFFAOYSA-N 0.000 description 2
- 206010018852 Haematoma Diseases 0.000 description 2
- WOBHKFSMXKNTIM-UHFFFAOYSA-N Hydroxyethyl methacrylate Chemical compound CC(=C)C(=O)OCCO WOBHKFSMXKNTIM-UHFFFAOYSA-N 0.000 description 2
- 208000003623 Hypoalbuminemia Diseases 0.000 description 2
- 206010021519 Impaired healing Diseases 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- 206010023330 Keloid scar Diseases 0.000 description 2
- NPGIHFRTRXVWOY-UHFFFAOYSA-N Oil red O Chemical compound Cc1ccc(C)c(c1)N=Nc1cc(C)c(cc1C)N=Nc1c(O)ccc2ccccc12 NPGIHFRTRXVWOY-UHFFFAOYSA-N 0.000 description 2
- 206010031252 Osteomyelitis Diseases 0.000 description 2
- 229910019142 PO4 Inorganic materials 0.000 description 2
- 206010033799 Paralysis Diseases 0.000 description 2
- 208000009344 Penetrating Wounds Diseases 0.000 description 2
- 108091005804 Peptidases Proteins 0.000 description 2
- 229920002845 Poly(methacrylic acid) Polymers 0.000 description 2
- 239000004952 Polyamide Substances 0.000 description 2
- 108010050808 Procollagen Proteins 0.000 description 2
- 229910052772 Samarium Inorganic materials 0.000 description 2
- YIQKLZYTHXTDDT-UHFFFAOYSA-H Sirius red F3B Chemical compound C1=CC(=CC=C1N=NC2=CC(=C(C=C2)N=NC3=C(C=C4C=C(C=CC4=C3[O-])NC(=O)NC5=CC6=CC(=C(C(=C6C=C5)[O-])N=NC7=C(C=C(C=C7)N=NC8=CC=C(C=C8)S(=O)(=O)[O-])S(=O)(=O)[O-])S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)[O-])S(=O)(=O)[O-].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+] YIQKLZYTHXTDDT-UHFFFAOYSA-H 0.000 description 2
- 206010040844 Skin exfoliation Diseases 0.000 description 2
- 206010072170 Skin wound Diseases 0.000 description 2
- 206010040954 Skin wrinkling Diseases 0.000 description 2
- FHNINJWBTRXEBC-UHFFFAOYSA-N Sudan III Chemical compound OC1=CC=C2C=CC=CC2=C1N=NC(C=C1)=CC=C1N=NC1=CC=CC=C1 FHNINJWBTRXEBC-UHFFFAOYSA-N 0.000 description 2
- GLNADSQYFUSGOU-GPTZEZBUSA-J Trypan blue Chemical compound [Na+].[Na+].[Na+].[Na+].C1=C(S([O-])(=O)=O)C=C2C=C(S([O-])(=O)=O)C(/N=N/C3=CC=C(C=C3C)C=3C=C(C(=CC=3)\N=N\C=3C(=CC4=CC(=CC(N)=C4C=3O)S([O-])(=O)=O)S([O-])(=O)=O)C)=C(O)C2=C1N GLNADSQYFUSGOU-GPTZEZBUSA-J 0.000 description 2
- 238000001792 White test Methods 0.000 description 2
- 229910052769 Ytterbium Inorganic materials 0.000 description 2
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 2
- 230000002159 abnormal effect Effects 0.000 description 2
- 230000001133 acceleration Effects 0.000 description 2
- DGOBMKYRQHEFGQ-UHFFFAOYSA-L acid green 5 Chemical compound [Na+].[Na+].C=1C=C(C(=C2C=CC(C=C2)=[N+](CC)CC=2C=C(C=CC=2)S([O-])(=O)=O)C=2C=CC(=CC=2)S([O-])(=O)=O)C=CC=1N(CC)CC1=CC=CC(S([O-])(=O)=O)=C1 DGOBMKYRQHEFGQ-UHFFFAOYSA-L 0.000 description 2
- YJVBLROMQZEFPA-UHFFFAOYSA-L acid red 26 Chemical compound [Na+].[Na+].CC1=CC(C)=CC=C1N=NC1=C(O)C(S([O-])(=O)=O)=CC2=CC(S([O-])(=O)=O)=CC=C12 YJVBLROMQZEFPA-UHFFFAOYSA-L 0.000 description 2
- FUGCXLNGEHFIOA-UHFFFAOYSA-L acid red 44 Chemical compound [Na+].[Na+].C1=CC=C2C(N=NC3=C4C(=CC(=CC4=CC=C3O)S([O-])(=O)=O)S([O-])(=O)=O)=CC=CC2=C1 FUGCXLNGEHFIOA-UHFFFAOYSA-L 0.000 description 2
- 230000002378 acidificating effect Effects 0.000 description 2
- 230000001154 acute effect Effects 0.000 description 2
- 239000000853 adhesive Substances 0.000 description 2
- 238000004026 adhesive bonding Methods 0.000 description 2
- 230000001070 adhesive effect Effects 0.000 description 2
- PBTFWNIEMRWXLI-UHFFFAOYSA-L alcian yellow Chemical compound [Cl-].[Cl-].CN(C)C(=[N+](C)C)SCC1=C(C)C=C2SC(C3=CC=C(C=C3)N=NC3=CC=C(C=C3)C3=NC=4C=C(C(=CC=4S3)C)CSC(N(C)C)=[N+](C)C)=NC2=C1 PBTFWNIEMRWXLI-UHFFFAOYSA-L 0.000 description 2
- 150000001340 alkali metals Chemical class 0.000 description 2
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 description 2
- 230000033115 angiogenesis Effects 0.000 description 2
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- KSCQDDRPFHTIRL-UHFFFAOYSA-N auramine O Chemical compound [H+].[Cl-].C1=CC(N(C)C)=CC=C1C(=N)C1=CC=C(N(C)C)C=C1 KSCQDDRPFHTIRL-UHFFFAOYSA-N 0.000 description 2
- TVWOWDDBXAFQDG-DQRAZIAOSA-N azorubine Chemical compound C1=CC=C2C(\N=N/C3=C(C4=CC=CC=C4C(=C3)S(O)(=O)=O)O)=CC=C(S(O)(=O)=O)C2=C1 TVWOWDDBXAFQDG-DQRAZIAOSA-N 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 235000010233 benzoic acid Nutrition 0.000 description 2
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 description 2
- 239000011230 binding agent Substances 0.000 description 2
- IISBACLAFKSPIT-UHFFFAOYSA-N bisphenol A Chemical class C=1C=C(O)C=CC=1C(C)(C)C1=CC=C(O)C=C1 IISBACLAFKSPIT-UHFFFAOYSA-N 0.000 description 2
- 210000000988 bone and bone Anatomy 0.000 description 2
- DBZJJPROPLPMSN-UHFFFAOYSA-N bromoeosin Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC(Br)=C(O)C(Br)=C1OC1=C(Br)C(O)=C(Br)C=C21 DBZJJPROPLPMSN-UHFFFAOYSA-N 0.000 description 2
- XVBRCOKDZVQYAY-UHFFFAOYSA-N bronidox Chemical compound [O-][N+](=O)C1(Br)COCOC1 XVBRCOKDZVQYAY-UHFFFAOYSA-N 0.000 description 2
- CRPUJAZIXJMDBK-UHFFFAOYSA-N camphene Chemical compound C1CC2C(=C)C(C)(C)C1C2 CRPUJAZIXJMDBK-UHFFFAOYSA-N 0.000 description 2
- 239000004917 carbon fiber Substances 0.000 description 2
- YCIMNLLNPGFGHC-UHFFFAOYSA-N catechol Chemical compound OC1=CC=CC=C1O YCIMNLLNPGFGHC-UHFFFAOYSA-N 0.000 description 2
- 230000005779 cell damage Effects 0.000 description 2
- 230000004663 cell proliferation Effects 0.000 description 2
- 230000001413 cellular effect Effects 0.000 description 2
- 239000002738 chelating agent Substances 0.000 description 2
- FFUMCSDSJNSMQH-HEXQVDJKSA-K chromoxane cyanin R Chemical compound [Na+].[Na+].[Na+].C1=C(C([O-])=O)C(=O)C(C)=C\C1=C(C=1C(=CC=CC=1)S([O-])(=O)=O)\C1=CC(C)=C(O)C(C([O-])=O)=C1 FFUMCSDSJNSMQH-HEXQVDJKSA-K 0.000 description 2
- GJWSUKYXUMVMGX-UHFFFAOYSA-N citronellic acid Chemical compound OC(=O)CC(C)CCC=C(C)C GJWSUKYXUMVMGX-UHFFFAOYSA-N 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 239000003636 conditioned culture medium Substances 0.000 description 2
- VFLDPWHFBUODDF-FCXRPNKRSA-N curcumin Chemical compound C1=C(O)C(OC)=CC(\C=C\C(=O)CC(=O)\C=C\C=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-FCXRPNKRSA-N 0.000 description 2
- 238000006731 degradation reaction Methods 0.000 description 2
- 239000000412 dendrimer Substances 0.000 description 2
- 229920000736 dendritic polymer Polymers 0.000 description 2
- 230000008021 deposition Effects 0.000 description 2
- 206010012601 diabetes mellitus Diseases 0.000 description 2
- SOROIESOUPGGFO-UHFFFAOYSA-N diazolidinylurea Chemical compound OCNC(=O)N(CO)C1N(CO)C(=O)N(CO)C1=O SOROIESOUPGGFO-UHFFFAOYSA-N 0.000 description 2
- NJDNXYGOVLYJHP-UHFFFAOYSA-L disodium;2-(3-oxido-6-oxoxanthen-9-yl)benzoate Chemical class [Na+].[Na+].[O-]C(=O)C1=CC=CC=C1C1=C2C=CC(=O)C=C2OC2=CC([O-])=CC=C21 NJDNXYGOVLYJHP-UHFFFAOYSA-L 0.000 description 2
- YSVBPNGJESBVRM-UHFFFAOYSA-L disodium;4-[(1-oxido-4-sulfonaphthalen-2-yl)diazenyl]naphthalene-1-sulfonate Chemical compound [Na+].[Na+].C1=CC=C2C(N=NC3=C(C4=CC=CC=C4C(=C3)S([O-])(=O)=O)O)=CC=C(S([O-])(=O)=O)C2=C1 YSVBPNGJESBVRM-UHFFFAOYSA-L 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 229920001971 elastomer Polymers 0.000 description 2
- 230000003511 endothelial effect Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000002255 enzymatic effect Effects 0.000 description 2
- 229960001483 eosin Drugs 0.000 description 2
- QGAYMQGSQUXCQO-UHFFFAOYSA-L eosin b Chemical compound [Na+].[Na+].O1C(=O)C2=CC=CC=C2C21C1=CC([N+]([O-])=O)=C([O-])C(Br)=C1OC1=C2C=C([N+]([O-])=O)C([O-])=C1Br QGAYMQGSQUXCQO-UHFFFAOYSA-L 0.000 description 2
- 210000000981 epithelium Anatomy 0.000 description 2
- JVICFMRAVNKDOE-UHFFFAOYSA-M ethyl violet Chemical compound [Cl-].C1=CC(N(CC)CC)=CC=C1C(C=1C=CC(=CC=1)N(CC)CC)=C1C=CC(=[N+](CC)CC)C=C1 JVICFMRAVNKDOE-UHFFFAOYSA-M 0.000 description 2
- RRAFCDWBNXTKKO-UHFFFAOYSA-N eugenol Chemical compound COC1=CC(CC=C)=CC=C1O RRAFCDWBNXTKKO-UHFFFAOYSA-N 0.000 description 2
- 210000003414 extremity Anatomy 0.000 description 2
- 238000002189 fluorescence spectrum Methods 0.000 description 2
- 239000006260 foam Substances 0.000 description 2
- 238000005187 foaming Methods 0.000 description 2
- HKIOYBQGHSTUDB-UHFFFAOYSA-N folpet Chemical compound C1=CC=C2C(=O)N(SC(Cl)(Cl)Cl)C(=O)C2=C1 HKIOYBQGHSTUDB-UHFFFAOYSA-N 0.000 description 2
- 238000001879 gelation Methods 0.000 description 2
- 235000010492 gellan gum Nutrition 0.000 description 2
- 239000000216 gellan gum Substances 0.000 description 2
- 235000021472 generally recognized as safe Nutrition 0.000 description 2
- 239000003365 glass fiber Substances 0.000 description 2
- 230000005283 ground state Effects 0.000 description 2
- 229910052736 halogen Inorganic materials 0.000 description 2
- 150000002367 halogens Chemical class 0.000 description 2
- 229940109738 hematin Drugs 0.000 description 2
- 230000003054 hormonal effect Effects 0.000 description 2
- 235000003642 hunger Nutrition 0.000 description 2
- 230000036571 hydration Effects 0.000 description 2
- 238000006703 hydration reaction Methods 0.000 description 2
- 229920001477 hydrophilic polymer Polymers 0.000 description 2
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 2
- ZCTXEAQXZGPWFG-UHFFFAOYSA-N imidurea Chemical compound O=C1NC(=O)N(CO)C1NC(=O)NCNC(=O)NC1C(=O)NC(=O)N1CO ZCTXEAQXZGPWFG-UHFFFAOYSA-N 0.000 description 2
- 230000001771 impaired effect Effects 0.000 description 2
- 230000006698 induction Effects 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 210000000265 leukocyte Anatomy 0.000 description 2
- XMGQYMWWDOXHJM-UHFFFAOYSA-N limonene Chemical compound CC(=C)C1CCC(C)=CC1 XMGQYMWWDOXHJM-UHFFFAOYSA-N 0.000 description 2
- RLSSMJSEOOYNOY-UHFFFAOYSA-N m-cresol Chemical compound CC1=CC=CC(O)=C1 RLSSMJSEOOYNOY-UHFFFAOYSA-N 0.000 description 2
- 238000002844 melting Methods 0.000 description 2
- 230000008018 melting Effects 0.000 description 2
- MCPLVIGCWWTHFH-UHFFFAOYSA-L methyl blue Chemical compound [Na+].[Na+].C1=CC(S(=O)(=O)[O-])=CC=C1NC1=CC=C(C(=C2C=CC(C=C2)=[NH+]C=2C=CC(=CC=2)S([O-])(=O)=O)C=2C=CC(NC=3C=CC(=CC=3)S([O-])(=O)=O)=CC=2)C=C1 MCPLVIGCWWTHFH-UHFFFAOYSA-L 0.000 description 2
- DWCZIOOZPIDHAB-UHFFFAOYSA-L methyl green Chemical compound [Cl-].[Cl-].C1=CC(N(C)C)=CC=C1C(C=1C=CC(=CC=1)[N+](C)(C)C)=C1C=CC(=[N+](C)C)C=C1 DWCZIOOZPIDHAB-UHFFFAOYSA-L 0.000 description 2
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 2
- 238000013508 migration Methods 0.000 description 2
- 239000002557 mineral fiber Substances 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 238000013425 morphometry Methods 0.000 description 2
- 230000000926 neurological effect Effects 0.000 description 2
- 230000037311 normal skin Effects 0.000 description 2
- IFSXZLJQEKGQAF-UHFFFAOYSA-M nuclear fast red Chemical compound [Na+].O=C1C2=CC=CC=C2C(=O)C2=C1C(O)=C(S([O-])(=O)=O)C(O)=C2N IFSXZLJQEKGQAF-UHFFFAOYSA-M 0.000 description 2
- QWVGKYWNOKOFNN-UHFFFAOYSA-N o-cresol Chemical compound CC1=CC=CC=C1O QWVGKYWNOKOFNN-UHFFFAOYSA-N 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 235000019198 oils Nutrition 0.000 description 2
- 235000010292 orthophenyl phenol Nutrition 0.000 description 2
- 230000003204 osmotic effect Effects 0.000 description 2
- IWDCLRJOBJJRNH-UHFFFAOYSA-N p-cresol Chemical compound CC1=CC=C(O)C=C1 IWDCLRJOBJJRNH-UHFFFAOYSA-N 0.000 description 2
- 206010033675 panniculitis Diseases 0.000 description 2
- 230000036961 partial effect Effects 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 230000035515 penetration Effects 0.000 description 2
- 201000001245 periodontitis Diseases 0.000 description 2
- 150000004965 peroxy acids Chemical class 0.000 description 2
- 230000002085 persistent effect Effects 0.000 description 2
- 150000002989 phenols Chemical class 0.000 description 2
- 229950000688 phenothiazine Drugs 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 2
- 239000010452 phosphate Substances 0.000 description 2
- 229920000233 poly(alkylene oxides) Polymers 0.000 description 2
- 229920000747 poly(lactic acid) Polymers 0.000 description 2
- 229920002239 polyacrylonitrile Polymers 0.000 description 2
- 229920002647 polyamide Polymers 0.000 description 2
- 229920000139 polyethylene terephthalate Polymers 0.000 description 2
- 239000005020 polyethylene terephthalate Substances 0.000 description 2
- 229920000223 polyglycerol Polymers 0.000 description 2
- 238000006116 polymerization reaction Methods 0.000 description 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 2
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 2
- 235000019238 ponceau 6R Nutrition 0.000 description 2
- 230000003389 potentiating effect Effects 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 239000003755 preservative agent Substances 0.000 description 2
- 230000002062 proliferating effect Effects 0.000 description 2
- 230000035755 proliferation Effects 0.000 description 2
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 2
- DASFNRASQHZIIW-XOTKKQSBSA-M protochlorophyll a Chemical compound [Mg+2].N1=C2C3=C([N-]4)C(CCC(=O)OC\C=C(/C)CCCC(C)CCCC(C)CCCC(C)C)=C(C)C4=CC(C(=C4C=C)C)=NC4=CC(C(C)=C4CC)=NC4=CC1=C(C)C2=C([O-])C3C(=O)OC DASFNRASQHZIIW-XOTKKQSBSA-M 0.000 description 2
- 238000007388 punch biopsy Methods 0.000 description 2
- 230000008929 regeneration Effects 0.000 description 2
- 238000011069 regeneration method Methods 0.000 description 2
- 238000002165 resonance energy transfer Methods 0.000 description 2
- 230000000717 retained effect Effects 0.000 description 2
- OARRHUQTFTUEOS-UHFFFAOYSA-N safranin Chemical compound [Cl-].C=12C=C(N)C(C)=CC2=NC2=CC(C)=C(N)C=C2[N+]=1C1=CC=CC=C1 OARRHUQTFTUEOS-UHFFFAOYSA-N 0.000 description 2
- KZUNJOHGWZRPMI-UHFFFAOYSA-N samarium atom Chemical compound [Sm] KZUNJOHGWZRPMI-UHFFFAOYSA-N 0.000 description 2
- 229920006395 saturated elastomer Polymers 0.000 description 2
- 230000036573 scar formation Effects 0.000 description 2
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 2
- 230000008470 skin growth Effects 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M sodium chloride Inorganic materials [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- GEHJYWRUCIMESM-UHFFFAOYSA-L sodium sulfite Chemical compound [Na+].[Na+].[O-]S([O-])=O GEHJYWRUCIMESM-UHFFFAOYSA-L 0.000 description 2
- 239000008247 solid mixture Substances 0.000 description 2
- 238000002798 spectrophotometry method Methods 0.000 description 2
- 230000037351 starvation Effects 0.000 description 2
- 210000004304 subcutaneous tissue Anatomy 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 238000009121 systemic therapy Methods 0.000 description 2
- 229960000943 tartrazine Drugs 0.000 description 2
- 239000002562 thickening agent Substances 0.000 description 2
- JADVWWSKYZXRGX-UHFFFAOYSA-M thioflavine T Chemical compound [Cl-].C1=CC(N(C)C)=CC=C1C1=[N+](C)C2=CC=C(C)C=C2S1 JADVWWSKYZXRGX-UHFFFAOYSA-M 0.000 description 2
- MGSRCZKZVOBKFT-UHFFFAOYSA-N thymol Chemical compound CC(C)C1=CC=C(C)C=C1O MGSRCZKZVOBKFT-UHFFFAOYSA-N 0.000 description 2
- 230000000451 tissue damage Effects 0.000 description 2
- 231100000827 tissue damage Toxicity 0.000 description 2
- 230000009772 tissue formation Effects 0.000 description 2
- 239000003860 topical agent Substances 0.000 description 2
- 230000007704 transition Effects 0.000 description 2
- ICUTUKXCWQYESQ-UHFFFAOYSA-N triclocarban Chemical compound C1=CC(Cl)=CC=C1NC(=O)NC1=CC=C(Cl)C(Cl)=C1 ICUTUKXCWQYESQ-UHFFFAOYSA-N 0.000 description 2
- 229960003500 triclosan Drugs 0.000 description 2
- MDYOLVRUBBJPFM-UHFFFAOYSA-N tropolone Chemical compound OC1=CC=CC=CC1=O MDYOLVRUBBJPFM-UHFFFAOYSA-N 0.000 description 2
- AODQPPLFAXTBJS-UHFFFAOYSA-M victoria blue 4R Chemical compound [Cl-].C1=CC(N(C)C)=CC=C1C(C=1C=CC(=CC=1)N(C)C)=C(C=C1)C2=CC=CC=C2C1=[N+](C)C1=CC=CC=C1 AODQPPLFAXTBJS-UHFFFAOYSA-M 0.000 description 2
- LLWJPGAKXJBKKA-UHFFFAOYSA-N victoria blue B Chemical compound [Cl-].C1=CC(N(C)C)=CC=C1C(C=1C=CC(=CC=1)N(C)C)=C(C=C1)C2=CC=CC=C2C1=[NH+]C1=CC=CC=C1 LLWJPGAKXJBKKA-UHFFFAOYSA-N 0.000 description 2
- 230000000007 visual effect Effects 0.000 description 2
- XOSXWYQMOYSSKB-LDKJGXKFSA-L water blue Chemical compound CC1=CC(/C(\C(C=C2)=CC=C2NC(C=C2)=CC=C2S([O-])(=O)=O)=C(\C=C2)/C=C/C\2=N\C(C=C2)=CC=C2S([O-])(=O)=O)=CC(S(O)(=O)=O)=C1N.[Na+].[Na+] XOSXWYQMOYSSKB-LDKJGXKFSA-L 0.000 description 2
- 239000002023 wood Substances 0.000 description 2
- 210000002268 wool Anatomy 0.000 description 2
- 230000037303 wrinkles Effects 0.000 description 2
- 239000001018 xanthene dye Substances 0.000 description 2
- NAWDYIZEMPQZHO-UHFFFAOYSA-N ytterbium Chemical compound [Yb] NAWDYIZEMPQZHO-UHFFFAOYSA-N 0.000 description 2
- 229910052725 zinc Inorganic materials 0.000 description 2
- 239000011701 zinc Substances 0.000 description 2
- FQTLCLSUCSAZDY-UHFFFAOYSA-N (+) E(S) nerolidol Natural products CC(C)=CCCC(C)=CCCC(C)(O)C=C FQTLCLSUCSAZDY-UHFFFAOYSA-N 0.000 description 1
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 1
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical class CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 description 1
- CRDAMVZIKSXKFV-FBXUGWQNSA-N (2-cis,6-cis)-farnesol Chemical compound CC(C)=CCC\C(C)=C/CC\C(C)=C/CO CRDAMVZIKSXKFV-FBXUGWQNSA-N 0.000 description 1
- 239000000260 (2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-ol Substances 0.000 description 1
- OMDQUFIYNPYJFM-XKDAHURESA-N (2r,3r,4s,5r,6s)-2-(hydroxymethyl)-6-[[(2r,3s,4r,5s,6r)-4,5,6-trihydroxy-3-[(2s,3s,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]methoxy]oxane-3,4,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O[C@H]2[C@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)[C@H](O)[C@H](O)[C@H](O)O1 OMDQUFIYNPYJFM-XKDAHURESA-N 0.000 description 1
- WCDDVEOXEIYWFB-VXORFPGASA-N (2s,3s,4r,5r,6r)-3-[(2s,3r,5s,6r)-3-acetamido-5-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4,5,6-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@@H]1C[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](C(O)=O)O[C@@H](O)[C@H](O)[C@H]1O WCDDVEOXEIYWFB-VXORFPGASA-N 0.000 description 1
- LDVVMCZRFWMZSG-OLQVQODUSA-N (3ar,7as)-2-(trichloromethylsulfanyl)-3a,4,7,7a-tetrahydroisoindole-1,3-dione Chemical compound C1C=CC[C@H]2C(=O)N(SC(Cl)(Cl)Cl)C(=O)[C@H]21 LDVVMCZRFWMZSG-OLQVQODUSA-N 0.000 description 1
- CVCQAQVBOPNTFI-AAONGDSNSA-N (3r,4r,5s,6r)-3-amino-6-(hydroxymethyl)oxane-2,4,5-triol;sulfuric acid Chemical compound OS(O)(=O)=O.N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O.N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O CVCQAQVBOPNTFI-AAONGDSNSA-N 0.000 description 1
- MTDHILKWIRSIHB-UHFFFAOYSA-N (5-azaniumyl-3,4,6-trihydroxyoxan-2-yl)methyl sulfate Chemical compound NC1C(O)OC(COS(O)(=O)=O)C(O)C1O MTDHILKWIRSIHB-UHFFFAOYSA-N 0.000 description 1
- PVPBBTJXIKFICP-UHFFFAOYSA-N (7-aminophenothiazin-3-ylidene)azanium;chloride Chemical compound [Cl-].C1=CC(=[NH2+])C=C2SC3=CC(N)=CC=C3N=C21 PVPBBTJXIKFICP-UHFFFAOYSA-N 0.000 description 1
- KSEBMYQBYZTDHS-HWKANZROSA-M (E)-Ferulic acid Natural products COC1=CC(\C=C\C([O-])=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-M 0.000 description 1
- LLDSAQJCCUZHBA-UHFFFAOYSA-N 1,2,4,5,8-pentahydroxyanthracene-9,10-dione Chemical compound O=C1C2=C(O)C(O)=CC(O)=C2C(=O)C2=C1C(O)=CC=C2O LLDSAQJCCUZHBA-UHFFFAOYSA-N 0.000 description 1
- XZSUEVFAMOKROK-UHFFFAOYSA-N 1,2-dihydroxy-3-nitroanthracene-9,10-dione Chemical compound O=C1C2=CC=CC=C2C(=O)C2=C1C(O)=C(O)C([N+]([O-])=O)=C2 XZSUEVFAMOKROK-UHFFFAOYSA-N 0.000 description 1
- 150000005207 1,3-dihydroxybenzenes Chemical class 0.000 description 1
- QOSTVEDABRQTSU-UHFFFAOYSA-N 1,4-bis(methylamino)anthracene-9,10-dione Chemical compound O=C1C2=CC=CC=C2C(=O)C2=C1C(NC)=CC=C2NC QOSTVEDABRQTSU-UHFFFAOYSA-N 0.000 description 1
- WEEGYLXZBRQIMU-UHFFFAOYSA-N 1,8-cineole Natural products C1CC2CCC1(C)OC2(C)C WEEGYLXZBRQIMU-UHFFFAOYSA-N 0.000 description 1
- QDGIEIGBQXURRS-UHFFFAOYSA-N 1-(3-chlorophenyl)-3-(3,4-dichlorophenyl)urea Chemical compound ClC1=CC=CC(NC(=O)NC=2C=C(Cl)C(Cl)=CC=2)=C1 QDGIEIGBQXURRS-UHFFFAOYSA-N 0.000 description 1
- VAZJLPXFVQHDFB-UHFFFAOYSA-N 1-(diaminomethylidene)-2-hexylguanidine Chemical compound CCCCCCN=C(N)N=C(N)N VAZJLPXFVQHDFB-UHFFFAOYSA-N 0.000 description 1
- WFQFCIAYZRUHQI-UHFFFAOYSA-N 1-chloro-4-(2-phenylethoxy)benzene Chemical compound C1=CC(Cl)=CC=C1OCCC1=CC=CC=C1 WFQFCIAYZRUHQI-UHFFFAOYSA-N 0.000 description 1
- JWYVGKFDLWWQJX-UHFFFAOYSA-N 1-ethenylazepan-2-one Chemical compound C=CN1CCCCCC1=O JWYVGKFDLWWQJX-UHFFFAOYSA-N 0.000 description 1
- 125000004804 1-methylmethylene group Chemical group [H]C([H])([H])C([H])([*:2])[*:1] 0.000 description 1
- IBLKWZIFZMJLFL-UHFFFAOYSA-N 1-phenoxypropan-2-ol Chemical compound CC(O)COC1=CC=CC=C1 IBLKWZIFZMJLFL-UHFFFAOYSA-N 0.000 description 1
- WBLLWHYYHNSTFH-UHFFFAOYSA-N 2',4',5',7'-tetrachloro-3',6'-dihydroxyspiro[2-benzofuran-3,9'-xanthene]-1-one Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC(Cl)=C(O)C(Cl)=C1OC1=C(Cl)C(O)=C(Cl)C=C21 WBLLWHYYHNSTFH-UHFFFAOYSA-N 0.000 description 1
- YNBZQSXWRWAXMV-UHFFFAOYSA-N 2',7'-dibromo-3',6'-dihydroxyspiro[2-benzofuran-3,9'-xanthene]-1-one Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC(Br)=C(O)C=C1OC1=C2C=C(Br)C(O)=C1 YNBZQSXWRWAXMV-UHFFFAOYSA-N 0.000 description 1
- VFNKZQNIXUFLBC-UHFFFAOYSA-N 2',7'-dichlorofluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC(Cl)=C(O)C=C1OC1=C2C=C(Cl)C(O)=C1 VFNKZQNIXUFLBC-UHFFFAOYSA-N 0.000 description 1
- BKUSIKGSPSFQAC-RRKCRQDMSA-N 2'-deoxyinosine-5'-diphosphate Chemical compound O1[C@H](CO[P@@](O)(=O)OP(O)(O)=O)[C@@H](O)C[C@@H]1N1C(NC=NC2=O)=C2N=C1 BKUSIKGSPSFQAC-RRKCRQDMSA-N 0.000 description 1
- GGIDUULRWQOXLR-UHFFFAOYSA-N 2,3,4,5-tetrabromo-6-methylphenol Chemical compound CC1=C(O)C(Br)=C(Br)C(Br)=C1Br GGIDUULRWQOXLR-UHFFFAOYSA-N 0.000 description 1
- CDULGHZNHURECF-UHFFFAOYSA-N 2,3-dimethylaniline 2,4-dimethylaniline 2,5-dimethylaniline 2,6-dimethylaniline 3,4-dimethylaniline 3,5-dimethylaniline Chemical group CC1=CC=C(N)C(C)=C1.CC1=CC=C(C)C(N)=C1.CC1=CC(C)=CC(N)=C1.CC1=CC=C(N)C=C1C.CC1=CC=CC(N)=C1C.CC1=CC=CC(C)=C1N CDULGHZNHURECF-UHFFFAOYSA-N 0.000 description 1
- IYOLBFFHPZOQGW-UHFFFAOYSA-N 2,4-dichloro-3,5-dimethylphenol Chemical compound CC1=CC(O)=C(Cl)C(C)=C1Cl IYOLBFFHPZOQGW-UHFFFAOYSA-N 0.000 description 1
- FFRBMBIXVSCUFS-UHFFFAOYSA-N 2,4-dinitro-1-naphthol Chemical compound C1=CC=C2C(O)=C([N+]([O-])=O)C=C([N+]([O-])=O)C2=C1 FFRBMBIXVSCUFS-UHFFFAOYSA-N 0.000 description 1
- KUFFULVDNCHOFZ-UHFFFAOYSA-N 2,4-xylenol Chemical compound CC1=CC=C(O)C(C)=C1 KUFFULVDNCHOFZ-UHFFFAOYSA-N 0.000 description 1
- CFSOXRGHLCXRNB-UHFFFAOYSA-N 2-(3-phenylpropyl)benzene-1,3-diol Chemical compound OC1=CC=CC(O)=C1CCCC1=CC=CC=C1 CFSOXRGHLCXRNB-UHFFFAOYSA-N 0.000 description 1
- RFIMISVNSAUMBU-UHFFFAOYSA-N 2-(hydroxymethyl)-2-(prop-2-enoxymethyl)propane-1,3-diol Chemical compound OCC(CO)(CO)COCC=C RFIMISVNSAUMBU-UHFFFAOYSA-N 0.000 description 1
- CEQFOVLGLXCDCX-UHFFFAOYSA-N 2-[[4-(dimethylamino)phenyl]diazenyl]benzoic acid Chemical compound C1=CC(N(C)C)=CC=C1N=NC1=CC=CC=C1C(O)=O CEQFOVLGLXCDCX-UHFFFAOYSA-N 0.000 description 1
- UGIJCMNGQCUTPI-UHFFFAOYSA-N 2-aminoethyl prop-2-enoate Chemical compound NCCOC(=O)C=C UGIJCMNGQCUTPI-UHFFFAOYSA-N 0.000 description 1
- IYXUFNCIWJHFBR-UHFFFAOYSA-N 2-benzyl-4-chloro-3-methylphenol Chemical compound CC1=C(Cl)C=CC(O)=C1CC1=CC=CC=C1 IYXUFNCIWJHFBR-UHFFFAOYSA-N 0.000 description 1
- WPMBXQJYQZTSGS-UHFFFAOYSA-N 2-benzyl-4-chlorobenzene-1,3-diol Chemical compound OC1=CC=C(Cl)C(O)=C1CC1=CC=CC=C1 WPMBXQJYQZTSGS-UHFFFAOYSA-N 0.000 description 1
- RKDMDAVSHRCXQZ-UHFFFAOYSA-N 2-benzylbenzene-1,3-diol Chemical compound OC1=CC=CC(O)=C1CC1=CC=CC=C1 RKDMDAVSHRCXQZ-UHFFFAOYSA-N 0.000 description 1
- KSDMMSMHJOPTSY-UHFFFAOYSA-N 2-bromo-3-(2-methylbutan-2-yl)phenol Chemical compound CCC(C)(C)C1=CC=CC(O)=C1Br KSDMMSMHJOPTSY-UHFFFAOYSA-N 0.000 description 1
- COVGKJSMQVFLDP-UHFFFAOYSA-N 2-bromo-3-hexylphenol Chemical compound CCCCCCC1=CC=CC(O)=C1Br COVGKJSMQVFLDP-UHFFFAOYSA-N 0.000 description 1
- TYBHZVUFOINFDV-UHFFFAOYSA-N 2-bromo-6-[(3-bromo-5-chloro-2-hydroxyphenyl)methyl]-4-chlorophenol Chemical compound OC1=C(Br)C=C(Cl)C=C1CC1=CC(Cl)=CC(Br)=C1O TYBHZVUFOINFDV-UHFFFAOYSA-N 0.000 description 1
- VADKRMSMGWJZCF-UHFFFAOYSA-N 2-bromophenol Chemical compound OC1=CC=CC=C1Br VADKRMSMGWJZCF-UHFFFAOYSA-N 0.000 description 1
- BRYHBLAGEXUHSL-UHFFFAOYSA-N 2-butan-2-yl-4-chloro-5-methylphenol Chemical compound CCC(C)C1=CC(Cl)=C(C)C=C1O BRYHBLAGEXUHSL-UHFFFAOYSA-N 0.000 description 1
- COSYXLHTXXMVGM-UHFFFAOYSA-N 2-butyl-4-chlorophenol Chemical compound CCCCC1=CC(Cl)=CC=C1O COSYXLHTXXMVGM-UHFFFAOYSA-N 0.000 description 1
- FZLKMKSAXYZVJW-UHFFFAOYSA-N 2-chloro-3-(2-methylbutan-2-yl)phenol Chemical compound CCC(C)(C)C1=CC=CC(O)=C1Cl FZLKMKSAXYZVJW-UHFFFAOYSA-N 0.000 description 1
- UNRRZPJVYQDQPL-UHFFFAOYSA-N 2-chloro-3-ethylphenol Chemical compound CCC1=CC=CC(O)=C1Cl UNRRZPJVYQDQPL-UHFFFAOYSA-N 0.000 description 1
- NVIHKOLBNJOVTD-UHFFFAOYSA-N 2-chloro-3-heptylphenol Chemical compound CCCCCCCC1=CC=CC(O)=C1Cl NVIHKOLBNJOVTD-UHFFFAOYSA-N 0.000 description 1
- KHWKJUTXTSNBKW-UHFFFAOYSA-N 2-chloro-3-propylphenol Chemical compound CCCC1=CC=CC(O)=C1Cl KHWKJUTXTSNBKW-UHFFFAOYSA-N 0.000 description 1
- HKHXLHGVIHQKMK-UHFFFAOYSA-N 2-chloro-m-cresol Chemical compound CC1=CC=CC(O)=C1Cl HKHXLHGVIHQKMK-UHFFFAOYSA-N 0.000 description 1
- ISPYQTSUDJAMAB-UHFFFAOYSA-N 2-chlorophenol Chemical compound OC1=CC=CC=C1Cl ISPYQTSUDJAMAB-UHFFFAOYSA-N 0.000 description 1
- NYEZZYQZRQDLEH-UHFFFAOYSA-N 2-ethyl-4,5-dihydro-1,3-oxazole Chemical compound CCC1=NCCO1 NYEZZYQZRQDLEH-UHFFFAOYSA-N 0.000 description 1
- DWVXFVWWARTDCQ-UHFFFAOYSA-N 2-ethylbenzene-1,3-diol Chemical compound CCC1=C(O)C=CC=C1O DWVXFVWWARTDCQ-UHFFFAOYSA-N 0.000 description 1
- GOUWRHHYANYVLG-UHFFFAOYSA-N 2-heptylbenzene-1,3-diol Chemical compound CCCCCCCC1=C(O)C=CC=C1O GOUWRHHYANYVLG-UHFFFAOYSA-N 0.000 description 1
- NCTHQZTWNVDWGT-UHFFFAOYSA-N 2-hexylbenzene-1,3-diol Chemical compound CCCCCCC1=C(O)C=CC=C1O NCTHQZTWNVDWGT-UHFFFAOYSA-N 0.000 description 1
- GUXJXWKCUUWCLX-UHFFFAOYSA-N 2-methyl-2-oxazoline Chemical compound CC1=NCCO1 GUXJXWKCUUWCLX-UHFFFAOYSA-N 0.000 description 1
- 229940100555 2-methyl-4-isothiazolin-3-one Drugs 0.000 description 1
- ZTMADXFOCUXMJE-UHFFFAOYSA-N 2-methylbenzene-1,3-diol Chemical compound CC1=C(O)C=CC=C1O ZTMADXFOCUXMJE-UHFFFAOYSA-N 0.000 description 1
- 229940044120 2-n-octyl-4-isothiazolin-3-one Drugs 0.000 description 1
- IEIHCSFJLQYKGJ-UHFFFAOYSA-N 2-nonylbenzene-1,3-diol Chemical compound CCCCCCCCCC1=C(O)C=CC=C1O IEIHCSFJLQYKGJ-UHFFFAOYSA-N 0.000 description 1
- HHSCZZZCAYSVRK-UHFFFAOYSA-N 2-octylbenzene-1,3-diol Chemical compound CCCCCCCCC1=C(O)C=CC=C1O HHSCZZZCAYSVRK-UHFFFAOYSA-N 0.000 description 1
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 description 1
- UPXZHXVOMCGZDS-UHFFFAOYSA-N 2-phenylbenzene-1,3-diol Chemical compound OC1=CC=CC(O)=C1C1=CC=CC=C1 UPXZHXVOMCGZDS-UHFFFAOYSA-N 0.000 description 1
- 229940061334 2-phenylphenol Drugs 0.000 description 1
- XDCMHOFEBFTMNL-UHFFFAOYSA-N 2-propylbenzene-1,3-diol Chemical compound CCCC1=C(O)C=CC=C1O XDCMHOFEBFTMNL-UHFFFAOYSA-N 0.000 description 1
- OALHHIHQOFIMEF-UHFFFAOYSA-N 3',6'-dihydroxy-2',4',5',7'-tetraiodo-3h-spiro[2-benzofuran-1,9'-xanthene]-3-one Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC(I)=C(O)C(I)=C1OC1=C(I)C(O)=C(I)C=C21 OALHHIHQOFIMEF-UHFFFAOYSA-N 0.000 description 1
- YUOSDRMYPOJFCP-UHFFFAOYSA-N 3',6'-dihydroxy-2',7'-diiodospiro[2-benzofuran-3,9'-xanthene]-1-one Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC(I)=C(O)C=C1OC1=C2C=C(I)C(O)=C1 YUOSDRMYPOJFCP-UHFFFAOYSA-N 0.000 description 1
- DSVUBXQDJGJGIC-UHFFFAOYSA-N 3',6'-dihydroxy-4',5'-diiodospiro[2-benzofuran-3,9'-xanthene]-1-one Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C(I)=C1OC1=C(I)C(O)=CC=C21 DSVUBXQDJGJGIC-UHFFFAOYSA-N 0.000 description 1
- HDJBTCAJIMNXEW-UHFFFAOYSA-N 3-(1-methylpyrrolidin-2-yl)pyridine;hydrochloride Chemical compound Cl.CN1CCCC1C1=CC=CN=C1 HDJBTCAJIMNXEW-UHFFFAOYSA-N 0.000 description 1
- NNMALANKTSRILL-LXENMSTPSA-N 3-[(2z,5e)-2-[[3-(2-carboxyethyl)-5-[(z)-[(3e,4r)-3-ethylidene-4-methyl-5-oxopyrrolidin-2-ylidene]methyl]-4-methyl-1h-pyrrol-2-yl]methylidene]-5-[(4-ethyl-3-methyl-5-oxopyrrol-2-yl)methylidene]-4-methylpyrrol-3-yl]propanoic acid Chemical compound O=C1C(CC)=C(C)C(\C=C\2C(=C(CCC(O)=O)C(=C/C3=C(C(C)=C(\C=C/4\C(\[C@@H](C)C(=O)N\4)=C\C)N3)CCC(O)=O)/N/2)C)=N1 NNMALANKTSRILL-LXENMSTPSA-N 0.000 description 1
- OAOFCENSKJNHQG-UHFFFAOYSA-N 3-butyl-2-chlorophenol Chemical compound CCCCC1=CC=CC(O)=C1Cl OAOFCENSKJNHQG-UHFFFAOYSA-N 0.000 description 1
- WHNPOQXWAMXPTA-UHFFFAOYSA-N 3-methylbut-2-enamide Chemical compound CC(C)=CC(N)=O WHNPOQXWAMXPTA-UHFFFAOYSA-N 0.000 description 1
- TZZGHGKTHXIOMN-UHFFFAOYSA-N 3-trimethoxysilyl-n-(3-trimethoxysilylpropyl)propan-1-amine Chemical compound CO[Si](OC)(OC)CCCNCCC[Si](OC)(OC)OC TZZGHGKTHXIOMN-UHFFFAOYSA-N 0.000 description 1
- ZDTNHRWWURISAA-UHFFFAOYSA-N 4',5'-dibromo-3',6'-dihydroxyspiro[2-benzofuran-3,9'-xanthene]-1-one Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C(Br)=C1OC1=C(Br)C(O)=CC=C21 ZDTNHRWWURISAA-UHFFFAOYSA-N 0.000 description 1
- WLHLYHWMNUCWEV-UHFFFAOYSA-N 4',5'-dichloro-3',6'-dihydroxyspiro[2-benzofuran-3,9'-xanthene]-1-one Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C(Cl)=C1OC1=C(Cl)C(O)=CC=C21 WLHLYHWMNUCWEV-UHFFFAOYSA-N 0.000 description 1
- PQSXNIMHIHYFEE-UHFFFAOYSA-N 4-(1-phenylethyl)benzene-1,3-diol Chemical compound C=1C=C(O)C=C(O)C=1C(C)C1=CC=CC=C1 PQSXNIMHIHYFEE-UHFFFAOYSA-N 0.000 description 1
- IJALWSVNUBBQRA-UHFFFAOYSA-N 4-Isopropyl-3-methylphenol Chemical compound CC(C)C1=CC=C(O)C=C1C IJALWSVNUBBQRA-UHFFFAOYSA-N 0.000 description 1
- KLSLBUSXWBJMEC-UHFFFAOYSA-N 4-Propylphenol Chemical compound CCCC1=CC=C(O)C=C1 KLSLBUSXWBJMEC-UHFFFAOYSA-N 0.000 description 1
- ATVXBMXBDVUKPM-UHFFFAOYSA-N 4-bromo-2-butylphenol Chemical compound CCCCC1=CC(Br)=CC=C1O ATVXBMXBDVUKPM-UHFFFAOYSA-N 0.000 description 1
- QQVRKOIEEIGPMK-UHFFFAOYSA-N 4-bromo-2-cyclohexylphenol Chemical compound OC1=CC=C(Br)C=C1C1CCCCC1 QQVRKOIEEIGPMK-UHFFFAOYSA-N 0.000 description 1
- MAAADQMBQYSOOG-UHFFFAOYSA-N 4-bromo-2-ethylphenol Chemical compound CCC1=CC(Br)=CC=C1O MAAADQMBQYSOOG-UHFFFAOYSA-N 0.000 description 1
- NBJOEVNMBJIEBA-UHFFFAOYSA-N 4-bromo-2-hexylphenol Chemical compound CCCCCCC1=CC(Br)=CC=C1O NBJOEVNMBJIEBA-UHFFFAOYSA-N 0.000 description 1
- IWJGMJHAIUBWKT-UHFFFAOYSA-N 4-bromo-2-methylphenol Chemical compound CC1=CC(Br)=CC=C1O IWJGMJHAIUBWKT-UHFFFAOYSA-N 0.000 description 1
- IBNNFYOOPXNGIL-UHFFFAOYSA-N 4-bromo-2-pentan-2-ylphenol Chemical compound CCCC(C)C1=CC(Br)=CC=C1O IBNNFYOOPXNGIL-UHFFFAOYSA-N 0.000 description 1
- AEHYMMFSHCSYAA-UHFFFAOYSA-N 4-bromo-2-propylphenol Chemical compound CCCC1=CC(Br)=CC=C1O AEHYMMFSHCSYAA-UHFFFAOYSA-N 0.000 description 1
- RCMXKDPMOKHQKG-UHFFFAOYSA-N 4-bromophenol;4-chloro-3-methylphenol Chemical compound OC1=CC=C(Br)C=C1.CC1=CC(O)=CC=C1Cl RCMXKDPMOKHQKG-UHFFFAOYSA-N 0.000 description 1
- LYOFHYLVYHTGBK-UHFFFAOYSA-N 4-chloro-1,5-dimethylcyclohexa-2,4-dien-1-ol Chemical compound CC1=C(Cl)C=CC(C)(O)C1 LYOFHYLVYHTGBK-UHFFFAOYSA-N 0.000 description 1
- GKCCTCWZNGMJKG-UHFFFAOYSA-N 4-chloro-2-[(5-chloro-2-hydroxyphenyl)methylsulfanylmethyl]phenol Chemical compound OC1=CC=C(Cl)C=C1CSCC1=CC(Cl)=CC=C1O GKCCTCWZNGMJKG-UHFFFAOYSA-N 0.000 description 1
- XRUHXAQEOJDPEG-UHFFFAOYSA-N 4-chloro-2-cyclohexylphenol Chemical compound OC1=CC=C(Cl)C=C1C1CCCCC1 XRUHXAQEOJDPEG-UHFFFAOYSA-N 0.000 description 1
- WBQFGBDPSGGESL-UHFFFAOYSA-N 4-chloro-2-ethyl-3,5-dimethylphenol Chemical compound CCC1=C(C)C(Cl)=C(C)C=C1O WBQFGBDPSGGESL-UHFFFAOYSA-N 0.000 description 1
- LKPNWNSJHHGYLU-UHFFFAOYSA-N 4-chloro-2-ethyl-3-methyl-6-propan-2-ylphenol Chemical compound CCC1=C(C)C(Cl)=CC(C(C)C)=C1O LKPNWNSJHHGYLU-UHFFFAOYSA-N 0.000 description 1
- ZSTDEWVWZHPUCW-UHFFFAOYSA-N 4-chloro-2-ethyl-5-methylphenol Chemical compound CCC1=CC(Cl)=C(C)C=C1O ZSTDEWVWZHPUCW-UHFFFAOYSA-N 0.000 description 1
- QCEDDUSMBLCRNH-UHFFFAOYSA-N 4-chloro-2-ethylphenol Chemical compound CCC1=CC(Cl)=CC=C1O QCEDDUSMBLCRNH-UHFFFAOYSA-N 0.000 description 1
- LAMKHMJVAKQLOO-UHFFFAOYSA-N 4-chloro-2-heptylphenol Chemical compound CCCCCCCC1=CC(Cl)=CC=C1O LAMKHMJVAKQLOO-UHFFFAOYSA-N 0.000 description 1
- UUBASQRIVIRMIQ-UHFFFAOYSA-N 4-chloro-2-hexylphenol Chemical compound CCCCCCC1=CC(Cl)=CC=C1O UUBASQRIVIRMIQ-UHFFFAOYSA-N 0.000 description 1
- LGIGBKMDIHECCC-UHFFFAOYSA-N 4-chloro-2-pentan-2-ylphenol Chemical compound CCCC(C)C1=CC(Cl)=CC=C1O LGIGBKMDIHECCC-UHFFFAOYSA-N 0.000 description 1
- GLXDMSOEJKXENG-UHFFFAOYSA-N 4-chloro-2-propylphenol Chemical compound CCCC1=CC(Cl)=CC=C1O GLXDMSOEJKXENG-UHFFFAOYSA-N 0.000 description 1
- HFHNPIHVXJLWNW-UHFFFAOYSA-N 4-chloro-3,5-dimethyl-2-pentan-2-ylphenol Chemical compound CCCC(C)C1=C(C)C(Cl)=C(C)C=C1O HFHNPIHVXJLWNW-UHFFFAOYSA-N 0.000 description 1
- QFVWWVICQQINNI-UHFFFAOYSA-N 4-chloro-3,5-dimethyl-2-propan-2-ylphenol Chemical compound CC(C)C1=C(C)C(Cl)=C(C)C=C1O QFVWWVICQQINNI-UHFFFAOYSA-N 0.000 description 1
- FDFTZPSQIKUAMS-UHFFFAOYSA-N 4-chloro-3-methyl-2-(2-phenylethyl)phenol Chemical compound CC1=C(Cl)C=CC(O)=C1CCC1=CC=CC=C1 FDFTZPSQIKUAMS-UHFFFAOYSA-N 0.000 description 1
- KFZXVMNBUMVKLN-UHFFFAOYSA-N 4-chloro-5-methyl-2-propan-2-ylphenol Chemical compound CC(C)C1=CC(Cl)=C(C)C=C1O KFZXVMNBUMVKLN-UHFFFAOYSA-N 0.000 description 1
- PBDKPFIVQQUKMK-UHFFFAOYSA-N 4-chloro-5-methyl-2-propylphenol Chemical compound CCCC1=CC(Cl)=C(C)C=C1O PBDKPFIVQQUKMK-UHFFFAOYSA-N 0.000 description 1
- MNVMYTVDDOXZLS-UHFFFAOYSA-N 4-methoxyguaiacol Natural products COC1=CC=C(O)C(OC)=C1 MNVMYTVDDOXZLS-UHFFFAOYSA-N 0.000 description 1
- CYYZDBDROVLTJU-UHFFFAOYSA-N 4-n-Butylphenol Chemical compound CCCCC1=CC=C(O)C=C1 CYYZDBDROVLTJU-UHFFFAOYSA-N 0.000 description 1
- CSHZYWUPJWVTMQ-UHFFFAOYSA-N 4-n-Butylresorcinol Chemical compound CCCCC1=CC=C(O)C=C1O CSHZYWUPJWVTMQ-UHFFFAOYSA-N 0.000 description 1
- KNDDEFBFJLKPFE-UHFFFAOYSA-N 4-n-Heptylphenol Chemical compound CCCCCCCC1=CC=C(O)C=C1 KNDDEFBFJLKPFE-UHFFFAOYSA-N 0.000 description 1
- SZWBRVPZWJYIHI-UHFFFAOYSA-N 4-n-Hexylphenol Chemical compound CCCCCCC1=CC=C(O)C=C1 SZWBRVPZWJYIHI-UHFFFAOYSA-N 0.000 description 1
- ZNPSUQQXTRRSBM-UHFFFAOYSA-N 4-n-Pentylphenol Chemical compound CCCCCC1=CC=C(O)C=C1 ZNPSUQQXTRRSBM-UHFFFAOYSA-N 0.000 description 1
- UZDMJPAQQFSMMV-UHFFFAOYSA-N 4-oxo-4-(2-prop-2-enoyloxyethoxy)butanoic acid Chemical compound OC(=O)CCC(=O)OCCOC(=O)C=C UZDMJPAQQFSMMV-UHFFFAOYSA-N 0.000 description 1
- 229940046305 5-bromo-5-nitro-1,3-dioxane Drugs 0.000 description 1
- QYYMDNHUJFIDDQ-UHFFFAOYSA-N 5-chloro-2-methyl-1,2-thiazol-3-one;2-methyl-1,2-thiazol-3-one Chemical compound CN1SC=CC1=O.CN1SC(Cl)=CC1=O QYYMDNHUJFIDDQ-UHFFFAOYSA-N 0.000 description 1
- VDBJCDWTNCKRTF-UHFFFAOYSA-N 6'-hydroxyspiro[2-benzofuran-3,9'-9ah-xanthene]-1,3'-dione Chemical compound O1C(=O)C2=CC=CC=C2C21C1C=CC(=O)C=C1OC1=CC(O)=CC=C21 VDBJCDWTNCKRTF-UHFFFAOYSA-N 0.000 description 1
- BKFKUFSCVKISDQ-UHFFFAOYSA-N 6-bromo-1,5-dimethylcyclohexa-2,4-dien-1-ol Chemical compound CC1=CC=CC(C)(O)C1Br BKFKUFSCVKISDQ-UHFFFAOYSA-N 0.000 description 1
- KVAWWXSLBDVXHJ-UHFFFAOYSA-N 6-bromo-5-chloro-3h-1,3-benzoxazol-2-one Chemical compound C1=C(Br)C(Cl)=CC2=C1OC(=O)N2 KVAWWXSLBDVXHJ-UHFFFAOYSA-N 0.000 description 1
- REPMZEQSQQAHJR-UHFFFAOYSA-N 7-(diethylamino)-3,4-dioxo-10H-phenoxazine-1-carboxamide hydrochloride Chemical compound [Cl-].OC(=[NH2+])C1=CC(=O)C(=O)C2=C1NC1=CC=C(N(CC)CC)C=C1O2 REPMZEQSQQAHJR-UHFFFAOYSA-N 0.000 description 1
- ALJHHTHBYJROOG-UHFFFAOYSA-N 7-(dimethylamino)phenothiazin-3-one Chemical compound C1=CC(=O)C=C2SC3=CC(N(C)C)=CC=C3N=C21 ALJHHTHBYJROOG-UHFFFAOYSA-N 0.000 description 1
- NGZUCVGMNQGGNA-UHFFFAOYSA-N 7-[5-(2-acetamidoethyl)-2-hydroxyphenyl]-3,5,6,8-tetrahydroxy-9,10-dioxoanthracene-1,2-dicarboxylic acid 7-[5-(2-amino-2-carboxyethyl)-2-hydroxyphenyl]-3,5,6,8-tetrahydroxy-9,10-dioxoanthracene-1,2-dicarboxylic acid 3,5,6,8-tetrahydroxy-7-[2-hydroxy-5-(2-hydroxyethyl)phenyl]-9,10-dioxoanthracene-1,2-dicarboxylic acid 3,6,8-trihydroxy-1-methyl-9,10-dioxoanthracene-2-carboxylic acid Chemical compound Cc1c(C(O)=O)c(O)cc2C(=O)c3cc(O)cc(O)c3C(=O)c12.OCCc1ccc(O)c(c1)-c1c(O)c(O)c2C(=O)c3cc(O)c(C(O)=O)c(C(O)=O)c3C(=O)c2c1O.CC(=O)NCCc1ccc(O)c(c1)-c1c(O)c(O)c2C(=O)c3cc(O)c(C(O)=O)c(C(O)=O)c3C(=O)c2c1O.NC(Cc1ccc(O)c(c1)-c1c(O)c(O)c2C(=O)c3cc(O)c(C(O)=O)c(C(O)=O)c3C(=O)c2c1O)C(O)=O NGZUCVGMNQGGNA-UHFFFAOYSA-N 0.000 description 1
- CKLBXIYTBHXJEH-UHFFFAOYSA-J 75881-23-1 Chemical compound [Cl-].[Cl-].[Cl-].[Cl-].[Cu+2].[N-]1C(N=C2C3=CC=C(CSC(N(C)C)=[N+](C)C)C=C3C(N=C3C4=CC=C(CSC(N(C)C)=[N+](C)C)C=C4C(=N4)[N-]3)=N2)=C(C=C(CSC(N(C)C)=[N+](C)C)C=C2)C2=C1N=C1C2=CC(CSC(N(C)C)=[N+](C)C)=CC=C2C4=N1 CKLBXIYTBHXJEH-UHFFFAOYSA-J 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 description 1
- 229920000936 Agarose Polymers 0.000 description 1
- 244000198134 Agave sisalana Species 0.000 description 1
- 235000011624 Agave sisalana Nutrition 0.000 description 1
- 102000009027 Albumins Human genes 0.000 description 1
- 108010088751 Albumins Proteins 0.000 description 1
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 description 1
- CEZCCHQBSQPRMU-LLIZZRELSA-L Allura red AC Chemical compound [Na+].[Na+].COC1=CC(S([O-])(=O)=O)=C(C)C=C1\N=N\C1=C(O)C=CC2=CC(S([O-])(=O)=O)=CC=C12 CEZCCHQBSQPRMU-LLIZZRELSA-L 0.000 description 1
- 235000009328 Amaranthus caudatus Nutrition 0.000 description 1
- 240000001592 Amaranthus caudatus Species 0.000 description 1
- AOMZHDJXSYHPKS-DROYEMJCSA-L Amido Black 10B Chemical compound [Na+].[Na+].[O-]S(=O)(=O)C1=CC2=CC(S([O-])(=O)=O)=C(\N=N\C=3C=CC=CC=3)C(O)=C2C(N)=C1\N=N\C1=CC=C(N(=O)=O)C=C1 AOMZHDJXSYHPKS-DROYEMJCSA-L 0.000 description 1
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 1
- 206010003694 Atrophy Diseases 0.000 description 1
- MOZDKDIOPSPTBH-UHFFFAOYSA-N Benzyl parahydroxybenzoate Chemical compound C1=CC(O)=CC=C1C(=O)OCC1=CC=CC=C1 MOZDKDIOPSPTBH-UHFFFAOYSA-N 0.000 description 1
- VVAVKBBTPWYADW-UHFFFAOYSA-L Biebrich scarlet Chemical compound [Na+].[Na+].OC1=CC=C2C=CC=CC2=C1N=NC(C(=C1)S([O-])(=O)=O)=CC=C1N=NC1=CC=C(S([O-])(=O)=O)C=C1 VVAVKBBTPWYADW-UHFFFAOYSA-L 0.000 description 1
- 229930185605 Bisphenol Natural products 0.000 description 1
- LVDKZNITIUWNER-UHFFFAOYSA-N Bronopol Chemical compound OCC(Br)(CO)[N+]([O-])=O LVDKZNITIUWNER-UHFFFAOYSA-N 0.000 description 1
- 244000025254 Cannabis sativa Species 0.000 description 1
- 235000012766 Cannabis sativa ssp. sativa var. sativa Nutrition 0.000 description 1
- 235000012765 Cannabis sativa ssp. sativa var. spontanea Nutrition 0.000 description 1
- 239000005745 Captan Substances 0.000 description 1
- 235000009024 Ceanothus sanguineus Nutrition 0.000 description 1
- 108010001857 Cell Surface Receptors Proteins 0.000 description 1
- PTHCMJGKKRQCBF-UHFFFAOYSA-N Cellulose, microcrystalline Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC)C(CO)O1 PTHCMJGKKRQCBF-UHFFFAOYSA-N 0.000 description 1
- 229910052684 Cerium Inorganic materials 0.000 description 1
- NPBVQXIMTZKSBA-UHFFFAOYSA-N Chavibetol Natural products COC1=CC=C(CC=C)C=C1O NPBVQXIMTZKSBA-UHFFFAOYSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 244000223760 Cinnamomum zeylanicum Species 0.000 description 1
- 229930008398 Citronellate Natural products 0.000 description 1
- 235000005979 Citrus limon Nutrition 0.000 description 1
- 244000131522 Citrus pyriformis Species 0.000 description 1
- IQFVPQOLBLOTPF-UHFFFAOYSA-L Congo Red Chemical compound [Na+].[Na+].C1=CC=CC2=C(N)C(N=NC3=CC=C(C=C3)C3=CC=C(C=C3)N=NC3=C(C4=CC=CC=C4C(=C3)S([O-])(=O)=O)N)=CC(S([O-])(=O)=O)=C21 IQFVPQOLBLOTPF-UHFFFAOYSA-L 0.000 description 1
- ZWYHVBGOBINPHN-AVRYKWKFSA-L Congo corinth Chemical compound [Na+].[Na+].Nc1c(cc(c2ccccc12)S([O-])(=O)=O)\N=N\c1ccc(cc1)-c1ccc(cc1)\N=N\c1cc(c2ccccc2c1[O-])S(O)(=O)=O ZWYHVBGOBINPHN-AVRYKWKFSA-L 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 229920002261 Corn starch Polymers 0.000 description 1
- 240000004784 Cymbopogon citratus Species 0.000 description 1
- 235000017897 Cymbopogon citratus Nutrition 0.000 description 1
- 244000166675 Cymbopogon nardus Species 0.000 description 1
- 235000018791 Cymbopogon nardus Nutrition 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Polymers OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 1
- PHMNXPYGVPEQSJ-UHFFFAOYSA-N Dimethoxane Chemical compound CC1CC(OC(C)=O)OC(C)O1 PHMNXPYGVPEQSJ-UHFFFAOYSA-N 0.000 description 1
- 206010058314 Dysplasia Diseases 0.000 description 1
- 229910052692 Dysprosium Inorganic materials 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 229910052691 Erbium Inorganic materials 0.000 description 1
- WEEGYLXZBRQIMU-WAAGHKOSSA-N Eucalyptol Chemical compound C1C[C@H]2CC[C@]1(C)OC2(C)C WEEGYLXZBRQIMU-WAAGHKOSSA-N 0.000 description 1
- 244000166124 Eucalyptus globulus Species 0.000 description 1
- 239000005770 Eugenol Substances 0.000 description 1
- 229910052693 Europium Inorganic materials 0.000 description 1
- 208000034347 Faecal incontinence Diseases 0.000 description 1
- RZSYLLSAWYUBPE-UHFFFAOYSA-L Fast green FCF Chemical compound [Na+].[Na+].C=1C=C(C(=C2C=CC(C=C2)=[N+](CC)CC=2C=C(C=CC=2)S([O-])(=O)=O)C=2C(=CC(O)=CC=2)S([O-])(=O)=O)C=CC=1N(CC)CC1=CC=CC(S([O-])(=O)=O)=C1 RZSYLLSAWYUBPE-UHFFFAOYSA-L 0.000 description 1
- 102000009123 Fibrin Human genes 0.000 description 1
- 108010073385 Fibrin Proteins 0.000 description 1
- 229910052688 Gadolinium Inorganic materials 0.000 description 1
- 229920000926 Galactomannan Polymers 0.000 description 1
- 241000125974 Galene <Rhodophyta> Species 0.000 description 1
- 240000001238 Gaultheria procumbens Species 0.000 description 1
- 235000007297 Gaultheria procumbens Nutrition 0.000 description 1
- 239000005792 Geraniol Substances 0.000 description 1
- GLZPCOQZEFWAFX-YFHOEESVSA-N Geraniol Natural products CC(C)=CCC\C(C)=C/CO GLZPCOQZEFWAFX-YFHOEESVSA-N 0.000 description 1
- 241000208152 Geranium Species 0.000 description 1
- 102100031181 Glyceraldehyde-3-phosphate dehydrogenase Human genes 0.000 description 1
- 229920002683 Glycosaminoglycan Polymers 0.000 description 1
- 229910052689 Holmium Inorganic materials 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 101000868273 Homo sapiens CD44 antigen Proteins 0.000 description 1
- 101000896726 Homo sapiens Lanosterol 14-alpha demethylase Proteins 0.000 description 1
- 240000005979 Hordeum vulgare Species 0.000 description 1
- 235000007340 Hordeum vulgare Nutrition 0.000 description 1
- 235000008694 Humulus lupulus Nutrition 0.000 description 1
- 244000025221 Humulus lupulus Species 0.000 description 1
- 108010003272 Hyaluronate lyase Proteins 0.000 description 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
- 102000005755 Intercellular Signaling Peptides and Proteins Human genes 0.000 description 1
- 108010070716 Intercellular Signaling Peptides and Proteins Proteins 0.000 description 1
- 208000003618 Intervertebral Disc Displacement Diseases 0.000 description 1
- 206010050296 Intervertebral disc protrusion Diseases 0.000 description 1
- OWYWGLHRNBIFJP-UHFFFAOYSA-N Ipazine Chemical compound CCN(CC)C1=NC(Cl)=NC(NC(C)C)=N1 OWYWGLHRNBIFJP-UHFFFAOYSA-N 0.000 description 1
- XPJVKCRENWUEJH-UHFFFAOYSA-N Isobutylparaben Chemical compound CC(C)COC(=O)C1=CC=C(O)C=C1 XPJVKCRENWUEJH-UHFFFAOYSA-N 0.000 description 1
- CMHMMKSPYOOVGI-UHFFFAOYSA-N Isopropylparaben Chemical compound CC(C)OC(=O)C1=CC=C(O)C=C1 CMHMMKSPYOOVGI-UHFFFAOYSA-N 0.000 description 1
- 241001446187 Kermes Species 0.000 description 1
- 229920002752 Konjac Polymers 0.000 description 1
- 102100021695 Lanosterol 14-alpha demethylase Human genes 0.000 description 1
- 241001133829 Latania Species 0.000 description 1
- 244000165082 Lavanda vera Species 0.000 description 1
- 235000010663 Lavandula angustifolia Nutrition 0.000 description 1
- 240000003553 Leptospermum scoparium Species 0.000 description 1
- 229910052765 Lutetium Inorganic materials 0.000 description 1
- 235000015459 Lycium barbarum Nutrition 0.000 description 1
- 229920000433 Lyocell Polymers 0.000 description 1
- 235000016257 Mentha pulegium Nutrition 0.000 description 1
- 244000246386 Mentha pulegium Species 0.000 description 1
- 235000004357 Mentha x piperita Nutrition 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- WWKGVZASJYXZKN-UHFFFAOYSA-N Methyl violet 2B Chemical compound [Cl-].C1=CC(N(C)C)=CC=C1C(C=1C=CC(N)=CC=1)=C1C=CC(=[N+](C)C)C=C1 WWKGVZASJYXZKN-UHFFFAOYSA-N 0.000 description 1
- BAVYZALUXZFZLV-UHFFFAOYSA-N Methylamine Chemical compound NC BAVYZALUXZFZLV-UHFFFAOYSA-N 0.000 description 1
- 239000004368 Modified starch Substances 0.000 description 1
- 229920000881 Modified starch Polymers 0.000 description 1
- 239000004909 Moisturizer Substances 0.000 description 1
- 240000009023 Myrrhis odorata Species 0.000 description 1
- 235000007265 Myrrhis odorata Nutrition 0.000 description 1
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- FQTLCLSUCSAZDY-ATGUSINASA-N Nerolidol Chemical compound CC(C)=CCC\C(C)=C\CC[C@](C)(O)C=C FQTLCLSUCSAZDY-ATGUSINASA-N 0.000 description 1
- 229920000459 Nitrile rubber Polymers 0.000 description 1
- 235000010676 Ocimum basilicum Nutrition 0.000 description 1
- 240000007926 Ocimum gratissimum Species 0.000 description 1
- 239000004218 Orcein Substances 0.000 description 1
- WYNCHZVNFNFDNH-UHFFFAOYSA-N Oxazolidine Chemical compound C1COCN1 WYNCHZVNFNFDNH-UHFFFAOYSA-N 0.000 description 1
- 206010033372 Pain and discomfort Diseases 0.000 description 1
- 102000035195 Peptidases Human genes 0.000 description 1
- CXOFVDLJLONNDW-UHFFFAOYSA-N Phenytoin Chemical compound N1C(=O)NC(=O)C1(C=1C=CC=CC=1)C1=CC=CC=C1 CXOFVDLJLONNDW-UHFFFAOYSA-N 0.000 description 1
- 108010004729 Phycoerythrin Proteins 0.000 description 1
- 235000012550 Pimpinella anisum Nutrition 0.000 description 1
- 206010035226 Plasma cell myeloma Diseases 0.000 description 1
- 229920001311 Poly(hydroxyethyl acrylate) Polymers 0.000 description 1
- 229920002413 Polyhexanide Polymers 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- 229920005830 Polyurethane Foam Polymers 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 229910052777 Praseodymium Inorganic materials 0.000 description 1
- PXRCIOIWVGAZEP-UHFFFAOYSA-N Primaeres Camphenhydrat Natural products C1CC2C(O)(C)C(C)(C)C1C2 PXRCIOIWVGAZEP-UHFFFAOYSA-N 0.000 description 1
- 241000245063 Primula Species 0.000 description 1
- 235000000497 Primula Nutrition 0.000 description 1
- 229910052773 Promethium Inorganic materials 0.000 description 1
- 239000004365 Protease Substances 0.000 description 1
- 108010067787 Proteoglycans Proteins 0.000 description 1
- UVMRYBDEERADNV-UHFFFAOYSA-N Pseudoeugenol Natural products COC1=CC(C(C)=C)=CC=C1O UVMRYBDEERADNV-UHFFFAOYSA-N 0.000 description 1
- 208000006311 Pyoderma Diseases 0.000 description 1
- 241000700157 Rattus norvegicus Species 0.000 description 1
- 230000010799 Receptor Interactions Effects 0.000 description 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 description 1
- 244000178231 Rosmarinus officinalis Species 0.000 description 1
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 description 1
- 206010040030 Sensory loss Diseases 0.000 description 1
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 1
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 1
- FBPFZTCFMRRESA-NQAPHZHOSA-N Sorbitol Polymers OCC(O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-NQAPHZHOSA-N 0.000 description 1
- 235000000126 Styrax benzoin Nutrition 0.000 description 1
- 244000028419 Styrax benzoin Species 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- 235000008411 Sumatra benzointree Nutrition 0.000 description 1
- 206010042496 Sunburn Diseases 0.000 description 1
- 235000016639 Syzygium aromaticum Nutrition 0.000 description 1
- 244000223014 Syzygium aromaticum Species 0.000 description 1
- 229910052771 Terbium Inorganic materials 0.000 description 1
- 108010076830 Thionins Proteins 0.000 description 1
- 239000005844 Thymol Substances 0.000 description 1
- 235000007303 Thymus vulgaris Nutrition 0.000 description 1
- 240000002657 Thymus vulgaris Species 0.000 description 1
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 description 1
- 235000021307 Triticum Nutrition 0.000 description 1
- 244000098338 Triticum aestivum Species 0.000 description 1
- 108010057266 Type A Botulinum Toxins Proteins 0.000 description 1
- 208000003443 Unconsciousness Diseases 0.000 description 1
- 235000012545 Vaccinium macrocarpon Nutrition 0.000 description 1
- 244000291414 Vaccinium oxycoccus Species 0.000 description 1
- 235000002118 Vaccinium oxycoccus Nutrition 0.000 description 1
- 235000007212 Verbena X moechina Moldenke Nutrition 0.000 description 1
- 240000001519 Verbena officinalis Species 0.000 description 1
- 235000001594 Verbena polystachya Kunth Nutrition 0.000 description 1
- 235000007200 Verbena x perriana Moldenke Nutrition 0.000 description 1
- 235000002270 Verbena x stuprosa Moldenke Nutrition 0.000 description 1
- QYKIQEUNHZKYBP-UHFFFAOYSA-N Vinyl ether Chemical compound C=COC=C QYKIQEUNHZKYBP-UHFFFAOYSA-N 0.000 description 1
- QCWXUUIWCKQGHC-UHFFFAOYSA-N Zirconium Chemical compound [Zr] QCWXUUIWCKQGHC-UHFFFAOYSA-N 0.000 description 1
- GMCVSEFMPYGLOB-UHFFFAOYSA-N [6-amino-2,4,5,7-tetrabromo-9-(2-methoxycarbonylphenyl)xanthen-3-ylidene]azanium;chloride Chemical compound [Cl-].COC(=O)C1=CC=CC=C1C1=C2C=C(Br)C(=[NH2+])C(Br)=C2OC2=C(Br)C(N)=C(Br)C=C21 GMCVSEFMPYGLOB-UHFFFAOYSA-N 0.000 description 1
- JRMSLDWZFJZLAS-UHFFFAOYSA-M [7-(dimethylamino)-1,9-dimethylphenothiazin-3-ylidene]-dimethylazanium;chloride Chemical compound [Cl-].CC1=CC(N(C)C)=CC2=[S+]C3=CC(N(C)C)=CC(C)=C3N=C21 JRMSLDWZFJZLAS-UHFFFAOYSA-M 0.000 description 1
- QIRDPEPUXNCOLD-UHFFFAOYSA-N [9-(diethylamino)benzo[a]phenoxazin-5-ylidene]azanium;sulfate Chemical compound [O-]S([O-])(=O)=O.C1=CC=C2C3=NC4=CC=C(N(CC)CC)C=C4OC3=CC(=[NH2+])C2=C1.C1=CC=C2C3=NC4=CC=C(N(CC)CC)C=C4OC3=CC(=[NH2+])C2=C1 QIRDPEPUXNCOLD-UHFFFAOYSA-N 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- GXEAXHYQKZAJGB-UHFFFAOYSA-L acid red 29 Chemical compound [Na+].[Na+].OC1=C2C(O)=CC(S([O-])(=O)=O)=CC2=CC(S([O-])(=O)=O)=C1N=NC1=CC=CC=C1 GXEAXHYQKZAJGB-UHFFFAOYSA-L 0.000 description 1
- ZXGIHDNEIWPDFW-UHFFFAOYSA-M acid red 4 Chemical compound [Na+].COC1=CC=CC=C1N=NC1=CC(S([O-])(=O)=O)=C(C=CC=C2)C2=C1O ZXGIHDNEIWPDFW-UHFFFAOYSA-M 0.000 description 1
- 239000012190 activator Substances 0.000 description 1
- 238000009098 adjuvant therapy Methods 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- MACGOVWEZWQBMW-UHFFFAOYSA-L alizarin cyanin BBS Chemical compound [Na+].[Na+].O=C1C2=C(O)C(O)=C(S([O-])(=O)=O)C(O)=C2C(=O)C2=C1C(O)=C(S([O-])(=O)=O)C(O)=C2O MACGOVWEZWQBMW-UHFFFAOYSA-L 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 150000004973 alkali metal peroxides Chemical class 0.000 description 1
- 150000001336 alkenes Chemical class 0.000 description 1
- 125000005250 alkyl acrylate group Chemical group 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 125000005360 alkyl sulfoxide group Chemical group 0.000 description 1
- 229960000458 allantoin Drugs 0.000 description 1
- 235000012741 allura red AC Nutrition 0.000 description 1
- 239000004191 allura red AC Substances 0.000 description 1
- 229940086737 allyl sucrose Drugs 0.000 description 1
- XCPQUQHBVVXMRQ-UHFFFAOYSA-N alpha-Fenchene Natural products C1CC2C(=C)CC1C2(C)C XCPQUQHBVVXMRQ-UHFFFAOYSA-N 0.000 description 1
- TUFYVOCKVJOUIR-UHFFFAOYSA-N alpha-Thujaplicin Natural products CC(C)C=1C=CC=CC(=O)C=1O TUFYVOCKVJOUIR-UHFFFAOYSA-N 0.000 description 1
- WUOACPNHFRMFPN-UHFFFAOYSA-N alpha-terpineol Chemical compound CC1=CCC(C(C)(C)O)CC1 WUOACPNHFRMFPN-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 235000012735 amaranth Nutrition 0.000 description 1
- 239000004178 amaranth Substances 0.000 description 1
- WLDHEUZGFKACJH-UHFFFAOYSA-K amaranth Chemical compound [Na+].[Na+].[Na+].C12=CC=C(S([O-])(=O)=O)C=C2C=C(S([O-])(=O)=O)C(O)=C1N=NC1=CC=C(S([O-])(=O)=O)C2=CC=CC=C12 WLDHEUZGFKACJH-UHFFFAOYSA-K 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 239000000908 ammonium hydroxide Substances 0.000 description 1
- CKGWFZQGEQJZIL-UHFFFAOYSA-N amylmetacresol Chemical compound CCCCCC1=CC=C(C)C=C1O CKGWFZQGEQJZIL-UHFFFAOYSA-N 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000002491 angiogenic effect Effects 0.000 description 1
- MWPLVEDNUUSJAV-UHFFFAOYSA-N anthracene Chemical compound C1=CC=CC2=CC3=CC=CC=C3C=C21 MWPLVEDNUUSJAV-UHFFFAOYSA-N 0.000 description 1
- MMRNCQMFQXTUGO-UHFFFAOYSA-N anthracene blue SWR Chemical compound OC1=CC(O)=C2C(=O)C3=C(O)C(O)=CC(O)=C3C(=O)C2=C1O MMRNCQMFQXTUGO-UHFFFAOYSA-N 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 239000003429 antifungal agent Substances 0.000 description 1
- 229940121375 antifungal agent Drugs 0.000 description 1
- 239000003443 antiviral agent Substances 0.000 description 1
- 210000002403 aortic endothelial cell Anatomy 0.000 description 1
- 230000001640 apoptogenic effect Effects 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 239000004760 aramid Substances 0.000 description 1
- 229910052786 argon Inorganic materials 0.000 description 1
- 229920003235 aromatic polyamide Polymers 0.000 description 1
- 229910052785 arsenic Inorganic materials 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 239000010425 asbestos Substances 0.000 description 1
- 230000037444 atrophy Effects 0.000 description 1
- GIXWDMTZECRIJT-UHFFFAOYSA-N aurintricarboxylic acid Chemical compound C1=CC(=O)C(C(=O)O)=CC1=C(C=1C=C(C(O)=CC=1)C(O)=O)C1=CC=C(O)C(C(O)=O)=C1 GIXWDMTZECRIJT-UHFFFAOYSA-N 0.000 description 1
- 239000000987 azo dye Substances 0.000 description 1
- QZKHGYGBYOUFGK-UHFFFAOYSA-L azocarmine B Chemical compound [Na+].[Na+].[O-]S(=O)(=O)C1=CC(S(=O)(=O)[O-])=CC=C1NC(C1=CC(=CC=C1C1=NC2=CC=CC=C22)S([O-])(=O)=O)=CC1=[N+]2C1=CC=CC=C1 QZKHGYGBYOUFGK-UHFFFAOYSA-L 0.000 description 1
- LUERODMRBLNCFK-UHFFFAOYSA-M azocarmine G Chemical compound [Na+].C1=CC(S(=O)(=O)[O-])=CC=C1NC(C1=CC(=CC=C1C1=NC2=CC=CC=C22)S([O-])(=O)=O)=CC1=[N+]2C1=CC=CC=C1 LUERODMRBLNCFK-UHFFFAOYSA-M 0.000 description 1
- 230000003385 bacteriostatic effect Effects 0.000 description 1
- 210000002469 basement membrane Anatomy 0.000 description 1
- 229940052223 basic fuchsin Drugs 0.000 description 1
- 229960002130 benzoin Drugs 0.000 description 1
- 235000019445 benzyl alcohol Nutrition 0.000 description 1
- 229940034794 benzylparaben Drugs 0.000 description 1
- FUWUEFKEXZQKKA-UHFFFAOYSA-N beta-thujaplicin Chemical compound CC(C)C=1C=CC=C(O)C(=O)C=1 FUWUEFKEXZQKKA-UHFFFAOYSA-N 0.000 description 1
- VVAVKBBTPWYADW-RVTJCSDESA-L biebrich scarlet Chemical compound [Na+].[Na+].OC1=CC=C2C=CC=CC2=C1\N=N\C(C(=C1)S([O-])(=O)=O)=CC=C1\N=N\C1=CC=C(S([O-])(=O)=O)C=C1 VVAVKBBTPWYADW-RVTJCSDESA-L 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 238000001574 biopsy Methods 0.000 description 1
- 229910052797 bismuth Inorganic materials 0.000 description 1
- JCXGWMGPZLAOME-UHFFFAOYSA-N bismuth atom Chemical compound [Bi] JCXGWMGPZLAOME-UHFFFAOYSA-N 0.000 description 1
- JFIOVJDNOJYLKP-UHFFFAOYSA-N bithionol Chemical compound OC1=C(Cl)C=C(Cl)C=C1SC1=CC(Cl)=CC(Cl)=C1O JFIOVJDNOJYLKP-UHFFFAOYSA-N 0.000 description 1
- 229920001400 block copolymer Polymers 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 230000036770 blood supply Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 239000001045 blue dye Substances 0.000 description 1
- 229940089093 botox Drugs 0.000 description 1
- 229960003168 bronopol Drugs 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 230000003139 buffering effect Effects 0.000 description 1
- 210000001217 buttock Anatomy 0.000 description 1
- 229940067596 butylparaben Drugs 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 235000009120 camo Nutrition 0.000 description 1
- 229930006739 camphene Natural products 0.000 description 1
- ZYPYEBYNXWUCEA-UHFFFAOYSA-N camphenilone Natural products C1CC2C(=O)C(C)(C)C1C2 ZYPYEBYNXWUCEA-UHFFFAOYSA-N 0.000 description 1
- 229940117949 captan Drugs 0.000 description 1
- AIXAANGOTKPUOY-UHFFFAOYSA-N carbachol Chemical compound [Cl-].C[N+](C)(C)CCOC(N)=O AIXAANGOTKPUOY-UHFFFAOYSA-N 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 235000012730 carminic acid Nutrition 0.000 description 1
- DGQLVPJVXFOQEV-JNVSTXMASA-N carminic acid Chemical compound OC1=C2C(=O)C=3C(C)=C(C(O)=O)C(O)=CC=3C(=O)C2=C(O)C(O)=C1[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O DGQLVPJVXFOQEV-JNVSTXMASA-N 0.000 description 1
- 235000021466 carotenoid Nutrition 0.000 description 1
- 150000001747 carotenoids Chemical class 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 230000030833 cell death Effects 0.000 description 1
- 208000037887 cell injury Diseases 0.000 description 1
- 230000012292 cell migration Effects 0.000 description 1
- 230000009087 cell motility Effects 0.000 description 1
- ZMIGMASIKSOYAM-UHFFFAOYSA-N cerium Chemical compound [Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce] ZMIGMASIKSOYAM-UHFFFAOYSA-N 0.000 description 1
- 235000005607 chanvre indien Nutrition 0.000 description 1
- OIQPTROHQCGFEF-UHFFFAOYSA-L chembl1371409 Chemical compound [Na+].[Na+].OC1=CC=C2C=C(S([O-])(=O)=O)C=CC2=C1N=NC1=CC=C(S([O-])(=O)=O)C=C1 OIQPTROHQCGFEF-UHFFFAOYSA-L 0.000 description 1
- GLNADSQYFUSGOU-UHFFFAOYSA-J chembl1640 Chemical compound [Na+].[Na+].[Na+].[Na+].C1=C(S([O-])(=O)=O)C=C2C=C(S([O-])(=O)=O)C(N=NC3=CC=C(C=C3C)C=3C=C(C(=CC=3)N=NC=3C(=CC4=CC(=CC(N)=C4C=3O)S([O-])(=O)=O)S([O-])(=O)=O)C)=C(O)C2=C1N GLNADSQYFUSGOU-UHFFFAOYSA-J 0.000 description 1
- PSWOBQSIXLVPDV-CXUHLZMHSA-N chembl2105120 Chemical compound C1=C(O)C(OC)=CC(\C=N\NC(=O)C=2C=CN=CC=2)=C1 PSWOBQSIXLVPDV-CXUHLZMHSA-N 0.000 description 1
- VYXSBFYARXAAKO-WTKGSRSZSA-N chembl402140 Chemical compound Cl.C1=2C=C(C)C(NCC)=CC=2OC2=C\C(=N/CC)C(C)=CC2=C1C1=CC=CC=C1C(=O)OCC VYXSBFYARXAAKO-WTKGSRSZSA-N 0.000 description 1
- 238000010382 chemical cross-linking Methods 0.000 description 1
- VXIVSQZSERGHQP-UHFFFAOYSA-N chloroacetamide Chemical compound NC(=O)CCl VXIVSQZSERGHQP-UHFFFAOYSA-N 0.000 description 1
- OSASVXMJTNOKOY-UHFFFAOYSA-N chlorobutanol Chemical compound CC(C)(O)C(Cl)(Cl)Cl OSASVXMJTNOKOY-UHFFFAOYSA-N 0.000 description 1
- 229960004926 chlorobutanol Drugs 0.000 description 1
- 229930002863 chlorophyll d Natural products 0.000 description 1
- QXWRYZIMSXOOPY-SKHCYZARSA-M chlorophyll d Chemical compound C1([C@H](C2=O)C(=O)OC)=C(N3[Mg]N45)C2=C(C)\C3=C\C(=N2)C(CC)=C(C)\C2=C\C4=C(C=O)C(C)=C5\C=C/2[C@@H](C)[C@H](CCC(=O)OC\C=C(/C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)C1=N\2 QXWRYZIMSXOOPY-SKHCYZARSA-M 0.000 description 1
- 229940099898 chlorophyllin Drugs 0.000 description 1
- 235000019805 chlorophyllin Nutrition 0.000 description 1
- 229960005233 cineole Drugs 0.000 description 1
- 235000017803 cinnamon Nutrition 0.000 description 1
- 230000001112 coagulating effect Effects 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- IQFVPQOLBLOTPF-HKXUKFGYSA-L congo red Chemical compound [Na+].[Na+].C1=CC=CC2=C(N)C(/N=N/C3=CC=C(C=C3)C3=CC=C(C=C3)/N=N/C3=C(C4=CC=CC=C4C(=C3)S([O-])(=O)=O)N)=CC(S([O-])(=O)=O)=C21 IQFVPQOLBLOTPF-HKXUKFGYSA-L 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 210000000555 contractile cell Anatomy 0.000 description 1
- 208000006111 contracture Diseases 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 239000008120 corn starch Substances 0.000 description 1
- 229940099112 cornstarch Drugs 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 235000004634 cranberry Nutrition 0.000 description 1
- SEBIKDIMAPSUBY-RTJKDTQDSA-N crocin-1 Chemical compound C([C@H]1O[C@H]([C@@H]([C@@H](O)[C@@H]1O)O)OC(=O)C(/C)=C/C=C/C(/C)=C/C=C/C=C(\C)/C=C/C=C(\C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO[C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)O1)O)O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O SEBIKDIMAPSUBY-RTJKDTQDSA-N 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 238000009109 curative therapy Methods 0.000 description 1
- 235000012754 curcumin Nutrition 0.000 description 1
- 229940109262 curcumin Drugs 0.000 description 1
- 239000004148 curcumin Substances 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 231100000135 cytotoxicity Toxicity 0.000 description 1
- 230000003013 cytotoxicity Effects 0.000 description 1
- 230000000254 damaging effect Effects 0.000 description 1
- 230000007123 defense Effects 0.000 description 1
- 239000007857 degradation product Substances 0.000 description 1
- 230000023753 dehiscence Effects 0.000 description 1
- SQIFACVGCPWBQZ-UHFFFAOYSA-N delta-terpineol Natural products CC(C)(O)C1CCC(=C)CC1 SQIFACVGCPWBQZ-UHFFFAOYSA-N 0.000 description 1
- 239000003398 denaturant Substances 0.000 description 1
- 210000004443 dendritic cell Anatomy 0.000 description 1
- 230000035618 desquamation Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 230000001627 detrimental effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- GUJOJGAPFQRJSV-UHFFFAOYSA-N dialuminum;dioxosilane;oxygen(2-);hydrate Chemical compound O.[O-2].[O-2].[O-2].[Al+3].[Al+3].O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O GUJOJGAPFQRJSV-UHFFFAOYSA-N 0.000 description 1
- 125000000664 diazo group Chemical group [N-]=[N+]=[*] 0.000 description 1
- 229960001083 diazolidinylurea Drugs 0.000 description 1
- 150000008056 dicarboxyimides Chemical class 0.000 description 1
- 229960004698 dichlorobenzyl alcohol Drugs 0.000 description 1
- 229960003887 dichlorophen Drugs 0.000 description 1
- VADJQOXWNSPOQA-UHFFFAOYSA-L dichlorozinc;3-n,3-n,6-n,6-n-tetramethylacridine-3,6-diamine;hydrochloride Chemical compound Cl.[Cl-].[Cl-].[Zn+2].C1=CC(N(C)C)=CC2=NC3=CC(N(C)C)=CC=C3C=C21 VADJQOXWNSPOQA-UHFFFAOYSA-L 0.000 description 1
- VFLDPWHFBUODDF-UHFFFAOYSA-N diferuloylmethane Natural products C1=C(O)C(OC)=CC(C=CC(=O)CC(=O)C=CC=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-UHFFFAOYSA-N 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- XVLXYDXJEKLXHN-UHFFFAOYSA-M dioc6 Chemical compound [I-].O1C2=CC=CC=C2[N+](CCCCCC)=C1C=CC=C1N(CCCCCC)C2=CC=CC=C2O1 XVLXYDXJEKLXHN-UHFFFAOYSA-M 0.000 description 1
- 229910001882 dioxygen Inorganic materials 0.000 description 1
- USIUVYZYUHIAEV-UHFFFAOYSA-N diphenyl ether Natural products C=1C=CC=CC=1OC1=CC=CC=C1 USIUVYZYUHIAEV-UHFFFAOYSA-N 0.000 description 1
- 238000007598 dipping method Methods 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- MILGFEGRENAPRI-UHFFFAOYSA-L disodium 2-(hydroxymethylamino)acetate 2-phenylphenol Chemical compound [Na+].[Na+].OCNCC([O-])=O.OCNCC([O-])=O.Oc1ccccc1-c1ccccc1 MILGFEGRENAPRI-UHFFFAOYSA-L 0.000 description 1
- WZRZTHMJPHPAMU-UHFFFAOYSA-L disodium;(3e)-3-[(4-amino-3-sulfonatophenyl)-(4-amino-3-sulfophenyl)methylidene]-6-imino-5-methylcyclohexa-1,4-diene-1-sulfonate Chemical compound [Na+].[Na+].C1=C(S([O-])(=O)=O)C(=N)C(C)=CC1=C(C=1C=C(C(N)=CC=1)S([O-])(=O)=O)C1=CC=C(N)C(S(O)(=O)=O)=C1 WZRZTHMJPHPAMU-UHFFFAOYSA-L 0.000 description 1
- XOSXWYQMOYSSKB-UHFFFAOYSA-M disodium;4-[4-[(4-amino-3-methyl-5-sulfophenyl)-[4-(4-sulfonatophenyl)azaniumylidenecyclohexa-2,5-dien-1-ylidene]methyl]anilino]benzenesulfonate Chemical compound [Na+].[Na+].OS(=O)(=O)C1=C(N)C(C)=CC(C(=C2C=CC(C=C2)=[NH+]C=2C=CC(=CC=2)S([O-])(=O)=O)C=2C=CC(NC=3C=CC(=CC=3)S([O-])(=O)=O)=CC=2)=C1 XOSXWYQMOYSSKB-UHFFFAOYSA-M 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000008846 dynamic interplay Effects 0.000 description 1
- KBQHZAAAGSGFKK-UHFFFAOYSA-N dysprosium atom Chemical class [Dy] KBQHZAAAGSGFKK-UHFFFAOYSA-N 0.000 description 1
- 230000002900 effect on cell Effects 0.000 description 1
- 230000002828 effect on organs or tissue Effects 0.000 description 1
- 239000003623 enhancer Substances 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 229940088598 enzyme Drugs 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- UYAHIZSMUZPPFV-UHFFFAOYSA-N erbium Chemical class [Er] UYAHIZSMUZPPFV-UHFFFAOYSA-N 0.000 description 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 1
- IDAQSADEMXDTKN-UHFFFAOYSA-L ethyl green Chemical compound [Cl-].[Br-].C1=CC([N+](C)(C)CC)=CC=C1C(C=1C=CC(=CC=1)N(C)C)=C1C=CC(=[N+](C)C)C=C1 IDAQSADEMXDTKN-UHFFFAOYSA-L 0.000 description 1
- 229960001617 ethyl hydroxybenzoate Drugs 0.000 description 1
- 235000010228 ethyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004403 ethyl p-hydroxybenzoate Substances 0.000 description 1
- NUVBSKCKDOMJSU-UHFFFAOYSA-N ethylparaben Chemical compound CCOC(=O)C1=CC=C(O)C=C1 NUVBSKCKDOMJSU-UHFFFAOYSA-N 0.000 description 1
- 229960002217 eugenol Drugs 0.000 description 1
- OGPBJKLSAFTDLK-UHFFFAOYSA-N europium atom Chemical compound [Eu] OGPBJKLSAFTDLK-UHFFFAOYSA-N 0.000 description 1
- 230000005281 excited state Effects 0.000 description 1
- 238000004299 exfoliation Methods 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 229930002886 farnesol Natural products 0.000 description 1
- 229940043259 farnesol Drugs 0.000 description 1
- GPPKNJIWDULNQH-UHFFFAOYSA-J fast blue salt B Chemical compound [Cl-].[Cl-].[Cl-].[Cl-].[Zn+2].C1=C([N+]#N)C(OC)=CC(C=2C=C(OC)C([N+]#N)=CC=2)=C1 GPPKNJIWDULNQH-UHFFFAOYSA-J 0.000 description 1
- 235000019240 fast green FCF Nutrition 0.000 description 1
- AXKAZKNOUOFMLN-UHFFFAOYSA-M fast red B Chemical compound COC1=CC([N+]([O-])=O)=CC=C1[N+]#N.C1=CC=C2C(S(=O)(=O)O)=CC=CC2=C1S([O-])(=O)=O AXKAZKNOUOFMLN-UHFFFAOYSA-M 0.000 description 1
- FPVGTPBMTFTMRT-NSKUCRDLSA-L fast yellow Chemical compound [Na+].[Na+].C1=C(S([O-])(=O)=O)C(N)=CC=C1\N=N\C1=CC=C(S([O-])(=O)=O)C=C1 FPVGTPBMTFTMRT-NSKUCRDLSA-L 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- KSEBMYQBYZTDHS-HWKANZROSA-N ferulic acid Chemical compound COC1=CC(\C=C\C(O)=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-N 0.000 description 1
- 229940114124 ferulic acid Drugs 0.000 description 1
- KSEBMYQBYZTDHS-UHFFFAOYSA-N ferulic acid Natural products COC1=CC(C=CC(O)=O)=CC=C1O KSEBMYQBYZTDHS-UHFFFAOYSA-N 0.000 description 1
- 235000001785 ferulic acid Nutrition 0.000 description 1
- 229950003499 fibrin Drugs 0.000 description 1
- 230000003176 fibrotic effect Effects 0.000 description 1
- 239000002657 fibrous material Substances 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000007850 fluorescent dye Substances 0.000 description 1
- 239000000576 food coloring agent Substances 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 125000000524 functional group Chemical group 0.000 description 1
- UIWYJDYFSGRHKR-UHFFFAOYSA-N gadolinium atom Chemical compound [Gd] UIWYJDYFSGRHKR-UHFFFAOYSA-N 0.000 description 1
- 229940113087 geraniol Drugs 0.000 description 1
- 229960002849 glucosamine sulfate Drugs 0.000 description 1
- 150000002303 glucose derivatives Polymers 0.000 description 1
- 150000002304 glucoses Polymers 0.000 description 1
- 125000002791 glucosyl group Polymers C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 1
- 108091005996 glycated proteins Proteins 0.000 description 1
- 108020004445 glyceraldehyde-3-phosphate dehydrogenase Proteins 0.000 description 1
- 150000002314 glycerols Chemical class 0.000 description 1
- 125000003976 glyceryl group Chemical group [H]C([*])([H])C(O[H])([H])C(O[H])([H])[H] 0.000 description 1
- 150000002334 glycols Chemical class 0.000 description 1
- 125000003147 glycosyl group Chemical group 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 230000037313 granulation tissue formation Effects 0.000 description 1
- 210000000527 greater trochanter Anatomy 0.000 description 1
- 235000019382 gum benzoic Nutrition 0.000 description 1
- 239000013003 healing agent Substances 0.000 description 1
- 230000007407 health benefit Effects 0.000 description 1
- 230000017525 heat dissipation Effects 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 230000002439 hemostatic effect Effects 0.000 description 1
- 239000011487 hemp Substances 0.000 description 1
- ACGUYXCXAPNIKK-UHFFFAOYSA-N hexachlorophene Chemical compound OC1=C(Cl)C=C(Cl)C(Cl)=C1CC1=C(O)C(Cl)=CC(Cl)=C1Cl ACGUYXCXAPNIKK-UHFFFAOYSA-N 0.000 description 1
- 229920006158 high molecular weight polymer Polymers 0.000 description 1
- KJZYNXUDTRRSPN-UHFFFAOYSA-N holmium atom Chemical class [Ho] KJZYNXUDTRRSPN-UHFFFAOYSA-N 0.000 description 1
- 231100000652 hormesis Toxicity 0.000 description 1
- 235000001050 hortel pimenta Nutrition 0.000 description 1
- 229940014041 hyaluronate Drugs 0.000 description 1
- 239000000416 hydrocolloid Substances 0.000 description 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
- UACSZOWTRIJIFU-UHFFFAOYSA-N hydroxymethyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCO UACSZOWTRIJIFU-UHFFFAOYSA-N 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 229960004657 indocyanine green Drugs 0.000 description 1
- MOFVSTNWEDAEEK-UHFFFAOYSA-M indocyanine green Chemical compound [Na+].[O-]S(=O)(=O)CCCCN1C2=CC=C3C=CC=CC3=C2C(C)(C)C1=CC=CC=CC=CC1=[N+](CCCCS([O-])(=O)=O)C2=CC=C(C=CC=C3)C3=C2C1(C)C MOFVSTNWEDAEEK-UHFFFAOYSA-M 0.000 description 1
- 230000002458 infectious effect Effects 0.000 description 1
- 230000028709 inflammatory response Effects 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- JORABGDXCIBAFL-UHFFFAOYSA-M iodonitrotetrazolium chloride Chemical compound [Cl-].C1=CC([N+](=O)[O-])=CC=C1N1[N+](C=2C=CC(I)=CC=2)=NC(C=2C=CC=CC=2)=N1 JORABGDXCIBAFL-UHFFFAOYSA-M 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 208000028867 ischemia Diseases 0.000 description 1
- 229940113094 isopropylparaben Drugs 0.000 description 1
- 230000001530 keratinolytic effect Effects 0.000 description 1
- 230000002147 killing effect Effects 0.000 description 1
- 239000000252 konjac Substances 0.000 description 1
- 235000019823 konjac gum Nutrition 0.000 description 1
- VMPHSYLJUKZBJJ-UHFFFAOYSA-N lauric acid triglyceride Natural products CCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCC)COC(=O)CCCCCCCCCCC VMPHSYLJUKZBJJ-UHFFFAOYSA-N 0.000 description 1
- 239000001102 lavandula vera Substances 0.000 description 1
- 235000018219 lavender Nutrition 0.000 description 1
- 210000002414 leg Anatomy 0.000 description 1
- 230000031700 light absorption Effects 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 229940087305 limonene Drugs 0.000 description 1
- 235000001510 limonene Nutrition 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 229920001684 low density polyethylene Polymers 0.000 description 1
- 239000004702 low-density polyethylene Substances 0.000 description 1
- 238000004020 luminiscence type Methods 0.000 description 1
- OHSVLFRHMCKCQY-UHFFFAOYSA-N lutetium atom Chemical class [Lu] OHSVLFRHMCKCQY-UHFFFAOYSA-N 0.000 description 1
- 230000001926 lymphatic effect Effects 0.000 description 1
- DGNIJJSSARBJSH-NLJAFYFLSA-L magnesium (E)-3-[(3R)-16-ethenyl-11-ethyl-3-methoxycarbonyl-12,17,21,26-tetramethyl-4-oxo-7,24-diaza-23,25-diazanidahexacyclo[18.2.1.15,8.110,13.115,18.02,6]hexacosa-1(22),2(6),5(26),7,9,11,13,15(24),16,18,20-undecaen-22-yl]prop-2-enoic acid Chemical compound [Mg++].CCc1c(C)c2cc3nc(cc4[n-]c(c(\C=C\C(O)=O)c4C)c4[C@@H](C(=O)OC)C(=O)c5c(C)c(cc1[n-]2)nc45)c(C)c3C=C DGNIJJSSARBJSH-NLJAFYFLSA-L 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 108010082117 matrigel Proteins 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 102000006240 membrane receptors Human genes 0.000 description 1
- 229940041616 menthol Drugs 0.000 description 1
- SQFDQLBYJKFDDO-UHFFFAOYSA-K merbromin Chemical compound [Na+].[Na+].C=12C=C(Br)C(=O)C=C2OC=2C([Hg]O)=C([O-])C(Br)=CC=2C=1C1=CC=CC=C1C([O-])=O SQFDQLBYJKFDDO-UHFFFAOYSA-K 0.000 description 1
- 229940008716 mercurochrome Drugs 0.000 description 1
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 1
- 229910052753 mercury Inorganic materials 0.000 description 1
- 229910021645 metal ion Inorganic materials 0.000 description 1
- NYGZLYXAPMMJTE-UHFFFAOYSA-M metanil yellow Chemical compound [Na+].[O-]S(=O)(=O)C1=CC=CC(N=NC=2C=CC(NC=3C=CC=CC=3)=CC=2)=C1 NYGZLYXAPMMJTE-UHFFFAOYSA-M 0.000 description 1
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical compound C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 description 1
- QDBPSMVYZMGGGG-UHFFFAOYSA-N methyl 2-(3-amino-4,5-dibromo-6-iminoxanthen-9-yl)benzoate Chemical compound COC(=O)C1=CC=CC=C1C1=C2C=CC(=N)C(Br)=C2OC2=C(Br)C(N)=CC=C21 QDBPSMVYZMGGGG-UHFFFAOYSA-N 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 150000004702 methyl esters Chemical class 0.000 description 1
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 1
- CEQFOVLGLXCDCX-WUKNDPDISA-N methyl red Chemical compound C1=CC(N(C)C)=CC=C1\N=N\C1=CC=CC=C1C(O)=O CEQFOVLGLXCDCX-WUKNDPDISA-N 0.000 description 1
- ASHGTJPOSUFTGB-UHFFFAOYSA-N methyl resorcinol Natural products COC1=CC=CC(O)=C1 ASHGTJPOSUFTGB-UHFFFAOYSA-N 0.000 description 1
- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- BEGLCMHJXHIJLR-UHFFFAOYSA-N methylisothiazolinone Chemical compound CN1SC=CC1=O BEGLCMHJXHIJLR-UHFFFAOYSA-N 0.000 description 1
- 229960002216 methylparaben Drugs 0.000 description 1
- 229960003476 methylparaben sodium Drugs 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 230000003278 mimic effect Effects 0.000 description 1
- 235000019426 modified starch Nutrition 0.000 description 1
- 230000001333 moisturizer Effects 0.000 description 1
- 210000001616 monocyte Anatomy 0.000 description 1
- 150000002772 monosaccharides Chemical class 0.000 description 1
- 230000004899 motility Effects 0.000 description 1
- 210000000214 mouth Anatomy 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 210000000651 myofibroblast Anatomy 0.000 description 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- JMXROTHPANUTOJ-UHFFFAOYSA-H naphthol green b Chemical compound [Na+].[Na+].[Na+].[Fe+3].C1=C(S([O-])(=O)=O)C=CC2=C(N=O)C([O-])=CC=C21.C1=C(S([O-])(=O)=O)C=CC2=C(N=O)C([O-])=CC=C21.C1=C(S([O-])(=O)=O)C=CC2=C(N=O)C([O-])=CC=C21 JMXROTHPANUTOJ-UHFFFAOYSA-H 0.000 description 1
- WASNIKZYIWZQIP-AWEZNQCLSA-N nerolidol Natural products CC(=CCCC(=CCC[C@@H](O)C=C)C)C WASNIKZYIWZQIP-AWEZNQCLSA-N 0.000 description 1
- 230000002981 neuropathic effect Effects 0.000 description 1
- IPSIPYMEZZPCPY-UHFFFAOYSA-N new fuchsin Chemical compound [Cl-].C1=CC(=[NH2+])C(C)=CC1=C(C=1C=C(C)C(N)=CC=1)C1=CC=C(N)C(C)=C1 IPSIPYMEZZPCPY-UHFFFAOYSA-N 0.000 description 1
- NTPMRTUYLKDNSS-UHFFFAOYSA-N night blue Chemical compound [Cl-].C1=CC(N(CC)CC)=CC=C1C(C=1C2=CC=CC=C2C(NC=2C=CC=CC=2)=CC=1)=C1C=CC(=[N+](CC)CC)C=C1 NTPMRTUYLKDNSS-UHFFFAOYSA-N 0.000 description 1
- VOFUROIFQGPCGE-UHFFFAOYSA-N nile red Chemical compound C1=CC=C2C3=NC4=CC=C(N(CC)CC)C=C4OC3=CC(=O)C2=C1 VOFUROIFQGPCGE-UHFFFAOYSA-N 0.000 description 1
- FSVCQIDHPKZJSO-UHFFFAOYSA-L nitro blue tetrazolium dichloride Chemical compound [Cl-].[Cl-].COC1=CC(C=2C=C(OC)C(=CC=2)[N+]=2N(N=C(N=2)C=2C=CC=CC=2)C=2C=CC(=CC=2)[N+]([O-])=O)=CC=C1[N+]1=NC(C=2C=CC=CC=2)=NN1C1=CC=C([N+]([O-])=O)C=C1 FSVCQIDHPKZJSO-UHFFFAOYSA-L 0.000 description 1
- JPXMTWWFLBLUCD-UHFFFAOYSA-N nitro blue tetrazolium(2+) Chemical compound COC1=CC(C=2C=C(OC)C(=CC=2)[N+]=2N(N=C(N=2)C=2C=CC=CC=2)C=2C=CC(=CC=2)[N+]([O-])=O)=CC=C1[N+]1=NC(C=2C=CC=CC=2)=NN1C1=CC=C([N+]([O-])=O)C=C1 JPXMTWWFLBLUCD-UHFFFAOYSA-N 0.000 description 1
- 231100001083 no cytotoxicity Toxicity 0.000 description 1
- JPMIIZHYYWMHDT-UHFFFAOYSA-N octhilinone Chemical compound CCCCCCCCN1SC=CC1=O JPMIIZHYYWMHDT-UHFFFAOYSA-N 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- JRZJOMJEPLMPRA-UHFFFAOYSA-N olefin Natural products CCCCCCCC=C JRZJOMJEPLMPRA-UHFFFAOYSA-N 0.000 description 1
- 229920001542 oligosaccharide Polymers 0.000 description 1
- 150000002482 oligosaccharides Chemical class 0.000 description 1
- 239000013307 optical fiber Substances 0.000 description 1
- 235000019248 orcein Nutrition 0.000 description 1
- 150000001451 organic peroxides Chemical class 0.000 description 1
- 201000008482 osteoarthritis Diseases 0.000 description 1
- 125000004430 oxygen atom Chemical group O* 0.000 description 1
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 description 1
- NRZWYNLTFLDQQX-UHFFFAOYSA-N p-tert-Amylphenol Chemical compound CCC(C)(C)C1=CC=C(O)C=C1 NRZWYNLTFLDQQX-UHFFFAOYSA-N 0.000 description 1
- WOTPFVNWMLFMFW-ISLYRVAYSA-N para red Chemical compound OC1=CC=C2C=CC=CC2=C1\N=N\C1=CC=C(N(=O)=O)C=C1 WOTPFVNWMLFMFW-ISLYRVAYSA-N 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- WXZMFSXDPGVJKK-UHFFFAOYSA-N pentaerythritol Chemical compound OCC(CO)(CO)CO WXZMFSXDPGVJKK-UHFFFAOYSA-N 0.000 description 1
- 230000000737 periodic effect Effects 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 239000012466 permeate Substances 0.000 description 1
- 238000001050 pharmacotherapy Methods 0.000 description 1
- 229960005323 phenoxyethanol Drugs 0.000 description 1
- 229940106026 phenoxyisopropanol Drugs 0.000 description 1
- 229940106025 phenylethyl resorcinol Drugs 0.000 description 1
- ZYIBVBKZZZDFOY-UHFFFAOYSA-N phloxine O Chemical compound O1C(=O)C(C(=C(Cl)C(Cl)=C2Cl)Cl)=C2C21C1=CC(Br)=C(O)C(Br)=C1OC1=C(Br)C(O)=C(Br)C=C21 ZYIBVBKZZZDFOY-UHFFFAOYSA-N 0.000 description 1
- 238000000016 photochemical curing Methods 0.000 description 1
- IEQIEDJGQAUEQZ-UHFFFAOYSA-N phthalocyanine Chemical compound N1C(N=C2C3=CC=CC=C3C(N=C3C4=CC=CC=C4C(=N4)N3)=N2)=C(C=CC=C2)C2=C1N=C1C2=CC=CC=C2C4=N1 IEQIEDJGQAUEQZ-UHFFFAOYSA-N 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- OXNIZHLAWKMVMX-UHFFFAOYSA-N picric acid Chemical compound OC1=C([N+]([O-])=O)C=C([N+]([O-])=O)C=C1[N+]([O-])=O OXNIZHLAWKMVMX-UHFFFAOYSA-N 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 229950001046 piroctone Drugs 0.000 description 1
- BTSZTGGZJQFALU-UHFFFAOYSA-N piroctone olamine Chemical compound NCCO.CC(C)(C)CC(C)CC1=CC(C)=CC(=O)N1O BTSZTGGZJQFALU-UHFFFAOYSA-N 0.000 description 1
- 229920000765 poly(2-oxazolines) Polymers 0.000 description 1
- 229920003213 poly(N-isopropyl acrylamide) Polymers 0.000 description 1
- 239000005014 poly(hydroxyalkanoate) Substances 0.000 description 1
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 1
- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 description 1
- 229920001707 polybutylene terephthalate Polymers 0.000 description 1
- 229920000903 polyhydroxyalkanoate Polymers 0.000 description 1
- 229920002338 polyhydroxyethylmethacrylate Polymers 0.000 description 1
- 239000004626 polylactic acid Substances 0.000 description 1
- 229920001444 polymaleic acid Polymers 0.000 description 1
- 229920006254 polymer film Polymers 0.000 description 1
- 239000004926 polymethyl methacrylate Substances 0.000 description 1
- 229920005862 polyol Polymers 0.000 description 1
- 150000003077 polyols Chemical class 0.000 description 1
- 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 229920006327 polystyrene foam Polymers 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- 229920003009 polyurethane dispersion Polymers 0.000 description 1
- 239000011496 polyurethane foam Substances 0.000 description 1
- 239000004800 polyvinyl chloride Substances 0.000 description 1
- 229920000915 polyvinyl chloride Polymers 0.000 description 1
- 229920001290 polyvinyl ester Polymers 0.000 description 1
- 235000015277 pork Nutrition 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- ZBWBYBYOJRDPDE-UHFFFAOYSA-K potassium titanium(4+) phosphate Chemical compound P(=O)([O-])([O-])[O-].[Ti+4].[K+] ZBWBYBYOJRDPDE-UHFFFAOYSA-K 0.000 description 1
- PUDIUYLPXJFUGB-UHFFFAOYSA-N praseodymium atom Chemical compound [Pr] PUDIUYLPXJFUGB-UHFFFAOYSA-N 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 238000002203 pretreatment Methods 0.000 description 1
- 208000022256 primary systemic amyloidosis Diseases 0.000 description 1
- 238000007639 printing Methods 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- VQMWBBYLQSCNPO-UHFFFAOYSA-N promethium atom Chemical compound [Pm] VQMWBBYLQSCNPO-UHFFFAOYSA-N 0.000 description 1
- QTECDUFMBMSHKR-UHFFFAOYSA-N prop-2-enyl prop-2-enoate Chemical group C=CCOC(=O)C=C QTECDUFMBMSHKR-UHFFFAOYSA-N 0.000 description 1
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
- 229960004063 propylene glycol Drugs 0.000 description 1
- 229960003415 propylparaben Drugs 0.000 description 1
- 229960005359 propylparaben sodium Drugs 0.000 description 1
- 238000004080 punching Methods 0.000 description 1
- CXZRDVVUVDYSCQ-UHFFFAOYSA-M pyronin B Chemical compound [Cl-].C1=CC(=[N+](CC)CC)C=C2OC3=CC(N(CC)CC)=CC=C3C=C21 CXZRDVVUVDYSCQ-UHFFFAOYSA-M 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
- 230000000171 quenching effect Effects 0.000 description 1
- 229920005604 random copolymer Polymers 0.000 description 1
- 239000002964 rayon Substances 0.000 description 1
- 230000007420 reactivation Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000007115 recruitment Effects 0.000 description 1
- 230000000306 recurrent effect Effects 0.000 description 1
- 230000037309 reepithelialization Effects 0.000 description 1
- 230000003716 rejuvenation Effects 0.000 description 1
- 230000010410 reperfusion Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- MYFATKRONKHHQL-UHFFFAOYSA-N rhodamine 123 Chemical compound [Cl-].COC(=O)C1=CC=CC=C1C1=C2C=CC(=[NH2+])C=C2OC2=CC(N)=CC=C21 MYFATKRONKHHQL-UHFFFAOYSA-N 0.000 description 1
- 229940043267 rhodamine b Drugs 0.000 description 1
- 239000001022 rhodamine dye Substances 0.000 description 1
- 229910052895 riebeckite Inorganic materials 0.000 description 1
- 229960003138 rose bengal sodium Drugs 0.000 description 1
- SOUHUMACVWVDME-UHFFFAOYSA-N safranin O Chemical compound [Cl-].C12=CC(N)=CC=C2N=C2C=CC(N)=CC2=[N+]1C1=CC=CC=C1 SOUHUMACVWVDME-UHFFFAOYSA-N 0.000 description 1
- 229910052706 scandium Inorganic materials 0.000 description 1
- SIXSYDAISGFNSX-UHFFFAOYSA-N scandium atom Chemical compound [Sc] SIXSYDAISGFNSX-UHFFFAOYSA-N 0.000 description 1
- RCTGMCJBQGBLKT-PAMTUDGESA-N scarlet red Chemical compound CC1=CC=CC=C1\N=N\C(C=C1C)=CC=C1\N=N\C1=C(O)C=CC2=CC=CC=C12 RCTGMCJBQGBLKT-PAMTUDGESA-N 0.000 description 1
- 229910052711 selenium Inorganic materials 0.000 description 1
- 239000011669 selenium Substances 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
- 230000008417 skin turnover Effects 0.000 description 1
- 231100000019 skin ulcer Toxicity 0.000 description 1
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 description 1
- 235000010265 sodium sulphite Nutrition 0.000 description 1
- PESXGULMKCKJCC-UHFFFAOYSA-M sodium;4-methoxycarbonylphenolate Chemical compound [Na+].COC(=O)C1=CC=C([O-])C=C1 PESXGULMKCKJCC-UHFFFAOYSA-M 0.000 description 1
- IXMINYBUNCWGER-UHFFFAOYSA-M sodium;4-propoxycarbonylphenolate Chemical compound [Na+].CCCOC(=O)C1=CC=C([O-])C=C1 IXMINYBUNCWGER-UHFFFAOYSA-M 0.000 description 1
- KVMUSGMZFRRCAS-UHFFFAOYSA-N sodium;5-oxo-1-(4-sulfophenyl)-4-[(4-sulfophenyl)diazenyl]-4h-pyrazole-3-carboxylic acid Chemical compound [Na+].OC(=O)C1=NN(C=2C=CC(=CC=2)S(O)(=O)=O)C(=O)C1N=NC1=CC=C(S(O)(=O)=O)C=C1 KVMUSGMZFRRCAS-UHFFFAOYSA-N 0.000 description 1
- 229940033816 solvent red 27 Drugs 0.000 description 1
- 230000001148 spastic effect Effects 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 230000009221 stress response pathway Effects 0.000 description 1
- 229910052712 strontium Inorganic materials 0.000 description 1
- CIOAGBVUUVVLOB-UHFFFAOYSA-N strontium atom Chemical compound [Sr] CIOAGBVUUVVLOB-UHFFFAOYSA-N 0.000 description 1
- YCUVUDODLRLVIC-VPHDGDOJSA-N sudan black b Chemical compound C1=CC(=C23)NC(C)(C)NC2=CC=CC3=C1\N=N\C(C1=CC=CC=C11)=CC=C1\N=N\C1=CC=CC=C1 YCUVUDODLRLVIC-VPHDGDOJSA-N 0.000 description 1
- 229940099373 sudan iii Drugs 0.000 description 1
- 229910021653 sulphate ion Inorganic materials 0.000 description 1
- 238000011477 surgical intervention Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 239000011885 synergistic combination Substances 0.000 description 1
- 235000010491 tara gum Nutrition 0.000 description 1
- 239000000213 tara gum Substances 0.000 description 1
- GZCRRIHWUXGPOV-UHFFFAOYSA-N terbium atom Chemical compound [Tb] GZCRRIHWUXGPOV-UHFFFAOYSA-N 0.000 description 1
- 229940116411 terpineol Drugs 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 229960000790 thymol Drugs 0.000 description 1
- 239000001585 thymus vulgaris Substances 0.000 description 1
- 229910052718 tin Inorganic materials 0.000 description 1
- 208000037816 tissue injury Diseases 0.000 description 1
- HNONEKILPDHFOL-UHFFFAOYSA-M tolonium chloride Chemical compound [Cl-].C1=C(C)C(N)=CC2=[S+]C3=CC(N(C)C)=CC=C3N=C21 HNONEKILPDHFOL-UHFFFAOYSA-M 0.000 description 1
- 239000012049 topical pharmaceutical composition Substances 0.000 description 1
- 238000012876 topography Methods 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- CRDAMVZIKSXKFV-UHFFFAOYSA-N trans-Farnesol Natural products CC(C)=CCCC(C)=CCCC(C)=CCO CRDAMVZIKSXKFV-UHFFFAOYSA-N 0.000 description 1
- QURCVMIEKCOAJU-UHFFFAOYSA-N trans-isoferulic acid Natural products COC1=CC=C(C=CC(O)=O)C=C1O QURCVMIEKCOAJU-UHFFFAOYSA-N 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
- 229960001325 triclocarban Drugs 0.000 description 1
- SWGJCIMEBVHMTA-UHFFFAOYSA-K trisodium;6-oxido-4-sulfo-5-[(4-sulfonatonaphthalen-1-yl)diazenyl]naphthalene-2-sulfonate Chemical compound [Na+].[Na+].[Na+].C1=CC=C2C(N=NC3=C4C(=CC(=CC4=CC=C3O)S([O-])(=O)=O)S([O-])(=O)=O)=CC=C(S([O-])(=O)=O)C2=C1 SWGJCIMEBVHMTA-UHFFFAOYSA-K 0.000 description 1
- DKBXPLYSDKSFEQ-UHFFFAOYSA-L turquoise gll Chemical compound [Na+].[Na+].[Cu+2].N1=C(N=C2[N-]3)[C]4C(S(=O)(=O)[O-])=CC=CC4=C1N=C([N-]1)C4=CC=CC(S([O-])(=O)=O)=C4C1=NC(C=1C4=CC=CC=1)=NC4=NC3=C1[C]2C=CC=C1 DKBXPLYSDKSFEQ-UHFFFAOYSA-L 0.000 description 1
- 210000001215 vagina Anatomy 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- 150000003751 zinc Chemical class 0.000 description 1
- 229910052726 zirconium Inorganic materials 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0038—Radiosensitizing, i.e. administration of pharmaceutical agents that enhance the effect of radiotherapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0028—Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0066—Medicaments; Biocides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
- A61N5/062—Photodynamic therapy, i.e. excitation of an agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K11/00—Luminescent, e.g. electroluminescent, chemiluminescent materials
- C09K11/06—Luminescent, e.g. electroluminescent, chemiluminescent materials containing organic luminescent materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0658—Radiation therapy using light characterised by the wavelength of light used
- A61N2005/0662—Visible light
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K2211/00—Chemical nature of organic luminescent or tenebrescent compounds
- C09K2211/10—Non-macromolecular compounds
- C09K2211/1003—Carbocyclic compounds
- C09K2211/1011—Condensed systems
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K2211/00—Chemical nature of organic luminescent or tenebrescent compounds
- C09K2211/10—Non-macromolecular compounds
- C09K2211/1018—Heterocyclic compounds
- C09K2211/1025—Heterocyclic compounds characterised by ligands
- C09K2211/1088—Heterocyclic compounds characterised by ligands containing oxygen as the only heteroatom
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Materials Engineering (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Pathology (AREA)
- Biophysics (AREA)
- Radiology & Medical Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dermatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2019084697A JP6980717B2 (ja) | 2013-07-03 | 2019-04-25 | 発色団およびゲル化剤を含む、創傷を治療するための生体光組成物 |
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361842433P | 2013-07-03 | 2013-07-03 | |
US61/842,433 | 2013-07-03 | ||
US201361904204P | 2013-11-14 | 2013-11-14 | |
US61/904,204 | 2013-11-14 | ||
PCT/CA2014/000536 WO2015000058A1 (fr) | 2013-07-03 | 2014-07-02 | Compositions biophotoniques comprenant un chromophore et un agent gélifiant pour traiter des plaies |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2019084697A Division JP6980717B2 (ja) | 2013-07-03 | 2019-04-25 | 発色団およびゲル化剤を含む、創傷を治療するための生体光組成物 |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2016523263A JP2016523263A (ja) | 2016-08-08 |
JP2016523263A5 JP2016523263A5 (fr) | 2017-08-10 |
JP6932304B2 true JP6932304B2 (ja) | 2021-09-08 |
Family
ID=52142956
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2016522147A Active JP6932304B2 (ja) | 2013-07-03 | 2014-07-02 | 発色団およびゲル化剤を含む、創傷を治療するための生体光組成物 |
JP2019084697A Active JP6980717B2 (ja) | 2013-07-03 | 2019-04-25 | 発色団およびゲル化剤を含む、創傷を治療するための生体光組成物 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2019084697A Active JP6980717B2 (ja) | 2013-07-03 | 2019-04-25 | 発色団およびゲル化剤を含む、創傷を治療するための生体光組成物 |
Country Status (13)
Country | Link |
---|---|
US (2) | US10881736B2 (fr) |
EP (1) | EP3016686A4 (fr) |
JP (2) | JP6932304B2 (fr) |
KR (3) | KR20160029795A (fr) |
CN (1) | CN105473160A (fr) |
AU (1) | AU2014286868B2 (fr) |
CA (1) | CA2916337C (fr) |
HK (1) | HK1219890A1 (fr) |
IL (1) | IL243327A0 (fr) |
MX (1) | MX366292B (fr) |
RU (1) | RU2016103321A (fr) |
WO (1) | WO2015000058A1 (fr) |
ZA (1) | ZA201600120B (fr) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20130281913A1 (en) | 2012-04-20 | 2013-10-24 | Klox Technologies Inc. | Biophotonic compositions and methods for providing biophotonic treatment |
AU2015240385B2 (en) | 2014-04-01 | 2019-02-28 | Klox Technologies Inc. | Tissue filler compositions and methods of use |
CA2951056A1 (fr) * | 2014-06-04 | 2015-12-10 | Klox Technologies Inc. | Hydrogels biophotoniques |
JP7017311B2 (ja) * | 2014-06-09 | 2022-02-08 | 広東科洛克生物医薬集団有限公司 | シリコンベースの生体光組成物およびその使用 |
CA2966010C (fr) | 2014-10-31 | 2023-04-11 | Klox Technologies Inc. | Fibres et supports de tissu photoactivatables |
KR20160142199A (ko) * | 2015-06-02 | 2016-12-12 | 삼성메디슨 주식회사 | 광음향 영상화를 위한 조영 조성물 및 그를 사용한 광음향 영상화하는 방법 |
EP3397283A4 (fr) | 2015-12-28 | 2019-05-22 | Klox Technologies Limited | Compositions biophotoniques sans peroxyde et procédés |
US20190022218A1 (en) * | 2016-01-11 | 2019-01-24 | Klox Technologies Limited | Biophotonic compositions for the treatment of pyoderma |
CA3010886A1 (fr) | 2016-01-11 | 2017-07-20 | Klox Technologies Limited | Compositions biophotoniques pour le traitement de plaies de la peau et des tissus mous affectes d'infections non resistantes ou resistantes ou des deux |
WO2018053646A1 (fr) | 2016-09-23 | 2018-03-29 | Klox Technologies Inc. | Compositions biophotoniques, procédés et kits pour inhiber et interrompre les biofilms |
WO2018053641A1 (fr) * | 2016-09-23 | 2018-03-29 | Klox Technologies Inc. | Compositions et procédés biophotoniques destinés à réduire la formation de cicatrice |
JP2018048100A (ja) * | 2016-09-23 | 2018-03-29 | クロクス テクノロジーズ インコーポレイテッド | 疼痛の軽減のためのバイオフォトンの組成物、方法およびキット |
WO2018137043A1 (fr) * | 2017-01-27 | 2018-08-02 | Klox Technologies Inc. | Procédés de photobiomodulation de processus biologiques utilisant la fluorescence générée et émise depuis une composition biophotonique ou d'un système biophotonique |
CN110650753A (zh) * | 2017-02-22 | 2020-01-03 | 通用医疗公司 | 用于伤口愈合的光化学处理方法 |
MX2020000249A (es) | 2017-07-12 | 2020-09-03 | Termir Inc | Composiciones antimicrobianas efectivas contra bacterias y hongos. |
US20200147214A1 (en) * | 2017-07-19 | 2020-05-14 | Klox Technologies Inc. | Tissue filler compositions for photo-biomodulation and methods for achieving same |
US20210170027A1 (en) * | 2017-11-17 | 2021-06-10 | Klox Technologies Limited | Biophotonic compositions, methods and kits for enhancing hair growth |
WO2019232628A1 (fr) * | 2018-06-05 | 2019-12-12 | Klox Technologies Inc. | Système de fibres biophotoniques absorbantes |
WO2021081642A1 (fr) * | 2019-10-28 | 2021-05-06 | Zago Michela | Compositions biophotoniques, utilisations et procédés de modulation de la dynamique mitochondriale et de la fonctionnalité dans des affections de la peau et de tissu mou |
US11529153B2 (en) | 2020-08-21 | 2022-12-20 | University Of Washington | Vaccine generation |
US11612669B2 (en) | 2020-08-21 | 2023-03-28 | University Of Washington | Disinfection method and apparatus |
WO2022051279A1 (fr) * | 2020-09-02 | 2022-03-10 | University Of Washington | Combinaison de photosensibilisateurs |
US11425905B2 (en) | 2020-09-02 | 2022-08-30 | University Of Washington | Antimicrobial preventive netting |
WO2022103775A1 (fr) | 2020-11-12 | 2022-05-19 | Singletto Inc. | Désinfection microbienne pour équipement de protection personnelle |
CN113694243B (zh) * | 2021-08-20 | 2022-05-13 | 中国地质大学(武汉) | 一种光敏剂/粘土复合材料及其制备方法和应用 |
Family Cites Families (181)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2877221A (en) | 1954-03-17 | 1959-03-10 | Pfizer & Co C | 11, 14-peroxides of substituted ergostadiene compounds |
US3309274A (en) | 1962-07-23 | 1967-03-14 | Brilliant Herbert | Use of fluorescent dyes in dental diagnostic methods |
US3141321A (en) | 1963-04-12 | 1964-07-21 | Scovill Manufacturing Co | Key retaining member |
US3293127A (en) | 1964-07-22 | 1966-12-20 | Gold Crest Chemical Corp Inc | Arterial embalming fluid and method for embalming therewith |
DE1617744A1 (de) | 1964-07-24 | 1970-09-10 | Peter Strong & Co Inc | Reinigungsmittel fuer Zahnprothesen |
NL152290B (nl) | 1965-09-08 | 1977-02-15 | American Cyanamid Co | Werkwijze ter bereiding van chemiluminescerende mengsels. |
US3372125A (en) | 1965-11-15 | 1968-03-05 | Peter Strong & Company Inc | Denture cleanser |
US3595798A (en) | 1967-12-18 | 1971-07-27 | Lever Brothers Ltd | Cleansing compositions |
US3671450A (en) | 1969-09-22 | 1972-06-20 | American Cyanamid Co | Chemiluminescent compositions |
US3728446A (en) | 1971-01-11 | 1973-04-17 | Colgate Palmolive Co | Speckled dentifrice gel |
FR2463613A1 (fr) | 1979-08-20 | 1981-02-27 | Thorel Jean Noel | Nouvelles compositions pour la revelation de la plaque dentaire |
DE2935450A1 (de) | 1979-09-01 | 1981-03-19 | Hermann Dr.Med.Dent. 4044 Kaarst Gertenbach | Zahnputzmittel |
US4402959A (en) | 1980-06-02 | 1983-09-06 | Merck & Co., Inc. | Antimicrobial compositions |
US4320140A (en) | 1980-10-09 | 1982-03-16 | Sterling Drug Inc. | Synergistic insecticidal compositions |
US4430381A (en) | 1982-06-25 | 1984-02-07 | The Buckeye Cellulose Corporation | Monocarboxylic acid antimicrobials in fabrics |
US4625026A (en) | 1982-12-30 | 1986-11-25 | Biomeasure, Inc. | 2-amino-4-oxo-tricyclicpyrimidines having antiviral activities against herpes simplex virus type II infections |
US4647578A (en) | 1983-12-02 | 1987-03-03 | Sterling Drug Inc. | Phototoxic insecticidal compositions and method of use thereof |
US4533435A (en) | 1984-06-07 | 1985-08-06 | Microban Products Company | Antimicrobial paper |
US4574097A (en) | 1984-08-10 | 1986-03-04 | Isopedix Corporation | Reinforced thixotropic gel composition |
US4736467A (en) | 1986-12-24 | 1988-04-12 | Burlington Industries, Inc. | Operating room clothing system |
US4855139A (en) | 1987-01-20 | 1989-08-08 | Med. Fab (Lafayette), Inc. | Fungicidally active cellulosic textile compositions, or articles of manufacture |
JPH01279838A (ja) | 1988-04-30 | 1989-11-10 | Kiyuukiyuu Yakuhin Kogyo Kk | 塩化リゾチーム含有歯肉炎・歯槽膿漏用貼付剤 |
US5453275A (en) | 1988-05-05 | 1995-09-26 | Interface, Inc. | Biocidal polymeric coating for heat exchanger coils |
US4891211A (en) | 1988-06-29 | 1990-01-02 | Church & Dwight Co., Inc. | Stable hydrogen peroxide-releasing dentifice |
DE3834130A1 (de) | 1988-10-07 | 1990-04-12 | Basf Ag | Verfahren zum herstellen von homopolymerisaten des ethens sowie copolymerisaten des ethens mit hoeheren (alpha)-monoolefinen mittels eines ziegler-katalysator-systems |
US5091102A (en) | 1988-11-15 | 1992-02-25 | Nordico, Inc. | Method of making a dry antimicrobial fabric |
NL8900165A (nl) | 1989-01-24 | 1990-08-16 | Matthijs Cornelis Evers | Wondpoeder. |
CA2028136A1 (fr) | 1989-02-28 | 1990-09-29 | Marc N. Benhuri | Methode et composition pour le traitement des paradontopathies |
JPH0383927A (ja) | 1989-08-25 | 1991-04-09 | Sunstar Inc | 歯周組織再生促進剤 |
US4992256A (en) | 1989-09-27 | 1991-02-12 | Colgate-Palmolive Company | Plaque disclosing compositions |
DE4007428A1 (de) | 1990-03-09 | 1991-09-12 | Hoechst Ag | Photopolymerisierbares gemisch und daraus hergestelltes aufzeichnungsmaterial |
US5069907A (en) | 1990-03-23 | 1991-12-03 | Phoenix Medical Technology | Surgical drape having incorporated therein a broad spectrum antimicrobial agent |
US5292362A (en) | 1990-07-27 | 1994-03-08 | The Trustees Of Columbia University In The City Of New York | Tissue bonding and sealing composition and method of using the same |
JP4564596B2 (ja) | 1992-04-30 | 2010-10-20 | ユーシーエル ビジネス ピーエルシー | レーザー治療 |
US5800373A (en) | 1995-03-23 | 1998-09-01 | Focal, Inc. | Initiator priming for improved adherence of gels to substrates |
US5749968A (en) | 1993-03-01 | 1998-05-12 | Focal, Inc. | Device for priming for improved adherence of gels to substrates |
US5567372A (en) | 1993-06-11 | 1996-10-22 | Kimberly-Clark Corporation | Method for preparing a nonwoven web containing antimicrobial siloxane quaternary ammonium salts |
US5705357A (en) | 1994-08-29 | 1998-01-06 | Johnson & Johnson Clinical Diagnostics, Inc. | Chemiluminescent reagent and assay using a substituted acetanilide for light generation |
GB9500116D0 (en) | 1995-01-05 | 1995-03-01 | Ciba Geigy Ag | Pharmaceutical compositions |
WO1996029370A2 (fr) | 1995-03-23 | 1996-09-26 | Focal, Inc. | Systemes d'oxydoreducteur et de photoamorceur pour appretage afin d'ameliorer l'adherence de gels sur des substrats |
US5658148A (en) | 1995-04-26 | 1997-08-19 | Ceramoptec Industries, Inc. | Dental laser brushing or cleaning device |
JPH092925A (ja) | 1995-06-16 | 1997-01-07 | Shiseido Co Ltd | 2剤混合式化粧料 |
US5885557A (en) | 1996-02-08 | 1999-03-23 | Estee Lauder Inc. | Compositions useful in the phototherapeutic treatment of proliferative skin disorders |
US5894042A (en) | 1996-02-26 | 1999-04-13 | Technology Licensing Company | Bacteriostatic coating of polymeric conduit |
US6541460B2 (en) | 1996-08-07 | 2003-04-01 | George D. Petito | Method for use of hyaluronic acid in wound management |
AU4185397A (en) | 1996-09-16 | 1998-04-02 | Procter & Gamble Company, The | Antimicrobial oral care compositions |
US5913884A (en) | 1996-09-19 | 1999-06-22 | The General Hospital Corporation | Inhibition of fibrosis by photodynamic therapy |
US7353829B1 (en) | 1996-10-30 | 2008-04-08 | Provectus Devicetech, Inc. | Methods and apparatus for multi-photon photo-activation of therapeutic agents |
US7390668B2 (en) | 1996-10-30 | 2008-06-24 | Provectus Pharmatech, Inc. | Intracorporeal medicaments for photodynamic treatment of disease |
US8182473B2 (en) | 1999-01-08 | 2012-05-22 | Palomar Medical Technologies | Cooling system for a photocosmetic device |
FR2756741B1 (fr) | 1996-12-05 | 1999-01-08 | Cird Galderma | Utilisation d'un chromophore dans une composition destinee a etre appliquee sur la peau avant un traitement laser |
JPH10182390A (ja) | 1996-12-25 | 1998-07-07 | Lion Corp | 口腔用組成物 |
US5785527A (en) | 1997-01-10 | 1998-07-28 | Ultradent Products, Inc. | Stable light or heat activated dental bleaching compositions |
US5858332A (en) | 1997-01-10 | 1999-01-12 | Ultradent Products, Inc. | Dental bleaching compositions with high concentrations of hydrogen peroxide |
EP0956280B1 (fr) | 1997-01-30 | 2002-10-30 | Ciba SC Holding AG | Esters phenylglyoxaliques non volatils |
US5922331A (en) | 1997-03-26 | 1999-07-13 | Chanel, Inc. | Skin cream composition |
JPH10330235A (ja) | 1997-06-02 | 1998-12-15 | Lion Corp | 義歯洗浄剤 |
US8974363B2 (en) | 1997-12-11 | 2015-03-10 | Provectus Pharmatech, Inc. | Topical medicaments and methods for photodynamic treatment of disease |
US6161544A (en) | 1998-01-28 | 2000-12-19 | Keratoform, Inc. | Methods for accelerated orthokeratology |
US5919554A (en) | 1998-01-30 | 1999-07-06 | Microban Products Company | Antimicrobial fiberglass reinforced plastic composite |
BR9907849A (pt) | 1998-02-13 | 2002-05-07 | Britesmile Inc | Composição alvejante dental ativada por luz e método de uso da mesma |
US20030198605A1 (en) | 1998-02-13 | 2003-10-23 | Montgomery R. Eric | Light-activated tooth whitening composition and method of using same |
US6149895A (en) | 1998-02-17 | 2000-11-21 | Kreativ, Inc | Dental bleaching compositions, kits & methods |
AU3371799A (en) | 1998-03-30 | 1999-10-18 | Fibermark, Inc. | Light-activated antimicrobial polymeric materials |
US6663659B2 (en) | 2000-01-13 | 2003-12-16 | Mcdaniel David H. | Method and apparatus for the photomodulation of living cells |
US6676655B2 (en) | 1998-11-30 | 2004-01-13 | Light Bioscience L.L.C. | Low intensity light therapy for the manipulation of fibroblast, and fibroblast-derived mammalian cells and collagen |
US6887260B1 (en) | 1998-11-30 | 2005-05-03 | Light Bioscience, Llc | Method and apparatus for acne treatment |
US6183773B1 (en) | 1999-01-04 | 2001-02-06 | The General Hospital Corporation | Targeting of sebaceous follicles as a treatment of sebaceous gland disorders |
IT1306679B1 (it) | 1999-06-29 | 2001-10-02 | Fidia Advanced Biopolymers Srl | Uso dei derivati dell'acido ialuronico per la preparazione dicomposizoni farmaceutiche e biomateriali per la prevenzione della |
IL148139A0 (en) | 1999-08-13 | 2002-09-12 | Photogen Inc | Improved topical medicaments and methods for photodynamic treatment of disease |
EP1244424A2 (fr) * | 1999-11-19 | 2002-10-02 | The Procter & Gamble Company | Articles de soins personnels comprenant un agent tonifiant hydrophile possedant une valeur de dissolution definie |
US6475498B1 (en) | 1999-12-08 | 2002-11-05 | The Procter & Gamble Company | Method to inhibit tartar and stain using denture adhesive compositions |
US6905672B2 (en) | 1999-12-08 | 2005-06-14 | The Procter & Gamble Company | Compositions and methods to inhibit tartar and microbes using denture adhesive compositions with colorants |
WO2001041712A1 (fr) | 1999-12-08 | 2001-06-14 | The Procter & Gamble Company | Compositions de ciment anti-tartre pour prothese dentaire |
US6444725B1 (en) | 2000-01-21 | 2002-09-03 | 3M Innovative Properties Company | Color-changing dental compositions |
US6551608B2 (en) | 2000-03-06 | 2003-04-22 | Porex Technologies Corporation | Porous plastic media with antiviral or antimicrobial properties and processes for making the same |
GB2360459B (en) | 2000-03-23 | 2002-08-07 | Photo Therapeutics Ltd | Therapeutic light source and method |
US7083610B1 (en) | 2000-06-07 | 2006-08-01 | Laserscope | Device for irradiating tissue |
WO2002011539A1 (fr) | 2000-08-08 | 2002-02-14 | Cytopharm, Inc. | Methodes et compositions de traitement d'ulceres cutanes par therapie photodynamique topique |
AU2000268991A1 (en) | 2000-08-10 | 2002-02-25 | Paradyne Corporation | Filter system and method to suppress interference imposed upon a frequency-division multiplexed channel |
DE10056114A1 (de) | 2000-11-04 | 2002-05-29 | Wolfgang Malodobry | Narbenfreie Entfernung von Tätowierungen |
US6485709B2 (en) | 2001-01-23 | 2002-11-26 | Addent Inc. | Dental bleaching gel composition, activator system and method for activating a dental bleaching gel |
JP2002233612A (ja) | 2001-02-07 | 2002-08-20 | Daito Giken:Kk | 遊技台 |
JP2002293747A (ja) | 2001-03-29 | 2002-10-09 | Jinen:Kk | 皮膚外用剤 |
ITMI20011315A1 (it) | 2001-06-21 | 2002-12-21 | Herbariorum Medicaminum Offici | Composizione per pasta dentifricia antiplacca con rilevatore di placca |
US20030009158A1 (en) | 2001-07-09 | 2003-01-09 | Perricone Nicholas V. | Skin treatments using blue and violet light |
US20040199227A1 (en) | 2001-11-29 | 2004-10-07 | Altshuler Gregory B. | Biostimulation of the oral cavity |
US20040147984A1 (en) | 2001-11-29 | 2004-07-29 | Palomar Medical Technologies, Inc. | Methods and apparatus for delivering low power optical treatments |
JP2005517638A (ja) * | 2001-12-04 | 2005-06-16 | ジェイ.ウールバートン クリストファー | 保存安定性のあるフィブリンシーラント |
JP2005527493A (ja) | 2002-01-23 | 2005-09-15 | ライト サイエンシーズ コーポレイション | 光線力学療法のためのシステムおよび方法 |
JP2003231347A (ja) | 2002-02-12 | 2003-08-19 | Fuji Photo Film Co Ltd | インクジェット記録用シート |
US7081128B2 (en) | 2002-03-04 | 2006-07-25 | Hart Barry M | Phototherapy device and method of use |
CA2478567A1 (fr) | 2002-03-15 | 2003-09-25 | Brian Zelickson | Dispositif et procede de traitement de surfaces externes d'un corps au moyen d'un contenant emetteur de lumiere |
EP1496992A1 (fr) | 2002-04-16 | 2005-01-19 | Lumerx, Inc. | Source lumineuse chimiluminescente utilisant la lumiere visible en biotherapie |
JP4549006B2 (ja) * | 2002-05-07 | 2010-09-22 | ロート製薬株式会社 | ゲル軟膏 |
US6949240B2 (en) | 2002-05-23 | 2005-09-27 | The Procter & Gamble Company | Tooth whitening products |
US7201766B2 (en) | 2002-07-03 | 2007-04-10 | Life Support Technologies, Inc. | Methods and apparatus for light therapy |
US20050098766A1 (en) | 2002-09-19 | 2005-05-12 | Watson David L.Jr. | Chemiluminescent processes and systems |
GB0222091D0 (en) | 2002-09-24 | 2002-10-30 | Boots Co Plc | Dental compositions and methods |
US20080091250A1 (en) | 2002-09-26 | 2008-04-17 | Lumiport, Llc | Light therapy desk lamp |
JP2006503080A (ja) | 2002-10-11 | 2006-01-26 | ノボセル インコーポレイテッド | 疾患治療用のカプセルで包んだ生物材料の移植 |
AU2003296475A1 (en) | 2002-12-10 | 2004-06-30 | University Of Florida | Phototherapy bandage |
US7923030B2 (en) | 2003-03-14 | 2011-04-12 | Sol-Gel Technologies, Inc. | Agent-encapsulating micro- and nanoparticles, methods for preparation of same and products containing same |
US20040191330A1 (en) | 2003-03-31 | 2004-09-30 | Keefe Candace R. | Daily skin care regimen |
RU2005134239A (ru) | 2003-04-04 | 2006-05-10 | Тиссьюмед Лимитед (Gb) | Составы тканевых клеев |
WO2005002510A2 (fr) | 2003-06-16 | 2005-01-13 | Loma Linda University Medical Center | Agent hemostatique multifonctionnel deployable |
JP2003339875A (ja) | 2003-06-16 | 2003-12-02 | Hirokatsu Kimura | 入れ墨消去装置 |
KR100960687B1 (ko) | 2003-06-24 | 2010-06-01 | 엘지디스플레이 주식회사 | 구리(또는 구리합금층)를 포함하는 이중금속층을 일괄식각하기위한 식각액 |
CA2533406C (fr) | 2003-07-31 | 2013-01-22 | Sol-Gel Technologies Ltd. | Microcapsules chargees d'ingredients actifs et procede de preparation |
BRPI0413142A (pt) | 2003-08-01 | 2006-10-03 | Glotell Products Inc | soluções de corante para uso em métodos para detectar a evaporação prévia de amÈnia anidra e a produção de drogas ilìcitas |
US8795693B2 (en) | 2003-08-04 | 2014-08-05 | Foamix Ltd. | Compositions with modulating agents |
US20050042712A1 (en) | 2003-08-22 | 2005-02-24 | Advanced Medical Optics, Inc. | Methods, compositions and instruments to predict antimicrobial or preservative activity |
US20050059731A1 (en) | 2003-09-16 | 2005-03-17 | Ceramoptec Industries, Inc. | Erythrosin-based antimicrobial photodynamic therapy compound and its use |
WO2005051305A2 (fr) | 2003-11-19 | 2005-06-09 | Barnes-Jewish Hospital | Apport ameliore d'un medicament |
CA2457214A1 (fr) | 2004-02-06 | 2005-08-06 | Qlt Inc. | Therapie photodynamique pour le traitement de l'acne |
US20070244195A1 (en) | 2004-05-18 | 2007-10-18 | Burkhart Craig N | Treatment methods with peroxides and tertiary amines |
EP1749532B1 (fr) | 2004-05-21 | 2014-04-23 | Tottori University | Médicament pour la guérison ou le traitement d'une blessure |
WO2005123023A1 (fr) | 2004-06-10 | 2005-12-29 | Segan Industries, Inc. | Stimuli, elements et dentifrices activateurs de modifications optiques |
US20050281890A1 (en) | 2004-06-18 | 2005-12-22 | San Chandan K | Methods and compositions for wound healing |
CA2573020A1 (fr) | 2004-07-08 | 2006-02-09 | 3M Innovative Properties Company | Procedes dentaires, compositions et kits comprenant des teintures sensibles a l'acide |
GB0420888D0 (en) | 2004-09-20 | 2004-10-20 | Photopharmica Ltd | Compounds and uses |
CA2486475A1 (fr) | 2004-11-02 | 2006-05-02 | John Kennedy | Methode de traitement contre les micro-organismes dans la cavite buccale |
GB0424422D0 (en) | 2004-11-04 | 2004-12-08 | Bp Chem Int Ltd | Polymerisation catalysts |
WO2006072243A1 (fr) | 2005-01-03 | 2006-07-13 | Novozymes Biopolymer A/S | Fraction acide hyaluronique ayant des proprietes hydratantes et antirides |
EP1853598B1 (fr) | 2005-03-01 | 2012-11-21 | Life Technologies Corporation | Composes de sonde chimique devenant fluorescents lors de leur reduction, et leurs methodes d'utilisation |
US20060217690A1 (en) | 2005-03-22 | 2006-09-28 | Bastin Norman J | Method for treating various dermatological and muscular conditions using electromagnetic radiation |
US20060246020A1 (en) | 2005-04-29 | 2006-11-02 | Cole Curtis A | Topical composition detection |
EP1733762A1 (fr) | 2005-05-25 | 2006-12-20 | 3M Espe AG | Composition dentaire pour la détection des caries, méthode de détection |
US20090285766A1 (en) | 2005-06-13 | 2009-11-19 | National University Of Singapore | Photosensitising Composition and Uses Thereof |
KR100721198B1 (ko) | 2005-06-29 | 2007-05-23 | 주식회사 하이닉스반도체 | 내부전압 자동 변경이 가능한 반도체장치의내부전압발생회로 |
US20070021807A1 (en) * | 2005-07-20 | 2007-01-25 | Eastman Kodak Company | Device for optically stimulating collagen formation in tissue |
EP1933941A2 (fr) | 2005-08-25 | 2008-06-25 | Philip R. Houle | Solutions sensibilisantes ameliorees, systemes, et procedes d'utilisation |
US20070092469A1 (en) | 2005-10-26 | 2007-04-26 | Eric Jacobs | Topically applied Glucosamine Sulfate and all its related, precursor, and derivative compounds significantly increases the skin's natural produciton of hyaluronic acid for the rejuvenation of healthier younger-looking skin; while PhosphatidylCholine is required to replace its deficiency caused by topical Dimethylaminoethanol (DMAE) |
EP1779891A1 (fr) | 2005-10-28 | 2007-05-02 | Abdula Kurkayev | Méthode d'activation d'un photosensibilisateur |
JP5366553B2 (ja) | 2005-11-09 | 2013-12-11 | クロックス テクノロジーズ インコーポレイテッド | 歯のホワイトニング組成物及び方法 |
US20070142762A1 (en) | 2005-12-16 | 2007-06-21 | Eastman Kodak Company | Wound dressing |
US8999933B2 (en) | 2006-01-18 | 2015-04-07 | Biolitec Pharma Marketing Ltd | Photodynamic cosmetic procedure and healing method |
CA2635947A1 (fr) | 2006-01-23 | 2007-08-02 | The Procter & Gamble Company | Compositions contenant une enzyme et un agent de photoblanchiment |
US20100028407A1 (en) * | 2006-04-27 | 2010-02-04 | University Of Louisville Research Foundation, Inc. | Layered bio-adhesive compositions and uses thereof |
EP2026756B1 (fr) | 2006-05-22 | 2020-06-17 | Syncera, Inc. | Compositions polymériques résorbables à usage médical, dentaire et chirurgical |
US20070286824A1 (en) | 2006-06-07 | 2007-12-13 | Thomas Elliot Rabe | Bleed-resistant colored microparticles and skin care compositions comprising them |
US8454991B2 (en) | 2006-07-24 | 2013-06-04 | Quest Pharmatech Inc. | Method and device for photodynamic therapy |
WO2008013962A2 (fr) | 2006-07-28 | 2008-01-31 | Ceramoptec Industries, Inc. | Procédé et mélange pour la réticulation photochimique in vivo du collagène |
KR101551590B1 (ko) | 2006-10-24 | 2015-09-08 | 캘리포니아 인스티튜트 오브 테크놀로지 | 신체 조직의 물리적 및/또는 화학적 성질에 영향을 주는 광화학적 요법 |
US20080108681A1 (en) | 2006-10-27 | 2008-05-08 | Access Business Group International Llc | Use of allantoin as a pro-collagen synthesis agent in cosmetic compositions |
US20100266989A1 (en) | 2006-11-09 | 2010-10-21 | Klox Technologies Inc. | Teeth whitening compositions and methods |
US20080113037A1 (en) | 2006-11-10 | 2008-05-15 | Green Barbara A | Topical Compositions Comprising Polyhydroxy Acids and/or Lactones for Improved Cutaneous Effects of Oxidative Therapeutic Drugs |
US20080138289A1 (en) | 2006-12-08 | 2008-06-12 | Evident Technologies, Inc. | Systems and methods for detecting infrared emitting composites and medical applications therefor |
JP2010514839A (ja) | 2007-01-03 | 2010-05-06 | バーナム インスティテュート フォー メディカル リサーチ | クロット結合化合物に関連する方法および組成物 |
JP2008231010A (ja) | 2007-03-20 | 2008-10-02 | Shiseido Co Ltd | 皮膚外用剤 |
WO2008139601A1 (fr) | 2007-05-14 | 2008-11-20 | Alcare Co., Ltd. | Timbre transdermique pour la surface du corps |
JP5138995B2 (ja) | 2007-07-06 | 2013-02-06 | 株式会社カネカ | 皮膚貼付用粘着シートおよび経皮吸収製剤 |
EP2190469B1 (fr) | 2007-09-04 | 2015-02-25 | Compugen Ltd. | Polypeptides et polynucléotides, et leurs utilisations comme cibles de médicaments pour la production de médicaments et de substances biologiques |
US9079022B2 (en) | 2007-09-27 | 2015-07-14 | Led Intellectual Properties, Llc | LED based phototherapy device for photo-rejuvenation of cells |
US20090131499A1 (en) | 2007-11-15 | 2009-05-21 | Ceramoptec Industries Inc. | Photodynamic therapy for skin related problems |
FR2924021B1 (fr) | 2007-11-27 | 2010-08-13 | Du Vernet Michele Eymard | Composition pour le traitement de la peau par therapie photodynamique |
JP4740934B2 (ja) | 2007-12-07 | 2011-08-03 | シャープ株式会社 | 照明装置 |
BRPI0905679A2 (pt) | 2008-01-08 | 2015-07-07 | Quick Med Technologies Inc | Método para fabricar e desinfetar um substrato e composição para conferir atividade antimicrobiana durável em um substrato |
US7935364B2 (en) | 2008-03-04 | 2011-05-03 | Wisconsin Alumni Research Foundation | Patterned gradient wound dressing and methods of using same to promote wound healing |
US8658219B2 (en) | 2008-11-07 | 2014-02-25 | Klox Technologies Inc. | Oxidatitive photoactivated skin rejeuvenation composition comprising hyaluronic acid, glucosamine, or allantoin |
GB0823265D0 (en) | 2008-12-20 | 2009-01-28 | Convatec Technologies Inc | Antimicrobial Composition |
US20100227799A1 (en) | 2009-03-09 | 2010-09-09 | Medtronic Vascular, Inc. | Simultaneous photodynamic therapy and photo induced polymerization |
US8747071B2 (en) | 2009-07-07 | 2014-06-10 | Fujikoki Corporation | Drain pump |
US8685466B2 (en) | 2009-07-17 | 2014-04-01 | Klox Technologies Inc. | Combination of an oxidant, a photosensitizer and a wound healing agent for oral disinfection and treatment of oral disease |
CN107080895A (zh) | 2009-10-27 | 2017-08-22 | 克洛克斯科技公司 | 用于光治疗的个人使用的设备 |
US20110171310A1 (en) | 2010-01-13 | 2011-07-14 | Allergan Industrie, Sas | Hydrogel compositions comprising vasoconstricting and anti-hemorrhagic agents for dermatological use |
GB201012217D0 (en) | 2010-07-21 | 2010-09-08 | Republic Polytechnic | Compounds for photodynamic therapy |
GB201020236D0 (en) | 2010-11-30 | 2011-01-12 | Convatec Technologies Inc | A composition for detecting biofilms on viable tissues |
WO2012110178A1 (fr) | 2011-02-14 | 2012-08-23 | Merck Patent Gmbh | Dispositif et procédé de traitement de cellules et de tissu cellulaire |
KR102185635B1 (ko) | 2011-03-03 | 2020-12-03 | 네오다인 바이오사이언시스, 인코포레이티드 | 피부 타이트닝을 위한 장치 및 방법 |
CN102133208A (zh) | 2011-03-17 | 2011-07-27 | 北京化工大学 | 一种可用于光动力疗法的光敏微胶囊及其制备方法 |
US11116841B2 (en) | 2012-04-20 | 2021-09-14 | Klox Technologies Inc. | Biophotonic compositions, kits and methods |
US20130281913A1 (en) | 2012-04-20 | 2013-10-24 | Klox Technologies Inc. | Biophotonic compositions and methods for providing biophotonic treatment |
EP3329938B1 (fr) * | 2012-09-14 | 2021-06-23 | KLOX Technologies, Inc. | Combinaison de chromophores à usages biophotoniques |
EP3366274A1 (fr) | 2012-09-14 | 2018-08-29 | KLOX Technologies, Inc. | Compositions cosmétiques biophotoniques |
CA2883717A1 (fr) | 2012-09-14 | 2014-03-20 | Klox Technologies Inc. | Combinaison de chromophores a usages biophotoniques |
MX351267B (es) | 2012-09-14 | 2017-10-06 | Valeant Pharmaceuticals Int Inc | Composiciones y metodos para blanqueamiento dental. |
WO2014131115A1 (fr) | 2013-03-01 | 2014-09-04 | Klox Technologies Inc. | Dispositif photothérapeutique, méthode et utilisation |
US20140276354A1 (en) | 2013-03-14 | 2014-09-18 | Klox Technologies Inc. | Biophotonic materials and uses thereof |
CA2966010C (fr) | 2014-10-31 | 2023-04-11 | Klox Technologies Inc. | Fibres et supports de tissu photoactivatables |
WO2017201615A1 (fr) | 2016-05-23 | 2017-11-30 | Orphaderm Limited | Compositions biophotoniques comprenant un chromophore d'origine fongique |
-
2014
- 2014-07-02 KR KR1020167000516A patent/KR20160029795A/ko not_active IP Right Cessation
- 2014-07-02 KR KR1020217036975A patent/KR20210142011A/ko not_active Application Discontinuation
- 2014-07-02 CA CA2916337A patent/CA2916337C/fr active Active
- 2014-07-02 AU AU2014286868A patent/AU2014286868B2/en not_active Ceased
- 2014-07-02 WO PCT/CA2014/000536 patent/WO2015000058A1/fr active Application Filing
- 2014-07-02 MX MX2015017974A patent/MX366292B/es active IP Right Grant
- 2014-07-02 JP JP2016522147A patent/JP6932304B2/ja active Active
- 2014-07-02 US US14/901,246 patent/US10881736B2/en active Active
- 2014-07-02 CN CN201480037725.6A patent/CN105473160A/zh active Pending
- 2014-07-02 KR KR1020217027352A patent/KR20210108505A/ko not_active Application Discontinuation
- 2014-07-02 RU RU2016103321A patent/RU2016103321A/ru not_active Application Discontinuation
- 2014-07-02 EP EP14820041.3A patent/EP3016686A4/fr not_active Withdrawn
-
2015
- 2015-12-24 IL IL243327A patent/IL243327A0/en unknown
-
2016
- 2016-01-07 ZA ZA2016/00120A patent/ZA201600120B/en unknown
- 2016-07-08 HK HK16107989.0A patent/HK1219890A1/zh unknown
-
2019
- 2019-04-25 JP JP2019084697A patent/JP6980717B2/ja active Active
-
2020
- 2020-12-22 US US17/130,587 patent/US20210177969A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
JP2019151648A (ja) | 2019-09-12 |
ZA201600120B (en) | 2019-07-31 |
JP6980717B2 (ja) | 2021-12-15 |
AU2014286868B2 (en) | 2019-12-19 |
JP2016523263A (ja) | 2016-08-08 |
EP3016686A4 (fr) | 2017-01-25 |
HK1219890A1 (zh) | 2017-04-21 |
CA2916337A1 (fr) | 2015-01-08 |
AU2014286868A1 (en) | 2016-01-21 |
WO2015000058A1 (fr) | 2015-01-08 |
KR20210142011A (ko) | 2021-11-23 |
US20210177969A1 (en) | 2021-06-17 |
KR20210108505A (ko) | 2021-09-02 |
US20160193338A1 (en) | 2016-07-07 |
RU2016103321A3 (fr) | 2018-06-29 |
CA2916337C (fr) | 2022-03-22 |
RU2016103321A (ru) | 2017-08-08 |
IL243327A0 (en) | 2016-02-29 |
KR20160029795A (ko) | 2016-03-15 |
US10881736B2 (en) | 2021-01-05 |
MX2015017974A (es) | 2016-10-21 |
MX366292B (es) | 2019-07-04 |
EP3016686A1 (fr) | 2016-05-11 |
CN105473160A (zh) | 2016-04-06 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP6980717B2 (ja) | 発色団およびゲル化剤を含む、創傷を治療するための生体光組成物 | |
JP7097924B2 (ja) | 生体光組成物、キットおよび方法 | |
JP2022003081A (ja) | 生体光組成物 | |
US11116841B2 (en) | Biophotonic compositions, kits and methods | |
JP2019501950A (ja) | 膿皮症治療のためのバイオフォトニック組成物 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A821 Effective date: 20160314 |
|
RD01 | Notification of change of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7426 Effective date: 20160314 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20170630 |
|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20170630 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20180403 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20180703 |
|
A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20181225 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20190425 |
|
C60 | Trial request (containing other claim documents, opposition documents) |
Free format text: JAPANESE INTERMEDIATE CODE: C60 Effective date: 20190425 |
|
C11 | Written invitation by the commissioner to file amendments |
Free format text: JAPANESE INTERMEDIATE CODE: C11 Effective date: 20190521 |
|
A911 | Transfer to examiner for re-examination before appeal (zenchi) |
Free format text: JAPANESE INTERMEDIATE CODE: A911 Effective date: 20190617 |
|
C21 | Notice of transfer of a case for reconsideration by examiners before appeal proceedings |
Free format text: JAPANESE INTERMEDIATE CODE: C21 Effective date: 20190618 |
|
A912 | Re-examination (zenchi) completed and case transferred to appeal board |
Free format text: JAPANESE INTERMEDIATE CODE: A912 Effective date: 20190726 |
|
C211 | Notice of termination of reconsideration by examiners before appeal proceedings |
Free format text: JAPANESE INTERMEDIATE CODE: C211 Effective date: 20190730 |
|
C22 | Notice of designation (change) of administrative judge |
Free format text: JAPANESE INTERMEDIATE CODE: C22 Effective date: 20200204 |
|
C13 | Notice of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: C13 Effective date: 20200407 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20200624 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20200803 |
|
C22 | Notice of designation (change) of administrative judge |
Free format text: JAPANESE INTERMEDIATE CODE: C22 Effective date: 20200804 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20200821 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20201006 |
|
C23 | Notice of termination of proceedings |
Free format text: JAPANESE INTERMEDIATE CODE: C23 Effective date: 20201104 |
|
C03 | Trial/appeal decision taken |
Free format text: JAPANESE INTERMEDIATE CODE: C03 Effective date: 20201215 |
|
C30A | Notification sent |
Free format text: JAPANESE INTERMEDIATE CODE: C3012 Effective date: 20201215 |
|
A711 | Notification of change in applicant |
Free format text: JAPANESE INTERMEDIATE CODE: A711 Effective date: 20210113 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20210114 |
|
A711 | Notification of change in applicant |
Free format text: JAPANESE INTERMEDIATE CODE: A711 Effective date: 20210114 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20210114 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A821 Effective date: 20210114 Free format text: JAPANESE INTERMEDIATE CODE: A821 Effective date: 20210115 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20210701 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 6932304 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |