JP6931730B1 - 光学測定装置及び光学測定方法 - Google Patents

光学測定装置及び光学測定方法 Download PDF

Info

Publication number
JP6931730B1
JP6931730B1 JP2020066069A JP2020066069A JP6931730B1 JP 6931730 B1 JP6931730 B1 JP 6931730B1 JP 2020066069 A JP2020066069 A JP 2020066069A JP 2020066069 A JP2020066069 A JP 2020066069A JP 6931730 B1 JP6931730 B1 JP 6931730B1
Authority
JP
Japan
Prior art keywords
light
signal
irradiation
detection
calibration
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2020066069A
Other languages
English (en)
Japanese (ja)
Other versions
JP2021162509A (ja
Inventor
房宣 近藤
房宣 近藤
直樹 岩田
直樹 岩田
朋和 松村
朋和 松村
照雄 竹下
照雄 竹下
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hamamatsu Photonics KK
Original Assignee
Hamamatsu Photonics KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to JP2020066069A priority Critical patent/JP6931730B1/ja
Application filed by Hamamatsu Photonics KK filed Critical Hamamatsu Photonics KK
Priority to PCT/JP2021/002104 priority patent/WO2021199605A1/ja
Priority to EP21779692.9A priority patent/EP4123291A4/en
Priority to CN202180026082.5A priority patent/CN115398210B/zh
Priority to KR1020227031968A priority patent/KR20220159971A/ko
Priority to US17/914,434 priority patent/US20230124819A1/en
Priority to TW110109328A priority patent/TWI895383B/zh
Priority to JP2021132233A priority patent/JP7348933B2/ja
Application granted granted Critical
Publication of JP6931730B1 publication Critical patent/JP6931730B1/ja
Publication of JP2021162509A publication Critical patent/JP2021162509A/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/645Specially adapted constructive features of fluorimeters
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/27Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection ; circuits for computing concentration
    • G01N21/274Calibration, base line adjustment, drift correction
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47Scattering, i.e. diffuse reflection
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47Scattering, i.e. diffuse reflection
    • G01N21/4738Diffuse reflection, e.g. also for testing fluids, fibrous materials
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/6408Fluorescence; Phosphorescence with measurement of decay time, time resolved fluorescence
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/84Systems specially adapted for particular applications
    • G01N21/8483Investigating reagent band
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47Scattering, i.e. diffuse reflection
    • G01N2021/473Compensating for unwanted scatter, e.g. reliefs, marks
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/645Specially adapted constructive features of fluorimeters
    • G01N2021/6463Optics
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N2021/7756Sensor type
    • G01N2021/7759Dipstick; Test strip
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N2021/7769Measurement method of reaction-produced change in sensor
    • G01N2021/7786Fluorescence
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00Features of devices classified in G01N21/00
    • G01N2201/12Circuits of general importance; Signal processing
    • G01N2201/127Calibration; base line adjustment; drift compensation

Landscapes

  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Theoretical Computer Science (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Mathematical Physics (AREA)
  • Molecular Biology (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
JP2020066069A 2020-04-01 2020-04-01 光学測定装置及び光学測定方法 Active JP6931730B1 (ja)

Priority Applications (8)

Application Number Priority Date Filing Date Title
JP2020066069A JP6931730B1 (ja) 2020-04-01 2020-04-01 光学測定装置及び光学測定方法
EP21779692.9A EP4123291A4 (en) 2020-04-01 2021-01-21 OPTICAL MEASURING DEVICE AND OPTICAL MEASURING METHOD
CN202180026082.5A CN115398210B (zh) 2020-04-01 2021-01-21 光学测定装置及光学测定方法
KR1020227031968A KR20220159971A (ko) 2020-04-01 2021-01-21 광학 측정 장치 및 광학 측정 방법
PCT/JP2021/002104 WO2021199605A1 (ja) 2020-04-01 2021-01-21 光学測定装置及び光学測定方法
US17/914,434 US20230124819A1 (en) 2020-04-01 2021-01-21 Optical measurement device and optical measurement method
TW110109328A TWI895383B (zh) 2020-04-01 2021-03-16 光學測定裝置及光學測定方法
JP2021132233A JP7348933B2 (ja) 2020-04-01 2021-08-16 光学測定装置及び光学測定方法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2020066069A JP6931730B1 (ja) 2020-04-01 2020-04-01 光学測定装置及び光学測定方法

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2021132233A Division JP7348933B2 (ja) 2020-04-01 2021-08-16 光学測定装置及び光学測定方法

Publications (2)

Publication Number Publication Date
JP6931730B1 true JP6931730B1 (ja) 2021-09-08
JP2021162509A JP2021162509A (ja) 2021-10-11

Family

ID=77549888

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2020066069A Active JP6931730B1 (ja) 2020-04-01 2020-04-01 光学測定装置及び光学測定方法
JP2021132233A Active JP7348933B2 (ja) 2020-04-01 2021-08-16 光学測定装置及び光学測定方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2021132233A Active JP7348933B2 (ja) 2020-04-01 2021-08-16 光学測定装置及び光学測定方法

Country Status (7)

Country Link
US (1) US20230124819A1 (enExample)
EP (1) EP4123291A4 (enExample)
JP (2) JP6931730B1 (enExample)
KR (1) KR20220159971A (enExample)
CN (1) CN115398210B (enExample)
TW (1) TWI895383B (enExample)
WO (1) WO2021199605A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6923702B1 (ja) * 2020-04-01 2021-08-25 浜松ホトニクス株式会社 光学測定装置及び光学測定方法
TW202245178A (zh) 2021-01-21 2022-11-16 日商邦德科技股份有限公司 接合方法、接合裝置及接合系統
WO2024085899A1 (en) * 2022-10-19 2024-04-25 Wang ying ting Methods and apparatuses for fluorospectrometric measurements of low photon budget samples
TWI849658B (zh) * 2022-12-29 2024-07-21 致茂電子股份有限公司 複合式校正片

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS613043A (ja) * 1984-06-18 1986-01-09 Hitachi Ltd 核酸塩基配列決定装置
WO1990009637A1 (en) * 1989-02-13 1990-08-23 Research Corporation Technologies, Inc. Method and means for parallel frequency acquisition in frequency domain fluorometry
JPH04106470A (ja) * 1990-08-28 1992-04-08 Hitachi Ltd 粒子免疫測定方法及びその装置
US5270548A (en) * 1992-07-31 1993-12-14 The United States Of America As Represented By The United States Department Of Energy Phase-sensitive flow cytometer
JP3483217B2 (ja) * 1994-02-08 2004-01-06 チノン株式会社 画像読取装置
JPH1151856A (ja) * 1997-08-07 1999-02-26 Nippon Telegr & Teleph Corp <Ntt> フォトリフレクタンスマッピング測定法
CA2310672A1 (en) * 1997-11-19 1999-05-27 University Of Washington High throughput optical scanner
US6251688B1 (en) * 1998-03-20 2001-06-26 Ia, Inc. Method and apparatus for measurement of binding between a protein and a nucleotide
JP2001137173A (ja) * 1999-11-11 2001-05-22 Fuji Photo Film Co Ltd 蛍光画像測定方法および装置
JP4660691B2 (ja) * 2005-04-08 2011-03-30 コニカミノルタセンシング株式会社 蛍光試料の光学特性測定方法及びこれを用いた光学特性測定装置
JP2010518394A (ja) 2007-02-06 2010-05-27 ナンヤン・テクノロジカル・ユニバーシティー 基板上に置かれた蛍光サンプルを分析するための装置および方法
US7630072B2 (en) * 2007-06-20 2009-12-08 Carestream Health, Inc. Fluorescence calibrator for multiple band flat field correction
JP5094484B2 (ja) * 2008-03-11 2012-12-12 富士フイルム株式会社 蛍光検出方法および蛍光検出装置
JP5239442B2 (ja) * 2008-03-25 2013-07-17 コニカミノルタオプティクス株式会社 蛍光試料の光学特性測定方法および装置
US20100032582A1 (en) * 2008-08-07 2010-02-11 General Electric Company Fluorescence detection system and method
CN102150035A (zh) * 2008-09-19 2011-08-10 三井造船株式会社 采用强度调制激光的荧光检测装置和荧光检测方法
JP5558178B2 (ja) * 2010-04-07 2014-07-23 オリンパス株式会社 蛍光観察装置
JP5487150B2 (ja) * 2011-03-31 2014-05-07 富士フイルム株式会社 光学的測定方法および光学的測定装置
JP2013200125A (ja) * 2012-03-23 2013-10-03 Mitsui Eng & Shipbuild Co Ltd 蛍光検出装置及び蛍光検出方法
JP5944843B2 (ja) * 2013-02-04 2016-07-05 浜松ホトニクス株式会社 分光測定装置及び分光測定方法
CA2904031A1 (en) * 2013-03-14 2014-10-02 Profusa, Inc. Method and device for correcting optical signals
US10031063B2 (en) * 2013-07-23 2018-07-24 Sony Corporation Particle analysis apparatus and method for optically detecting particles
TW201512648A (zh) * 2013-09-27 2015-04-01 Frank Jiann-Fu Yang 智慧型自動化化學物質定性及定量之檢測裝置及檢測方法
FR3036187B1 (fr) * 2015-05-12 2019-09-13 Commissariat A L'energie Atomique Et Aux Energies Alternatives Procede de correction d’une image de fluorescence
KR102444477B1 (ko) * 2016-05-19 2022-09-16 후지 덴키 가부시키가이샤 수질 분석계
US10401605B2 (en) * 2017-05-02 2019-09-03 SCREEN Holdings, Co., Ltd. Structured illumination in inverted light sheet microscopy
CN112912715B (zh) * 2018-10-25 2024-08-09 浜松光子学株式会社 光学测定装置及光学测定方法
JP6923702B1 (ja) * 2020-04-01 2021-08-25 浜松ホトニクス株式会社 光学測定装置及び光学測定方法

Also Published As

Publication number Publication date
EP4123291A4 (en) 2024-04-24
WO2021199605A1 (ja) 2021-10-07
JP2021162509A (ja) 2021-10-11
KR20220159971A (ko) 2022-12-05
US20230124819A1 (en) 2023-04-20
TW202141022A (zh) 2021-11-01
JP7348933B2 (ja) 2023-09-21
TWI895383B (zh) 2025-09-01
CN115398210B (zh) 2025-11-07
EP4123291A1 (en) 2023-01-25
JP2021179447A (ja) 2021-11-18
CN115398210A (zh) 2022-11-25

Similar Documents

Publication Publication Date Title
JP6931730B1 (ja) 光学測定装置及び光学測定方法
JP7021288B2 (ja) 光学測定装置及び光学測定方法
JP6923702B1 (ja) 光学測定装置及び光学測定方法
TW200844439A (en) Method for measuring immunochromato test piece
JP2001194305A (ja) 蛍光相関分光解析装置
KR101774886B1 (ko) 자동초점 면역 크로마토그래피 고감도 검출 시스템
TWI906930B (zh) 光學測定方法
JP2002310881A (ja) 走査型近接場顕微鏡
JP2025023485A (ja) 光学測定装置及び光学測定方法
JP2010091428A (ja) 走査光学系
JP2000206047A (ja) スペクトル測定装置
JPH10186241A (ja) 暗視野落射顕微鏡装置
JPH11133152A (ja) 光距離計測装置
JP2006300857A (ja) 蛍光検出装置の調整用装置、蛍光検出装置の調整方法および製造方法
JPH04294256A (ja) フォトルミネッセンス測定装置

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20210608

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20210608

A871 Explanation of circumstances concerning accelerated examination

Free format text: JAPANESE INTERMEDIATE CODE: A871

Effective date: 20210608

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20210803

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20210816

R150 Certificate of patent or registration of utility model

Ref document number: 6931730

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250