JP6925970B2 - 副甲状腺機能低下症の治療 - Google Patents

副甲状腺機能低下症の治療 Download PDF

Info

Publication number
JP6925970B2
JP6925970B2 JP2017541786A JP2017541786A JP6925970B2 JP 6925970 B2 JP6925970 B2 JP 6925970B2 JP 2017541786 A JP2017541786 A JP 2017541786A JP 2017541786 A JP2017541786 A JP 2017541786A JP 6925970 B2 JP6925970 B2 JP 6925970B2
Authority
JP
Japan
Prior art keywords
pth
composition
snac
protease inhibitor
administration
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2017541786A
Other languages
English (en)
Japanese (ja)
Other versions
JP2018504445A (ja
JP2018504445A5 (enExample
Inventor
グレゴリー バーシュテイン
グレゴリー バーシュテイン
アリエル ロスナー
アリエル ロスナー
フィリップ エム シュワルツ
フィリップ エム シュワルツ
ヒレル ガリッツァー
ヒレル ガリッツァー
Original Assignee
エンテラ バイオ エルティーディー．
エンテラ バイオ エルティーディー．
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by エンテラ バイオ エルティーディー．, エンテラ バイオ エルティーディー． filed Critical エンテラ バイオ エルティーディー．
Publication of JP2018504445A publication Critical patent/JP2018504445A/ja
Publication of JP2018504445A5 publication Critical patent/JP2018504445A5/ja
Priority to JP2021128296A priority Critical patent/JP2021176914A/ja
Application granted granted Critical
Publication of JP6925970B2 publication Critical patent/JP6925970B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/29—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2886—Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Nutrition Science (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Physiology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Display Devices Of Pinball Game Machines (AREA)
  • Superconductors And Manufacturing Methods Therefor (AREA)
JP2017541786A 2015-02-09 2016-02-09 副甲状腺機能低下症の治療 Active JP6925970B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2021128296A JP2021176914A (ja) 2015-02-09 2021-08-04 副甲状腺機能低下症の治療

Applications Claiming Priority (15)

Application Number Priority Date Filing Date Title
US201562113625P 2015-02-09 2015-02-09
US201562113604P 2015-02-09 2015-02-09
US201562113600P 2015-02-09 2015-02-09
US201562113629P 2015-02-09 2015-02-09
US201562113619P 2015-02-09 2015-02-09
US201562113638P 2015-02-09 2015-02-09
US201562113673P 2015-02-09 2015-02-09
US62/113,638 2015-02-09
US62/113,600 2015-02-09
US62/113,673 2015-02-09
US62/113,625 2015-02-09
US62/113,619 2015-02-09
US62/113,629 2015-02-09
US62/113,604 2015-02-09
PCT/IL2016/050151 WO2016128970A1 (en) 2015-02-09 2016-02-09 Treatment of hypoparathyroidism

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2021128296A Division JP2021176914A (ja) 2015-02-09 2021-08-04 副甲状腺機能低下症の治療

Publications (3)

Publication Number Publication Date
JP2018504445A JP2018504445A (ja) 2018-02-15
JP2018504445A5 JP2018504445A5 (enExample) 2019-03-07
JP6925970B2 true JP6925970B2 (ja) 2021-08-25

Family

ID=56614456

Family Applications (6)

Application Number Title Priority Date Filing Date
JP2017541786A Active JP6925970B2 (ja) 2015-02-09 2016-02-09 副甲状腺機能低下症の治療
JP2017541780A Active JP6925969B2 (ja) 2015-02-09 2016-02-09 医薬組成物
JP2021128296A Pending JP2021176914A (ja) 2015-02-09 2021-08-04 副甲状腺機能低下症の治療
JP2021128281A Active JP7275207B2 (ja) 2015-02-09 2021-08-04 骨粗鬆症の治療
JP2023015960A Active JP7775239B2 (ja) 2015-02-09 2023-02-06 骨粗鬆症の治療
JP2023078011A Pending JP2023100920A (ja) 2015-02-09 2023-05-10 副甲状腺機能低下症の治療

Family Applications After (5)

Application Number Title Priority Date Filing Date
JP2017541780A Active JP6925969B2 (ja) 2015-02-09 2016-02-09 医薬組成物
JP2021128296A Pending JP2021176914A (ja) 2015-02-09 2021-08-04 副甲状腺機能低下症の治療
JP2021128281A Active JP7275207B2 (ja) 2015-02-09 2021-08-04 骨粗鬆症の治療
JP2023015960A Active JP7775239B2 (ja) 2015-02-09 2023-02-06 骨粗鬆症の治療
JP2023078011A Pending JP2023100920A (ja) 2015-02-09 2023-05-10 副甲状腺機能低下症の治療

Country Status (9)

Country Link
US (8) US20180028622A1 (enExample)
EP (5) EP3256153A4 (enExample)
JP (6) JP6925970B2 (enExample)
CN (5) CN114949185A (enExample)
CA (5) CA3011654A1 (enExample)
HK (5) HK1247838A1 (enExample)
IL (7) IL303216A (enExample)
MX (2) MX2017010220A (enExample)
WO (5) WO2016128971A1 (enExample)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2600440C3 (ru) 2010-12-16 2021-12-10 Ново Нордиск А/С Твердые композиции, содержащие агонист glp-1 и соль n-(8-(2-гидроксибензоил)амино)каприловой кислоты
CA2832811A1 (en) 2011-04-12 2012-10-18 Novo Nordisk A/S Double-acylated glp-1 derivatives
US10933120B2 (en) 2012-03-22 2021-03-02 Novo Nordisk A/S Compositions of GLP-1 peptides and preparation thereof
ES2715308T3 (es) 2012-03-22 2019-06-03 Novo Nordisk As Composiciones que comprenden un agente de suministro y su preparación
ES2871328T3 (es) 2012-06-20 2021-10-28 Novo Nordisk As Formulación de comprimido que comprende un péptido y un agente de suministro
AU2014261336B2 (en) 2013-05-02 2019-02-28 Novo Nordisk A/S Oral dosing of GLP-1 compounds
CN114949185A (zh) 2015-02-09 2022-08-30 安特拉贝欧有限公司 骨质疏松症的治疗
NZ751668A (en) * 2016-08-17 2022-07-29 Entera Bio Ltd Formulations for oral administration of active agents
BR112020014624A2 (pt) * 2018-02-02 2020-12-08 Novo Nordisk A/S Composições sólidas compreendendo agonista de glp-1, sal de ácido n-(8-(2-hidroxibenzoil) amino)caprílico e lubrificante
TWI821541B (zh) * 2019-03-08 2023-11-11 奧孟亞股份有限公司 Pth類似物之口服製劑及治療
CA3152944A1 (en) * 2019-09-03 2021-03-11 Amgen Inc. Il-22 oral, intra-rectal, or other gut-related compositions and methods of use thereof
CN114306249A (zh) * 2020-09-28 2022-04-12 深圳翰宇药业股份有限公司 一种特立帕肽冻干药物组合物及其制备方法
US12251208B2 (en) * 2020-11-30 2025-03-18 International Business Machines Corporation Time controlled medication
CN114288388B (zh) * 2022-01-25 2023-11-03 华中科技大学同济医学院附属协和医院 网膜素在制备炎症性肠病治疗药物中的应用
MX2024010389A (es) * 2022-02-24 2024-09-04 Entera Bio Ltd Formulaciones que comprenden un polimero neutralizante de acido para la administracion oral de hormona paratiroidea.
WO2023161936A1 (en) * 2022-02-24 2023-08-31 Entera Bio Ltd. Formulations comprising acid-neutralizing polymer for oral administration of growth hormone-releasing hormone
WO2023161935A1 (en) * 2022-02-24 2023-08-31 Entera Bio Ltd. Formulations comprising acid-neutralizing polymer for oral administration of growth hormone
CA3251865A1 (en) * 2022-02-24 2023-08-31 Entera Bio Ltd FORMULATIONS COMPRISING AN ACID-NEUTRALIZING POLYMER FOR ORAL ADMINISTRATION OF GLUCAGON-TYPE PEPTIDE-2
JP2025506821A (ja) * 2022-02-24 2025-03-13 エンテラ バイオ エルティーディー． 活性薬剤の経口投与用の酸中和ポリマーを含む製剤
EP4482514A1 (en) * 2022-02-24 2025-01-01 Entera Bio Ltd. Formulations comprising acid-neutralizing polymer for oral administration of glucagon-like peptide-1 and analogs thereof
WO2023161938A1 (en) * 2022-02-24 2023-08-31 Entera Bio Ltd. Formulations comprising acid-neutralizing polymer for oral administration of kappa opioid receptor agonist peptide
WO2025046590A1 (en) * 2023-08-30 2025-03-06 Entera Bio Ltd. Formulations for oral administration of active agents
WO2025046589A1 (en) * 2023-08-30 2025-03-06 Entera Bio Ltd. Formulations comprising a combination of acid-neutralizing polymeric and non-polymeric substances for oral administration of active agents
WO2025146144A1 (zh) * 2024-01-05 2025-07-10 成都国为生物医药有限公司 一种地非法林的口服药物组合物
US12466883B1 (en) 2024-05-13 2025-11-11 Lumen Bioscience, Inc. Leptin compositions and methods of making and using the same to support weight loss and/or maintenance

Family Cites Families (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5360793A (en) * 1993-05-24 1994-11-01 Sterling Winthrop Inc. Rafting antacid formulation
CN1162917A (zh) * 1994-10-07 1997-10-22 伯温德药品服务公司 肠内涂层组合物，用其涂覆的方法和涂覆制品
US5650386A (en) 1995-03-31 1997-07-22 Emisphere Technologies, Inc. Compositions for oral delivery of active agents
CA2220301C (en) * 1995-06-02 2006-02-21 Alza Corporation Osmotic device with delayed activation of drug delivery and complete drug release
JP3880093B2 (ja) 1995-08-08 2007-02-14 エーザイ・アール・アンド・ディー・マネジメント株式会社 錠剤
JP3220373B2 (ja) 1995-11-28 2001-10-22 バイエル薬品株式会社 持続性ニフエジピン製剤
IT1282650B1 (it) * 1996-02-19 1998-03-31 Jagotec Ag Compressa farmaceutica,caratterizzata da elevato aumento di volume a contatto con liquidi biologici
WO1998009645A1 (en) 1996-09-04 1998-03-12 Dott Research Laboratory Peptide-containing drug compositions for oral administration
CA2290443A1 (en) 1997-05-14 1998-11-19 Rhone-Poulenc Rorer Pharmaceuticals Inc. Peptide parathyroid hormone analogs
US6531152B1 (en) 1998-09-30 2003-03-11 Dexcel Pharma Technologies Ltd. Immediate release gastrointestinal drug delivery system
WO2000048589A1 (en) * 1999-02-22 2000-08-24 Emisphere Holdings, Inc. Solid oral dosage form containing heparin or a heparinoid in combination with a carrier
EP1163209A4 (en) 1999-02-26 2004-12-29 Emisphere Tech Inc COMPOUNDS AND COMPOSITIONS FOR ADMINISTRATION OF ACTIVE INGREDIENTS
DE60017888T2 (de) 1999-04-05 2006-01-19 Emisphere Technologies, Inc. Dinatrium-salze, monohydrate und ethanol-solvate
US6632451B2 (en) 1999-06-04 2003-10-14 Dexcel Pharma Technologies Ltd. Delayed total release two pulse gastrointestinal drug delivery system
WO2001032130A2 (en) 1999-11-05 2001-05-10 Emisphere Technologies, Inc. Phenyl amine carboxylic acid compounds and compositions for delivering active agents
AU2226901A (en) * 1999-12-28 2001-07-09 Ajinomoto Co., Inc. Oral preparations for diabetes
ATE443527T1 (de) * 2001-08-17 2009-10-15 Novartis Pharma Gmbh 5-cnac zur oralen verabreichung von parathormonfragmenten
MXPA04004567A (es) 2001-11-13 2004-09-10 Emisphere Tech Inc Compuestos y composiciones de fenoxi amina para adminstrar agentes activos.
US20040259952A1 (en) * 2001-11-29 2004-12-23 Richat Abbas Formulations for oral administration of cromolyn sodium
CN1606434A (zh) 2001-12-19 2005-04-13 株式会社三和化学研究所 控制释放成型品
US20030198666A1 (en) 2002-01-07 2003-10-23 Richat Abbas Oral insulin therapy
US20050054557A1 (en) 2002-05-09 2005-03-10 Goldberg Michael M. Compositions for delivering parathyroid hormone and calcitonin
AR040737A1 (es) 2002-08-01 2005-04-20 Novartis Ag Administracion oral de calcitonina
JP2007525472A (ja) * 2003-07-04 2007-09-06 ニコメド ダンマーク エイピーエス 経口使用のための副甲状腺ホルモン（ｐｔｈ）含有医薬組成物
JP2005281231A (ja) 2004-03-30 2005-10-13 Bioserentack Co Ltd 小腸ターゲットタイプの経口ｄｄｓ製剤
US20060052306A1 (en) * 2004-05-10 2006-03-09 Nastech Pharmaceutical Company Inc. GRAS composition for enhanced mucosal delivery of parathyroid hormone
EP1781257B1 (en) 2004-08-13 2018-12-19 Emisphere Technologies, Inc. Pharmaceutical formulations containing microparticles or nanoparticles of a delivery agent
JP2006111558A (ja) 2004-10-14 2006-04-27 Bioserentack Co Ltd 多層構造を有する錠剤状の小腸粘膜付着性経口製剤
NZ555244A (en) 2004-11-19 2010-06-25 Smithkline Beecham Corp Manufacture process for pharmaceutical product allowing delivery of a plurality of active agents
US8110547B2 (en) 2005-01-12 2012-02-07 Emisphere Technologies, Inc. Compositions for buccal delivery of parathyroid hormone
ES2540929T3 (es) 2005-02-01 2015-07-14 Emisphere Technologies, Inc. Sistema de administración de retención gástrica y liberación controlada
US8673352B2 (en) 2005-04-15 2014-03-18 Mcneil-Ppc, Inc. Modified release dosage form
JP5123471B2 (ja) 2005-08-18 2013-01-23 帝人ファーマ株式会社 用量調整が容易な製剤
CA2621577C (en) 2005-09-06 2013-12-24 Oramed Pharmaceuticals, Inc. Methods and compositions for oral administration of proteins
US20080255048A1 (en) 2005-11-17 2008-10-16 Moise Azria Pharmaceutical Composition
US20070178155A1 (en) * 2006-01-31 2007-08-02 Jiang David Yihai Preparation for gastric buoyant sustained drug release dosage form
BRPI0710503A2 (pt) 2006-04-07 2011-08-16 Merrion Res Iii Ltd uso de uma composição farmacêutica, composição farmacêutica, e, forma de dosagem oral
US8927015B2 (en) 2006-04-12 2015-01-06 Emisphere Technologies, Inc. Formulations for delivering insulin
US8703821B2 (en) 2006-04-18 2014-04-22 Emisphere Technologies Inc. Dialkyl ether delivery agents
JP4642115B2 (ja) * 2006-12-12 2011-03-02 株式会社堀場エステック 流量比率制御装置
EP2380564B1 (en) 2007-04-04 2014-10-22 Sigmoid Pharma Limited An oral pharmaceutical composition
WO2008132727A2 (en) 2007-04-26 2008-11-06 Technion Research And Development Foundation Ltd Oral delivery of proteins and peptides
CN101801353A (zh) * 2007-09-11 2010-08-11 奥拉黑尔斯公司 具有用于治疗咽喉、食管和胃的局部活性成分的粘附性锭剂
WO2009080764A2 (en) * 2007-12-20 2009-07-02 Abylnx N.V. Oral or nasal administration of compounds comprising amino acid sequences
IT1393244B1 (it) 2008-07-18 2012-04-12 Universita' Degli Studi Di Milano Sistema per il rilascio al colon di farmaci suscettibili di degradazione enzimatica e/o scarsamente assorbiti nel tratto gastrointestinale
RU2494755C2 (ru) * 2008-08-18 2013-10-10 Интера Био Лтд. Способы и композиции для перорального введения белков
US20110182985A1 (en) 2010-01-28 2011-07-28 Coughlan David C Solid Pharmaceutical Composition with Enhancers and Methods of Preparing thereof
AU2011239935A1 (en) 2010-04-16 2012-11-08 Novartis Ag Methods and compositions for improving implant osseointegration
RU2600440C3 (ru) * 2010-12-16 2021-12-10 Ново Нордиск А/С Твердые композиции, содержащие агонист glp-1 и соль n-(8-(2-гидроксибензоил)амино)каприловой кислоты
WO2013032934A1 (en) 2011-08-26 2013-03-07 Aegis Therapeutics, Llc Compositions and methods thereof for oral administration of drugs
WO2013067309A1 (en) 2011-11-04 2013-05-10 Xion Pharmaceutical Corporation Methods and compositions for oral administration of melanocortin receptor agonist compounds
ES2871328T3 (es) 2012-06-20 2021-10-28 Novo Nordisk As Formulación de comprimido que comprende un péptido y un agente de suministro
CN114949185A (zh) 2015-02-09 2022-08-30 安特拉贝欧有限公司 骨质疏松症的治疗
NZ751668A (en) 2016-08-17 2022-07-29 Entera Bio Ltd Formulations for oral administration of active agents
JP7419862B2 (ja) 2020-02-14 2024-01-23 株式会社リコー 潤滑剤供給装置、プロセスカートリッジ、及び、画像形成装置

Also Published As

Publication number Publication date
EP3256149A4 (en) 2019-08-14
US20180036234A1 (en) 2018-02-08
EP3256114A1 (en) 2017-12-20
CN114949185A (zh) 2022-08-30
CN113713090B (zh) 2023-06-02
CN113694190A (zh) 2021-11-26
JP2023100920A (ja) 2023-07-19
IL283258B2 (en) 2023-11-01
JP2023055902A (ja) 2023-04-18
IL253803B (en) 2021-06-30
MX2022014313A (es) 2022-12-07
IL292417B2 (en) 2024-12-01
BR112017017112A2 (pt) 2018-04-03
JP7775239B2 (ja) 2025-11-25
CA3011657A1 (en) 2016-08-18
WO2016128973A1 (en) 2016-08-18
HK1247838A1 (zh) 2018-10-05
CA2975710C (en) 2023-08-08
EP3256152A4 (en) 2018-11-14
JP7275207B2 (ja) 2023-05-17
US20180050096A1 (en) 2018-02-22
IL253804A0 (en) 2017-09-28
WO2016128972A1 (en) 2016-08-18
IL253802A0 (en) 2017-09-28
US20180036382A1 (en) 2018-02-08
IL292218A (en) 2022-06-01
IL283258A (en) 2021-07-29
EP3256113A4 (en) 2018-11-14
IL292218B1 (en) 2024-06-01
EP3256152A1 (en) 2017-12-20
IL253802B (en) 2022-06-01
CA2975578A1 (en) 2016-08-18
IL253803A0 (en) 2017-09-28
IL253804B (en) 2022-05-01
CA3011654A1 (en) 2016-08-18
HK1247823A1 (zh) 2018-10-05
JP2018504445A (ja) 2018-02-15
WO2016128970A1 (en) 2016-08-18
WO2016128974A1 (en) 2016-08-18
IL292218B2 (en) 2024-10-01
HK1247835A1 (zh) 2018-10-05
EP3256153A1 (en) 2017-12-20
JP2021176913A (ja) 2021-11-11
EP3256114A4 (en) 2018-11-21
US20200138913A1 (en) 2020-05-07
IL303216A (en) 2023-07-01
US12076373B2 (en) 2024-09-03
MX2017010220A (es) 2018-02-21
IL283258B1 (en) 2023-07-01
HK1247843A1 (zh) 2018-10-05
JP2018504444A (ja) 2018-02-15
US20240398904A1 (en) 2024-12-05
IL292417A (en) 2022-06-01
CN113730556A (zh) 2021-12-03
EP3256113B1 (en) 2025-04-02
CN113694190B (zh) 2024-05-07
EP3256113A1 (en) 2017-12-20
JP2021176914A (ja) 2021-11-11
CN113713090A (zh) 2021-11-30
US20180028622A1 (en) 2018-02-01
CA2975676A1 (en) 2016-08-18
EP3256149A1 (en) 2017-12-20
US10583177B2 (en) 2020-03-10
JP6925969B2 (ja) 2021-08-25
WO2016128971A1 (en) 2016-08-18
CN107427481A (zh) 2017-12-01
HK1247822A1 (zh) 2018-10-05
US20240181020A1 (en) 2024-06-06
CA2975710A1 (en) 2016-08-18
EP3256153A4 (en) 2018-11-21
IL292417B1 (en) 2024-08-01
US20180021272A1 (en) 2018-01-25

Similar Documents

Publication Publication Date Title
JP6925970B2 (ja) 副甲状腺機能低下症の治療
JP2004525123A (ja) 経口ペプチド医薬投与形および製造方法
JP2011518148A (ja) カルビドパ／レボドパ胃内滞留性薬物供給
WO2014116871A1 (en) Methods and pharmaceutical compositions for treating celiac disease and gluten intolerance
JP2011528344A (ja) 胃腸管において酵素分解に付される、および／または吸収されにくい薬剤の結腸への送達系
KR20060083198A (ko) 위산 분비의 억제를 필요로하는 병상의 치료를 위한 조성물
HK40064924B (en) Treatment of osteoporosis
HK40064568B (zh) 骨质疏松症的治疗
HK40078392A (en) Treatment of osteoporosis
HK40064924A (en) Treatment of osteoporosis
HK40064568A (en) Treatment of osteoporosis
HK40064572A (en) Treatment of osteoporosis
EP3666262A1 (en) Pharmaceutical oral dosage forms for treatment of metabolic disorders and related diseases through orchestrated release of enterokines
BR112017017112B1 (pt) Composição farmacêutica
JP2007506730A (ja) ペンタガストリンを含む胃酸分泌刺激用経口組成物

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20171005

RD01 Notification of change of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7426

Effective date: 20171004

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20190128

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20190128

RD02 Notification of acceptance of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7422

Effective date: 20190710

RD04 Notification of resignation of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7424

Effective date: 20190819

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20191007

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20191015

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20200109

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20200414

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20201006

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20201223

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20210402

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20210706

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20210804

R150 Certificate of patent or registration of utility model

Ref document number: 6925970

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250