JP6916185B2 - Ｂｔｋ阻害剤としてのイソキノロン類 - Google Patents
Ｂｔｋ阻害剤としてのイソキノロン類 Download PDFInfo
- Publication number
- JP6916185B2 JP6916185B2 JP2018536252A JP2018536252A JP6916185B2 JP 6916185 B2 JP6916185 B2 JP 6916185B2 JP 2018536252 A JP2018536252 A JP 2018536252A JP 2018536252 A JP2018536252 A JP 2018536252A JP 6916185 B2 JP6916185 B2 JP 6916185B2
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- JP
- Japan
- Prior art keywords
- mmol
- formula
- pharmaceutically acceptable
- compounds
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 0 *Cc(c(Br)ccc1)c1N Chemical compound *Cc(c(Br)ccc1)c1N 0.000 description 5
- WMKXKTBMKMFGMR-BQYQJAHWSA-N CC(C(N)=O)N(C)/C=C(\C)/C(C)(C)C Chemical compound CC(C(N)=O)N(C)/C=C(\C)/C(C)(C)C WMKXKTBMKMFGMR-BQYQJAHWSA-N 0.000 description 1
- YASSJEIIZFGGTD-UHFFFAOYSA-N CC1=C=CNC=C1 Chemical compound CC1=C=CNC=C1 YASSJEIIZFGGTD-UHFFFAOYSA-N 0.000 description 1
- BFPUVKWJCDKPJU-UHFFFAOYSA-N Cc1c(C(O)=O)c(F)cc(C2CC2)c1 Chemical compound Cc1c(C(O)=O)c(F)cc(C2CC2)c1 BFPUVKWJCDKPJU-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662278085P | 2016-01-13 | 2016-01-13 | |
| US62/278,085 | 2016-01-13 | ||
| PCT/US2017/013100 WO2017123695A1 (en) | 2016-01-13 | 2017-01-12 | Isoquinolones as btk inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019501927A JP2019501927A (ja) | 2019-01-24 |
| JP2019501927A5 JP2019501927A5 (https=) | 2020-02-13 |
| JP6916185B2 true JP6916185B2 (ja) | 2021-08-11 |
Family
ID=57907002
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018536252A Active JP6916185B2 (ja) | 2016-01-13 | 2017-01-12 | Ｂｔｋ阻害剤としてのイソキノロン類 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US10570118B2 (https=) |
| EP (1) | EP3402789B1 (https=) |
| JP (1) | JP6916185B2 (https=) |
| WO (1) | WO2017123695A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108884068B (zh) * | 2016-03-24 | 2021-02-26 | 特殊治疗有限公司 | 作为dub抑制剂的1-氰基-吡咯烷衍生物 |
| WO2018119142A1 (en) | 2016-12-21 | 2018-06-28 | Amgen Inc. | Anti-tnf alpha antibody formulations |
| EA202192575A1 (ru) | 2019-03-21 | 2022-01-14 | Онксео | Соединения dbait в сочетании с ингибиторами киназ для лечения рака |
| WO2020234103A1 (en) * | 2019-05-21 | 2020-11-26 | Bayer Aktiengesellschaft | Identification and use of kras inhibitors |
| BR112021023110A2 (pt) * | 2019-05-23 | 2022-04-12 | Novartis Ag | Métodos de tratamento de síndrome de sjögren com o uso de um inibidor de tirosina quinase de bruton |
| CN114761006A (zh) | 2019-11-08 | 2022-07-15 | Inserm(法国国家健康医学研究院) | 对激酶抑制剂产生耐药性的癌症的治疗方法 |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
| US20240100172A1 (en) | 2020-12-21 | 2024-03-28 | Hangzhou Jijing Pharmaceutical Technology Limited | Methods and compounds for targeted autophagy |
| CN115650851A (zh) * | 2022-11-10 | 2023-01-31 | 无锡双启科技有限公司 | 一种2-氟-4-溴-6-甲基苯甲酸甲酯的制备方法 |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9608435D0 (en) | 1996-04-24 | 1996-06-26 | Celltech Therapeutics Ltd | Chemical compounds |
| ATE325608T1 (de) | 2001-08-13 | 2006-06-15 | Janssen Pharmaceutica Nv | 2,4,5-trisubstituted thiazolyl derivative und deren antiinflammatorische wirkung |
| EP1436265A4 (en) | 2001-09-27 | 2004-12-15 | Smithkline Beecham Corp | CHEMICALS |
| FR2881426B1 (fr) | 2005-02-03 | 2007-03-30 | Aventis Pharma Sa | Pyrolles et imidazoles substitues, compositions les contenant, procede de frabrication et utilisation |
| CA2648923A1 (en) | 2006-04-11 | 2007-10-18 | Vertex Pharmaceuticals Incorporated | Thiazoles, imidazoles, and pyrazoles useful as inhibitors of protein kinases |
| DK2526933T3 (en) | 2006-09-22 | 2015-05-18 | Pharmacyclics Inc | Inhibitors of Bruton's tyrosine kinase |
| SG10202107066WA (en) | 2007-03-28 | 2021-07-29 | Pharmacyclics Llc | Inhibitors of bruton's tyrosine kinase |
| PL2242749T3 (pl) * | 2008-02-05 | 2013-09-30 | Hoffmann La Roche | Nowe pirydynony i pirydazynony |
| PH12012502374A1 (en) * | 2008-06-24 | 2014-11-12 | Hoffmann La Roche | Novel substituted pyridin-2-ones and pyridazin-3-ones |
| ES2445099T3 (es) | 2008-07-29 | 2014-02-28 | Université de Liège | Una prueba de marcador genético para braquispina y fertilidad en ganado vacuno |
| GB0820819D0 (en) | 2008-11-13 | 2008-12-24 | Sareum Ltd | Pharmaceutical compounds |
| WO2010090716A1 (en) | 2009-01-30 | 2010-08-12 | Millennium Pharmaceuticals, Inc. | Heteroaryls and their use as pi3k inhibitors |
| US8299077B2 (en) * | 2009-03-02 | 2012-10-30 | Roche Palo Alto Llc | Inhibitors of Bruton's tyrosine kinase |
| CA2784647A1 (en) | 2009-12-17 | 2011-07-14 | Merck Patent Gmbh | Inhibitors of sphingosine kinase |
| TWI500617B (zh) | 2010-05-31 | 2015-09-21 | Ono Pharmaceutical Co | Purine ketone derivatives |
| US8859768B2 (en) | 2010-08-11 | 2014-10-14 | Millennium Pharmaceuticals, Inc. | Heteroaryls and uses thereof |
| AU2012257802A1 (en) * | 2011-05-17 | 2013-10-31 | F. Hoffmann-La Roche Ag | Inhibitors of Bruton's tyrosine kinase |
| US8377946B1 (en) | 2011-12-30 | 2013-02-19 | Pharmacyclics, Inc. | Pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine compounds as kinase inhibitors |
| CN104080789B (zh) | 2012-01-31 | 2016-05-11 | 南京奥昭生物科技有限公司 | 作为布鲁顿酪氨酸激酶抑制剂的环状分子 |
| JP6182593B2 (ja) * | 2012-04-20 | 2017-08-16 | アドヴィーナス セラピューティクス リミテッド | 置換ヘテロ二環化合物、組成物及び医薬並びにそれらの用途 |
| SG11201500499TA (en) | 2012-08-10 | 2015-03-30 | Boehringer Ingelheim Int | Heteroaromatic compounds as bruton's tyrosine kinase (btk) inhibitors |
| WO2014040965A1 (en) | 2012-09-13 | 2014-03-20 | F. Hoffmann-La Roche Ag | Inhibitors of bruton's tyrosine kinase |
| KR101668574B1 (ko) | 2012-11-02 | 2016-10-24 | 화이자 인코포레이티드 | 브루톤 티로신 키나제 억제제 |
| CN103848810A (zh) | 2012-11-30 | 2014-06-11 | 北京赛林泰医药技术有限公司 | 鲁顿酪氨酸激酶抑制剂 |
| CN105745202A (zh) * | 2013-09-03 | 2016-07-06 | 卡尔那生物科学株式会社 | 新型2,6-二氨基嘧啶衍生物 |
| WO2015050703A1 (en) * | 2013-10-04 | 2015-04-09 | Yi Chen | Inhibitors of bruton's tyrosine kinase |
| JP6486954B2 (ja) | 2014-01-29 | 2019-03-20 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｂｔｋ阻害剤としてのピラゾール化合物 |
| LT3390390T (lt) | 2015-12-16 | 2021-11-25 | Boehringer Ingelheim International Gmbh | Bipirazolilo dariniai, tinkami naudoti autoimuninių ligų gydymui |
-
2017
- 2017-01-12 US US16/069,046 patent/US10570118B2/en active Active
- 2017-01-12 JP JP2018536252A patent/JP6916185B2/ja active Active
- 2017-01-12 WO PCT/US2017/013100 patent/WO2017123695A1/en not_active Ceased
- 2017-01-12 EP EP17701778.7A patent/EP3402789B1/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| WO2017123695A1 (en) | 2017-07-20 |
| EP3402789B1 (en) | 2020-03-18 |
| JP2019501927A (ja) | 2019-01-24 |
| EP3402789A1 (en) | 2018-11-21 |
| US20190023686A1 (en) | 2019-01-24 |
| US10570118B2 (en) | 2020-02-25 |
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