JP6909156B2 - 化学ライゲーション及びハプテン移行を用いた近接アッセイ - Google Patents

化学ライゲーション及びハプテン移行を用いた近接アッセイ Download PDF

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JP6909156B2
JP6909156B2 JP2017527719A JP2017527719A JP6909156B2 JP 6909156 B2 JP6909156 B2 JP 6909156B2 JP 2017527719 A JP2017527719 A JP 2017527719A JP 2017527719 A JP2017527719 A JP 2017527719A JP 6909156 B2 JP6909156 B2 JP 6909156B2
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antibody
chemical ligation
group
binding molecule
cross
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JP2017536548A5 (enExample
JP2017536548A (ja
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クリストファー ビーニアーツ，
クリストファー ビーニアーツ，
ルイ ホン，
ルイ ホン，
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ヴェンタナ メディカル システムズ， インク．
ヴェンタナ メディカル システムズ， インク．
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54353—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2440/00—Post-translational modifications [PTMs] in chemical analysis of biological material

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP2017527719A 2014-11-25 2015-11-24 化学ライゲーション及びハプテン移行を用いた近接アッセイ Active JP6909156B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462084452P 2014-11-25 2014-11-25
US62/084,452 2014-11-25
US201562116962P 2015-02-17 2015-02-17
US62/116,962 2015-02-17
PCT/EP2015/077484 WO2016083364A1 (en) 2014-11-25 2015-11-24 Proximity assays using chemical ligation and hapten transfer

Publications (3)

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JP2017536548A JP2017536548A (ja) 2017-12-07
JP2017536548A5 JP2017536548A5 (enExample) 2020-01-16
JP6909156B2 true JP6909156B2 (ja) 2021-07-28

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JP2017527719A Active JP6909156B2 (ja) 2014-11-25 2015-11-24 化学ライゲーション及びハプテン移行を用いた近接アッセイ

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US (3) US10620217B2 (enExample)
EP (1) EP3224621B1 (enExample)
JP (1) JP6909156B2 (enExample)
CN (1) CN107003323B (enExample)
AU (1) AU2015352625B2 (enExample)
CA (1) CA2965872C (enExample)
DK (1) DK3224621T3 (enExample)
WO (1) WO2016083364A1 (enExample)

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EP3555622B1 (en) * 2016-12-19 2023-02-22 Ventana Medical Systems, Inc. Methods and systems for quantitative immunohistochemistry
GB2562721A (en) 2017-05-16 2018-11-28 Fastbase Solutions Ltd Kits, methods and their uses for detecting cell-cell interactions in a sample
WO2019200326A1 (en) 2018-04-13 2019-10-17 Rarecyte, Inc. Kits for labeling of biomarkers and methods of using the same
ES3047385T3 (en) * 2018-06-11 2025-12-03 Merck Sharp & Dohme Llc Cut vertex method for identifying complex molecule substructures
WO2020102094A1 (en) * 2018-11-15 2020-05-22 Arizona Board Of Regents On Behalf Ofarizona State University Cleavable fluorescent tyramide for sensitive and multiplexed analysis of biological samples
EP4281779A1 (en) * 2021-01-25 2023-11-29 Ventana Medical Systems, Inc. Stained biological specimens including one or more biomarkers labeled with one or more detectable moieties
CN113552362B (zh) * 2021-07-23 2024-08-09 湖北百奥斯生物科技有限公司 一种新型信号放大的免疫荧光试剂盒
WO2023058624A1 (ja) * 2021-10-08 2023-04-13 コニカミノルタ株式会社 染色方法、評価方法および標本

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US4711955A (en) 1981-04-17 1987-12-08 Yale University Modified nucleotides and methods of preparing and using same
US5266684A (en) 1988-05-02 1993-11-30 The Reagents Of The University Of California Peptide mixtures
CH683667A5 (fr) 1992-02-26 1994-04-29 Nestle Sa Matière première aromatique.
US5654419A (en) 1994-02-01 1997-08-05 The Regents Of The University Of California Fluorescent labels and their use in separations
ATE214396T1 (de) 1995-06-21 2002-03-15 Martek Biosciences Corp Kombinatorische bibliotheken aus markierten biochemischen verbindungen und verfahren zu ihrer herstellung
US5661028A (en) 1995-09-29 1997-08-26 Lockheed Martin Energy Systems, Inc. Large scale DNA microsequencing device
US6444421B1 (en) * 1997-11-19 2002-09-03 The United States Of America As Represented By The Department Of Health And Human Services Methods for detecting intermolecular interactions in vivo and in vitro
EP1681983A4 (en) * 2003-10-14 2008-12-10 Monogram Biosciences Inc RECEPTOR TYROSINE KINASE SIGNAL PATH ANALYSIS FOR DIAGNOSIS AND THERAPY
WO2006116742A2 (en) 2005-04-28 2006-11-02 Ventana Medical Systems, Inc. Fluorescent nanoparticles conjugated to antibodies via a peg linker
JP5628476B2 (ja) 2005-04-28 2014-11-19 ベンタナ・メデイカル・システムズ・インコーポレーテツド 抗体コンジュゲート
ES2804129T3 (es) 2005-11-23 2021-02-03 Ventana Med Syst Inc Conjugado anticuerpo-enzima
DK3564674T3 (da) 2006-11-01 2021-10-18 Ventana Med Syst Inc Haptener, haptenkonjugater, sammensætninger deraf og fremgangsmåde til fremstilling og anvendelse deraf
EP2109689A4 (en) * 2007-02-07 2010-02-10 Perscitus Biosciences Llc DETECTION OF THE PROXIMITY OF A MOLECULE
EP2191275B1 (en) 2007-09-04 2012-08-08 Sanofi Identifying molecules that modulate protein- protein interactions using protease activated reporters
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CN101620233B (zh) * 2009-05-27 2012-10-31 华中科技大学 一种蛋白质相互作用的检测方法
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Publication number Publication date
DK3224621T3 (da) 2019-08-12
US20170254813A1 (en) 2017-09-07
US20200271662A1 (en) 2020-08-27
EP3224621B1 (en) 2019-06-12
AU2015352625A1 (en) 2017-04-20
CN107003323B (zh) 2019-06-04
US11808770B2 (en) 2023-11-07
WO2016083364A1 (en) 2016-06-02
US10620217B2 (en) 2020-04-14
AU2015352625B2 (en) 2019-07-25
CN107003323A (zh) 2017-08-01
CA2965872C (en) 2022-02-22
EP3224621A1 (en) 2017-10-04
CA2965872A1 (en) 2016-06-02
JP2017536548A (ja) 2017-12-07
US20240069034A1 (en) 2024-02-29

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