AU2015352625B2 - Proximity assays using chemical ligation and hapten transfer - Google Patents

Proximity assays using chemical ligation and hapten transfer Download PDF

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Publication number
AU2015352625B2
AU2015352625B2 AU2015352625A AU2015352625A AU2015352625B2 AU 2015352625 B2 AU2015352625 B2 AU 2015352625B2 AU 2015352625 A AU2015352625 A AU 2015352625A AU 2015352625 A AU2015352625 A AU 2015352625A AU 2015352625 B2 AU2015352625 B2 AU 2015352625B2
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chemical ligation
antibody
bridge component
cleavable bridge
binding molecule
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AU2015352625A
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AU2015352625A1 (en
Inventor
Christopher Bieniarz
Rui Hong
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Ventana Medical Systems Inc
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Ventana Medical Systems Inc
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54353—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent
    • G01N33/5759—
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2440/00—Post-translational modifications [PTMs] in chemical analysis of biological material

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AU2015352625A 2014-11-25 2015-11-24 Proximity assays using chemical ligation and hapten transfer Active AU2015352625B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462084452P 2014-11-25 2014-11-25
US62/084,452 2014-11-25
US201562116962P 2015-02-17 2015-02-17
US62/116,962 2015-02-17
PCT/EP2015/077484 WO2016083364A1 (en) 2014-11-25 2015-11-24 Proximity assays using chemical ligation and hapten transfer

Publications (2)

Publication Number Publication Date
AU2015352625A1 AU2015352625A1 (en) 2017-04-20
AU2015352625B2 true AU2015352625B2 (en) 2019-07-25

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
AU2015352625A Active AU2015352625B2 (en) 2014-11-25 2015-11-24 Proximity assays using chemical ligation and hapten transfer

Country Status (8)

Country Link
US (3) US10620217B2 (enExample)
EP (1) EP3224621B1 (enExample)
JP (1) JP6909156B2 (enExample)
CN (1) CN107003323B (enExample)
AU (1) AU2015352625B2 (enExample)
CA (1) CA2965872C (enExample)
DK (1) DK3224621T3 (enExample)
WO (1) WO2016083364A1 (enExample)

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CN107923915B (zh) 2015-08-28 2021-05-04 文塔纳医疗系统公司 使用经掩蔽的半抗原在福尔马林固定石蜡包埋的组织中的蛋白质邻近测定
WO2018118786A1 (en) * 2016-12-19 2018-06-28 Ventana Medical Systems, Inc. Methods and systems for quantitative immunohistochemistry
GB2562721A (en) * 2017-05-16 2018-11-28 Fastbase Solutions Ltd Kits, methods and their uses for detecting cell-cell interactions in a sample
WO2019200326A1 (en) 2018-04-13 2019-10-17 Rarecyte, Inc. Kits for labeling of biomarkers and methods of using the same
CN112567465B (zh) * 2018-06-11 2024-02-20 默沙东有限责任公司 复杂分子子结构的识别系统、装置和方法
WO2020102094A1 (en) * 2018-11-15 2020-05-22 Arizona Board Of Regents On Behalf Ofarizona State University Cleavable fluorescent tyramide for sensitive and multiplexed analysis of biological samples
EP4281779A1 (en) * 2021-01-25 2023-11-29 Ventana Medical Systems, Inc. Stained biological specimens including one or more biomarkers labeled with one or more detectable moieties
CN113552362B (zh) * 2021-07-23 2024-08-09 湖北百奥斯生物科技有限公司 一种新型信号放大的免疫荧光试剂盒
WO2023058624A1 (ja) * 2021-10-08 2023-04-13 コニカミノルタ株式会社 染色方法、評価方法および標本

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CH683667A5 (fr) 1992-02-26 1994-04-29 Nestle Sa Matière première aromatique.
US5654419A (en) 1994-02-01 1997-08-05 The Regents Of The University Of California Fluorescent labels and their use in separations
JPH11509086A (ja) 1995-06-21 1999-08-17 マーテック・バイオサイエンシズ・コーポレイション 標識生化学化合物の組合わせライブラリーとその作成方法
US5661028A (en) 1995-09-29 1997-08-26 Lockheed Martin Energy Systems, Inc. Large scale DNA microsequencing device
US6444421B1 (en) * 1997-11-19 2002-09-03 The United States Of America As Represented By The Department Of Health And Human Services Methods for detecting intermolecular interactions in vivo and in vitro
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EP3144675A1 (en) 2005-04-28 2017-03-22 Ventana Medical Systems, Inc. Enzymes conjugated to antibodies via a peg heterobifuctional linker
EP1893241A2 (en) 2005-04-28 2008-03-05 Ventana Medical Systems, Inc. Fluorescent nanoparticles conjugated to antibodies via a peg linker
CN101535244B (zh) 2005-11-23 2014-07-23 文塔納医疗系统公司 分子缀合物
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Also Published As

Publication number Publication date
CN107003323A (zh) 2017-08-01
US20240069034A1 (en) 2024-02-29
AU2015352625A1 (en) 2017-04-20
WO2016083364A1 (en) 2016-06-02
CN107003323B (zh) 2019-06-04
DK3224621T3 (da) 2019-08-12
US11808770B2 (en) 2023-11-07
US20170254813A1 (en) 2017-09-07
US20200271662A1 (en) 2020-08-27
CA2965872C (en) 2022-02-22
JP6909156B2 (ja) 2021-07-28
EP3224621A1 (en) 2017-10-04
JP2017536548A (ja) 2017-12-07
CA2965872A1 (en) 2016-06-02
US10620217B2 (en) 2020-04-14
EP3224621B1 (en) 2019-06-12

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