DK3224621T3 - Nærhedsanalyser under anvendelse af kemisk ligering og haptenoverførsel - Google Patents
Nærhedsanalyser under anvendelse af kemisk ligering og haptenoverførsel Download PDFInfo
- Publication number
- DK3224621T3 DK3224621T3 DK15798449.3T DK15798449T DK3224621T3 DK 3224621 T3 DK3224621 T3 DK 3224621T3 DK 15798449 T DK15798449 T DK 15798449T DK 3224621 T3 DK3224621 T3 DK 3224621T3
- Authority
- DK
- Denmark
- Prior art keywords
- hapten
- analyzes
- proximity
- transfer
- chemical ligation
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
- G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54353—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
- G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2440/00—Post-translational modifications [PTMs] in chemical analysis of biological material
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Food Science & Technology (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Bioinformatics & Computational Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462084452P | 2014-11-25 | 2014-11-25 | |
| US201562116962P | 2015-02-17 | 2015-02-17 | |
| PCT/EP2015/077484 WO2016083364A1 (en) | 2014-11-25 | 2015-11-24 | Proximity assays using chemical ligation and hapten transfer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3224621T3 true DK3224621T3 (da) | 2019-08-12 |
Family
ID=54697581
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK15798449.3T DK3224621T3 (da) | 2014-11-25 | 2015-11-24 | Nærhedsanalyser under anvendelse af kemisk ligering og haptenoverførsel |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US10620217B2 (enExample) |
| EP (1) | EP3224621B1 (enExample) |
| JP (1) | JP6909156B2 (enExample) |
| CN (1) | CN107003323B (enExample) |
| AU (1) | AU2015352625B2 (enExample) |
| CA (1) | CA2965872C (enExample) |
| DK (1) | DK3224621T3 (enExample) |
| WO (1) | WO2016083364A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3341734B1 (en) * | 2015-08-28 | 2024-08-07 | Ventana Medical Systems, Inc. | Protein proximity assay in formalin fixed paffafin embedded tissue using caged haptens |
| EP3555622B1 (en) * | 2016-12-19 | 2023-02-22 | Ventana Medical Systems, Inc. | Methods and systems for quantitative immunohistochemistry |
| GB2562721A (en) | 2017-05-16 | 2018-11-28 | Fastbase Solutions Ltd | Kits, methods and their uses for detecting cell-cell interactions in a sample |
| WO2019200326A1 (en) | 2018-04-13 | 2019-10-17 | Rarecyte, Inc. | Kits for labeling of biomarkers and methods of using the same |
| ES3047385T3 (en) * | 2018-06-11 | 2025-12-03 | Merck Sharp & Dohme Llc | Cut vertex method for identifying complex molecule substructures |
| WO2020102094A1 (en) * | 2018-11-15 | 2020-05-22 | Arizona Board Of Regents On Behalf Ofarizona State University | Cleavable fluorescent tyramide for sensitive and multiplexed analysis of biological samples |
| EP4281779A1 (en) * | 2021-01-25 | 2023-11-29 | Ventana Medical Systems, Inc. | Stained biological specimens including one or more biomarkers labeled with one or more detectable moieties |
| CN113552362B (zh) * | 2021-07-23 | 2024-08-09 | 湖北百奥斯生物科技有限公司 | 一种新型信号放大的免疫荧光试剂盒 |
| WO2023058624A1 (ja) * | 2021-10-08 | 2023-04-13 | コニカミノルタ株式会社 | 染色方法、評価方法および標本 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4711955A (en) | 1981-04-17 | 1987-12-08 | Yale University | Modified nucleotides and methods of preparing and using same |
| US5266684A (en) | 1988-05-02 | 1993-11-30 | The Reagents Of The University Of California | Peptide mixtures |
| CH683667A5 (fr) | 1992-02-26 | 1994-04-29 | Nestle Sa | Matière première aromatique. |
| US5654419A (en) | 1994-02-01 | 1997-08-05 | The Regents Of The University Of California | Fluorescent labels and their use in separations |
| ATE214396T1 (de) | 1995-06-21 | 2002-03-15 | Martek Biosciences Corp | Kombinatorische bibliotheken aus markierten biochemischen verbindungen und verfahren zu ihrer herstellung |
| US5661028A (en) | 1995-09-29 | 1997-08-26 | Lockheed Martin Energy Systems, Inc. | Large scale DNA microsequencing device |
| US6444421B1 (en) * | 1997-11-19 | 2002-09-03 | The United States Of America As Represented By The Department Of Health And Human Services | Methods for detecting intermolecular interactions in vivo and in vitro |
| EP1681983A4 (en) * | 2003-10-14 | 2008-12-10 | Monogram Biosciences Inc | RECEPTOR TYROSINE KINASE SIGNAL PATH ANALYSIS FOR DIAGNOSIS AND THERAPY |
| WO2006116742A2 (en) | 2005-04-28 | 2006-11-02 | Ventana Medical Systems, Inc. | Fluorescent nanoparticles conjugated to antibodies via a peg linker |
| JP5628476B2 (ja) | 2005-04-28 | 2014-11-19 | ベンタナ・メデイカル・システムズ・インコーポレーテツド | 抗体コンジュゲート |
| ES2804129T3 (es) | 2005-11-23 | 2021-02-03 | Ventana Med Syst Inc | Conjugado anticuerpo-enzima |
| DK3564674T3 (da) | 2006-11-01 | 2021-10-18 | Ventana Med Syst Inc | Haptener, haptenkonjugater, sammensætninger deraf og fremgangsmåde til fremstilling og anvendelse deraf |
| EP2109689A4 (en) * | 2007-02-07 | 2010-02-10 | Perscitus Biosciences Llc | DETECTION OF THE PROXIMITY OF A MOLECULE |
| EP2191275B1 (en) | 2007-09-04 | 2012-08-08 | Sanofi | Identifying molecules that modulate protein- protein interactions using protease activated reporters |
| EP2387717B1 (en) | 2009-01-15 | 2014-12-10 | Laboratory Corporation of America Holdings | Methods of determining patient response by measurement of her-2 expression |
| CN101620233B (zh) * | 2009-05-27 | 2012-10-31 | 华中科技大学 | 一种蛋白质相互作用的检测方法 |
| US20120129248A1 (en) * | 2009-07-31 | 2012-05-24 | Prognosys Biosciences, Inc. | Assay tools and methods of use |
| GB0918712D0 (en) | 2009-10-26 | 2009-12-09 | Axis Shield Diagnostics Ltd | An assay |
| JP6101782B2 (ja) | 2012-03-27 | 2017-03-22 | ヴェンタナ メディカル システムズ， インク． | シグナリングコンジュゲート及び使用法 |
| US9663814B2 (en) * | 2013-03-12 | 2017-05-30 | Ventana Medical Systems, Inc. | Proximity assay for in situ detection of targets |
| CN103245789B (zh) * | 2013-04-27 | 2014-10-29 | 深圳先进技术研究院 | 用于肿瘤病理诊断的试剂盒及对组织切片进行染色的方法 |
-
2015
- 2015-11-24 CN CN201580063800.0A patent/CN107003323B/zh active Active
- 2015-11-24 AU AU2015352625A patent/AU2015352625B2/en active Active
- 2015-11-24 EP EP15798449.3A patent/EP3224621B1/en active Active
- 2015-11-24 WO PCT/EP2015/077484 patent/WO2016083364A1/en not_active Ceased
- 2015-11-24 JP JP2017527719A patent/JP6909156B2/ja active Active
- 2015-11-24 DK DK15798449.3T patent/DK3224621T3/da active
- 2015-11-24 CA CA2965872A patent/CA2965872C/en active Active
-
2017
- 2017-05-23 US US15/603,079 patent/US10620217B2/en active Active
-
2020
- 2020-03-04 US US16/809,290 patent/US11808770B2/en active Active
-
2023
- 2023-09-27 US US18/373,328 patent/US20240069034A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20170254813A1 (en) | 2017-09-07 |
| US20200271662A1 (en) | 2020-08-27 |
| EP3224621B1 (en) | 2019-06-12 |
| AU2015352625A1 (en) | 2017-04-20 |
| CN107003323B (zh) | 2019-06-04 |
| US11808770B2 (en) | 2023-11-07 |
| WO2016083364A1 (en) | 2016-06-02 |
| US10620217B2 (en) | 2020-04-14 |
| AU2015352625B2 (en) | 2019-07-25 |
| CN107003323A (zh) | 2017-08-01 |
| CA2965872C (en) | 2022-02-22 |
| EP3224621A1 (en) | 2017-10-04 |
| CA2965872A1 (en) | 2016-06-02 |
| JP2017536548A (ja) | 2017-12-07 |
| US20240069034A1 (en) | 2024-02-29 |
| JP6909156B2 (ja) | 2021-07-28 |
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