DK3224621T3 - Nærhedsanalyser under anvendelse af kemisk ligering og haptenoverførsel - Google Patents

Nærhedsanalyser under anvendelse af kemisk ligering og haptenoverførsel Download PDF

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Publication number
DK3224621T3
DK3224621T3 DK15798449.3T DK15798449T DK3224621T3 DK 3224621 T3 DK3224621 T3 DK 3224621T3 DK 15798449 T DK15798449 T DK 15798449T DK 3224621 T3 DK3224621 T3 DK 3224621T3
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DK
Denmark
Prior art keywords
hapten
analyzes
proximity
transfer
chemical ligation
Prior art date
Application number
DK15798449.3T
Other languages
English (en)
Inventor
Christopher Bieniarz
Rui Hong
Original Assignee
Ventana Med Syst Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ventana Med Syst Inc filed Critical Ventana Med Syst Inc
Application granted granted Critical
Publication of DK3224621T3 publication Critical patent/DK3224621T3/da

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54353—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2440/00—Post-translational modifications [PTMs] in chemical analysis of biological material

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DK15798449.3T 2014-11-25 2015-11-24 Nærhedsanalyser under anvendelse af kemisk ligering og haptenoverførsel DK3224621T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462084452P 2014-11-25 2014-11-25
US201562116962P 2015-02-17 2015-02-17
PCT/EP2015/077484 WO2016083364A1 (en) 2014-11-25 2015-11-24 Proximity assays using chemical ligation and hapten transfer

Publications (1)

Publication Number Publication Date
DK3224621T3 true DK3224621T3 (da) 2019-08-12

Family

ID=54697581

Family Applications (1)

Application Number Title Priority Date Filing Date
DK15798449.3T DK3224621T3 (da) 2014-11-25 2015-11-24 Nærhedsanalyser under anvendelse af kemisk ligering og haptenoverførsel

Country Status (8)

Country Link
US (3) US10620217B2 (da)
EP (1) EP3224621B1 (da)
JP (1) JP6909156B2 (da)
CN (1) CN107003323B (da)
AU (1) AU2015352625B2 (da)
CA (1) CA2965872C (da)
DK (1) DK3224621T3 (da)
WO (1) WO2016083364A1 (da)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107923915B (zh) * 2015-08-28 2021-05-04 文塔纳医疗系统公司 使用经掩蔽的半抗原在福尔马林固定石蜡包埋的组织中的蛋白质邻近测定
CN110337588B (zh) * 2016-12-19 2023-02-17 文塔纳医疗系统公司 用于定量免疫组织化学的方法和系统
GB2562721A (en) * 2017-05-16 2018-11-28 Fastbase Solutions Ltd Kits, methods and their uses for detecting cell-cell interactions in a sample
US10871485B2 (en) 2018-04-13 2020-12-22 Rarecyte, Inc. Kits for labeling of biomarkers and methods of using the same
CN112534508B (zh) * 2018-06-11 2024-03-01 默沙东有限责任公司 用于标识复杂分子子结构的割点法
US20220026433A1 (en) * 2018-11-15 2022-01-27 Arizona Board Of Regents On Behalf Of Arizona State University Cleavable fluorescent tyramide for sensitive and multiplexed analysis of biological samples
CN113552362A (zh) * 2021-07-23 2021-10-26 湖北百奥斯生物科技有限公司 一种新型信号放大的免疫荧光试剂盒
WO2023058624A1 (ja) * 2021-10-08 2023-04-13 コニカミノルタ株式会社 染色方法、評価方法および標本

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4711955A (en) 1981-04-17 1987-12-08 Yale University Modified nucleotides and methods of preparing and using same
US5266684A (en) 1988-05-02 1993-11-30 The Reagents Of The University Of California Peptide mixtures
CH683667A5 (fr) 1992-02-26 1994-04-29 Nestle Sa Matière première aromatique.
US5654419A (en) 1994-02-01 1997-08-05 The Regents Of The University Of California Fluorescent labels and their use in separations
WO1997000887A1 (en) 1995-06-21 1997-01-09 Martek Biosciences Corporation Combinatorial libraries of labeled biochemical compounds and methods for producing same
US5661028A (en) 1995-09-29 1997-08-26 Lockheed Martin Energy Systems, Inc. Large scale DNA microsequencing device
US6444421B1 (en) * 1997-11-19 2002-09-03 The United States Of America As Represented By The Department Of Health And Human Services Methods for detecting intermolecular interactions in vivo and in vitro
EP1681983A4 (en) * 2003-10-14 2008-12-10 Monogram Biosciences Inc RECEPTOR TYROSINE KINASE SIGNAL PATH ANALYSIS FOR DIAGNOSIS AND THERAPY
JP2008541015A (ja) 2005-04-28 2008-11-20 ベンタナ・メデイカル・システムズ・インコーポレーテツド ナノ粒子コンジュゲート
EP3144675A1 (en) 2005-04-28 2017-03-22 Ventana Medical Systems, Inc. Enzymes conjugated to antibodies via a peg heterobifuctional linker
US20070117153A1 (en) 2005-11-23 2007-05-24 Christopher Bieniarz Molecular conjugate
ES2570600T3 (es) 2006-11-01 2016-05-19 Ventana Med Syst Inc Haptenos, conjugados de haptenos, composiciones de los mismos y método para su preparación y uso
EP2109689A4 (en) * 2007-02-07 2010-02-10 Perscitus Biosciences Llc DETECTION OF THE PROXIMITY OF A MOLECULE
MY155343A (en) 2007-09-04 2015-10-15 Sanofi Aventis Identifying molecules that modulate protein-protein interactions using protease activated reporters
KR20110120890A (ko) 2009-01-15 2011-11-04 래버러토리 코포레이션 오브 아메리카 홀딩스 Ｈｅｒ－２ 발현의 측정에 의한 환자 반응의 결정 방법
CN101620233B (zh) * 2009-05-27 2012-10-31 华中科技大学 一种蛋白质相互作用的检测方法
US20120129248A1 (en) * 2009-07-31 2012-05-24 Prognosys Biosciences, Inc. Assay tools and methods of use
GB0918712D0 (en) 2009-10-26 2009-12-09 Axis Shield Diagnostics Ltd An assay
WO2013148498A1 (en) 2012-03-27 2013-10-03 Ventana Medical Systems, Inc. Signaling conjugates and methods of use
WO2014139980A1 (en) * 2013-03-12 2014-09-18 Ventana Medical Systems, Inc. Proximity assay for in situ detection of targets
CN103245789B (zh) * 2013-04-27 2014-10-29 深圳先进技术研究院 用于肿瘤病理诊断的试剂盒及对组织切片进行染色的方法

Also Published As

Publication number Publication date
CA2965872C (en) 2022-02-22
CA2965872A1 (en) 2016-06-02
US20240069034A1 (en) 2024-02-29
US11808770B2 (en) 2023-11-07
EP3224621B1 (en) 2019-06-12
WO2016083364A1 (en) 2016-06-02
CN107003323A (zh) 2017-08-01
US10620217B2 (en) 2020-04-14
CN107003323B (zh) 2019-06-04
JP6909156B2 (ja) 2021-07-28
EP3224621A1 (en) 2017-10-04
AU2015352625B2 (en) 2019-07-25
US20170254813A1 (en) 2017-09-07
AU2015352625A1 (en) 2017-04-20
US20200271662A1 (en) 2020-08-27
JP2017536548A (ja) 2017-12-07

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