JP6901402B2 - 単量体抗体Ｆａｂ−ｄｓＦｖ多量体種のパーセンテージを増加させる方法 - Google Patents

単量体抗体Ｆａｂ−ｄｓＦｖ多量体種のパーセンテージを増加させる方法 Download PDF

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JP6901402B2
JP6901402B2 JP2017555395A JP2017555395A JP6901402B2 JP 6901402 B2 JP6901402 B2 JP 6901402B2 JP 2017555395 A JP2017555395 A JP 2017555395A JP 2017555395 A JP2017555395 A JP 2017555395A JP 6901402 B2 JP6901402 B2 JP 6901402B2
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antibody
reducing agent
variable domain
range
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JP2018515453A (ja
JP2018515453A5 (enExample
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ヘイウッド、サム、フィリップ
ワイルド、ギャヴィン、バリー
パージュ、クリストファー、ジョン ル
パージュ、クリストファー、ジョン ル
ハニフ、ラズワン
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ユーシービー バイオファルマ エスアールエル
ユーシービー バイオファルマ エスアールエル
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/624—Disulfide-stabilized antibody (dsFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/66—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a swap of domains, e.g. CH3-CH2, VH-CL or VL-CH1

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2017555395A 2015-04-22 2016-04-22 単量体抗体Ｆａｂ−ｄｓＦｖ多量体種のパーセンテージを増加させる方法 Active JP6901402B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1506869.5 2015-04-22
GBGB1506869.5A GB201506869D0 (en) 2015-04-22 2015-04-22 Method
PCT/EP2016/059050 WO2016170137A1 (en) 2015-04-22 2016-04-22 Method for increasing the percentage of monomeric antibody fab-dsfv multimeric species

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JP2018515453A JP2018515453A (ja) 2018-06-14
JP2018515453A5 JP2018515453A5 (enExample) 2019-05-30
JP6901402B2 true JP6901402B2 (ja) 2021-07-14

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US (2) US10829565B2 (enExample)
EP (1) EP3286220A1 (enExample)
JP (1) JP6901402B2 (enExample)
KR (1) KR20170138551A (enExample)
CN (1) CN107683290B (enExample)
AU (1) AU2016251960A1 (enExample)
BR (1) BR112017022472A2 (enExample)
CA (1) CA2983537A1 (enExample)
CL (1) CL2017002677A1 (enExample)
CO (1) CO2017010845A2 (enExample)
EA (1) EA201792325A1 (enExample)
GB (1) GB201506869D0 (enExample)
IL (1) IL255094A0 (enExample)
MX (1) MX2017013419A (enExample)
SG (1) SG11201708430VA (enExample)
WO (1) WO2016170137A1 (enExample)

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MY190770A (en) * 2016-12-09 2022-05-12 Ose Immunotherapeutics Antibodies and polypeptides directed against cd127

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Also Published As

Publication number Publication date
EA201792325A1 (ru) 2018-04-30
GB201506869D0 (en) 2015-06-03
WO2016170137A1 (en) 2016-10-27
JP2018515453A (ja) 2018-06-14
AU2016251960A1 (en) 2017-11-02
CL2017002677A1 (es) 2018-03-23
IL255094A0 (en) 2017-12-31
MX2017013419A (es) 2018-02-09
US20210079120A1 (en) 2021-03-18
US10829565B2 (en) 2020-11-10
CN107683290B (zh) 2022-01-04
US20180142039A1 (en) 2018-05-24
SG11201708430VA (en) 2017-11-29
CO2017010845A2 (es) 2018-03-20
KR20170138551A (ko) 2017-12-15
BR112017022472A2 (pt) 2018-07-17
EP3286220A1 (en) 2018-02-28
US11834514B2 (en) 2023-12-05
CN107683290A (zh) 2018-02-09
CA2983537A1 (en) 2016-10-27

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