AU2016251960A1 - Method for increasing the percentage of monomeric antibody Fab-dsFv multimeric species - Google Patents
Method for increasing the percentage of monomeric antibody Fab-dsFv multimeric species Download PDFInfo
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- AU2016251960A1 AU2016251960A1 AU2016251960A AU2016251960A AU2016251960A1 AU 2016251960 A1 AU2016251960 A1 AU 2016251960A1 AU 2016251960 A AU2016251960 A AU 2016251960A AU 2016251960 A AU2016251960 A AU 2016251960A AU 2016251960 A1 AU2016251960 A1 AU 2016251960A1
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- 229960001278 teniposide Drugs 0.000 description 1
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- GKCBAIGFKIBETG-UHFFFAOYSA-N tetracaine Chemical compound CCCCNC1=CC=C(C(=O)OCCN(C)C)C=C1 GKCBAIGFKIBETG-UHFFFAOYSA-N 0.000 description 1
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- 229960003087 tioguanine Drugs 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/624—Disulfide-stabilized antibody (dsFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/66—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a swap of domains, e.g. CH3-CH2, VH-CL or VL-CH1
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1506869.5 | 2015-04-22 | ||
| GBGB1506869.5A GB201506869D0 (en) | 2015-04-22 | 2015-04-22 | Method |
| PCT/EP2016/059050 WO2016170137A1 (en) | 2015-04-22 | 2016-04-22 | Method for increasing the percentage of monomeric antibody fab-dsfv multimeric species |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2016251960A1 true AU2016251960A1 (en) | 2017-11-02 |
Family
ID=53299018
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2016251960A Abandoned AU2016251960A1 (en) | 2015-04-22 | 2016-04-22 | Method for increasing the percentage of monomeric antibody Fab-dsFv multimeric species |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US10829565B2 (enExample) |
| EP (1) | EP3286220A1 (enExample) |
| JP (1) | JP6901402B2 (enExample) |
| KR (1) | KR20170138551A (enExample) |
| CN (1) | CN107683290B (enExample) |
| AU (1) | AU2016251960A1 (enExample) |
| BR (1) | BR112017022472A2 (enExample) |
| CA (1) | CA2983537A1 (enExample) |
| CL (1) | CL2017002677A1 (enExample) |
| CO (1) | CO2017010845A2 (enExample) |
| EA (1) | EA201792325A1 (enExample) |
| GB (1) | GB201506869D0 (enExample) |
| IL (1) | IL255094A0 (enExample) |
| MX (1) | MX2017013419A (enExample) |
| SG (1) | SG11201708430VA (enExample) |
| WO (1) | WO2016170137A1 (enExample) |
Families Citing this family (6)
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| GB201223276D0 (en) * | 2012-12-21 | 2013-02-06 | Ucb Pharma Sa | Antibodies and methods of producing same |
| GB201411320D0 (en) | 2014-06-25 | 2014-08-06 | Ucb Biopharma Sprl | Antibody construct |
| GB201506869D0 (en) * | 2015-04-22 | 2015-06-03 | Ucb Biopharma Sprl | Method |
| GB201506868D0 (en) | 2015-04-22 | 2015-06-03 | Ucb Biopharma Sprl | Method for protein purification |
| GB201506870D0 (en) | 2015-04-22 | 2015-06-03 | Ucb Biopharma Sprl | Method |
| RS61808B1 (sr) * | 2016-12-09 | 2021-06-30 | Ose Immunotherapeutics | Antitela i polipeptidi usmereni protiv cd127 |
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| EP2475682B1 (en) | 2009-09-10 | 2018-01-31 | UCB Biopharma SPRL | Multivalent antibodies |
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| GB0920127D0 (en) * | 2009-11-17 | 2009-12-30 | Ucb Pharma Sa | Antibodies |
| GB201000467D0 (en) | 2010-01-12 | 2010-02-24 | Ucb Pharma Sa | Antibodies |
| GB201001791D0 (en) * | 2010-02-03 | 2010-03-24 | Ucb Pharma Sa | Process for obtaining antibodies |
| GB201005064D0 (en) | 2010-03-25 | 2010-05-12 | Ucb Pharma Sa | Biological products |
| TR201903279T4 (tr) | 2010-03-25 | 2019-03-21 | Ucb Biopharma Sprl | Disülfür stabilize edilmiş DVD-IG molekülleri. |
| US9150663B2 (en) * | 2010-04-20 | 2015-10-06 | Genmab A/S | Heterodimeric antibody Fc-containing proteins and methods for production thereof |
| KR101860963B1 (ko) * | 2010-04-23 | 2018-05-24 | 제넨테크, 인크. | 이종다량체 단백질의 생산 |
| WO2012140214A1 (en) | 2011-04-13 | 2012-10-18 | Biomay Ag | IMMUNOAFFINITY SEPARATION MATERIALS COMPRISING ANTI-IgE ANTIBODY DERIVATIVES |
| JP6216321B2 (ja) | 2011-10-11 | 2017-10-18 | ジェネンテック， インコーポレイテッド | 二重特異性抗体の構築の改善 |
| UA112203C2 (uk) | 2011-11-11 | 2016-08-10 | Юсб Фарма С.А. | Злитий білок біоспецифічного антитіла, який зв'язується з ox40 людини та сироватковим альбуміном людини |
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| GB201208370D0 (en) | 2012-05-14 | 2012-06-27 | Ucb Pharma Sa | Antibodies |
| GB201223276D0 (en) * | 2012-12-21 | 2013-02-06 | Ucb Pharma Sa | Antibodies and methods of producing same |
| CN105764922B (zh) * | 2013-09-27 | 2020-07-17 | 中外制药株式会社 | 多肽异源多聚体的制备方法 |
| GB201411320D0 (en) | 2014-06-25 | 2014-08-06 | Ucb Biopharma Sprl | Antibody construct |
| GB201506869D0 (en) * | 2015-04-22 | 2015-06-03 | Ucb Biopharma Sprl | Method |
| GB201506868D0 (en) | 2015-04-22 | 2015-06-03 | Ucb Biopharma Sprl | Method for protein purification |
| GB201506870D0 (en) | 2015-04-22 | 2015-06-03 | Ucb Biopharma Sprl | Method |
| PH12018500362B1 (en) | 2015-08-17 | 2022-08-05 | Lupin Ltd | An improved refolding process for antibodys fragments |
-
2015
- 2015-04-22 GB GBGB1506869.5A patent/GB201506869D0/en not_active Ceased
-
2016
- 2016-04-22 JP JP2017555395A patent/JP6901402B2/ja active Active
- 2016-04-22 KR KR1020177033852A patent/KR20170138551A/ko not_active Abandoned
- 2016-04-22 SG SG11201708430VA patent/SG11201708430VA/en unknown
- 2016-04-22 BR BR112017022472A patent/BR112017022472A2/pt not_active Application Discontinuation
- 2016-04-22 EA EA201792325A patent/EA201792325A1/ru unknown
- 2016-04-22 EP EP16721103.6A patent/EP3286220A1/en active Pending
- 2016-04-22 CN CN201680031354.XA patent/CN107683290B/zh active Active
- 2016-04-22 CA CA2983537A patent/CA2983537A1/en active Pending
- 2016-04-22 WO PCT/EP2016/059050 patent/WO2016170137A1/en not_active Ceased
- 2016-04-22 US US15/568,018 patent/US10829565B2/en active Active
- 2016-04-22 MX MX2017013419A patent/MX2017013419A/es unknown
- 2016-04-22 AU AU2016251960A patent/AU2016251960A1/en not_active Abandoned
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2017
- 2017-10-17 IL IL255094A patent/IL255094A0/en unknown
- 2017-10-20 CL CL2017002677A patent/CL2017002677A1/es unknown
- 2017-10-25 CO CONC2017/0010845A patent/CO2017010845A2/es unknown
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2020
- 2020-10-23 US US17/078,130 patent/US11834514B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US11834514B2 (en) | 2023-12-05 |
| EP3286220A1 (en) | 2018-02-28 |
| SG11201708430VA (en) | 2017-11-29 |
| CL2017002677A1 (es) | 2018-03-23 |
| CO2017010845A2 (es) | 2018-03-20 |
| MX2017013419A (es) | 2018-02-09 |
| IL255094A0 (en) | 2017-12-31 |
| KR20170138551A (ko) | 2017-12-15 |
| BR112017022472A2 (pt) | 2018-07-17 |
| EA201792325A1 (ru) | 2018-04-30 |
| US20210079120A1 (en) | 2021-03-18 |
| GB201506869D0 (en) | 2015-06-03 |
| CN107683290A (zh) | 2018-02-09 |
| CA2983537A1 (en) | 2016-10-27 |
| US20180142039A1 (en) | 2018-05-24 |
| JP6901402B2 (ja) | 2021-07-14 |
| JP2018515453A (ja) | 2018-06-14 |
| US10829565B2 (en) | 2020-11-10 |
| CN107683290B (zh) | 2022-01-04 |
| WO2016170137A1 (en) | 2016-10-27 |
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