CA2983537A1 - Method for increasing the percentage of monomeric antibody fab-dsfv multimeric species - Google Patents
Method for increasing the percentage of monomeric antibody fab-dsfv multimeric speciesInfo
- Publication number
- CA2983537A1 CA2983537A1 CA2983537A CA2983537A CA2983537A1 CA 2983537 A1 CA2983537 A1 CA 2983537A1 CA 2983537 A CA2983537 A CA 2983537A CA 2983537 A CA2983537 A CA 2983537A CA 2983537 A1 CA2983537 A1 CA 2983537A1
- Authority
- CA
- Canada
- Prior art keywords
- antibody
- reducing agent
- domain
- fab
- range
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 description 1
- NRUKOCRGYNPUPR-QBPJDGROSA-N teniposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@@H](OC[C@H]4O3)C=3SC=CC=3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 NRUKOCRGYNPUPR-QBPJDGROSA-N 0.000 description 1
- 229960001278 teniposide Drugs 0.000 description 1
- 229960002372 tetracaine Drugs 0.000 description 1
- GKCBAIGFKIBETG-UHFFFAOYSA-N tetracaine Chemical compound CCCCNC1=CC=C(C(=O)OCCN(C)C)C=C1 GKCBAIGFKIBETG-UHFFFAOYSA-N 0.000 description 1
- 229940126622 therapeutic monoclonal antibody Drugs 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000001732 thrombotic effect Effects 0.000 description 1
- 229940104230 thymidine Drugs 0.000 description 1
- 229960003087 tioguanine Drugs 0.000 description 1
- 229960000187 tissue plasminogen activator Drugs 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/624—Disulfide-stabilized antibody (dsFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/66—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a swap of domains, e.g. CH3-CH2, VH-CL or VL-CH1
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1506869.5 | 2015-04-22 | ||
| GBGB1506869.5A GB201506869D0 (en) | 2015-04-22 | 2015-04-22 | Method |
| PCT/EP2016/059050 WO2016170137A1 (en) | 2015-04-22 | 2016-04-22 | Method for increasing the percentage of monomeric antibody fab-dsfv multimeric species |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2983537A1 true CA2983537A1 (en) | 2016-10-27 |
Family
ID=53299018
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2983537A Pending CA2983537A1 (en) | 2015-04-22 | 2016-04-22 | Method for increasing the percentage of monomeric antibody fab-dsfv multimeric species |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US10829565B2 (enExample) |
| EP (1) | EP3286220A1 (enExample) |
| JP (1) | JP6901402B2 (enExample) |
| KR (1) | KR20170138551A (enExample) |
| CN (1) | CN107683290B (enExample) |
| AU (1) | AU2016251960A1 (enExample) |
| BR (1) | BR112017022472A2 (enExample) |
| CA (1) | CA2983537A1 (enExample) |
| CL (1) | CL2017002677A1 (enExample) |
| CO (1) | CO2017010845A2 (enExample) |
| EA (1) | EA201792325A1 (enExample) |
| GB (1) | GB201506869D0 (enExample) |
| IL (1) | IL255094A0 (enExample) |
| MX (1) | MX2017013419A (enExample) |
| SG (1) | SG11201708430VA (enExample) |
| WO (1) | WO2016170137A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201223276D0 (en) * | 2012-12-21 | 2013-02-06 | Ucb Pharma Sa | Antibodies and methods of producing same |
| GB201411320D0 (en) | 2014-06-25 | 2014-08-06 | Ucb Biopharma Sprl | Antibody construct |
| GB201506869D0 (en) * | 2015-04-22 | 2015-06-03 | Ucb Biopharma Sprl | Method |
| GB201506870D0 (en) | 2015-04-22 | 2015-06-03 | Ucb Biopharma Sprl | Method |
| GB201506868D0 (en) | 2015-04-22 | 2015-06-03 | Ucb Biopharma Sprl | Method for protein purification |
| MY190770A (en) * | 2016-12-09 | 2022-05-12 | Ose Immunotherapeutics | Antibodies and polypeptides directed against cd127 |
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| DK336987D0 (da) | 1987-07-01 | 1987-07-01 | Novo Industri As | Immobiliseringsmetode |
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| FR2716640B1 (fr) | 1994-02-28 | 1996-05-03 | Procedes Machines Speciales | Dispositif de centrage et de blocage d'une pièce en vue de son rodage à l'aide d'un rodoir à expansion. |
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| GB9625640D0 (en) | 1996-12-10 | 1997-01-29 | Celltech Therapeutics Ltd | Biological products |
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| GB0202633D0 (en) * | 2002-02-05 | 2002-03-20 | Delta Biotechnology Ltd | Stabilization of protein preparations |
| EP1570267B1 (en) | 2002-12-03 | 2011-10-12 | UCB Pharma, S.A. | Assay for identifying antibody producing cells |
| GB0312481D0 (en) | 2003-05-30 | 2003-07-09 | Celltech R&D Ltd | Antibodies |
| GB0315457D0 (en) | 2003-07-01 | 2003-08-06 | Celltech R&D Ltd | Biological products |
| GB0315450D0 (en) * | 2003-07-01 | 2003-08-06 | Celltech R&D Ltd | Biological products |
| CA2527020A1 (en) | 2003-07-01 | 2005-01-13 | Celltech R & D Limited | Modified antibody fab fragments |
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| WO2006047340A2 (en) | 2004-10-22 | 2006-05-04 | Amgen Inc. | Methods for refolding of recombinant antibodies |
| GB0425534D0 (en) * | 2004-11-19 | 2004-12-22 | Celltech R&D Ltd | Process for obtaining antibodies |
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| GB0619291D0 (en) | 2006-09-29 | 2006-11-08 | Ucb Sa | Altered antibodies |
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| ES2667729T3 (es) | 2007-09-26 | 2018-05-14 | Ucb Biopharma Sprl | Fusiones de anticuerpos con doble especificidad |
| US20090269343A1 (en) | 2008-04-11 | 2009-10-29 | Duke University | Dual Specific Immunotoxin for Brain Tumor Therapy |
| JP5529869B2 (ja) | 2008-08-14 | 2014-06-25 | メルク・シャープ・アンド・ドーム・コーポレーション | プロテインａアフィニティークロマトグラフィーを用いる抗体の精製方法 |
| JP2012503487A (ja) * | 2008-09-26 | 2012-02-09 | シェーリング コーポレイション | 高力価抗体の製造 |
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| DK2982690T3 (da) * | 2009-04-30 | 2021-04-12 | Ablynx Nv | Fremgangsmåde til fremstilling af domæne-antistoffer |
| EP2475682B1 (en) | 2009-09-10 | 2018-01-31 | UCB Biopharma SPRL | Multivalent antibodies |
| GB201005063D0 (en) * | 2010-03-25 | 2010-05-12 | Ucb Pharma Sa | Biological products |
| GB0920127D0 (en) | 2009-11-17 | 2009-12-30 | Ucb Pharma Sa | Antibodies |
| GB201000467D0 (en) | 2010-01-12 | 2010-02-24 | Ucb Pharma Sa | Antibodies |
| GB201001791D0 (en) * | 2010-02-03 | 2010-03-24 | Ucb Pharma Sa | Process for obtaining antibodies |
| EP2550297B1 (en) | 2010-03-25 | 2019-01-23 | UCB Biopharma SPRL | Disulfide stabilized dvd-lg molecules |
| GB201005064D0 (en) | 2010-03-25 | 2010-05-12 | Ucb Pharma Sa | Biological products |
| CN110066339A (zh) * | 2010-04-20 | 2019-07-30 | 根马布股份公司 | 含异二聚体抗体fc的蛋白及其制备方法 |
| DK2560683T4 (da) * | 2010-04-23 | 2022-08-29 | Hoffmann La Roche | Fremstilling af heteromultimeriske proteiner |
| WO2012140214A1 (en) | 2011-04-13 | 2012-10-18 | Biomay Ag | IMMUNOAFFINITY SEPARATION MATERIALS COMPRISING ANTI-IgE ANTIBODY DERIVATIVES |
| ES2971444T3 (es) | 2011-10-11 | 2024-06-05 | F Hoffmann Lar Roche Ag | Ensamblaje mejorado de anticuerpos biespecíficos |
| SG11201401649VA (en) * | 2011-11-11 | 2014-07-30 | Ucb Pharma Sa | Albumin binding antibodies and binding fragments thereof |
| UA112203C2 (uk) | 2011-11-11 | 2016-08-10 | Юсб Фарма С.А. | Злитий білок біоспецифічного антитіла, який зв'язується з ox40 людини та сироватковим альбуміном людини |
| WO2013132268A1 (en) | 2012-03-09 | 2013-09-12 | Ucl Business Plc | Chemical modification of antibodies |
| GB201208370D0 (en) | 2012-05-14 | 2012-06-27 | Ucb Pharma Sa | Antibodies |
| GB201223276D0 (en) * | 2012-12-21 | 2013-02-06 | Ucb Pharma Sa | Antibodies and methods of producing same |
| ES2881306T3 (es) * | 2013-09-27 | 2021-11-29 | Chugai Pharmaceutical Co Ltd | Método para la producción de heteromultímeros de polipéptidos |
| GB201411320D0 (en) | 2014-06-25 | 2014-08-06 | Ucb Biopharma Sprl | Antibody construct |
| GB201506869D0 (en) * | 2015-04-22 | 2015-06-03 | Ucb Biopharma Sprl | Method |
| GB201506868D0 (en) | 2015-04-22 | 2015-06-03 | Ucb Biopharma Sprl | Method for protein purification |
| GB201506870D0 (en) | 2015-04-22 | 2015-06-03 | Ucb Biopharma Sprl | Method |
| LT3337820T (lt) | 2015-08-17 | 2021-02-10 | Lupin Limited | Patobulintas antikūnų fragmentų refoldingo būdas |
-
2015
- 2015-04-22 GB GBGB1506869.5A patent/GB201506869D0/en not_active Ceased
-
2016
- 2016-04-22 US US15/568,018 patent/US10829565B2/en active Active
- 2016-04-22 AU AU2016251960A patent/AU2016251960A1/en not_active Abandoned
- 2016-04-22 SG SG11201708430VA patent/SG11201708430VA/en unknown
- 2016-04-22 BR BR112017022472A patent/BR112017022472A2/pt not_active Application Discontinuation
- 2016-04-22 EA EA201792325A patent/EA201792325A1/ru unknown
- 2016-04-22 CN CN201680031354.XA patent/CN107683290B/zh active Active
- 2016-04-22 EP EP16721103.6A patent/EP3286220A1/en active Pending
- 2016-04-22 WO PCT/EP2016/059050 patent/WO2016170137A1/en not_active Ceased
- 2016-04-22 CA CA2983537A patent/CA2983537A1/en active Pending
- 2016-04-22 KR KR1020177033852A patent/KR20170138551A/ko not_active Abandoned
- 2016-04-22 MX MX2017013419A patent/MX2017013419A/es unknown
- 2016-04-22 JP JP2017555395A patent/JP6901402B2/ja active Active
-
2017
- 2017-10-17 IL IL255094A patent/IL255094A0/en unknown
- 2017-10-20 CL CL2017002677A patent/CL2017002677A1/es unknown
- 2017-10-25 CO CONC2017/0010845A patent/CO2017010845A2/es unknown
-
2020
- 2020-10-23 US US17/078,130 patent/US11834514B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EA201792325A1 (ru) | 2018-04-30 |
| GB201506869D0 (en) | 2015-06-03 |
| WO2016170137A1 (en) | 2016-10-27 |
| JP2018515453A (ja) | 2018-06-14 |
| AU2016251960A1 (en) | 2017-11-02 |
| CL2017002677A1 (es) | 2018-03-23 |
| IL255094A0 (en) | 2017-12-31 |
| MX2017013419A (es) | 2018-02-09 |
| US20210079120A1 (en) | 2021-03-18 |
| US10829565B2 (en) | 2020-11-10 |
| CN107683290B (zh) | 2022-01-04 |
| US20180142039A1 (en) | 2018-05-24 |
| SG11201708430VA (en) | 2017-11-29 |
| CO2017010845A2 (es) | 2018-03-20 |
| KR20170138551A (ko) | 2017-12-15 |
| BR112017022472A2 (pt) | 2018-07-17 |
| EP3286220A1 (en) | 2018-02-28 |
| US11834514B2 (en) | 2023-12-05 |
| CN107683290A (zh) | 2018-02-09 |
| JP6901402B2 (ja) | 2021-07-14 |
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