KR20170138551A - Fab-dsFv 다량체 종에서 단량체 항체의 백분율을 증가시키는 방법 - Google Patents

Fab-dsFv 다량체 종에서 단량체 항체의 백분율을 증가시키는 방법 Download PDF

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Publication number
KR20170138551A
KR20170138551A KR1020177033852A KR20177033852A KR20170138551A KR 20170138551 A KR20170138551 A KR 20170138551A KR 1020177033852 A KR1020177033852 A KR 1020177033852A KR 20177033852 A KR20177033852 A KR 20177033852A KR 20170138551 A KR20170138551 A KR 20170138551A
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South Korea
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ser
thr
antibody
gly
leu
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KR1020177033852A
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English (en)
Korean (ko)
Inventor
샘 필립 헤이우드
가빈 배리 와일드
라즈완 하니프
페이지 크리스토퍼 존 르
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유씨비 바이오파마 에스피알엘
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Publication of KR20170138551A publication Critical patent/KR20170138551A/ko
Abandoned legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46Hybrid immunoglobulins
    • C07K16/468Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/10Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14Specific host cells or culture conditions, e.g. components, pH or temperature
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52Constant or Fc region; Isotype
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55Fab or Fab'
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/60Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/624Disulfide-stabilized antibody (dsFv)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/60Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/66Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a swap of domains, e.g. CH3-CH2, VH-CL or VL-CH1

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
KR1020177033852A 2015-04-22 2016-04-22 Fab-dsFv 다량체 종에서 단량체 항체의 백분율을 증가시키는 방법 Abandoned KR20170138551A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1506869.5 2015-04-22
GBGB1506869.5A GB201506869D0 (en) 2015-04-22 2015-04-22 Method
PCT/EP2016/059050 WO2016170137A1 (en) 2015-04-22 2016-04-22 Method for increasing the percentage of monomeric antibody fab-dsfv multimeric species

Publications (1)

Publication Number Publication Date
KR20170138551A true KR20170138551A (ko) 2017-12-15

Family

ID=53299018

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020177033852A Abandoned KR20170138551A (ko) 2015-04-22 2016-04-22 Fab-dsFv 다량체 종에서 단량체 항체의 백분율을 증가시키는 방법

Country Status (16)

Country Link
US (2) US10829565B2 (enExample)
EP (1) EP3286220A1 (enExample)
JP (1) JP6901402B2 (enExample)
KR (1) KR20170138551A (enExample)
CN (1) CN107683290B (enExample)
AU (1) AU2016251960A1 (enExample)
BR (1) BR112017022472A2 (enExample)
CA (1) CA2983537A1 (enExample)
CL (1) CL2017002677A1 (enExample)
CO (1) CO2017010845A2 (enExample)
EA (1) EA201792325A1 (enExample)
GB (1) GB201506869D0 (enExample)
IL (1) IL255094A0 (enExample)
MX (1) MX2017013419A (enExample)
SG (1) SG11201708430VA (enExample)
WO (1) WO2016170137A1 (enExample)

Families Citing this family (6)

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MY190770A (en) * 2016-12-09 2022-05-12 Ose Immunotherapeutics Antibodies and polypeptides directed against cd127

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Also Published As

Publication number Publication date
EA201792325A1 (ru) 2018-04-30
US11834514B2 (en) 2023-12-05
IL255094A0 (en) 2017-12-31
CN107683290A (zh) 2018-02-09
JP6901402B2 (ja) 2021-07-14
WO2016170137A1 (en) 2016-10-27
JP2018515453A (ja) 2018-06-14
EP3286220A1 (en) 2018-02-28
SG11201708430VA (en) 2017-11-29
BR112017022472A2 (pt) 2018-07-17
US20180142039A1 (en) 2018-05-24
MX2017013419A (es) 2018-02-09
CO2017010845A2 (es) 2018-03-20
CA2983537A1 (en) 2016-10-27
CN107683290B (zh) 2022-01-04
US20210079120A1 (en) 2021-03-18
US10829565B2 (en) 2020-11-10
CL2017002677A1 (es) 2018-03-23
GB201506869D0 (en) 2015-06-03
AU2016251960A1 (en) 2017-11-02

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