JP6886921B2 - 皮膚の蛍光着色剤としてのHylocereus undatus果実抽出物の使用 - Google Patents
皮膚の蛍光着色剤としてのHylocereus undatus果実抽出物の使用 Download PDFInfo
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- JP6886921B2 JP6886921B2 JP2017541979A JP2017541979A JP6886921B2 JP 6886921 B2 JP6886921 B2 JP 6886921B2 JP 2017541979 A JP2017541979 A JP 2017541979A JP 2017541979 A JP2017541979 A JP 2017541979A JP 6886921 B2 JP6886921 B2 JP 6886921B2
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- fruit extract
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
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Description
(a)食用果肉を果皮から分離するステップと、
(b)果肉をすり潰してスラリーを得るステップと、
(c)スラリーから不溶性固形物を分離して果肉を含まない汁を得るステップと、
(d)果肉を含まない汁を加熱するステップと、
(e)加熱した果肉を含まない汁から不溶性固形物を分離して液体抽出物を得るステップと、
を含むプロセスによって作製される。
本明細書で使用される場合、「Hylocereus undatus果実の抽出物」または「H.undatus果実抽出物」または「抽出物」なる用語は、H.undatus(ピタハヤ)果実の多肉質の食用部分から分離された液体の画分を指す。この画分は、果肉をすり潰して固体破片を除去した後に得られる果肉を含まない汁を加熱し、加熱の間に生じた固体粒子を分離し、得られた透明な液体を回収することにより得られる。抽出物は、約380nmに発光のピークを有する、340nm〜395nmの波長を有する光を吸収した際の青色蛍光の発光を特徴とする。抽出物は、光学的増白剤を含まない白い紙の上に配置されて360nm〜370nmの波長範囲で照射された際、ヒトの肉眼には青色に見える。本明細書で使用される場合、「果肉を含まない汁」または「果肉を含まない果汁」なる用語は、食用果肉を果皮から分離し、果肉をすり潰してスラリーを得て、加熱することなくスラリーから、典型的には遠心分離によって、固形物を分離することにより得られるH.undatus果実の汁を指す。
(a)皮膚の欠陥の視認の低減を必要とするヒト対象を特定することと、
(b)対象の欠陥のある皮膚領域上にH.undatus果実抽出物またはそれを含む組成物を、欠陥のある皮膚領域に薄層による被覆をもたらすのに十分な量で適用し、それにより、UV光および/または太陽光に曝された場合に前記皮膚領域の欠陥の視認性を低減することと、
を含む。
熟したHylocereus Undatus果実を洗浄し、果肉を外皮から分離した。次に、均一になるまで(フードプロセッサまたは同様のものを用いて)果肉をすり潰し、得られたスラリーを遠心分離した(少なくとも1800gで15〜60分)。沈殿物を捨て、上清(果肉を含まない果汁)を回収した。
予想外にも、上記のように作製されたH.undatus果実抽出物は、UV光(358nm)を照射すると青色光を発するということが見出された。従って、広範囲の波長の検査を可能にする定量法を用いた、この抽出物の蛍光能を、蛍光光度計(FL920 Edinburgh Inc,英国)を用いて調べた。抽出物の蛍光を、H.undatusの果肉を含まない果汁の蛍光と比較した。上述の通り、果肉を含まない果汁は、すり潰した果肉のスラリーから不溶性固形物を除去した後(加熱および本発明の抽出物を得るためのさらなる処理の前)に得られる液体である。さらに、組成物への防腐剤および安定剤の添加(それぞれ、フェノキシエタノール(0.9%)およびメタ重亜硫酸ナトリウム(0.2%))の影響も調べた。
以下の表1は、H.undatus果実抽出物を1%含むクリームの例示的調合物である。
上記の実施例1に記載される通りに得られたH.undatus果実抽出物を含むクリームを、H.undatus果実抽出物のインビボでの有効性の予備的評価のために使用した(表1に提示されるクリーム調合物)。1人の健康な志願者が、このアッセイに参加した。フルスペクトル光の下で写真を撮影し、VISIA−CR(登録商標)による画像分析を用いて効果を評価した。志願者の顔の1枚目の写真(図2A)は、クリームの適用の前に撮影した。その後、クリームを適用して、顔を覆う薄膜を形成した。2枚目の写真(図2B)は、クリームを適用してから1時間後に撮影した。2枚の写真の比較から明らかなように、H.undatus果実抽出物を含むクリームは、均一な皮膚の色調の知覚をもたらし、皮膚の開いた毛穴および皮膚の染みの可視性を顕著に低減する。
Claims (24)
- 皮膚の欠陥の視認を低減するための方法であって、それを必要とするヒト対象の欠陥のある皮膚領域上にHylocereus undatus果実抽出物またはそれを含む組成物を、前記欠陥のある皮膚領域に薄層カバーをもたらすのに十分な量で適用し、それにより、紫外(UV)光を含む光源に曝された場合に前記皮膚領域の欠陥の視認を低減することを含み、
前記H.undatus果実抽出物は、
(a)食用果肉を果皮から分離するステップと、
(b)前記果肉をすり潰してスラリーを得るステップと、
(c)前記スラリーから不溶性固形物を分離して果肉を含まない汁を得るステップと、
(d)前記果肉を含まない汁を加熱するステップと、
(e)加熱した前記果肉を含まない汁から不溶性固形物を分離して液体抽出物を得るステップと、
を含むプロセスによって作製される、
方法。 - 前記それを必要とするヒト対象を特定するステップをさらに含む、請求項1に記載の方法。
- 前記ヒト対象の皮膚のアンダートーンカラーが、イエロー、イエロー〜オリーブおよびオリーブのアンダートーンからなる群より選択される、請求項1〜2のいずれか1項に記載の方法。
- 前記皮膚の欠陥が、皮膚の開いた毛穴、皮膚の変色、軽度の傷跡、痣およびそれらの任意の組み合わせからなる群より選択される、請求項1〜3のいずれか1項に記載の方法。
- 前記皮膚の欠陥が、開いた毛穴である、請求項4に記載の方法。
- 前記皮膚の欠陥が、不均一な皮膚の色調である、請求項4に記載の方法。
- 前記H.undatus果実抽出物が、340nm〜395nmの波長範囲にわたって励起された際の青領域における蛍光発光を特徴とする、請求項1に記載の方法。
- 前記H.undatus果実抽出物が、370nm〜390nmの波長を有する光で励起された際の460nm〜470nmの波長範囲にピークを有する蛍光発光を特徴とする、請求項7に記載の方法。
- 前記H.undatus果実抽出物を含む組成物が、化粧品に許容される安定剤、防腐剤またはそれらの組み合わせをさらに含む化粧品用組成物である、請求項1に記載の方法。
- 前記化粧品用組成物が、化粧品に許容される希釈剤、担体または賦形剤をさらに含む、請求項9に記載の方法。
- 前記化粧品用組成物が、粉末、溶液、クリーム、エマルジョン、懸濁液、分散系、軟膏およびスティックからなる群より選択される形態に調合される、請求項9〜10のいずれか1項に記載の方法。
- 前記化粧品用組成物が、ファンデーション、コンシーラー、フェイシャルパウダーおよびボディパウダーからなる群より選択される形態である、請求項9〜11のいずれか1項に記載の方法。
- 前記化粧品用組成物が、ブラッシュ、ハイライター、アイシャドウ、アイライナーおよび輪郭形成用調製物からなる群より選択される形態である、請求項9〜11のいずれか1項に記載の方法。
- 前記化粧品用組成物が、ノンカラーの化粧品用組成物である、請求項9〜13のいずれか1項に記載の方法。
- 前記化粧品用組成物が、カラー化粧品用組成物である、請求項9〜13のいずれか1項に記載の方法。
- 前記化粧品用組成物が、化粧品に許容される少なくとも1種の着色剤をさらに含む、請求項15に記載の方法。
- 前記少なくとも1種の着色剤が、無機顔料、天然着色剤、合成有機モノマー着色剤、合成有機ポリマー着色剤、セルフタナーおよびそれらの任意の組み合わせからなる群より選択される、請求項16に記載の方法。
- 前記化粧品用組成物が、メークアップ用組成物である、請求項9〜17のいずれか1項に記載の方法。
- 前記化粧品用組成物が、前記H.undatus果実抽出物を0.5%〜50%含む、請求項9〜18のいずれか1項に記載の方法。
- 前記化粧品用組成物が、前記H.undatus果実抽出物を0.5%〜5%含む、請求項19に記載の方法。
- 前記化粧品用組成物が、欠陥のある皮膚上に0.1g〜5.0gの量で適用される、請求項19〜20のいずれか1項に記載の方法。
- 皮膚の欠陥の視認の低減が、前記H.undatus果実抽出物またはそれを含む組成物を適用した時点から最大12時間持続する、請求項1に記載の方法。
- 皮膚の欠陥の視認の低減が、最大8時間持続する、請求項22に記載の方法。
- 皮膚の欠陥の視認の低減が、2〜4時間持続する、請求項23に記載の方法。
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