JP6862108B2 - 葉酸の安定性が優れた葉酸含有酸性組成物 - Google Patents
葉酸の安定性が優れた葉酸含有酸性組成物 Download PDFInfo
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Description
[1] 葉酸を含有する酸性組成物であって、プロトン性有機溶媒の含有量が0.1重量%未満であることを特徴とする、組成物。
[2] プロトン性有機溶媒がエタノール、グリセリン、メタノール、酢酸、ギ酸、ブチルアミンである、[1]の組成物。
[3] 容器詰め飲料又は容器詰めゼリー飲料である、[1]又は[2]の組成物。
[4] 葉酸を含有する酸性組成物の製造方法であって、プロトン性有機溶媒の配合量が0.1重量%未満となるように原材料を配合することを含む、方法。
[5] 酸性組成物中における葉酸の安定性を向上させる方法であって、該組成物中に含まれるプロトン性有機溶媒の量を0.1重量%未満とすることを含む、方法。
[6] プロトン性有機溶媒がエタノール、グリセリン、メタノール、酢酸、ギ酸、ブチルアミンである、[4]又は[5]の方法。
[7] 酸性組成物が容器詰め飲料又は容器詰めゼリー飲料である、[4]〜[6]のいずれかの方法。
1.標準原液
葉酸100mgを200mL褐色ビーカーに精秤し、0.1N水酸化ナトリウム溶液(和光純薬)を5mL添加して溶解した。次いで、特級エタノール(和光純薬)10mLを添加・混和後、イオン交換水100mLと0.1N塩酸(和光純薬)にて溶液のpHを7.0〜8.0に調整した。200mL褐色メスフラスコとイオン交換水を用いて所定量に定容し、HPLC測定における検量線作成のための標準原液とした。
葉酸を含む溶液サンプルは、重量を測定後、1.0N水酸化ナトリウム溶液(和光純薬)を用いてpH12.0(HORIBA製pHメーター(F−72))に調整した。次いで、10分間撹拌後(AS ONE製マグネティックスターラー(RSH−1AN))、1.0N塩酸(和光純薬)を用いてpH7.0に調整し、ろ過し(AS ONE製0.45μmフィルター(SY25TF))、得られたろ液をHPLC測定に付した。
HPLC測定は、以下の条件にて実施した。
カラム:Waters XBridge C18 5μm 6×250mm
温度:50℃
流量:1.2ml/min
移動相:12%メタノール(和光純薬)、0.3%酢酸(和光純薬)、1.08%オクタスルホン酸Na溶液(和光純薬)
イオン交換水にグラニュー糖2.5重量%、果糖1.2重量%、L−アスコルビン酸0.8重量%、クエン酸0.2重量%、クエン酸三ナトリウム0.2重量%、及び葉酸0.0003重量%を添加し、1.0N塩酸(和光純薬)、及び1.0N水酸化ナトリウム(和光純薬)を用いて、所定のpHに調整し、ベース液とした。
下記表1に示す組成にしたがって、ベース液、ならびに、エタノール、又は、アセトニトリルを含み、所定のpHを有する溶液(実施例1〜7、比較例1E〜7E(エタノール添加)、比較例1A〜7A(アセトニトリル添加))をそれぞれ調製した(0日目)。
下記表3に示す組成にしたがって、ベース液、及びエタノールを含み、pHを3.5とする溶液(実施例8、9、比較例8E)をそれぞれ調製した(0日目)。
下記表5に示す組成にしたがって、葉酸を含む溶液(実施例10、比較例9E)をそれぞれ調製した(0日目)。なお、香料1はエタノールを含まず中鎖脂肪酸とグリセリン脂肪酸エステルを溶媒として用いて、溶液化した香料であり、香料2は溶媒としてエタノールを50重量%(最終製品濃度0.1重量%)含む香料である。
Claims (2)
- pH4.5以下の酸性組成物中における葉酸の安定性を向上させる方法であって、該組成物中に含まれるエタノールの量を0.1重量%未満とすることを含む、方法。
- 酸性組成物が容器詰め飲料又は容器詰めゼリー飲料である、請求項1に記載の方法。
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