JP6843153B2 - 高含量のオイルを安定化したナノエマルジョン化粧料組成物 - Google Patents
高含量のオイルを安定化したナノエマルジョン化粧料組成物 Download PDFInfo
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- 239000000203 mixture Substances 0.000 title claims description 78
- 239000002537 cosmetic Substances 0.000 title claims description 40
- 239000007908 nanoemulsion Substances 0.000 title claims description 33
- 239000003921 oil Substances 0.000 claims description 34
- 239000003995 emulsifying agent Substances 0.000 claims description 29
- 239000002245 particle Substances 0.000 claims description 28
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 22
- 238000004945 emulsification Methods 0.000 claims description 20
- 229920005862 polyol Polymers 0.000 claims description 19
- 150000003077 polyols Chemical class 0.000 claims description 19
- 238000004519 manufacturing process Methods 0.000 claims description 15
- 239000004215 Carbon black (E152) Substances 0.000 claims description 10
- 239000010696 ester oil Substances 0.000 claims description 10
- 229930195733 hydrocarbon Natural products 0.000 claims description 10
- 150000002430 hydrocarbons Chemical class 0.000 claims description 10
- 229920002545 silicone oil Polymers 0.000 claims description 10
- 238000002156 mixing Methods 0.000 claims description 9
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 8
- XMSXQFUHVRWGNA-UHFFFAOYSA-N Decamethylcyclopentasiloxane Chemical compound C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1 XMSXQFUHVRWGNA-UHFFFAOYSA-N 0.000 claims description 4
- GHVNFZFCNZKVNT-UHFFFAOYSA-N decanoic acid Chemical compound CCCCCCCCCC(O)=O GHVNFZFCNZKVNT-UHFFFAOYSA-N 0.000 claims description 4
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 4
- 235000013870 dimethyl polysiloxane Nutrition 0.000 claims description 4
- 235000011187 glycerol Nutrition 0.000 claims description 4
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 4
- -1 polydimethylsiloxane Polymers 0.000 claims description 4
- 229940061570 polyglyceryl-10 stearate Drugs 0.000 claims description 4
- 230000001804 emulsifying effect Effects 0.000 claims description 3
- 239000002562 thickening agent Substances 0.000 claims description 3
- DGSZGZSCHSQXFV-UHFFFAOYSA-N 2,3-bis(2-ethylhexanoyloxy)propyl 2-ethylhexanoate Chemical compound CCCCC(CC)C(=O)OCC(OC(=O)C(CC)CCCC)COC(=O)C(CC)CCCC DGSZGZSCHSQXFV-UHFFFAOYSA-N 0.000 claims description 2
- LFESLSYSZQYEIZ-UHFFFAOYSA-N 3-octanoyloxybutyl octanoate Chemical compound CCCCCCCC(=O)OCCC(C)OC(=O)CCCCCCC LFESLSYSZQYEIZ-UHFFFAOYSA-N 0.000 claims description 2
- 239000005632 Capric acid (CAS 334-48-5) Substances 0.000 claims description 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims description 2
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 claims description 2
- IUMSDRXLFWAGNT-UHFFFAOYSA-N Dodecamethylcyclohexasiloxane Chemical compound C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1 IUMSDRXLFWAGNT-UHFFFAOYSA-N 0.000 claims description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 2
- SZKKRCSOSQAJDE-UHFFFAOYSA-N Schradan Chemical group CN(C)P(=O)(N(C)C)OP(=O)(N(C)C)N(C)C SZKKRCSOSQAJDE-UHFFFAOYSA-N 0.000 claims description 2
- DRRMRHKHTQRWMB-UHFFFAOYSA-N [3-(2-ethylhexanoyloxy)-2,2-bis(2-ethylhexanoyloxymethyl)propyl] 2-ethylhexanoate Chemical compound CCCCC(CC)C(=O)OCC(COC(=O)C(CC)CCCC)(COC(=O)C(CC)CCCC)COC(=O)C(CC)CCCC DRRMRHKHTQRWMB-UHFFFAOYSA-N 0.000 claims description 2
- ADANNTOYRVPQLJ-UHFFFAOYSA-N [dimethyl(trimethylsilyloxy)silyl]oxy-[[dimethyl(trimethylsilyloxy)silyl]oxy-dimethylsilyl]oxy-dimethylsilane Chemical compound C[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)C ADANNTOYRVPQLJ-UHFFFAOYSA-N 0.000 claims description 2
- 229940114374 butylene glycol dicaprylate Drugs 0.000 claims description 2
- 229940086555 cyclomethicone Drugs 0.000 claims description 2
- 229940008099 dimethicone Drugs 0.000 claims description 2
- XJNUECKWDBNFJV-UHFFFAOYSA-N hexadecyl 2-ethylhexanoate Chemical compound CCCCCCCCCCCCCCCCOC(=O)C(CC)CCCC XJNUECKWDBNFJV-UHFFFAOYSA-N 0.000 claims description 2
- OIKBVOIOVNEVJR-UHFFFAOYSA-N hexadecyl 6-methylheptanoate Chemical compound CCCCCCCCCCCCCCCCOC(=O)CCCCC(C)C OIKBVOIOVNEVJR-UHFFFAOYSA-N 0.000 claims description 2
- DWMMZQMXUWUJME-UHFFFAOYSA-N hexadecyl octanoate Chemical compound CCCCCCCCCCCCCCCCOC(=O)CCCCCCC DWMMZQMXUWUJME-UHFFFAOYSA-N 0.000 claims description 2
- XUGNVMKQXJXZCD-UHFFFAOYSA-N isopropyl palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC(C)C XUGNVMKQXJXZCD-UHFFFAOYSA-N 0.000 claims description 2
- 229940075495 isopropyl palmitate Drugs 0.000 claims description 2
- 239000004200 microcrystalline wax Substances 0.000 claims description 2
- 235000019808 microcrystalline wax Nutrition 0.000 claims description 2
- HMMGMWAXVFQUOA-UHFFFAOYSA-N octamethylcyclotetrasiloxane Chemical compound C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1 HMMGMWAXVFQUOA-UHFFFAOYSA-N 0.000 claims description 2
- 239000012188 paraffin wax Substances 0.000 claims description 2
- 229940008424 tetradecamethylhexasiloxane Drugs 0.000 claims description 2
- 229940042585 tocopherol acetate Drugs 0.000 claims description 2
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 claims description 2
- ZQTYRTSKQFQYPQ-UHFFFAOYSA-N trisiloxane Chemical compound [SiH3]O[SiH2]O[SiH3] ZQTYRTSKQFQYPQ-UHFFFAOYSA-N 0.000 claims description 2
- 238000000034 method Methods 0.000 description 20
- 239000000839 emulsion Substances 0.000 description 19
- RFVNOJDQRGSOEL-UHFFFAOYSA-N 2-hydroxyethyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCO RFVNOJDQRGSOEL-UHFFFAOYSA-N 0.000 description 7
- 230000000052 comparative effect Effects 0.000 description 6
- 239000006210 lotion Substances 0.000 description 5
- 210000004209 hair Anatomy 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 239000004480 active ingredient Substances 0.000 description 3
- 238000012790 confirmation Methods 0.000 description 3
- 239000002994 raw material Substances 0.000 description 3
- 241001340526 Chrysoclista linneella Species 0.000 description 2
- 239000006071 cream Substances 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 239000000499 gel Substances 0.000 description 2
- 239000002736 nonionic surfactant Substances 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 230000036555 skin type Effects 0.000 description 2
- 239000007921 spray Substances 0.000 description 2
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 1
- 229940015975 1,2-hexanediol Drugs 0.000 description 1
- 230000005653 Brownian motion process Effects 0.000 description 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
- 239000004166 Lanolin Substances 0.000 description 1
- 239000004907 Macro-emulsion Substances 0.000 description 1
- 239000004909 Moisturizer Substances 0.000 description 1
- 238000001016 Ostwald ripening Methods 0.000 description 1
- 206010040880 Skin irritation Diseases 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000005537 brownian motion Methods 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 230000008094 contradictory effect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000012377 drug delivery Methods 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000000118 hair dye Substances 0.000 description 1
- ACCCMOQWYVYDOT-UHFFFAOYSA-N hexane-1,1-diol Chemical compound CCCCCC(O)O ACCCMOQWYVYDOT-UHFFFAOYSA-N 0.000 description 1
- FHKSXSQHXQEMOK-UHFFFAOYSA-N hexane-1,2-diol Chemical compound CCCCC(O)CO FHKSXSQHXQEMOK-UHFFFAOYSA-N 0.000 description 1
- 238000000265 homogenisation Methods 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 229940039717 lanolin Drugs 0.000 description 1
- 235000019388 lanolin Nutrition 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000001333 moisturizer Effects 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 239000002324 mouth wash Substances 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 239000002105 nanoparticle Substances 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 239000007764 o/w emulsion Substances 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- ULWHHBHJGPPBCO-UHFFFAOYSA-N propane-1,1-diol Chemical compound CCC(O)O ULWHHBHJGPPBCO-UHFFFAOYSA-N 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 210000004761 scalp Anatomy 0.000 description 1
- 238000004062 sedimentation Methods 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 239000002453 shampoo Substances 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 238000005063 solubilization Methods 0.000 description 1
- 230000007928 solubilization Effects 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000000606 toothpaste Substances 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/06—Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/06—Emulsions
- A61K8/062—Oil-in-water emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/31—Hydrocarbons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
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- A61K8/39—Derivatives containing from 2 to 10 oxyalkylene groups
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/58—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur or phosphorus
- A61K8/585—Organosilicon compounds
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- A—HUMAN NECESSITIES
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
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- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
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- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
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- A—HUMAN NECESSITIES
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Description
1)水と、ポリオール又はポリオール誘導体とを混合するステップと、
2)シリコーンオイル、エステル系オイル及び炭化水素系オイルからなる群から選択される一つ以上のオイルと、ポリグリセリル系乳化剤又はステアリン酸PEG系乳化剤とを混合するステップと、
3)前記ステップ1)の混合液と前記ステップ2)の混合物を混合し、混合物を高圧乳化するステップと、
を含む半透明の水中油型(O/W)ナノエマルジョン化粧料組成物の製造方法を提供する。
1)水と、ポリオール又はポリオール誘導体とを混合するステップと、
2)シリコーンオイル、エステル系オイル及び炭化水素系オイルからなる群から選択される一つ以上のオイルと、ポリグリセリル系乳化剤又はステアリン酸PEG系乳化剤とを混合するステップと、
3)前記ステップ1)の混合液と前記ステップ2)の混合物とを混合し、混合物を高圧乳化するステップと、
を含む半透明の水中油型(O/W)ナノエマルジョン化粧料組成物を含んでいてもよい。
以下、本発明の理解を助けるために実施例を挙げて詳細に説明する。しかし、本発明による実施例は多様な他の形態に変形することができ、本発明の範囲が下記実施例によって限定されるものと解釈されるべきではない。本発明の実施例は、当業界で平均的な知識を有した者に本発明をより完全に説明するために提供するものである。
実施例1及び比較例1〜3では、下記表1に記載した各成分及び含量により、以下の方法で化粧料組成物を製造した。
添付図面の図1は、ホモミキサーにかけた(Homo−Mixした)後に高圧乳化機を2回通過させた実施例1のナノエマルジョンの粒径を示した図である。平均粒径が100nm程度であることを示す結果である。通常的に200nm以下の粒径を示す場合、外観が半透明であると共に青っぽい特徴を有し、それのため、ナノエマルジョンがよく製造されたか否かを肉眼でも容易に判断することができる。また、組成物の安定性評価においても製造直後と同一に半透明した外観が持続する場合、安定性が維持されると判断することができる。ここで、粒子のサイズは、Particle size analyzer(Submicron Particle Sizer NICOMP 380)を用いて測定した。
実施例1のエマルジョンを製造し、40℃で30日保管した後の透明度を肉眼で観察した。その結果を、図2に示す。
製品の粘度は、Brookfield DV−E viscometerで測定し、cps(centi poise)単位で表示される。本実験で測定されたサンプルの粘度は、下記表2に示した。
実施例1及び比較例1〜3のエマルジョン組成物のそれぞれ1回の使用量(約0.5ml)を手の甲に塗布して外観、延展性、水分感、油分感、べたつき感、密着感、吸収力、使用後の感じ、持続力などの様々な感性品質を確認し、これを通じて全体的な製品満足度を評価することができる。実施例と比較例の使用感/特徴を、下記表2に示す。
Claims (9)
- 水と、
ポリグリセリル系乳化剤と、
組成物の総重量を基準として5〜30重量%の量の、シリコーンオイル、エステル系オイル及び炭化水素系オイルからなる群から選択される一つ以上のオイルと、
ポリオールと、
を含むことを特徴とする、水中油型(O/W)ナノエマルジョンの化粧料組成物であって、
前記ポリグリセリル系乳化剤は、ステアリン酸ポリグリセリル−10であり、かつ、組成物の総重量を基準として1〜5重量%の量で含まれ、
前記ナノエマルジョンの粒子サイズは、10〜250nmの範囲に分布しており、
但し、前記化粧料組成物は、ステアリン酸ポリグリセリル−10以外の乳化剤及び増粘剤を含まない、水中油型(O/W)ナノエマルジョンの化粧料組成物。 - 前記シリコーンオイルは、ジメチコン、シクロメチコン、ポリジメチルシロキサン、メチルフェニルポリシロキサン、メチルシクロポリシロキサン、オクタメチルシクロテトラシロキサン、デカメチルシクロペンタシロキサン、ドデカメチルシクロヘキサシロキサン、テトラデカメチルヘキサシロキサン及びオクタメチルトリシロキサンからなる群から選択される一つ以上であることを特徴とする、請求項1に記載の化粧料組成物。
- 前記エステル系オイルは、トリエチルヘキサノイン、セチルエチルヘキサノエート、セチルオクタノエート、セチルイソオクタノエート、オクチルドデシルミリステート、ペンタエリスリチルテトラエチルヘキサノエート、イソプロピルパルミテート、イソプロピルミリステート、カプリル/カプリン酸トリグリセライド、ブチレングリコールジカプリレート/ジカプレート、トコフェロールアセテート及びジカプリリックカーボネートからなる群から選択される一つ以上であることを特徴とする、請求項1に記載の化粧料組成物。
- 前記炭化水素系オイルは、パラフィン、セレシン及びマイクロクリスタリンワックスからなる群から選択される一つ以上であることを特徴とする、請求項1に記載の化粧料組成物。
- 前記ポリオールは、グリセリン、2価のアルコール及びこれらの混合物からなる群から選択される一つ以上であることを特徴とする、請求項1に記載の化粧料組成物。
- 前記ポリオールは、組成物の総重量を基準として1〜30重量%の量で含まれることを特徴とする、請求項1に記載の化粧料組成物。
- 前記ナノエマルジョンは、0〜5000cpsの粘度を有することを特徴とする、請求項1に記載の化粧料組成物。
- ナノエマルジョンは、平均粒径が10〜250nmであることを特徴とする、請求項1に記載の化粧料組成物。
- 1)水と、ポリオールとを混合するステップと、
2)シリコーンオイル、エステル系オイル及び炭化水素系オイルからなる群から選択される一つ以上のオイルと、ポリグリセリル系乳化剤とを混合するステップと、
3)前記ステップ1)の混合液と、前記ステップ2)の混合物とを混合し、混合物を500〜2500barの圧力下で高圧乳化するステップと、
を含むことを特徴とする、水中油型(O/W)ナノエマルジョン化粧料組成物の製造方法であって、
前記ナノエマルジョンの粒子サイズは、10〜250nmの範囲に分布し、
前記オイルは、組成物の総重量を基準として5〜30重量%の量で含まれ、
前記ポリグリセリル系乳化剤は、ステアリン酸ポリグリセリル−10であり、かつ、組成物の総重量を基準として1〜5重量%の量で含まれ、
但し、前記化粧料組成物は、ステアリン酸ポリグリセリル−10以外の乳化剤及び増粘剤を含まず、
前記高圧乳化が2回以上行われる、水中油型(O/W)ナノエマルジョン化粧料組成物の製造方法。
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US20210220234A1 (en) | 2021-07-22 |
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