JP6824876B2 - アミジン誘導体組成物及びそれらの使用 - Google Patents

アミジン誘導体組成物及びそれらの使用 Download PDF

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JP6824876B2
JP6824876B2 JP2017510576A JP2017510576A JP6824876B2 JP 6824876 B2 JP6824876 B2 JP 6824876B2 JP 2017510576 A JP2017510576 A JP 2017510576A JP 2017510576 A JP2017510576 A JP 2017510576A JP 6824876 B2 JP6824876 B2 JP 6824876B2
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present
vitamin
pharmaceutically acceptable
poly
polyethylene glycol
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JP2017525718A5 (enExample
JP2017525718A (ja
Inventor
バブー，ヤーラガッダ・エス
カマス，ビベカーナンド・ピー
ゴーワン，ウォルター
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バイオクライスト ファーマシューティカルズ， インコーポレイテッド
バイオクライスト ファーマシューティカルズ， インコーポレイテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Treating Waste Gases (AREA)
JP2017510576A 2014-08-22 2015-08-24 アミジン誘導体組成物及びそれらの使用 Active JP6824876B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462040836P 2014-08-22 2014-08-22
US62/040,836 2014-08-22
PCT/US2015/046578 WO2016029214A1 (en) 2014-08-22 2015-08-24 Compositions and uses of amidine derivatives

Publications (3)

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JP2017525718A JP2017525718A (ja) 2017-09-07
JP2017525718A5 JP2017525718A5 (enExample) 2018-09-27
JP6824876B2 true JP6824876B2 (ja) 2021-02-03

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JP2017510576A Active JP6824876B2 (ja) 2014-08-22 2015-08-24 アミジン誘導体組成物及びそれらの使用

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US (1) US10905683B2 (enExample)
EP (1) EP3182962B1 (enExample)
JP (1) JP6824876B2 (enExample)
AU (1) AU2015305214B2 (enExample)
CA (1) CA2959026C (enExample)
DK (1) DK3182962T3 (enExample)
ES (1) ES2954451T3 (enExample)
WO (1) WO2016029214A1 (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI636047B (zh) 2013-08-14 2018-09-21 英商卡爾維斯塔製藥有限公司 雜環衍生物
GB201421083D0 (en) 2014-11-27 2015-01-14 Kalvista Pharmaceuticals Ltd Enzyme inhibitors
GB201421085D0 (en) 2014-11-27 2015-01-14 Kalvista Pharmaceuticals Ltd New enzyme inhibitors
ME03794B (me) 2016-05-31 2021-04-20 Kalvista Pharmaceuticals Ltd Derivati pirazola kao inhibitori kalikreina plazme
GB201609603D0 (en) 2016-06-01 2016-07-13 Kalvista Pharmaceuticals Ltd Polymorphs of N-[(6-cyano-2-fluoro-3-methoxyphenyl)Methyl]-3-(methoxymethyl)-1-({4-[(2-ox opyridin-1-YL)Methyl]phenyl}methyl)pyrazole-4-carboxamide
GB201609607D0 (en) 2016-06-01 2016-07-13 Kalvista Pharmaceuticals Ltd Polymorphs of N-(3-Fluoro-4-methoxypyridin-2-yl)methyl)-3-(methoxymethyl)-1-({4-((2-oxopy ridin-1-yl)methyl)phenyl}methyl)pyrazole-4-carboxamide and salts
CN106565442B (zh) * 2016-08-24 2019-07-16 浙江美诺华药物化学有限公司 3-(3-氟苄基)-4-(3-氟苄氧基)苯甲醛的制备方法
CN106565521B (zh) * 2016-08-24 2019-03-08 浙江美诺华药物化学有限公司 (s)-2-[3-(3-氟苄基)-4-(3-氟苄氧基)苄氨基]丙酰胺及其盐的制备方法
CN106632223B (zh) * 2016-08-24 2019-04-23 浙江美诺华药物化学有限公司 2-(3-溴-4-(3-氟苄氧基)苯基)-1,3-二氧戊环及其制备方法
ES2942285T3 (es) 2016-10-31 2023-05-31 Biocryst Pharm Inc Profármacos de inhibidores de la calicreína
CN106977382A (zh) * 2017-04-28 2017-07-25 山东新华制药股份有限公司 4‑（3‑氟苄氧基）苯甲醛的制备方法
GB201719881D0 (en) 2017-11-29 2018-01-10 Kalvista Pharmaceuticals Ltd Solid forms of plasma kallikrein inhibitor and salts thereof
PL3716952T3 (pl) 2017-11-29 2022-05-02 Kalvista Pharmaceuticals Limited Postacie dawkowania zawierające inhibitor kalikreiny osoczowej
ES3072908T3 (en) * 2019-04-08 2026-07-06 Biocryst Pharm Inc Plasma kallikrein inhibitors and methods of use thereof in ocular disorders
WO2021028645A1 (en) 2019-08-09 2021-02-18 Kalvista Pharmaceuticals Limited Plasma kallikrein inhibitors
WO2022006232A2 (en) * 2020-07-01 2022-01-06 The Board Of Trustees Of The Leland Stanford Junior University Drug repurposing for treatment of viral infections
JP2024506191A (ja) * 2021-02-09 2024-02-09 フェブラ・ピーティーワイ・リミテッド 外用医薬組成物を調製する方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1540979A (en) 1923-04-11 1925-06-09 Swift & Co Machine for testing jelly strength of glues, gelatins, and the like
CA2426430C (en) * 2000-10-20 2014-10-07 Biocryst Pharmaceuticals, Inc. Biaryl compounds as serine protease inhibitors
DE60139510D1 (de) * 2001-04-06 2009-09-17 Biocryst Pharm Inc Biarylverbindungen als serinproteaseinhibitoren
MX369690B (es) * 2011-09-08 2019-11-19 Intrexon Corp Diacilhidrazina cristalina y sus usos.
WO2014057069A1 (en) 2012-10-10 2014-04-17 Novo Nordisk Health Care Ag Liquid pharmaceutical composition of factor vii polypeptide

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Publication number Publication date
ES2954451T3 (es) 2023-11-22
EP3182962A1 (en) 2017-06-28
CA2959026C (en) 2023-10-24
EP3182962B1 (en) 2023-06-07
AU2015305214B2 (en) 2020-04-23
AU2015305214A1 (en) 2017-03-16
DK3182962T3 (da) 2023-09-18
US10905683B2 (en) 2021-02-02
WO2016029214A1 (en) 2016-02-25
JP2017525718A (ja) 2017-09-07
US20170266172A1 (en) 2017-09-21
CA2959026A1 (en) 2016-02-25
WO2016029214A9 (en) 2017-01-05

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