JP6800750B2 - 固形腫瘍の処置方法 - Google Patents
固形腫瘍の処置方法 Download PDFInfo
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- JP6800750B2 JP6800750B2 JP2016531935A JP2016531935A JP6800750B2 JP 6800750 B2 JP6800750 B2 JP 6800750B2 JP 2016531935 A JP2016531935 A JP 2016531935A JP 2016531935 A JP2016531935 A JP 2016531935A JP 6800750 B2 JP6800750 B2 JP 6800750B2
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- Bioinformatics & Cheminformatics (AREA)
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| US8603521B2 (en) | 2009-04-17 | 2013-12-10 | Pharmacyclics, Inc. | Formulations of histone deacetylase inhibitor and uses thereof |
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| TWI662963B (zh) | 2012-06-04 | 2019-06-21 | 美商製藥有限責任公司 | 布魯頓氏酪胺酸激酶抑制劑之結晶形式 |
| US10954567B2 (en) | 2012-07-24 | 2021-03-23 | Pharmacyclics Llc | Mutations associated with resistance to inhibitors of Bruton's Tyrosine Kinase (BTK) |
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| EA201591051A1 (ru) | 2013-02-08 | 2016-06-30 | Селджен Авиломикс Рисерч, Инк. | Ингибиторы erk и варианты их применения |
| ES2709509T3 (es) | 2013-08-12 | 2019-04-16 | Pharmacyclics Llc | Procedimientos para el tratamiento de cáncer amplificado por HER2 |
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| MA38961A1 (fr) | 2013-09-30 | 2018-05-31 | Pharmacyclics Llc | Composés 3-phenyl-1h-pyrazolo[3,4-d]pyrimidin-4-ylamine substitués inhibiteurs de la tyrosine kinase de bruton utilisés pour traiter par exemple les maladies auto-immunes, respiratoires et inflammatoires, cancer, mastocytose et osteoporose |
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| WO2015187848A1 (en) * | 2014-06-04 | 2015-12-10 | Sampath Deepa | Hdac inhibitor and btk inhibitor combinations |
| US9533991B2 (en) | 2014-08-01 | 2017-01-03 | Pharmacyclics Llc | Inhibitors of Bruton's tyrosine kinase |
| KR20170033358A (ko) | 2014-08-07 | 2017-03-24 | 파마싸이클릭스 엘엘씨 | 브루톤 티로신 키나아제 저해제의 신규한 제제 |
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2014
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- 2014-08-01 US US14/450,068 patent/US9421208B2/en active Active
- 2014-08-01 AR ARP140102910A patent/AR097204A1/es unknown
- 2014-08-01 WO PCT/US2014/049459 patent/WO2015017812A1/en not_active Ceased
- 2014-08-01 TW TW103126513A patent/TWI649081B/zh not_active IP Right Cessation
- 2014-08-01 CA CA2919996A patent/CA2919996A1/en not_active Abandoned
- 2014-08-01 EP EP14831872.8A patent/EP3027192A4/en not_active Withdrawn
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|---|---|
| AR097204A1 (es) | 2016-02-24 |
| US9421208B2 (en) | 2016-08-23 |
| US20150038518A1 (en) | 2015-02-05 |
| TW201601727A (zh) | 2016-01-16 |
| TWI649081B (zh) | 2019-02-01 |
| JP2016529245A (ja) | 2016-09-23 |
| CA2919996A1 (en) | 2015-02-05 |
| WO2015017812A1 (en) | 2015-02-05 |
| EP3027192A4 (en) | 2017-03-22 |
| EP3027192A1 (en) | 2016-06-08 |
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