JP6782255B2 - ヒストンデアセチラーゼ阻害薬及び組成物並びにそれらの使用の方法 - Google Patents

ヒストンデアセチラーゼ阻害薬及び組成物並びにそれらの使用の方法 Download PDF

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Publication number
JP6782255B2
JP6782255B2 JP2017557413A JP2017557413A JP6782255B2 JP 6782255 B2 JP6782255 B2 JP 6782255B2 JP 2017557413 A JP2017557413 A JP 2017557413A JP 2017557413 A JP2017557413 A JP 2017557413A JP 6782255 B2 JP6782255 B2 JP 6782255B2
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pharmaceutically acceptable
alkyl
acceptable salt
mixture
compound according
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JP2018515492A5 (enExample
JP2018515492A (ja
Inventor
ドミンゲス，セリア
メイラード，マイケル，シー．
ブレッキア，ペルラ
ハウガン，アラン，エフ．
ジャーヴィス，レベッカ，イー．
ラックハースト，クリストファー，エー．
サヴィル−ストーンズ，エリザベス，エー．
ストット，アンドリュー，ジェイ．
デ ポエル，アマンダ ヴァン
デ ポエル，アマンダ ヴァン
ウォール，マイケル
ウィシャート，グラント
Original Assignee
シーエイチディーアイ ファウンデーション，インコーポレーテッド
シーエイチディーアイ ファウンデーション，インコーポレーテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
JP2017557413A 2015-05-07 2016-05-06 ヒストンデアセチラーゼ阻害薬及び組成物並びにそれらの使用の方法 Expired - Fee Related JP6782255B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562158379P 2015-05-07 2015-05-07
US62/158,379 2015-05-07
PCT/US2016/031329 WO2016179550A1 (en) 2015-05-07 2016-05-06 Histone deacetylase inhibitors and compositions and methods of use thereof

Publications (3)

Publication Number Publication Date
JP2018515492A JP2018515492A (ja) 2018-06-14
JP2018515492A5 JP2018515492A5 (enExample) 2019-06-13
JP6782255B2 true JP6782255B2 (ja) 2020-11-11

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US (2) US10047073B2 (enExample)
EP (1) EP3291809B1 (enExample)
JP (1) JP6782255B2 (enExample)
KR (1) KR20180002730A (enExample)
CN (1) CN107735087B (enExample)
AU (1) AU2016256917B2 (enExample)
BR (1) BR112017023710B1 (enExample)
CA (1) CA2984621C (enExample)
EA (1) EA035592B1 (enExample)
IL (1) IL255449B2 (enExample)
MX (1) MX379817B (enExample)
WO (1) WO2016179550A1 (enExample)

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KR102052844B1 (ko) 2019-01-31 2019-12-05 주식회사 아이스크림에듀 학습 분석 방법 및 시스템
CN114727974A (zh) 2019-07-30 2022-07-08 艾科尼佐治疗股份有限公司 Hdac6抑制剂及其用途
KR102232343B1 (ko) 2019-12-11 2021-03-26 주식회사 아이스크림에듀 인공지능 기반 맞춤형 학습 방법 및 시스템
KR102191671B1 (ko) 2019-12-20 2020-12-16 주식회사 아이스크림에듀 소셜 러닝 및 e포트폴리오 기반 맞춤형 학습 방법 및 시스템
KR102191672B1 (ko) 2019-12-20 2020-12-16 주식회사 아이스크림에듀 학습 분석 및 인공지능 기반 맞춤형 학습 방법 및 시스템
KR102191670B1 (ko) 2019-12-20 2020-12-16 주식회사 아이스크림에듀 문제은행 및 지식맵 기반 맞춤형 학습 방법 및 시스템
KR102197752B1 (ko) 2019-12-20 2021-01-04 주식회사 아이스크림에듀 맞춤형 자동 문항 생성을 통한 인공지능 기반 학습 방법 및 시스템
KR102232344B1 (ko) 2020-02-27 2021-03-26 주식회사 아이스크림에듀 빅데이터 및 인공지능 기반의 맞춤형 학습 방법 및 시스템
KR102258234B1 (ko) 2020-02-27 2021-05-31 주식회사 아이스크림에듀 인공지능 가정교사 인터페이스가 적용된 맞춤형 학습 방법 및 시스템
KR102258235B1 (ko) 2020-02-27 2021-05-31 주식회사 아이스크림에듀 실감 콘텐츠가 적용된 인공지능 기반의 맞춤형 학습 방법 및 시스템
CN111190006A (zh) * 2020-03-09 2020-05-22 上海市东方医院（同济大学附属东方医院） 组蛋白去乙酰化酶6在制备用于评估维持性腹膜透析患者腹膜功能的标志物中的用途
KR102222533B1 (ko) 2020-06-25 2021-03-05 주식회사 아이스크림미디어 고정형 웹 콘텐츠를 반응형 콘텐츠로 자동 변환하는 시스템 및 그 제어방법
CA3189738A1 (en) * 2020-08-07 2022-02-10 Italfarmaco S.P.A. Novel oxadiazole-based selective hdac6 inhibitors
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Publication number Publication date
BR112017023710A2 (pt) 2018-07-31
MX2017014299A (es) 2018-08-09
CN107735087A (zh) 2018-02-23
EP3291809A4 (en) 2018-10-03
EP3291809A1 (en) 2018-03-14
KR20180002730A (ko) 2018-01-08
US20190185463A1 (en) 2019-06-20
EA201792255A1 (ru) 2018-06-29
AU2016256917B2 (en) 2021-08-26
US10047073B2 (en) 2018-08-14
WO2016179550A1 (en) 2016-11-10
CN107735087B (zh) 2021-09-03
JP2018515492A (ja) 2018-06-14
CA2984621C (en) 2023-09-26
MX379817B (es) 2025-03-11
IL255449A0 (en) 2017-12-31
EA035592B1 (ru) 2020-07-13
IL255449B2 (en) 2023-07-01
IL255449B1 (en) 2023-03-01
AU2016256917A1 (en) 2017-11-23
HK1252489A1 (zh) 2019-05-24
EP3291809B1 (en) 2021-08-25
CA2984621A1 (en) 2016-11-10
BR112017023710B1 (pt) 2023-03-07
US20160333001A1 (en) 2016-11-17

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