JP6751208B2 - ロチゴチンベヘネート及びその調製方法並びに用途 - Google Patents
ロチゴチンベヘネート及びその調製方法並びに用途 Download PDFInfo
- Publication number
- JP6751208B2 JP6751208B2 JP2019524492A JP2019524492A JP6751208B2 JP 6751208 B2 JP6751208 B2 JP 6751208B2 JP 2019524492 A JP2019524492 A JP 2019524492A JP 2019524492 A JP2019524492 A JP 2019524492A JP 6751208 B2 JP6751208 B2 JP 6751208B2
- Authority
- JP
- Japan
- Prior art keywords
- rotigotine
- behenate
- crystalline form
- rotigotine behenate
- powder
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/08—Hydrogen atoms or radicals containing only hydrogen and carbon atoms
- C07D333/10—Thiophene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Psychology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CN2016/090803 WO2018014277A1 (zh) | 2016-07-21 | 2016-07-21 | 罗替戈汀山嵛酸酯及其制备方法和用途 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019523297A JP2019523297A (ja) | 2019-08-22 |
| JP2019523297A5 JP2019523297A5 (https=) | 2020-01-23 |
| JP6751208B2 true JP6751208B2 (ja) | 2020-09-02 |
Family
ID=60992805
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019524492A Active JP6751208B2 (ja) | 2016-07-21 | 2016-07-21 | ロチゴチンベヘネート及びその調製方法並びに用途 |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US10669249B2 (https=) |
| EP (1) | EP3489227B1 (https=) |
| JP (1) | JP6751208B2 (https=) |
| KR (1) | KR20190031314A (https=) |
| CN (1) | CN109415335B (https=) |
| AU (1) | AU2016415408B2 (https=) |
| BR (1) | BR112019001035A2 (https=) |
| CA (1) | CA3030043C (https=) |
| ES (1) | ES2855976T3 (https=) |
| MY (1) | MY195897A (https=) |
| PH (1) | PH12018550212A1 (https=) |
| PL (1) | PL3489227T3 (https=) |
| RU (1) | RU2717542C9 (https=) |
| SG (1) | SG11201811543XA (https=) |
| WO (1) | WO2018014277A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2717542C9 (ru) * | 2016-07-21 | 2020-08-12 | Шаньдун Луе Фармасьютикал Ко., Лтд. | Ротиготина бегенат, его способ получения и применение |
| CN108341798B (zh) * | 2017-01-23 | 2021-05-25 | 沈阳药科大学 | 罗替戈汀衍生物及其制备和应用 |
| CN114423746A (zh) * | 2019-09-30 | 2022-04-29 | 山东绿叶制药有限公司 | 化合物及其制备方法和用途 |
| JP7621009B2 (ja) * | 2020-10-27 | 2025-01-24 | ▲広▼州市恒▲諾▼康医▲薬▼科技有限公司 | テトラヒドロナフタレン系化合物、その医薬組成物及びその使用 |
| WO2024208226A1 (zh) * | 2023-04-04 | 2024-10-10 | 广州市恒诺康医药科技有限公司 | 四氢萘类化合物、其药物组合物及其用途 |
| CN119504742B (zh) * | 2024-11-18 | 2025-10-28 | 陕西师范大学 | 一种娃儿藤碱和安托芬的全合成方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2239196T3 (es) * | 2002-12-02 | 2005-09-16 | Schwarz Pharma Ag | Suministro iontoforetico de rotigotina para el tratamiento de la enfermedad de parkinson. |
| DE10361259A1 (de) * | 2003-12-24 | 2005-07-28 | Schwarz Pharma Ag | Verwendung von Rotigotine in einem Frühstadium von Morbus Parkinson zur Prävention des weiteren Neuronenverlustes |
| KR101481643B1 (ko) | 2010-11-25 | 2015-01-12 | 산동 루예 파마슈티칼 컴파니 리미티드 | 로티고틴, 이의 유도체 또는 로티고틴 또는 이의 유도체의 약제학적으로 허용가능한 염의 조성물 |
| WO2013168033A1 (en) * | 2012-05-10 | 2013-11-14 | Mahesh Kandula | Compositions and methods for treatment of neurologic diseases |
| US9956201B2 (en) * | 2014-07-21 | 2018-05-01 | Spriaso Llc | Compositions comprising bioreversible derivatives of hydroxy N-substituted-2-aminotetralins, and related dosage forms |
| WO2016014242A1 (en) * | 2014-07-21 | 2016-01-28 | Spriaso Llc | Compositions comprising bioreversible derivatives of hydroxy n-substituted-2-aminotetralins, dosage forms, and related methods |
| RU2717542C9 (ru) * | 2016-07-21 | 2020-08-12 | Шаньдун Луе Фармасьютикал Ко., Лтд. | Ротиготина бегенат, его способ получения и применение |
-
2016
- 2016-07-21 RU RU2018146096A patent/RU2717542C9/ru active
- 2016-07-21 SG SG11201811543XA patent/SG11201811543XA/en unknown
- 2016-07-21 PL PL16909205T patent/PL3489227T3/pl unknown
- 2016-07-21 US US16/309,807 patent/US10669249B2/en active Active
- 2016-07-21 KR KR1020197005257A patent/KR20190031314A/ko not_active Abandoned
- 2016-07-21 AU AU2016415408A patent/AU2016415408B2/en active Active
- 2016-07-21 ES ES16909205T patent/ES2855976T3/es active Active
- 2016-07-21 CN CN201680087177.7A patent/CN109415335B/zh active Active
- 2016-07-21 JP JP2019524492A patent/JP6751208B2/ja active Active
- 2016-07-21 CA CA3030043A patent/CA3030043C/en not_active Expired - Fee Related
- 2016-07-21 BR BR112019001035-1A patent/BR112019001035A2/pt not_active IP Right Cessation
- 2016-07-21 MY MYPI2018002909A patent/MY195897A/en unknown
- 2016-07-21 WO PCT/CN2016/090803 patent/WO2018014277A1/zh not_active Ceased
- 2016-07-21 EP EP16909205.3A patent/EP3489227B1/en active Active
-
2018
- 2018-12-26 PH PH12018550212A patent/PH12018550212A1/en unknown
-
2020
- 2020-04-27 US US16/860,037 patent/US11111227B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| BR112019001035A2 (pt) | 2019-04-30 |
| PL3489227T3 (pl) | 2021-05-04 |
| JP2019523297A (ja) | 2019-08-22 |
| MY195897A (en) | 2023-02-27 |
| US20200255396A1 (en) | 2020-08-13 |
| RU2717542C1 (ru) | 2020-03-24 |
| PH12018550212A1 (en) | 2019-10-28 |
| AU2016415408B2 (en) | 2019-04-11 |
| EP3489227B1 (en) | 2020-10-21 |
| US10669249B2 (en) | 2020-06-02 |
| CN109415335A (zh) | 2019-03-01 |
| AU2016415408A1 (en) | 2019-01-17 |
| CA3030043C (en) | 2021-01-19 |
| SG11201811543XA (en) | 2019-02-27 |
| WO2018014277A1 (zh) | 2018-01-25 |
| CN109415335B (zh) | 2020-06-05 |
| US20190330177A1 (en) | 2019-10-31 |
| EP3489227A4 (en) | 2020-01-22 |
| ES2855976T3 (es) | 2021-09-27 |
| EP3489227A1 (en) | 2019-05-29 |
| US11111227B2 (en) | 2021-09-07 |
| RU2717542C9 (ru) | 2020-08-12 |
| CA3030043A1 (en) | 2018-01-25 |
| KR20190031314A (ko) | 2019-03-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP6751208B2 (ja) | ロチゴチンベヘネート及びその調製方法並びに用途 | |
| JP2019523297A5 (https=) | ||
| JP6691218B2 (ja) | 選択的なｓ１ｐ１受容体アゴニストの新規な結晶形及びその製造方法 | |
| JP2019516804A (ja) | ナトリウム−グルコース共輸送体阻害薬の新規な結晶形及びその製造方法並びに用途 | |
| JP2024088796A (ja) | ウチデロン半水和物単結晶、並びにその調製方法及び応用 | |
| WO2023193563A1 (zh) | 一种噻吩并吡啶化合物的晶型a、制备方法及其药物组合物 | |
| TWI905090B (zh) | Mcl-1抑制劑之新結晶型, 其製備方法及包含其之醫藥組合物 | |
| CN108473507A (zh) | 噻吩并嘧啶化合物的结晶形式 | |
| CN104650109A (zh) | 紫杉烷类化合物 | |
| KR20240158968A (ko) | Vanin 효소 억제제의 염 형태, 결정형 및 이의 제조 방법과 용도 | |
| WO2018214877A1 (zh) | 一种地佐辛晶型及其制备方法 | |
| KR102350002B1 (ko) | 탁산 화합물, 이들의 제조 방법, 및 이들의 용도 | |
| CN107540589A (zh) | 一种艾尔骨化醇晶型、药物组合物及制备方法和应用 | |
| HK40004499A (en) | Rotigotine behenate, and manufacturing method and application thereof | |
| HK40004499B (en) | Rotigotine behenate, and manufacturing method and application thereof | |
| JP2022551176A (ja) | 置換窒素複素環化合物およびその麻酔作用 | |
| RU2844681C2 (ru) | Новые кристаллические формы mcl-1 ингибитора, способ их получения и содержащие их фармацевтические композиции | |
| RU2847971C2 (ru) | Новые кристаллические формы mcl-1 ингибитора, способ их получения и содержащие их фармацевтические композиции | |
| WO2020012245A1 (en) | Thienothiophene-naltrexone prodrugs for long-acting injectable compositions | |
| US20170044137A1 (en) | Omeprazole sodium semihydrate and preparation method thereof | |
| CN121419965A (zh) | 吡啶氮氧化合物的盐型、共晶及其制备方法和应用 | |
| EA044230B1 (ru) | Новые кристаллические формы mcl-1 ингибитора, способ их получения и содержащие их фармацевтические композиции | |
| HK40057196A (en) | New crystalline forms of a mcl-1 inhibitor, a process for their preparation and pharmaceutical compositions containing them |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20190719 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20191205 |
|
| RD04 | Notification of resignation of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7424 Effective date: 20191220 |
|
| A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20200611 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20200623 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20200722 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20200804 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20200813 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 6751208 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| S111 | Request for change of ownership or part of ownership |
Free format text: JAPANESE INTERMEDIATE CODE: R313113 |
|
| S531 | Written request for registration of change of domicile |
Free format text: JAPANESE INTERMEDIATE CODE: R313531 |
|
| R350 | Written notification of registration of transfer |
Free format text: JAPANESE INTERMEDIATE CODE: R350 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |