CN114423746A - 化合物及其制备方法和用途 - Google Patents

化合物及其制备方法和用途 Download PDF

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Publication number
CN114423746A
CN114423746A CN202080065958.2A CN202080065958A CN114423746A CN 114423746 A CN114423746 A CN 114423746A CN 202080065958 A CN202080065958 A CN 202080065958A CN 114423746 A CN114423746 A CN 114423746A
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CN
China
Prior art keywords
solution
stirring
dichloromethane
compound
reaction
Prior art date
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Withdrawn
Application number
CN202080065958.2A
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English (en)
Inventor
周凤梅
谭文娟
唐倩倩
王进荣
张睿
余飞
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shandong Luye Pharmaceutical Co Ltd
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Shandong Luye Pharmaceutical Co Ltd
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Filing date
Publication date
Application filed by Shandong Luye Pharmaceutical Co Ltd filed Critical Shandong Luye Pharmaceutical Co Ltd
Publication of CN114423746A publication Critical patent/CN114423746A/zh
Withdrawn legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/08—Hydrogen atoms or radicals containing only hydrogen and carbon atoms
    • C07D333/10—Thiophene
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/017—Esters of hydroxy compounds having the esterified hydroxy group bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/02—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen
    • C07C69/22—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen having three or more carbon atoms in the acid moiety
    • C07C69/24—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen having three or more carbon atoms in the acid moiety esterified with monohydroxylic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

提供罗替戈汀山嵛酸酯杂质新化合物，和含有重量百分比少于0.5％所述杂质化合物的罗替戈汀山嵛酸酯或其制剂，以及所述杂质化合物在罗替戈汀山嵛酸酯或其制剂的杂质检测中作为对照品的应用。

Description

PCT国内申请，说明书已公开。

Claims (10)

  1. PCT国内申请，权利要求书已公开。
CN202080065958.2A 2019-09-30 2020-09-29 化合物及其制备方法和用途 Withdrawn CN114423746A (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
CN201910944794 2019-09-30
CN2019109458944 2019-09-30
CN201910945863 2019-09-30
CN201910944794X 2019-09-30
CN2019109458639 2019-09-30
CN201910945894 2019-09-30
PCT/CN2020/118775 WO2021063347A1 (zh) 2019-09-30 2020-09-29 化合物及其制备方法和用途

Publications (1)

Publication Number Publication Date
CN114423746A true CN114423746A (zh) 2022-04-29

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ID=75337727

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202080065958.2A Withdrawn CN114423746A (zh) 2019-09-30 2020-09-29 化合物及其制备方法和用途

Country Status (5)

Country Link
US (1) US20220340539A1 (zh)
EP (1) EP4039678A4 (zh)
JP (1) JP2022550299A (zh)
CN (1) CN114423746A (zh)
WO (1) WO2021063347A1 (zh)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114354819B (zh) * 2022-03-15 2022-07-15 四川德成动物保健品有限公司 一种中药提取物残留成分的检测方法及装置

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1741704A1 (en) * 2004-04-20 2007-01-10 Ono Pharmaceutical Co., Ltd. Method for increasing specific surface area of slightly soluble drug
CN102952113A (zh) * 2011-08-17 2013-03-06 山东绿叶制药有限公司 化合物5,6,7,8-四氢-6-[n,n-二[(2-噻吩)乙基]]氨基-1-萘酚、制备方法及应用
WO2016014242A1 (en) * 2014-07-21 2016-01-28 Spriaso Llc Compositions comprising bioreversible derivatives of hydroxy n-substituted-2-aminotetralins, dosage forms, and related methods
WO2018014277A1 (zh) * 2016-07-21 2018-01-25 山东绿叶制药有限公司 罗替戈汀山嵛酸酯及其制备方法和用途

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1741704A1 (en) * 2004-04-20 2007-01-10 Ono Pharmaceutical Co., Ltd. Method for increasing specific surface area of slightly soluble drug
CN102952113A (zh) * 2011-08-17 2013-03-06 山东绿叶制药有限公司 化合物5,6,7,8-四氢-6-[n,n-二[(2-噻吩)乙基]]氨基-1-萘酚、制备方法及应用
WO2016014242A1 (en) * 2014-07-21 2016-01-28 Spriaso Llc Compositions comprising bioreversible derivatives of hydroxy n-substituted-2-aminotetralins, dosage forms, and related methods
WO2018014277A1 (zh) * 2016-07-21 2018-01-25 山东绿叶制药有限公司 罗替戈汀山嵛酸酯及其制备方法和用途

Also Published As

Publication number Publication date
WO2021063347A1 (zh) 2021-04-08
JP2022550299A (ja) 2022-12-01
US20220340539A1 (en) 2022-10-27
EP4039678A1 (en) 2022-08-10
EP4039678A4 (en) 2023-09-27

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