CN114423746A - 化合物及其制备方法和用途 - Google Patents
化合物及其制备方法和用途 Download PDFInfo
- Publication number
- CN114423746A CN114423746A CN202080065958.2A CN202080065958A CN114423746A CN 114423746 A CN114423746 A CN 114423746A CN 202080065958 A CN202080065958 A CN 202080065958A CN 114423746 A CN114423746 A CN 114423746A
- Authority
- CN
- China
- Prior art keywords
- solution
- stirring
- dichloromethane
- compound
- reaction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/08—Hydrogen atoms or radicals containing only hydrogen and carbon atoms
- C07D333/10—Thiophene
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/017—Esters of hydroxy compounds having the esterified hydroxy group bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/02—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen
- C07C69/22—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen having three or more carbon atoms in the acid moiety
- C07C69/24—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen having three or more carbon atoms in the acid moiety esterified with monohydroxylic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
提供罗替戈汀山嵛酸酯杂质新化合物,和含有重量百分比少于0.5%所述杂质化合物的罗替戈汀山嵛酸酯或其制剂,以及所述杂质化合物在罗替戈汀山嵛酸酯或其制剂的杂质检测中作为对照品的应用。
Description
PCT国内申请,说明书已公开。
Claims (10)
- PCT国内申请,权利要求书已公开。
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201910945894 | 2019-09-30 | ||
CN2019109458639 | 2019-09-30 | ||
CN2019109458944 | 2019-09-30 | ||
CN201910944794X | 2019-09-30 | ||
CN201910944794 | 2019-09-30 | ||
CN201910945863 | 2019-09-30 | ||
PCT/CN2020/118775 WO2021063347A1 (zh) | 2019-09-30 | 2020-09-29 | 化合物及其制备方法和用途 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN114423746A true CN114423746A (zh) | 2022-04-29 |
Family
ID=75337727
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202080065958.2A Withdrawn CN114423746A (zh) | 2019-09-30 | 2020-09-29 | 化合物及其制备方法和用途 |
Country Status (5)
Country | Link |
---|---|
US (1) | US20220340539A1 (zh) |
EP (1) | EP4039678A4 (zh) |
JP (1) | JP2022550299A (zh) |
CN (1) | CN114423746A (zh) |
WO (1) | WO2021063347A1 (zh) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN114354819B (zh) * | 2022-03-15 | 2022-07-15 | 四川德成动物保健品有限公司 | 一种中药提取物残留成分的检测方法及装置 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1741704A1 (en) * | 2004-04-20 | 2007-01-10 | Ono Pharmaceutical Co., Ltd. | Method for increasing specific surface area of slightly soluble drug |
CN102952113A (zh) * | 2011-08-17 | 2013-03-06 | 山东绿叶制药有限公司 | 化合物5,6,7,8-四氢-6-[n,n-二[(2-噻吩)乙基]]氨基-1-萘酚、制备方法及应用 |
WO2016014242A1 (en) * | 2014-07-21 | 2016-01-28 | Spriaso Llc | Compositions comprising bioreversible derivatives of hydroxy n-substituted-2-aminotetralins, dosage forms, and related methods |
WO2018014277A1 (zh) * | 2016-07-21 | 2018-01-25 | 山东绿叶制药有限公司 | 罗替戈汀山嵛酸酯及其制备方法和用途 |
-
2020
- 2020-09-29 WO PCT/CN2020/118775 patent/WO2021063347A1/zh unknown
- 2020-09-29 EP EP20872689.3A patent/EP4039678A4/en not_active Withdrawn
- 2020-09-29 CN CN202080065958.2A patent/CN114423746A/zh not_active Withdrawn
- 2020-09-29 JP JP2022518720A patent/JP2022550299A/ja not_active Withdrawn
- 2020-09-29 US US17/763,636 patent/US20220340539A1/en active Pending
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1741704A1 (en) * | 2004-04-20 | 2007-01-10 | Ono Pharmaceutical Co., Ltd. | Method for increasing specific surface area of slightly soluble drug |
CN102952113A (zh) * | 2011-08-17 | 2013-03-06 | 山东绿叶制药有限公司 | 化合物5,6,7,8-四氢-6-[n,n-二[(2-噻吩)乙基]]氨基-1-萘酚、制备方法及应用 |
WO2016014242A1 (en) * | 2014-07-21 | 2016-01-28 | Spriaso Llc | Compositions comprising bioreversible derivatives of hydroxy n-substituted-2-aminotetralins, dosage forms, and related methods |
WO2018014277A1 (zh) * | 2016-07-21 | 2018-01-25 | 山东绿叶制药有限公司 | 罗替戈汀山嵛酸酯及其制备方法和用途 |
Also Published As
Publication number | Publication date |
---|---|
EP4039678A4 (en) | 2023-09-27 |
WO2021063347A1 (zh) | 2021-04-08 |
US20220340539A1 (en) | 2022-10-27 |
JP2022550299A (ja) | 2022-12-01 |
EP4039678A1 (en) | 2022-08-10 |
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Legal Events
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PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
WW01 | Invention patent application withdrawn after publication |
Application publication date: 20220429 |
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WW01 | Invention patent application withdrawn after publication |