PH12018550212A1 - Rotigotine behenate and preparation method and use thereof - Google Patents
Rotigotine behenate and preparation method and use thereofInfo
- Publication number
- PH12018550212A1 PH12018550212A1 PH12018550212A PH12018550212A PH12018550212A1 PH 12018550212 A1 PH12018550212 A1 PH 12018550212A1 PH 12018550212 A PH12018550212 A PH 12018550212A PH 12018550212 A PH12018550212 A PH 12018550212A PH 12018550212 A1 PH12018550212 A1 PH 12018550212A1
- Authority
- PH
- Philippines
- Prior art keywords
- rotigotine behenate
- rotigotine
- behenate
- preparation
- manufacturing
- Prior art date
Links
- UKMSUNONTOPOIO-UHFFFAOYSA-M behenate Chemical compound CCCCCCCCCCCCCCCCCCCCCC([O-])=O UKMSUNONTOPOIO-UHFFFAOYSA-M 0.000 title abstract 7
- 229940116224 behenate Drugs 0.000 title abstract 7
- KFQYTPMOWPVWEJ-INIZCTEOSA-N rotigotine Chemical compound CCCN([C@@H]1CC2=CC=CC(O)=C2CC1)CCC1=CC=CS1 KFQYTPMOWPVWEJ-INIZCTEOSA-N 0.000 title abstract 7
- 229960003179 rotigotine Drugs 0.000 title abstract 7
- 238000002360 preparation method Methods 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 abstract 2
- 230000036470 plasma concentration Effects 0.000 abstract 2
- 102000015554 Dopamine receptor Human genes 0.000 abstract 1
- 108050004812 Dopamine receptor Proteins 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/08—Hydrogen atoms or radicals containing only hydrogen and carbon atoms
- C07D333/10—Thiophene
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Psychology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CN2016/090803 WO2018014277A1 (zh) | 2016-07-21 | 2016-07-21 | 罗替戈汀山嵛酸酯及其制备方法和用途 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PH12018550212A1 true PH12018550212A1 (en) | 2019-10-28 |
Family
ID=60992805
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PH12018550212A PH12018550212A1 (en) | 2016-07-21 | 2018-12-26 | Rotigotine behenate and preparation method and use thereof |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US10669249B2 (https=) |
| EP (1) | EP3489227B1 (https=) |
| JP (1) | JP6751208B2 (https=) |
| KR (1) | KR20190031314A (https=) |
| CN (1) | CN109415335B (https=) |
| AU (1) | AU2016415408B2 (https=) |
| BR (1) | BR112019001035A2 (https=) |
| CA (1) | CA3030043C (https=) |
| ES (1) | ES2855976T3 (https=) |
| MY (1) | MY195897A (https=) |
| PH (1) | PH12018550212A1 (https=) |
| PL (1) | PL3489227T3 (https=) |
| RU (1) | RU2717542C9 (https=) |
| SG (1) | SG11201811543XA (https=) |
| WO (1) | WO2018014277A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2717542C9 (ru) * | 2016-07-21 | 2020-08-12 | Шаньдун Луе Фармасьютикал Ко., Лтд. | Ротиготина бегенат, его способ получения и применение |
| CN108341798B (zh) * | 2017-01-23 | 2021-05-25 | 沈阳药科大学 | 罗替戈汀衍生物及其制备和应用 |
| CN114423746A (zh) * | 2019-09-30 | 2022-04-29 | 山东绿叶制药有限公司 | 化合物及其制备方法和用途 |
| JP7621009B2 (ja) * | 2020-10-27 | 2025-01-24 | ▲広▼州市恒▲諾▼康医▲薬▼科技有限公司 | テトラヒドロナフタレン系化合物、その医薬組成物及びその使用 |
| WO2024208226A1 (zh) * | 2023-04-04 | 2024-10-10 | 广州市恒诺康医药科技有限公司 | 四氢萘类化合物、其药物组合物及其用途 |
| CN119504742B (zh) * | 2024-11-18 | 2025-10-28 | 陕西师范大学 | 一种娃儿藤碱和安托芬的全合成方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2239196T3 (es) * | 2002-12-02 | 2005-09-16 | Schwarz Pharma Ag | Suministro iontoforetico de rotigotina para el tratamiento de la enfermedad de parkinson. |
| DE10361259A1 (de) * | 2003-12-24 | 2005-07-28 | Schwarz Pharma Ag | Verwendung von Rotigotine in einem Frühstadium von Morbus Parkinson zur Prävention des weiteren Neuronenverlustes |
| KR101481643B1 (ko) | 2010-11-25 | 2015-01-12 | 산동 루예 파마슈티칼 컴파니 리미티드 | 로티고틴, 이의 유도체 또는 로티고틴 또는 이의 유도체의 약제학적으로 허용가능한 염의 조성물 |
| WO2013168033A1 (en) * | 2012-05-10 | 2013-11-14 | Mahesh Kandula | Compositions and methods for treatment of neurologic diseases |
| US9956201B2 (en) * | 2014-07-21 | 2018-05-01 | Spriaso Llc | Compositions comprising bioreversible derivatives of hydroxy N-substituted-2-aminotetralins, and related dosage forms |
| WO2016014242A1 (en) * | 2014-07-21 | 2016-01-28 | Spriaso Llc | Compositions comprising bioreversible derivatives of hydroxy n-substituted-2-aminotetralins, dosage forms, and related methods |
| RU2717542C9 (ru) * | 2016-07-21 | 2020-08-12 | Шаньдун Луе Фармасьютикал Ко., Лтд. | Ротиготина бегенат, его способ получения и применение |
-
2016
- 2016-07-21 RU RU2018146096A patent/RU2717542C9/ru active
- 2016-07-21 SG SG11201811543XA patent/SG11201811543XA/en unknown
- 2016-07-21 PL PL16909205T patent/PL3489227T3/pl unknown
- 2016-07-21 US US16/309,807 patent/US10669249B2/en active Active
- 2016-07-21 KR KR1020197005257A patent/KR20190031314A/ko not_active Abandoned
- 2016-07-21 AU AU2016415408A patent/AU2016415408B2/en active Active
- 2016-07-21 ES ES16909205T patent/ES2855976T3/es active Active
- 2016-07-21 CN CN201680087177.7A patent/CN109415335B/zh active Active
- 2016-07-21 JP JP2019524492A patent/JP6751208B2/ja active Active
- 2016-07-21 CA CA3030043A patent/CA3030043C/en not_active Expired - Fee Related
- 2016-07-21 BR BR112019001035-1A patent/BR112019001035A2/pt not_active IP Right Cessation
- 2016-07-21 MY MYPI2018002909A patent/MY195897A/en unknown
- 2016-07-21 WO PCT/CN2016/090803 patent/WO2018014277A1/zh not_active Ceased
- 2016-07-21 EP EP16909205.3A patent/EP3489227B1/en active Active
-
2018
- 2018-12-26 PH PH12018550212A patent/PH12018550212A1/en unknown
-
2020
- 2020-04-27 US US16/860,037 patent/US11111227B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| BR112019001035A2 (pt) | 2019-04-30 |
| PL3489227T3 (pl) | 2021-05-04 |
| JP2019523297A (ja) | 2019-08-22 |
| MY195897A (en) | 2023-02-27 |
| US20200255396A1 (en) | 2020-08-13 |
| RU2717542C1 (ru) | 2020-03-24 |
| AU2016415408B2 (en) | 2019-04-11 |
| EP3489227B1 (en) | 2020-10-21 |
| US10669249B2 (en) | 2020-06-02 |
| CN109415335A (zh) | 2019-03-01 |
| AU2016415408A1 (en) | 2019-01-17 |
| CA3030043C (en) | 2021-01-19 |
| JP6751208B2 (ja) | 2020-09-02 |
| SG11201811543XA (en) | 2019-02-27 |
| WO2018014277A1 (zh) | 2018-01-25 |
| CN109415335B (zh) | 2020-06-05 |
| US20190330177A1 (en) | 2019-10-31 |
| EP3489227A4 (en) | 2020-01-22 |
| ES2855976T3 (es) | 2021-09-27 |
| EP3489227A1 (en) | 2019-05-29 |
| US11111227B2 (en) | 2021-09-07 |
| RU2717542C9 (ru) | 2020-08-12 |
| CA3030043A1 (en) | 2018-01-25 |
| KR20190031314A (ko) | 2019-03-25 |
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