JP6733014B2 - 三次元構造体の付加製造システム及びその方法 - Google Patents
三次元構造体の付加製造システム及びその方法 Download PDFInfo
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- JP6733014B2 JP6733014B2 JP2019122829A JP2019122829A JP6733014B2 JP 6733014 B2 JP6733014 B2 JP 6733014B2 JP 2019122829 A JP2019122829 A JP 2019122829A JP 2019122829 A JP2019122829 A JP 2019122829A JP 6733014 B2 JP6733014 B2 JP 6733014B2
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Description
本願は、2013年6月13日に出願された米国特許出願第61/834,420号のパリ条約に基づく優先権主張出願であり、この米国特許出願を参照により引用し、その記載内容全体を本明細書の一部とする。
1.スー・ジュン・シン(Su-Jung Shin)、ジ・ヨン・パーク(Ji-Young Park)、ジン・ヨン・リー(Jin-Young Lee)、ホー・パーク(Ho Park )、ヨン・ドゥ・パーク(Yong-Doo Park)、キュー・バック・リー(Kyu-Back Lee)、チャン・モー・ホワン(Chang-Mo Whang)、及びサン・フーン・リー(Sang-Hoon Lee)、「『オン・ザ・フライ』コンティニュアス・ジェネレーション・オブ・アルギネイト・ファイバーズ・ユージング・ア・マイクロフルイディック・デバイス(”On the fly” continuous generation of alginate fibers using a microfluidic device)」、ラングミューア(Langmuir)、2007年、第23巻、p.9104〜9108
2.サイフ・カーライル(Saif Khalil)、及びウェイ・サン(Wei Sun)、「バイオプリンティング・エンドシーリアル・セルズ・ウィズ・アルギネイト・フォア・3D・ティシュー・コンストラクツ(Bioprinting endothelial cells with alginate for 3D tissue constructs)」、ジャーナル・オブ・バイオメカニカル・エンジニアリング(Journal of Biomechanical Engineering)、2009年、第131号、p.111002‐1〜111002‐8
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Claims (17)
- 少なくとも1種類の第1の材料と少なくとも1種類の第2の材料から三次元(3D)構造体を印刷する印刷ヘッドであって、
前記印刷ヘッドは、前記材料を小出しするオリフィスと、材料を受け入れると共に前記印刷ヘッド内に配置されたマイクロフルイディックチャネルのそれぞれと流体連通状態にある少なくとも2つの入口と、を含み、
前記マイクロフルイディックチャネルは、前記少なくとも1種類の第1の材料を受け入れてこれを方向付ける2本の第1のチャネルと、前記少なくとも1種類の第2の材料を受け入れてこれを方向付ける2本の第2のチャネルと、前記オリフィスまで延びる小出しチャネルを形成するように第1の交点のところで前記第1のチャネルの各々と互いに繋がる第3のチャネルと、を含み、
前記2本の第2のチャネルは、前記第1の交点まで延びる前記第3のチャネルを形成するように第2の交点のところで交差すると共に互いに繋がり、
前記第3のチャネルは、前記第1のチャネルの各々と前記小出しチャネルの直径よりも小さな直径を有し、これにより前記第1のチャネルからの前記少なくとも1種類の第1の材料の流れが印刷時に前記小出しチャネル内で前記少なくとも1種類の第2の材料周りに同軸シースを形成する、印刷ヘッド。 - 前記少なくとも1種類の第1の材料は、シース流体を含み、前記少なくとも1種類の第2の材料は、ヒドロゲルを含む、請求項1記載の印刷ヘッド。
- 前記少なくとも1種類の第1の材料は、前記少なくとも1種類の第2の材料を前記第1の交点のところで及び/又は前記小出しチャネル内で前記少なくとも1種類の第1の材料との接触時に凝固させる架橋剤を含む、請求項2記載の印刷ヘッド。
- 前記少なくとも1種類の第2の材料は、生細胞を含み、オプションとして、前記2本の第2のチャネルは、それぞれ第2の材料を運搬するように構成されている、請求項2記載の印刷ヘッド。
- 各第1のチャネルは、前記第1の交点のところで前記第3のチャネルに横付けになるように構成されている、請求項1〜4のいずれか一項に記載の印刷ヘッド。
- 三次元構造体の付加製造のためのシステムであって、前記システムは、
‐前記少なくとも1種類の第1の材料と前記少なくとも1種類の第2の材料とを受け取って小出しする請求項1〜5のいずれか一項に記載の少なくとも1つの印刷ヘッドを含み、
‐各々が前記印刷ヘッド内の前記マイクロフルイディックチャネルの1つとそれぞれ対応すると共に作動時に前記印刷ヘッドの前記マイクロフルイディックチャネル内の流体の流れを許可し又は許可しないように構成されたフルイディックスイッチを含み、オプションとして、前記フルイディックスイッチは、弁を含み、
‐前記オリフィスから小出しされた前記材料の第1の層を受け取る受け取り面を含み、
‐前記印刷ヘッドの前記オリフィスを三次元空間内に位置決めする位置決めユニットを含み、前記位置決めユニットは、前記印刷ヘッドに作動的に結合され、
‐前記印刷ヘッドの前記オリフィスから前記材料を小出しする小出し手段を含み、オプションとして、前記小出し手段は、圧力制御ユニットを含む、システム。 - 前記位置決めユニットを制御すると共に前記受け取り面上への前記印刷ヘッドからの前記材料の小出しを制御する、プログラム可能制御プロセッサを更に含む、請求項6記載のシステム。
- 前記印刷ヘッドから小出しされた過剰の第1の材料を除去する流体除去特徴を更に含む、請求項6又は7に記載のシステム。
- 前記受け取り面は、前記過剰の第1の材料を流通させることができるように寸法決めされた細孔を有する多孔質メンブレンを含む、請求項8記載の印刷ヘッド。
- 前記流体除去特徴は、前記過剰の第1の材料を、前記受け取り面から又は前記受け取り面を通って吸い取る吸収材料又は真空を含む、請求項9記載のシステム。
- 前記材料を収容するリザーバを更に含み、前記リザーバは、前記入口と前記印刷ヘッド内のマイクロフルイディックチャネルとにそれぞれ流体結合されている、請求項6〜10のいずれか一項に記載のシステム。
- 前記印刷ヘッドは、前記オリフィスから前記受け取り面に向かって延びるように構成された中空突出部を更に有する、請求項6〜11のいずれか一項に記載のシステム。
- 三次元(3D)構造体を印刷する方法であって、前記方法は、
‐請求項6〜12のいずれか一項に記載の三次元構造体の付加製造のためのシステムを用意するステップを含み、
‐小出しされるべき材料を用意するステップを含み、前記小出しされるべき材料は、シース流体及び1種類又は2種類以上のヒドロゲルを含み、
‐前記システムを印刷されるべき3D構造体でエンコードするステップを含み、
‐小出しされるべき前記材料を前記印刷ヘッドオリフィスから小出しするステップを含み、前記シース流体及び前記ヒドロゲルは、同軸配置状態で小出しされ、前記シース流体は、前記ヒドロゲルを包み込み、
‐前記小出しされた材料の第1の層を前記受け取り面上に被着させるステップを含み、 ‐次に小出しされた材料を前記第1の層上に及び任意の次の小出し材料の層上に被着させることによって前記被着ステップを繰り返し、それにより層を小出し材料の層上に前記3D構造体に従って幾何学的配置状態で被着させるステップを含み、
‐前記印刷ヘッドオリフィスから小出しされた過剰のシース流体を被着ステップ中又は被着ステップ相互間における1つ又は2つ以上の時点で除去するステップを含む、方法。 - 前記シース流体は、前記ヒドロゲルを前記シース流体との接触時に架橋すると共に凝固させるのに適した架橋剤を含み、前記接触により、ヒドロゲル繊維が作製される、請求項13記載の方法。
- 前記被着ステップ及び前記除去ステップは、連続的に実施され、それにより、前記小出し材料の層が被着されると、前記過剰のシース流体を連続的に除去する、請求項13又は14記載の方法。
- 前記除去ステップは、前記被着ステップ相互間で間欠的に及び/又は前記被着ステップと同時に実施され、それにより、前記小出し材料層が被着されている時に前記過剰のシース流体を間欠的に除去する、請求項13又は14記載の方法。
- 前記1種類又は2種類以上のヒドロゲルは、該ヒドロゲル中に分散された生細胞の成長及び/又は増殖を支援するようになっている、請求項13に記載の方法。
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