JP6729878B2 - 多光子励起用スーパーコンティニウム光生成光源、多光子励起用スーパーコンティニウム光生成方法、多光子励起蛍光顕微鏡及び多光子励起方法 - Google Patents
多光子励起用スーパーコンティニウム光生成光源、多光子励起用スーパーコンティニウム光生成方法、多光子励起蛍光顕微鏡及び多光子励起方法 Download PDFInfo
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- JP6729878B2 JP6729878B2 JP2016178605A JP2016178605A JP6729878B2 JP 6729878 B2 JP6729878 B2 JP 6729878B2 JP 2016178605 A JP2016178605 A JP 2016178605A JP 2016178605 A JP2016178605 A JP 2016178605A JP 6729878 B2 JP6729878 B2 JP 6729878B2
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- light
- wavelength
- supercontinuum
- pulse
- waveguide
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- G—PHYSICS
- G02—OPTICS
- G02F—OPTICAL DEVICES OR ARRANGEMENTS FOR THE CONTROL OF LIGHT BY MODIFICATION OF THE OPTICAL PROPERTIES OF THE MEDIA OF THE ELEMENTS INVOLVED THEREIN; NON-LINEAR OPTICS; FREQUENCY-CHANGING OF LIGHT; OPTICAL LOGIC ELEMENTS; OPTICAL ANALOGUE/DIGITAL CONVERTERS
- G02F1/00—Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulating; Non-linear optics
- G02F1/35—Non-linear optics
- G02F1/365—Non-linear optics in an optical waveguide structure
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/6456—Spatial resolved fluorescence measurements; Imaging
- G01N21/6458—Fluorescence microscopy
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/16—Microscopes adapted for ultraviolet illumination ; Fluorescence microscopes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2201/00—Features of devices classified in G01N21/00
- G01N2201/06—Illumination; Optics
- G01N2201/069—Supply of sources
- G01N2201/0696—Pulsed
- G01N2201/0697—Pulsed lasers
-
- G—PHYSICS
- G02—OPTICS
- G02F—OPTICAL DEVICES OR ARRANGEMENTS FOR THE CONTROL OF LIGHT BY MODIFICATION OF THE OPTICAL PROPERTIES OF THE MEDIA OF THE ELEMENTS INVOLVED THEREIN; NON-LINEAR OPTICS; FREQUENCY-CHANGING OF LIGHT; OPTICAL LOGIC ELEMENTS; OPTICAL ANALOGUE/DIGITAL CONVERTERS
- G02F1/00—Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulating; Non-linear optics
- G02F1/35—Non-linear optics
- G02F1/3528—Non-linear optics for producing a supercontinuum
-
- G—PHYSICS
- G02—OPTICS
- G02F—OPTICAL DEVICES OR ARRANGEMENTS FOR THE CONTROL OF LIGHT BY MODIFICATION OF THE OPTICAL PROPERTIES OF THE MEDIA OF THE ELEMENTS INVOLVED THEREIN; NON-LINEAR OPTICS; FREQUENCY-CHANGING OF LIGHT; OPTICAL LOGIC ELEMENTS; OPTICAL ANALOGUE/DIGITAL CONVERTERS
- G02F2201/00—Constructional arrangements not provided for in groups G02F1/00 - G02F7/00
- G02F2201/02—Constructional arrangements not provided for in groups G02F1/00 - G02F7/00 fibre
Landscapes
- Physics & Mathematics (AREA)
- Nonlinear Science (AREA)
- General Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Microscoopes, Condenser (AREA)
- Optical Modulation, Optical Deflection, Nonlinear Optics, Optical Demodulation, Optical Logic Elements (AREA)
Priority Applications (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16/091,819 US11079656B2 (en) | 2016-04-05 | 2017-04-04 | Supercontinuum source, method for generating and emitting a supercontinuum, multiphoton excitation fluorescence microscope, and multiphoton excitation method |
| DE112017001881.1T DE112017001881B4 (de) | 2016-04-05 | 2017-04-04 | Superkontinuumquelle, Verfahren zum Erzeugen und Emittieren eines Superkontinuums, Multiphotonenanregungs-Fluoreszenzmikroskop und Multiphotonenanregungsverfahren |
| PCT/JP2017/014049 WO2017175747A1 (ja) | 2016-04-05 | 2017-04-04 | スーパーコンティニウム光生成光源、スーパーコンティニウム光生成方法、多光子励起蛍光顕微鏡及び多光子励起方法 |
| US17/192,879 US20210191229A1 (en) | 2016-04-05 | 2021-03-04 | Supercontinuum source, method for generating and emitting a supercontinuum, multiphoton excitation fluorescence microscope, and multiphoton excitation method |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2016076155 | 2016-04-05 | ||
| JP2016076155 | 2016-04-05 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017187465A JP2017187465A (ja) | 2017-10-12 |
| JP2017187465A5 JP2017187465A5 (enExample) | 2019-05-23 |
| JP6729878B2 true JP6729878B2 (ja) | 2020-07-29 |
Family
ID=60046341
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016178605A Active JP6729878B2 (ja) | 2016-04-05 | 2016-09-13 | 多光子励起用スーパーコンティニウム光生成光源、多光子励起用スーパーコンティニウム光生成方法、多光子励起蛍光顕微鏡及び多光子励起方法 |
Country Status (3)
| Country | Link |
|---|---|
| US (2) | US11079656B2 (enExample) |
| JP (1) | JP6729878B2 (enExample) |
| DE (1) | DE112017001881B4 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2563435A (en) * | 2017-06-16 | 2018-12-19 | The Univ Court Of The Univ Of St Andrews | Three-photon light sheet imaging |
| JP2019207338A (ja) * | 2018-05-30 | 2019-12-05 | オリンパス株式会社 | 観察装置、対物レンズ |
| KR102790954B1 (ko) * | 2018-09-05 | 2025-04-03 | 아이피지 포토닉스 코포레이션 | 펄스 구성 가능 섬유 레이저 유닛 |
| JP7215060B2 (ja) * | 2018-10-12 | 2023-01-31 | ウシオ電機株式会社 | 分光分析用光源、分光分析装置及び分光分析方法 |
| JP7265908B2 (ja) | 2019-03-27 | 2023-04-27 | ウシオ電機株式会社 | 錠剤検査方法及び錠剤検査装置 |
| JPWO2021024890A1 (enExample) * | 2019-08-02 | 2021-02-11 | ||
| DE102020205851B4 (de) * | 2020-05-08 | 2022-01-05 | Carl Zeiss Vision International Gmbh | Vorrichtung, Verfahren und Computerprogramm zur Erzeugung von zwei Punktlichtquellen derselben Wellenlänge auf einer Pupillenebene eines Auges sowie zur Bestimmung einer neuronalen Übertragungsfunktion einer Sehbahn |
| CN113156735B (zh) * | 2020-12-15 | 2022-08-16 | 北京邮电大学 | 一种反脊型铝镓砷波导及其方法 |
| CN117157517A (zh) * | 2021-04-30 | 2023-12-01 | 深圳华大智造科技股份有限公司 | 视场拼接系统及方法、生物样品识别装置及方法 |
| EP4119189A1 (en) * | 2021-07-16 | 2023-01-18 | Universitat Politècnica De Catalunya | Method and apparatus for selectively cancelling the effect of the active center of a molecule |
Family Cites Families (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3558499B2 (ja) | 1996-07-24 | 2004-08-25 | 住友電気工業株式会社 | 光ファイバ、光源装置及びシステム |
| JP3474773B2 (ja) | 1997-06-18 | 2003-12-08 | 日本電信電話株式会社 | 白色パルス光源 |
| US7190705B2 (en) * | 2000-05-23 | 2007-03-13 | Imra America. Inc. | Pulsed laser sources |
| JP2003149695A (ja) | 2001-11-08 | 2003-05-21 | Nippon Telegr & Teleph Corp <Ntt> | スーパーコンティニウム光源 |
| GB2385460B (en) * | 2002-02-18 | 2004-04-14 | Univ Southampton | "Pulsed light sources" |
| US6775447B2 (en) * | 2002-09-20 | 2004-08-10 | Fitel Usa Corp. | All fiber low noise supercontinuum source |
| DE10340964A1 (de) * | 2003-09-05 | 2005-03-31 | Leica Microsystems Heidelberg Gmbh | Lichtquelle mit einem mikrostrukturierten optischen Element |
| US6990270B2 (en) * | 2004-02-11 | 2006-01-24 | Fitel U.S.A. Corp. | Fiber amplifier for generating femtosecond pulses in single mode fiber |
| CN100438235C (zh) * | 2004-03-05 | 2008-11-26 | 古河电气工业株式会社 | 使用掺稀土元素光纤的光纤激光器及宽带光源 |
| US7403688B2 (en) * | 2004-12-16 | 2008-07-22 | University Of Rochester | Method and optical fiber device for production of low noise continuum |
| US7277169B2 (en) * | 2005-02-18 | 2007-10-02 | The Regents Of The University Of Michigan | Whole spectrum fluorescence detection with ultrafast white light excitation |
| US7715673B2 (en) * | 2005-06-16 | 2010-05-11 | Swinburne University Of Technology | Imaging system |
| US7809222B2 (en) * | 2005-10-17 | 2010-10-05 | Imra America, Inc. | Laser based frequency standards and their applications |
| US8571075B2 (en) * | 2010-11-29 | 2013-10-29 | Imra America, Inc. | Frequency comb source with large comb spacing |
| US8120778B2 (en) * | 2009-03-06 | 2012-02-21 | Imra America, Inc. | Optical scanning and imaging systems based on dual pulsed laser systems |
| WO2007105692A1 (ja) | 2006-03-15 | 2007-09-20 | Sumitomo Electric Industries, Ltd. | 光ファイバおよび広帯域光源 |
| WO2008067823A1 (en) | 2006-12-08 | 2008-06-12 | Koheras A/S | Deep blue extended super continuum light source |
| JP2008216716A (ja) * | 2007-03-06 | 2008-09-18 | Univ Nagoya | スーパーコンティニュアム光源 |
| DE102007048135B4 (de) * | 2007-10-05 | 2012-02-16 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Fluoreszenzlichtmikroskopisches Messen einer Probe mit rotverschobenen Stokes-Linien |
| GB0800936D0 (en) | 2008-01-19 | 2008-02-27 | Fianium Ltd | A source of optical supercontinuum generation having a selectable pulse repetition frequency |
| EP2417492A4 (en) * | 2009-04-08 | 2013-01-02 | Nkt Photonics As | HIGH-PERFORMANCE BROADBAND LIGHT SOURCE |
| US8305682B2 (en) * | 2009-09-16 | 2012-11-06 | The Board Of Trustees Of The University Of Illinois | Optical frequency up-conversion of femtosecond pulses into targeted single bands in the visible and ultraviolet |
| DE102009056092B4 (de) * | 2009-11-30 | 2013-02-28 | PicoQuant GmbH. Unternehmen für optoelektronische Forschung und Entwicklung | Lichtquelle mit einem Diodenlaser |
| US8526772B2 (en) * | 2010-08-26 | 2013-09-03 | The Board Of Trustees Of The University Of Illinois | Compression of polarized supercontinuum pulses generated in birefringent all normal-dispersion photonic crystal fiber |
| DE102010047578A1 (de) * | 2010-10-07 | 2012-04-12 | Jenlab Gmbh | Verwendung einer Kombination von Auswertungsverfahren in einer Vorrichtung zur Detektion von Tumoren sowie Vorrichtung zur Detektion von Tumoren |
| US8787410B2 (en) * | 2011-02-14 | 2014-07-22 | Imra America, Inc. | Compact, coherent, high brightness light sources for the mid and far IR |
| WO2012135073A2 (en) * | 2011-03-25 | 2012-10-04 | Board Of Trustees Of Michigan State University | Adaptive laser system for ophthalmic use |
| JP6290077B2 (ja) * | 2011-05-27 | 2018-03-07 | イムラ アメリカ インコーポレイテッド | コンパクトな光周波数コム・システム |
| GB2496214B (en) * | 2011-11-01 | 2016-03-16 | Fianium Ltd | Amplifying optical device pumped or seeded with nonlinearly generated light |
| US9213215B2 (en) * | 2012-01-19 | 2015-12-15 | The United States Of America, As Represented By The Secretary Of The Navy | IR fiber broadband mid-IR light source |
| FR2986668B1 (fr) | 2012-02-02 | 2014-02-21 | Ecole Polytech | Module d'excitation multi-couleurs pour un systeme d'imagerie multi-photonique, systeme et procede associes. |
| GB201205774D0 (en) * | 2012-03-30 | 2012-05-16 | Univ Heriot Watt | Fibre laser |
| US9071033B2 (en) * | 2012-05-08 | 2015-06-30 | Fianium Ltd. | Lasers and amplifiers having tapered elements |
| DK2875392T3 (da) * | 2012-07-23 | 2019-06-03 | Nkt Photonics As | Generering af lange bølgelængder i optisk fiber |
| US8804777B2 (en) * | 2012-11-09 | 2014-08-12 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Mid-infrared supercontinuum fiber laser |
| WO2014149255A1 (en) * | 2013-03-15 | 2014-09-25 | Imra America, Inc. | Trace gas detection system |
| CN103296566A (zh) * | 2013-06-01 | 2013-09-11 | 中国人民解放军国防科学技术大学 | 一种提高氟化物光纤中超连续谱长波功率比例的方法 |
| WO2015003714A1 (en) * | 2013-07-10 | 2015-01-15 | Nkt Photonics A/S | Supercontinuum generation in microstructured optical fibers by tapering and tailoring of zero-dispersion wavelength (s) |
| DE102013219338A1 (de) * | 2013-09-25 | 2015-03-26 | Forschungsverbund Berlin E.V. | Verfahren und Vorrichtung zur direkten Stabilisierung der Carrier-Envelope-Phase eines Laserverstärkersystems |
| WO2015073257A1 (en) * | 2013-11-12 | 2015-05-21 | Imra America, Inc. | Compact fiber short pulse laser sources |
| US9785033B2 (en) * | 2014-01-30 | 2017-10-10 | The United States Of America, As Represented By The Secretary Of The Navy | Compact infrared broadband source |
| GB2528023A (en) * | 2014-03-18 | 2016-01-13 | Stfc Science & Technology | High power laser with chirped pulse amplification |
| DE112015004310T5 (de) | 2014-09-22 | 2017-06-08 | Imra America, Inc. | Faseroszillatoren mit geringem trägerphasenrauschen |
| EP3145036B1 (en) * | 2015-09-17 | 2020-03-18 | Academia Sinica | Supercontinuum generation apparatus and method |
-
2016
- 2016-09-13 JP JP2016178605A patent/JP6729878B2/ja active Active
-
2017
- 2017-04-04 DE DE112017001881.1T patent/DE112017001881B4/de active Active
- 2017-04-04 US US16/091,819 patent/US11079656B2/en active Active
-
2021
- 2021-03-04 US US17/192,879 patent/US20210191229A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| DE112017001881T5 (de) | 2018-12-13 |
| US20190129278A1 (en) | 2019-05-02 |
| US20210191229A1 (en) | 2021-06-24 |
| JP2017187465A (ja) | 2017-10-12 |
| US11079656B2 (en) | 2021-08-03 |
| DE112017001881B4 (de) | 2024-07-18 |
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