JP6714043B2 - 微粒子が配置された弾性基質を有する挿入可能な医療機器、および薬物送達方法 - Google Patents
微粒子が配置された弾性基質を有する挿入可能な医療機器、および薬物送達方法 Download PDFInfo
- Publication number
- JP6714043B2 JP6714043B2 JP2018108900A JP2018108900A JP6714043B2 JP 6714043 B2 JP6714043 B2 JP 6714043B2 JP 2018108900 A JP2018108900 A JP 2018108900A JP 2018108900 A JP2018108900 A JP 2018108900A JP 6714043 B2 JP6714043 B2 JP 6714043B2
- Authority
- JP
- Japan
- Prior art keywords
- microparticles
- coating
- poly
- biodegradable
- balloon
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/04—Macromolecular materials
- A61L29/041—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/08—Materials for coatings
- A61L29/085—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
- A61L29/145—Hydrogels or hydrocolloids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
- A61L29/148—Materials at least partially resorbable by the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
- A61L29/16—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M25/104—Balloon catheters used for angioplasty
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/416—Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/602—Type of release, e.g. controlled, sustained, slow
- A61L2300/604—Biodegradation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/606—Coatings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/62—Encapsulated active agents, e.g. emulsified droplets
- A61L2300/622—Microcapsules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M25/1002—Balloon catheters characterised by balloon shape
- A61M2025/1004—Balloons with folds, e.g. folded or multifolded
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M25/1027—Making of balloon catheters
- A61M25/1029—Production methods of the balloon members, e.g. blow-moulding, extruding, deposition or by wrapping a plurality of layers of balloon material around a mandril
- A61M2025/1031—Surface processing of balloon members, e.g. coating or deposition; Mounting additional parts onto the balloon member's surface
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M2025/1043—Balloon catheters with special features or adapted for special applications
- A61M2025/105—Balloon catheters with special features or adapted for special applications having a balloon suitable for drug delivery, e.g. by using holes for delivery, drug coating or membranes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M2025/1043—Balloon catheters with special features or adapted for special applications
- A61M2025/1075—Balloon catheters with special features or adapted for special applications having a balloon composed of several layers, e.g. by coating or embedding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M25/1002—Balloon catheters characterised by balloon shape
Description
本発明は、出願人を同じくする仮出願61/072,234(出願日:2008年3月28日)の利益を享受する本出願である(発明の名称:微粒子が配置された弾性基質を有する挿入可能な医療機器、および薬物送達方法)。
本発明は、挿入可能な医療器具から薬物を送達する分野に関する。
移植された医療機器からの薬剤の放出は、機器の機能および様々な医療条件での治療にとって有益であることが示されている。例えば、装置の表面から薬剤を送達することにより、移植可能な装置の存在によって生じる細胞応答を避けることができる。また、装置から放出される薬剤は、移植に伴う装置の機能寿命を短縮させる条件を回避することができる。装置から放出された薬剤で、身体の罹患部の治療を行ってもよい。
本発明は、生物活性を有する薬剤を含む微粒子が配置された挿入可能な医療機器に関する。微粒子は、装置から放出され得るものであり、被検体に対して生物活性を有する薬剤を与え、標的部位に治療効果をもたらす。本発明に係る装置は、被覆材料を介して微粒子が配置された膨張可能な弾性表面を有している。
図1a〜図1cは、埋め込まれた微粒子を備えた可撓性ヒドロゲル被膜に覆われた弾性基質を有する機器の一部と、弾性基質の膨張直後の、ヒドロゲル被膜から組織への微粒子の送達とを示す。
本願に記載された本発明に係る実施形態は、包括的なものではなく、本発明を以下の詳細な説明に開示された形態に限定するものではない。むしろ、実施形態は、当業者が本発明の原理および実施を認識および理解できるように、選択および記載されている。
[-R1-Q1-R4-Q2-]x-[R2-Q3-R4-Q4-]y-[R3-Q5-R4-Q6-]z- (1)
[-R1-R2-R 1-Q1-R4-Q2-]x-[R3-Q2-R4-Q1]z- (2)
[-R2-R1-R 2-Q1-R4-Q2-]x-[R3-Q2-R4-Q1]zB- (3)
これらの化学式では、R1およびR2は、非晶性ポリエステル、非非晶性ポリエーテルエステル、または非晶性ポリカーボネート;あるいは混合エステル、エーテルおよび/またはカーボネート基から得られる非晶性プレポリマーである。R1およびR2は、ポリエステル基を含んでいてもよい。これは、重合開始剤としてこれらの化合物を使用する結果起こり、ポリエーテルは、室温において非晶性または結晶性である。しかし、そうして導入されるポリエーテルは、生理学的条件下において非晶性となる。R1およびR2は、非晶性プレポリマーまたはブロックAおよびBからそれぞれ抽出され、R1およびR2は、同一ではない。R1およびR2は、同時にポリエーテル基を含んでいてもよいが、好適には、それらのうちの1つのみがポリエーテル基を含む。zは、ゼロまたは正の整数である。R3は、ポリ(エチレングリコール)などのポリエーテルであり、(z ≠ 0)、すなわち(z=0)ではない場合に存在する。R3は、生理学的条件下において非晶性となる。R4は、脂肪族C2-C8アルキレン基である。このアルキレン基は、任意にC1-C10 アルキレンによって置換されていてもよく、脂肪族基は、線形または環状であり、R4は、好適にはブチレン(CH2)4−基であり、C1-C10 アルキレン側基は、保護されたS、N、PまたはO成分を含んでいてもよい。Xおよびyは、正の整数であり、好適には少なくとも1であり、xおよびyの合計(x+y)は好適には最大2000、より好適には最大500、最も好適には最大200である。Q1〜Q6は、プレポリマーと多機能連鎖延長剤との反応によって得られる結合ユニットである。Q1〜Q6は、それぞれアミン、ウレタン、アミド、カーボネート、エステルまたは無水物である。
バルーンカテーテルのバルーンの弾性表面に、パクリタキセル微粒子に覆われた可撓性ヒドロゲル被膜を設けた。被覆工程に使用したバルーンカテーテルは、Minnesota Medtec (Maple Grove, MN)から入手した。バルーンの弾性部は、ナイロン製であり、バルーン壁の厚さは5〜10μmである。
実施例1に記載の被覆工程を繰り返した。ただし、ヒドロゲル被覆層を形成するために異なる被膜組成物を用いた点が実施例1とは異なる。
バルーンカテーテルのバルーンの弾性表面に可撓性ヒドロゲル被膜を設け、ヒドロゲル表面上にパクリタキセル微粒子を形成させた。
シリコンチューブモデルにおいて、ヒドロゲル被膜を有するパクリタキセル微粒子被膜バルーンからの微粒子の送達を検査した。
シリコンチューブに送達されるパクリタキセルの量を表1に表す。
生体外Cモデルにおいて、ヒドロゲル被膜を有するパクリタキセル微粒子被覆バルーンからの微粒子の送達を検査した。
豚の動脈に送達されるパクリタキセルの量を表2に表す。
Claims (5)
- 被検体の血管に生物活性を有する薬剤を送達することができる、挿入可能な医療機器であって、
膨張可能な弾性部と、
上記膨張可能な弾性部の外側の表面上の、ポリ(アクリルアミド)、ポリ(メタクリルアミド)、ポリ(ビニルピロリドン)、ポリ(アクリル酸)、ポリ(エチレングリコール)、ポリ(ビニルアルコール)、ポリ(HEMA)、メチルビニルエーテル/無水マレイン酸共重合体、およびビニルピロリドン/(メタ)アクリルアミド共重合体からなる群から選択される可撓性の生体安定性ヒドロゲルマトリックスと、
上記弾性部の表面上に存在する生分解性被膜層と、
上記可撓性の生体安定性ヒドロゲルマトリックスの表面、上記生分解性被膜層の表面、または、可撓性の生体安定性ヒドロゲルマトリックスおよび生分解性被膜層の両表面、に形成された、100nm〜10μmの最大平均寸法を有する微粒子と、を含み、
上記生分解性被膜層は、上記膨張可能な弾性部の近位端から遠位端へと連続する円周方向の縞として形成され、
上記微粒子は、非水溶性の生物活性を有する薬剤を含み、上記弾性部が膨張して上記血管と接触する、医療機器。 - 上記可撓性の生体安定性ヒドロゲルマトリックスが、ペンデント反応性フォト基を有するポリマーをさらに含み、
上記ペンデント反応性フォト基は、上記可撓性の生体安定性ヒドロゲルマトリックス内にある他のポリマーから選択された標的および上記膨張可能な弾性部の外側の表面に対して上記ポリマーを共有結合させるものであることを特徴とする請求項1に記載の医療機器。 - 上記生物活性を有する薬剤が、抗増殖性物質、抗炎症薬、および抗血小板化合物からなる群から選択されることを特徴とする請求項1に記載の医療機器。
- 上記生物活性を有する薬剤が、パクリタキセルであることを特徴とする請求項1に記載の医療機器。
- 被検体に生物活性を有する薬剤を送達することができる血管形成術用バルーンを備えた、挿入可能な医療機器であって、
膨張可能な弾性バルーン部と、
上記膨張可能な弾性バルーン部の外側の表面上を被覆する、ポリ(アクリルアミド)、ポリ(メタクリルアミド)、ポリ(ビニルピロリドン)、ポリ(アクリル酸)、ポリ(エチレングリコール)、ポリ(ビニルアルコール)、ポリ(HEMA)、メチルビニルエーテル/無水マレイン酸共重合体、およびビニルピロリドン/(メタ)アクリルアミド共重合体からなる群から選択される可撓性の生体安定性ヒドロゲルマトリックスであって、さらに、ペンデント反応性アリルケトンフォト基を有するポリマーを含み、上記ペンデント反応性アリルケトンフォト基は、上記可撓性の生体安定性ヒドロゲルマトリックス内にある他のポリマーから選択された標的および上記膨張可能な弾性バルーン部の被膜に対して上記ポリマーを共有結合させるものであるマトリックスと、
上記弾性バルーン部の表面上に存在する生分解性被膜層と、
上記可撓性の生体安定性ヒドロゲルマトリックスの表面、上記生分解性被膜層の表面、または、可撓性の生体安定性ヒドロゲルマトリックスおよび生分解性被膜層の両表面、に形成された、100nm〜10μmの最大平均寸法を有する微粒子と、を含み、
上記生分解性被膜層は、上記膨張可能な弾性バルーン部の近位端から遠位端へと連続する円周方向の縞として形成され、
上記微粒子は、非水溶性の生物活性を有する薬剤を含み、上記弾性バルーン部が膨張して上記血管と接触する、医療機器。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US7223408P | 2008-03-28 | 2008-03-28 | |
US61/072,234 | 2008-03-28 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2016139332A Division JP6767185B2 (ja) | 2008-03-28 | 2016-07-14 | 微粒子が配置された弾性基質を有する挿入可能な医療機器、および薬物送達方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2018158129A JP2018158129A (ja) | 2018-10-11 |
JP6714043B2 true JP6714043B2 (ja) | 2020-06-24 |
Family
ID=41005085
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2011501815A Active JP5667559B2 (ja) | 2008-03-28 | 2009-03-27 | 微粒子が配置された弾性基質を有する挿入可能な医療機器、および薬物送達方法 |
JP2014209337A Active JP5973520B2 (ja) | 2008-03-28 | 2014-10-10 | 微粒子が配置された弾性基質を有する挿入可能な医療機器、および薬物送達方法 |
JP2016139332A Active JP6767185B2 (ja) | 2008-03-28 | 2016-07-14 | 微粒子が配置された弾性基質を有する挿入可能な医療機器、および薬物送達方法 |
JP2018108900A Active JP6714043B2 (ja) | 2008-03-28 | 2018-06-06 | 微粒子が配置された弾性基質を有する挿入可能な医療機器、および薬物送達方法 |
Family Applications Before (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2011501815A Active JP5667559B2 (ja) | 2008-03-28 | 2009-03-27 | 微粒子が配置された弾性基質を有する挿入可能な医療機器、および薬物送達方法 |
JP2014209337A Active JP5973520B2 (ja) | 2008-03-28 | 2014-10-10 | 微粒子が配置された弾性基質を有する挿入可能な医療機器、および薬物送達方法 |
JP2016139332A Active JP6767185B2 (ja) | 2008-03-28 | 2016-07-14 | 微粒子が配置された弾性基質を有する挿入可能な医療機器、および薬物送達方法 |
Country Status (6)
Country | Link |
---|---|
US (4) | US8951545B2 (ja) |
EP (2) | EP2689789B1 (ja) |
JP (4) | JP5667559B2 (ja) |
CA (1) | CA2719222C (ja) |
MX (1) | MX2010010663A (ja) |
WO (1) | WO2009120361A2 (ja) |
Families Citing this family (97)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7431710B2 (en) | 2002-04-08 | 2008-10-07 | Glaukos Corporation | Ocular implants with anchors and methods thereof |
US10076641B2 (en) | 2005-05-11 | 2018-09-18 | The Spectranetics Corporation | Methods and systems for delivering substances into luminal walls |
US20090062909A1 (en) | 2005-07-15 | 2009-03-05 | Micell Technologies, Inc. | Stent with polymer coating containing amorphous rapamycin |
US8298565B2 (en) | 2005-07-15 | 2012-10-30 | Micell Technologies, Inc. | Polymer coatings containing drug powder of controlled morphology |
US8414525B2 (en) | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Drug releasing coatings for medical devices |
US8414526B2 (en) | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Medical device rapid drug releasing coatings comprising oils, fatty acids, and/or lipids |
US9700704B2 (en) | 2006-11-20 | 2017-07-11 | Lutonix, Inc. | Drug releasing coatings for balloon catheters |
US8414909B2 (en) * | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Drug releasing coatings for medical devices |
US8414910B2 (en) | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Drug releasing coatings for medical devices |
US20080276935A1 (en) | 2006-11-20 | 2008-11-13 | Lixiao Wang | Treatment of asthma and chronic obstructive pulmonary disease with anti-proliferate and anti-inflammatory drugs |
US9737640B2 (en) | 2006-11-20 | 2017-08-22 | Lutonix, Inc. | Drug releasing coatings for medical devices |
US8998846B2 (en) | 2006-11-20 | 2015-04-07 | Lutonix, Inc. | Drug releasing coatings for balloon catheters |
US8425459B2 (en) * | 2006-11-20 | 2013-04-23 | Lutonix, Inc. | Medical device rapid drug releasing coatings comprising a therapeutic agent and a contrast agent |
US11426494B2 (en) | 2007-01-08 | 2022-08-30 | MT Acquisition Holdings LLC | Stents having biodegradable layers |
JP5603598B2 (ja) | 2007-01-08 | 2014-10-08 | ミセル テクノロジーズ、インコーポレイテッド | 生物分解層を有するステント |
PL2269664T3 (pl) | 2007-01-21 | 2013-03-29 | Hemoteq Ag | Wyrób medyczny do leczenia niedrożności układów ciała i do zapobiegania ponownej niedrożności |
US9192697B2 (en) | 2007-07-03 | 2015-11-24 | Hemoteq Ag | Balloon catheter for treating stenosis of body passages and for preventing threatening restenosis |
BRPI0906702A2 (pt) | 2008-01-09 | 2015-06-30 | Innovative Health Technologies Llc | Grânulos de implante e métodos para realizar a regeneração e preservação óssea |
US9510856B2 (en) | 2008-07-17 | 2016-12-06 | Micell Technologies, Inc. | Drug delivery medical device |
US9295820B2 (en) * | 2008-08-14 | 2016-03-29 | Surmodics, Inc. | Method and apparatus for coating balloon catheters |
WO2010024898A2 (en) * | 2008-08-29 | 2010-03-04 | Lutonix, Inc. | Methods and apparatuses for coating balloon catheters |
IT1394522B1 (it) | 2009-01-09 | 2012-07-05 | Invatec Technology Ct Gmbh | Dispositivo medicale con rilascio di farmaco |
JP2012522589A (ja) | 2009-04-01 | 2012-09-27 | ミシェル テクノロジーズ,インコーポレイテッド | 被覆ステント |
US10206813B2 (en) | 2009-05-18 | 2019-02-19 | Dose Medical Corporation | Implants with controlled drug delivery features and methods of using same |
RU2573045C2 (ru) * | 2009-06-02 | 2016-01-20 | Консепт Медикал Инк. | Медицинское устройство, доставляющее лекарственное средство, способ его получения и способ доставки лекарственного средства |
US20150079160A1 (en) * | 2009-06-02 | 2015-03-19 | Concept Medical Research Private Limited | Non-implantable medical device coated with nano-carriers for delivering one or more drugs to a body site |
EP2451496B1 (en) | 2009-07-10 | 2015-07-22 | Boston Scientific Scimed, Inc. | Use of nanocrystals for a drug delivery balloon |
US10080821B2 (en) | 2009-07-17 | 2018-09-25 | Boston Scientific Scimed, Inc. | Nucleation of drug delivery balloons to provide improved crystal size and density |
WO2011028419A1 (en) * | 2009-08-27 | 2011-03-10 | Boston Scientific Scimed, Inc. | Balloon catheter devices with drug-coated sheath |
WO2011090569A1 (en) * | 2009-12-30 | 2011-07-28 | Boston Scientific Scimed, Inc. | Drug-delivery balloons |
WO2011097103A1 (en) | 2010-02-02 | 2011-08-11 | Micell Technologies, Inc. | Stent and stent delivery system with improved deliverability |
EP2383000A1 (en) | 2010-04-19 | 2011-11-02 | InnoRa Gmbh | Limus-coated medical devices |
EP2380604A1 (en) | 2010-04-19 | 2011-10-26 | InnoRa Gmbh | Improved coating formulations for scoring or cutting balloon catheters |
EP2380605A1 (en) | 2010-04-19 | 2011-10-26 | InnoRa Gmbh | Improved formulations for drug-coated medical devices |
CA2797110C (en) | 2010-04-22 | 2020-07-21 | Micell Technologies, Inc. | Stents and other devices having extracellular matrix coating |
CA2803095C (en) * | 2010-06-30 | 2020-08-11 | Surmodics, Inc. | Catheter assembly sleeve having a plurality of openings |
CA2803361C (en) | 2010-06-30 | 2020-07-21 | Surmodics, Inc. | Lipid coating for medical devices delivering bioactive agent |
US20130172853A1 (en) | 2010-07-16 | 2013-07-04 | Micell Technologies, Inc. | Drug delivery medical device |
EP2611476B1 (en) | 2010-09-02 | 2016-08-10 | Boston Scientific Scimed, Inc. | Coating process for drug delivery balloons using heat-induced rewrap memory |
EP2629832A1 (en) * | 2010-10-18 | 2013-08-28 | Boston Scientific Scimed, Inc. | Drug eluting medical device utilizing bioadhesives |
US20130345629A1 (en) * | 2010-12-04 | 2013-12-26 | Alexander Rübben | Coating and coating method for the balloon of a balloon catheter, and balloon catheter with coated balloon |
US10245178B1 (en) | 2011-06-07 | 2019-04-02 | Glaukos Corporation | Anterior chamber drug-eluting ocular implant |
WO2013022458A1 (en) | 2011-08-05 | 2013-02-14 | Boston Scientific Scimed, Inc. | Methods of converting amorphous drug substance into crystalline form |
WO2013028208A1 (en) | 2011-08-25 | 2013-02-28 | Boston Scientific Scimed, Inc. | Medical device with crystalline drug coating |
WO2013053809A1 (en) | 2011-10-14 | 2013-04-18 | Innora Gmbh | Improved formulations for drug-coated medical devices |
US10188772B2 (en) | 2011-10-18 | 2019-01-29 | Micell Technologies, Inc. | Drug delivery medical device |
JP2015501178A (ja) * | 2011-10-18 | 2015-01-15 | ミセル テクノロジーズ,インク. | 薬物送達のための医療用デバイス |
WO2013091722A1 (en) | 2011-12-23 | 2013-06-27 | Innora Gmbh | Drug-coated medical devices |
CA2888776C (en) * | 2012-10-18 | 2020-12-29 | Micell Technologies, Inc. | Drug delivery medical device |
GB201301385D0 (en) * | 2013-01-26 | 2013-03-13 | Chowdhury Dewan F H | Particle structures for drug delivery |
CA2905419C (en) | 2013-03-12 | 2020-04-28 | Micell Technologies, Inc. | Bioabsorbable biomedical implants |
US11167063B2 (en) | 2013-03-14 | 2021-11-09 | W. L. Gore & Associates, Inc. | Porous composites with high-aspect ratio crystals |
US9675786B2 (en) * | 2013-03-15 | 2017-06-13 | University Of Rochester | Devices, systems and methods for diverting fluid trapped in a solid organ |
US9872940B2 (en) | 2013-04-01 | 2018-01-23 | Terumo Kabushiki Kaisha | Drug coating layer |
WO2014186532A1 (en) | 2013-05-15 | 2014-11-20 | Micell Technologies, Inc. | Bioabsorbable biomedical implants |
US9439892B2 (en) | 2013-05-16 | 2016-09-13 | Surmodics, Inc. | Macrolide particulates, methods for preparation, and medical devices associated therewith |
MX362180B (es) | 2013-06-12 | 2019-01-08 | Surmodics Inc | Metodos con disolvente para preparar particulados de macrolido cristalino, composiciones y articulos que continen particulados. |
EP3106199B1 (en) | 2014-04-01 | 2020-04-22 | Terumo Kabushiki Kaisha | Balloon coating method, coat layer control method and balloon coating device |
CN106132469B (zh) | 2014-04-01 | 2019-11-15 | 泰尔茂株式会社 | 球囊涂敷方法 |
EP3106198B1 (en) | 2014-04-01 | 2019-09-18 | Terumo Kabushiki Kaisha | Positioning method for balloon coating |
CN106132470B (zh) | 2014-04-01 | 2019-09-24 | 泰尔茂株式会社 | 用于球囊涂敷的定位方法 |
US10149925B2 (en) | 2014-05-16 | 2018-12-11 | Terumo Kabushiki Kaisha | Method of reducing the risk of embolization of peripheral blood vessels |
US10188771B2 (en) | 2014-05-16 | 2019-01-29 | Terumo Kabushiki Kaisha | Method of treating peripheral artery diseases in lower limbs |
US10143779B2 (en) | 2014-05-16 | 2018-12-04 | Terumo Kabushiki Kaisha | Method of inhibiting thickening of vascular intima |
JP6655610B2 (ja) | 2014-05-29 | 2020-02-26 | グローコス コーポレーション | 制御された薬物送達機能を備えるインプラント及びそれを使用する方法 |
US11406742B2 (en) | 2014-07-18 | 2022-08-09 | M.A. Med Alliance SA | Coating for intraluminal expandable catheter providing contact transfer of drug micro-reservoirs |
US9492594B2 (en) | 2014-07-18 | 2016-11-15 | M.A. Med Alliance SA | Coating for intraluminal expandable catheter providing contact transfer of drug micro-reservoirs |
WO2016115361A1 (en) | 2015-01-14 | 2016-07-21 | Surmodics, Inc. | Insertion tools for medical device |
US9901719B2 (en) | 2015-04-23 | 2018-02-27 | Terumo Kabushiki Kaisha | Balloon coating method, balloon rotating method and balloon coating apparatus |
WO2016171252A1 (ja) * | 2015-04-23 | 2016-10-27 | テルモ株式会社 | バルーンコーティング方法、バルーン回転方法およびバルーンコーティング装置 |
US11925578B2 (en) | 2015-09-02 | 2024-03-12 | Glaukos Corporation | Drug delivery implants with bi-directional delivery capacity |
ES2948679T3 (es) | 2015-09-15 | 2023-09-15 | Savage Medical Inc | Dispositivos para anclar una vaina en una cavidad tisular |
US11564833B2 (en) | 2015-09-25 | 2023-01-31 | Glaukos Corporation | Punctal implants with controlled drug delivery features and methods of using same |
JP6472572B2 (ja) * | 2016-03-23 | 2019-02-20 | テルモ株式会社 | バルーンカテーテルおよびその製造方法並びに処置方法 |
JP6832340B2 (ja) * | 2016-03-23 | 2021-02-24 | テルモ株式会社 | バルーンカテーテルおよびその製造方法 |
JP6697917B2 (ja) * | 2016-03-23 | 2020-05-27 | テルモ株式会社 | バルーンカテーテル及びその製造方法並びに処置方法 |
WO2017164281A1 (ja) * | 2016-03-23 | 2017-09-28 | テルモ株式会社 | バルーンカテーテル及びその製造方法並びに処置方法 |
JP6754423B2 (ja) * | 2016-03-23 | 2020-09-09 | テルモ株式会社 | バルーンカテーテル及びその製造方法 |
JP6668131B2 (ja) | 2016-03-23 | 2020-03-18 | テルモ株式会社 | バルーンカテーテルおよびその製造方法並びに処置方法 |
WO2017164279A1 (ja) * | 2016-03-23 | 2017-09-28 | テルモ株式会社 | バルーンカテーテルおよびその製造方法並びに処置方法 |
JP2017169738A (ja) | 2016-03-23 | 2017-09-28 | テルモ株式会社 | バルーンカテーテルおよびその製造方法並びに処置方法 |
WO2017173121A1 (en) | 2016-03-31 | 2017-10-05 | Surmodics, Inc. | Drug-containing particulate composition with cationic agent, associated medical devices, and methods for treatment |
CA3022830A1 (en) | 2016-04-20 | 2017-10-26 | Harold Alexander Heitzmann | Bioresorbable ocular drug delivery device |
JPWO2018008517A1 (ja) * | 2016-07-04 | 2019-04-18 | 株式会社カネカ | 灌流型バルーンカテーテル |
EP3512591A1 (en) | 2016-09-16 | 2019-07-24 | Surmodics, Inc. | Lubricious insertion tools for medical devices and methods for using |
CN108601927A (zh) * | 2016-11-22 | 2018-09-28 | 朝日英达科株式会社 | 气囊导管 |
US11123459B2 (en) | 2016-12-16 | 2021-09-21 | Surmodics, Inc. | Hydrophobic active agent particle coatings and methods for treatment |
JP6831722B2 (ja) * | 2017-03-16 | 2021-02-17 | テルモ株式会社 | バルーンカテーテルの製造方法および製造装置 |
JP7073338B2 (ja) * | 2017-03-16 | 2022-05-23 | テルモ株式会社 | バルーンカテーテルおよびその製造方法および製造装置 |
JP7073339B2 (ja) * | 2017-03-16 | 2022-05-23 | テルモ株式会社 | バルーンカテーテルおよびその製造方法 |
JP2018187229A (ja) * | 2017-05-10 | 2018-11-29 | テルモ株式会社 | 医療用長尺体 |
US11883617B2 (en) * | 2017-11-30 | 2024-01-30 | Kaneka Corporation | Balloon catheter and method for producing same |
EP3536468B1 (en) | 2018-03-09 | 2023-09-13 | BIC Violex Single Member S.A. | Razor cartridge with lubricating strip |
US11027102B2 (en) | 2018-07-20 | 2021-06-08 | Teleflex Life Sciences Limited | Perfusion catheters and related methods |
EP3837000A1 (en) * | 2018-08-16 | 2021-06-23 | Teleflex Life Sciences Limited | Eluting perfusion catheters |
CN113144376B (zh) * | 2021-04-16 | 2024-03-29 | 上海市胸科医院 | 一种纳米双抗深静脉导管 |
US11911572B2 (en) * | 2022-05-05 | 2024-02-27 | Innocare Urologics, Llc | Soft tip drug-eluting urinary drainage catheter |
Family Cites Families (73)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH616337A5 (ja) | 1977-10-21 | 1980-03-31 | Schneider Medintag Ag | |
US4490421A (en) | 1983-07-05 | 1984-12-25 | E. I. Du Pont De Nemours And Company | Balloon and manufacture thereof |
US5041089A (en) | 1987-12-11 | 1991-08-20 | Devices For Vascular Intervention, Inc. | Vascular dilation catheter construction |
US5087246A (en) | 1988-12-29 | 1992-02-11 | C. R. Bard, Inc. | Dilation catheter with fluted balloon |
US5318587A (en) | 1989-08-25 | 1994-06-07 | C. R. Bard, Inc. | Pleated balloon dilatation catheter and method of use |
US5674192A (en) * | 1990-12-28 | 1997-10-07 | Boston Scientific Corporation | Drug delivery |
US5304121A (en) * | 1990-12-28 | 1994-04-19 | Boston Scientific Corporation | Drug delivery system making use of a hydrogel polymer coating |
US5843089A (en) * | 1990-12-28 | 1998-12-01 | Boston Scientific Corporation | Stent lining |
US5252701A (en) | 1990-07-06 | 1993-10-12 | American Cyanamid Company | Segmented absorbable copolymer |
ATE121303T1 (de) | 1990-10-04 | 1995-05-15 | Schneider Europ Ag | Ballondilationskatheter. |
JP3372950B2 (ja) * | 1990-12-28 | 2003-02-04 | ボストン サイエンティフィック コーポレーション | ドラッグデリバリーシステム |
US5893840A (en) * | 1991-01-04 | 1999-04-13 | Medtronic, Inc. | Releasable microcapsules on balloon catheters |
US5102402A (en) * | 1991-01-04 | 1992-04-07 | Medtronic, Inc. | Releasable coatings on balloon catheters |
US5195969A (en) | 1991-04-26 | 1993-03-23 | Boston Scientific Corporation | Co-extruded medical balloons and catheter using such balloons |
US5500180A (en) | 1992-09-30 | 1996-03-19 | C. R. Bard, Inc. | Method of making a distensible dilatation balloon using a block copolymer |
US5414075A (en) * | 1992-11-06 | 1995-05-09 | Bsi Corporation | Restrained multifunctional reagent for surface modification |
US5981568A (en) * | 1993-01-28 | 1999-11-09 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
US5382234A (en) | 1993-04-08 | 1995-01-17 | Scimed Life Systems, Inc. | Over-the-wire balloon catheter |
US5464650A (en) * | 1993-04-26 | 1995-11-07 | Medtronic, Inc. | Intravascular stent and method |
US5344402A (en) | 1993-06-30 | 1994-09-06 | Cardiovascular Dynamics, Inc. | Low profile perfusion catheter |
US6896842B1 (en) | 1993-10-01 | 2005-05-24 | Boston Scientific Corporation | Medical device balloons containing thermoplastic elastomers |
WO1995022367A1 (en) | 1994-02-17 | 1995-08-24 | Scimed Life Systems, Inc. | Process improvements for preparing catheter balloons |
EP0748232B8 (en) | 1994-03-02 | 2009-03-25 | Boston Scientific Limited | Block copolymer elastomer catheter balloons |
WO1995028983A1 (en) | 1994-04-20 | 1995-11-02 | Solar Ronald J | Active perfusion dilatation catheter |
US5667493A (en) | 1994-12-30 | 1997-09-16 | Janacek; Jaroslav | Dilation catheter |
US5591199A (en) * | 1995-06-07 | 1997-01-07 | Porter; Christopher H. | Curable fiber composite stent and delivery system |
DE69611378T2 (de) | 1995-11-08 | 2001-04-26 | Scimed Life Systems Inc | Verfahren zur ballonherstellung durch kaltziehen/einhalsen |
US6143037A (en) * | 1996-06-12 | 2000-11-07 | The Regents Of The University Of Michigan | Compositions and methods for coating medical devices |
US5980948A (en) | 1996-08-16 | 1999-11-09 | Osteotech, Inc. | Polyetherester copolymers as drug delivery matrices |
EP0842657A1 (en) | 1996-11-19 | 1998-05-20 | OctoPlus B.V. | Microspheres for controlled release and processes to prepare these microspheres |
EP0973818B1 (en) | 1997-04-03 | 2004-10-13 | Guilford Pharmaceuticals Inc. | Biodegradable terephthalate polyester-poly(phosphate) polymers, compositions, articles, and methods for making and using the same |
CA2298543A1 (en) | 1997-08-13 | 1999-02-25 | James Barry | Loading and release of water-insoluble drugs |
WO1999016500A2 (en) * | 1997-10-01 | 1999-04-08 | Medtronic Ave, Inc. | Drug delivery and gene therapy delivery system |
US6517515B1 (en) | 1998-03-04 | 2003-02-11 | Scimed Life Systems, Inc. | Catheter having variable size guide wire lumen |
US6007833A (en) * | 1998-03-19 | 1999-12-28 | Surmodics, Inc. | Crosslinkable macromers bearing initiator groups |
US6364856B1 (en) * | 1998-04-14 | 2002-04-02 | Boston Scientific Corporation | Medical device with sponge coating for controlled drug release |
EP1174157B1 (en) | 1998-04-27 | 2005-06-29 | Surmodics Inc. | Bioactive agent release coating |
IL139043A0 (en) | 1998-05-15 | 2001-11-25 | Medgination Inc | Enhanced balloon dilatation system |
US6153212A (en) | 1998-10-02 | 2000-11-28 | Guilford Pharmaceuticals Inc. | Biodegradable terephthalate polyester-poly (phosphonate) compositions, articles, and methods of using the same |
US6419709B1 (en) | 1998-10-02 | 2002-07-16 | Guilford Pharmaceuticals, Inc. | Biodegradable terephthalate polyester-poly(Phosphite) compositions, articles, and methods of using the same |
FR2788959B1 (fr) * | 1999-02-01 | 2002-03-08 | Siemens Ag | Dispositif pour une tete de therapie servant a recevoir un dispositif de localisation et tete de therapie comportant un dispositif de ce genre |
CA2368617C (en) | 1999-04-12 | 2010-03-16 | Cornell Research Foundation, Inc. | Hydrogel-forming system with hydrophobic and hydrophilic components |
US6610317B2 (en) | 1999-05-27 | 2003-08-26 | Acusphere, Inc. | Porous paclitaxel matrices and methods of manufacture thereof |
US6278018B1 (en) | 1999-12-14 | 2001-08-21 | Surmodics, Inc. | Surface coating agents |
US6703040B2 (en) | 2000-01-11 | 2004-03-09 | Intralytix, Inc. | Polymer blends as biodegradable matrices for preparing biocomposites |
AU8130401A (en) * | 2000-08-15 | 2002-02-25 | Surmodics Inc | Medicament incorporation matrix |
US6503538B1 (en) | 2000-08-30 | 2003-01-07 | Cornell Research Foundation, Inc. | Elastomeric functional biodegradable copolyester amides and copolyester urethanes |
US6638246B1 (en) * | 2000-11-28 | 2003-10-28 | Scimed Life Systems, Inc. | Medical device for delivery of a biologically active material to a lumen |
US6623504B2 (en) | 2000-12-08 | 2003-09-23 | Scimed Life Systems, Inc. | Balloon catheter with radiopaque distal tip |
WO2003011212A2 (en) | 2001-08-02 | 2003-02-13 | Cornell Research Foundation, Inc. | Biodegradable polyhydric alcohol esters |
US6669980B2 (en) | 2001-09-18 | 2003-12-30 | Scimed Life Systems, Inc. | Method for spray-coating medical devices |
US20030064965A1 (en) * | 2001-10-02 | 2003-04-03 | Jacob Richter | Method of delivering drugs to a tissue using drug-coated medical devices |
ATE295155T1 (de) * | 2001-10-05 | 2005-05-15 | Surmodics Inc | Beschichtungen mit immobilisierten partikeln sowie verwendungen derselben |
US7060051B2 (en) * | 2002-09-24 | 2006-06-13 | Scimed Life Systems, Inc. | Multi-balloon catheter with hydrogel coating |
US7192484B2 (en) | 2002-09-27 | 2007-03-20 | Surmodics, Inc. | Advanced coating apparatus and method |
ES2325398T3 (es) | 2003-02-26 | 2009-09-03 | Boston Scientific Limited | Cateter de balon. |
EP1555278A1 (en) | 2004-01-15 | 2005-07-20 | Innocore Technologies B.V. | Biodegradable multi-block co-polymers |
CA2560507C (en) * | 2004-03-26 | 2011-08-16 | Surmodics, Inc. | Composition and method for preparing biocompatible surfaces |
CA2563069A1 (en) * | 2004-04-06 | 2005-10-27 | Surmodics, Inc. | Coating compositions for bioactive agents |
US8241655B2 (en) * | 2004-05-12 | 2012-08-14 | Surmodics, Inc. | Coatings for medical articles including natural biodegradable polysaccharides |
WO2006002399A2 (en) * | 2004-06-24 | 2006-01-05 | Surmodics, Inc. | Biodegradable implantable medical devices, methods and systems |
EP1617606A1 (en) | 2004-07-16 | 2006-01-18 | Matsushita Electric Industrial Co., Ltd. | Scheduling mode switching for uplink transmissions |
US7807750B2 (en) | 2004-08-06 | 2010-10-05 | Surmodics, Inc. | Thermally-reactive polymers |
CN101048589B (zh) | 2004-09-28 | 2010-05-26 | 电动内燃机公司 | 排放达标发动机的带抗阀门开启压力损失阀弹簧的喷油器 |
US20060182777A1 (en) * | 2005-02-15 | 2006-08-17 | Steve Kangas | Method of modulating drug release from a coated substrate |
CA2636716C (en) | 2006-01-13 | 2014-12-23 | Surmodics, Inc. | Microparticle containing matrices for drug delivery |
US20070212387A1 (en) | 2006-03-08 | 2007-09-13 | Sahajanand Medical Technologies Pvt. Ltd. | Coatings for implantable medical devices |
WO2007109069A2 (en) * | 2006-03-15 | 2007-09-27 | Surmodics, Inc. | Hydrophobic derivatives of natural biodegradable polysaccharides and uses thereof |
CA2656191C (en) * | 2006-06-28 | 2015-12-08 | Surmodics, Inc. | Hydrophilic active agent eluting polymeric matrices with microparticles |
PL2269664T3 (pl) * | 2007-01-21 | 2013-03-29 | Hemoteq Ag | Wyrób medyczny do leczenia niedrożności układów ciała i do zapobiegania ponownej niedrożności |
US8709827B2 (en) * | 2007-06-28 | 2014-04-29 | Surmodics, Inc. | Polypeptide microparticles |
EP2219620B1 (en) | 2007-11-13 | 2017-07-19 | Surmodics, Inc. | Viscous terpolymers as drug delivery platform |
US9295820B2 (en) * | 2008-08-14 | 2016-03-29 | Surmodics, Inc. | Method and apparatus for coating balloon catheters |
-
2009
- 2009-03-27 EP EP13189546.8A patent/EP2689789B1/en not_active Not-in-force
- 2009-03-27 WO PCT/US2009/001901 patent/WO2009120361A2/en active Application Filing
- 2009-03-27 CA CA2719222A patent/CA2719222C/en active Active
- 2009-03-27 MX MX2010010663A patent/MX2010010663A/es active IP Right Grant
- 2009-03-27 US US12/383,751 patent/US8951545B2/en active Active
- 2009-03-27 EP EP09723874.5A patent/EP2271379B1/en active Active
- 2009-03-27 JP JP2011501815A patent/JP5667559B2/ja active Active
-
2014
- 2014-10-10 JP JP2014209337A patent/JP5973520B2/ja active Active
-
2015
- 2015-02-04 US US14/613,777 patent/US9669192B2/en active Active
-
2016
- 2016-07-14 JP JP2016139332A patent/JP6767185B2/ja active Active
- 2016-08-03 US US15/227,458 patent/US9895516B2/en active Active
-
2018
- 2018-01-10 US US15/866,930 patent/US11020513B2/en active Active
- 2018-06-06 JP JP2018108900A patent/JP6714043B2/ja active Active
Also Published As
Publication number | Publication date |
---|---|
EP2271379A2 (en) | 2011-01-12 |
US9669192B2 (en) | 2017-06-06 |
JP2015042280A (ja) | 2015-03-05 |
EP2271379B1 (en) | 2015-11-25 |
WO2009120361A3 (en) | 2010-09-02 |
JP2018158129A (ja) | 2018-10-11 |
JP2016198543A (ja) | 2016-12-01 |
US20150165094A1 (en) | 2015-06-18 |
MX2010010663A (es) | 2010-11-09 |
US11020513B2 (en) | 2021-06-01 |
US9895516B2 (en) | 2018-02-20 |
US20090246252A1 (en) | 2009-10-01 |
US8951545B2 (en) | 2015-02-10 |
JP5973520B2 (ja) | 2016-08-23 |
EP2689789A1 (en) | 2014-01-29 |
CA2719222A1 (en) | 2009-10-01 |
EP2689789B1 (en) | 2019-03-13 |
JP6767185B2 (ja) | 2020-10-14 |
WO2009120361A2 (en) | 2009-10-01 |
JP5667559B2 (ja) | 2015-02-12 |
JP2011517589A (ja) | 2011-06-16 |
CA2719222C (en) | 2018-07-24 |
US20160339214A1 (en) | 2016-11-24 |
US20180126128A1 (en) | 2018-05-10 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP6714043B2 (ja) | 微粒子が配置された弾性基質を有する挿入可能な医療機器、および薬物送達方法 | |
Jagur‐Grodzinski | Polymers for tissue engineering, medical devices, and regenerative medicine. Concise general review of recent studies | |
EP2588157B1 (en) | Lipid coating for medical devices delivering bioactive agent | |
ES2550137T3 (es) | Dispositivos implantables que comprenden polímeros estrella biológicamente absorbibles y métodos para fabricar estos | |
CA2594030A1 (en) | Biodegradable coating compositions including multiple layers | |
JP2007530169A (ja) | 生物適合性表面を調製するための組成物及び方法 | |
EP1986603A2 (en) | Microparticle containing matrices for drug delivery | |
CA2798459C (en) | Glycerol ester active agent delivery systems and methods | |
JPWO2007116646A1 (ja) | 生体内留置物 | |
CN117815188A (zh) | 具有光激活效应的载药微储库以及相关产品、用途、制备的方法和喷涂的方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20180702 |
|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20180702 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20190611 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20190830 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20191001 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20191121 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20200512 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20200604 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 6714043 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |