JP7073339B2 - バルーンカテーテルおよびその製造方法 - Google Patents
バルーンカテーテルおよびその製造方法 Download PDFInfo
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- JP7073339B2 JP7073339B2 JP2019506300A JP2019506300A JP7073339B2 JP 7073339 B2 JP7073339 B2 JP 7073339B2 JP 2019506300 A JP2019506300 A JP 2019506300A JP 2019506300 A JP2019506300 A JP 2019506300A JP 7073339 B2 JP7073339 B2 JP 7073339B2
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- YYSFXUWWPNHNAZ-PKJQJFMNSA-N umirolimus Chemical compound C1[C@@H](OC)[C@H](OCCOCC)CC[C@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 YYSFXUWWPNHNAZ-PKJQJFMNSA-N 0.000 description 1
- 229920003169 water-soluble polymer Polymers 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/08—Materials for coatings
- A61L29/10—Inorganic materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/12—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
- A61L29/16—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
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- Child & Adolescent Psychology (AREA)
- Inorganic Chemistry (AREA)
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Description
前記薬剤結晶の少なくとも一部は、長尺な結晶形態型の薬剤結晶であり、前記長尺な結晶形態型の薬剤結晶は、前記金属層に覆われている薬剤結晶と、前記金属層に覆われていない薬剤結晶と、を含んでもよい。
上記目的を達成するバルーンカテーテルの他の態様は、生体管腔内に挿入可能なバルーンカテーテルであって、長尺なカテーテル本体と、前記カテーテル本体の遠位側に設けられて径方向へ拡張可能なバルーンと、前記バルーンの外表面に配置されて複数の薬剤結晶および添加剤を含むコート層と、前記バルーンの外表面に蒸着されずに前記コート層の外表面に蒸着された金属層と、を有する。
30 バルーン
37 金属層
40 コート層
41 添加剤
42 薬剤結晶
45 コーティング液
50 カテーテルの製造装置
60 回転機構部
80 移動機構部
90 コーティング液供給部
94 ディスペンシングチューブ
100 制御部
120 蒸着装置
Claims (9)
- 生体管腔内に挿入可能なバルーンカテーテルであって、
長尺なカテーテル本体と、
前記カテーテル本体の遠位側に設けられて径方向へ拡張可能なバルーンと、
前記バルーンの外表面に配置される複数の薬剤結晶を含むコート層と、
前記バルーンの外表面に蒸着されずに前記コート層の外表面に蒸着された金属層と、を有し、
前記複数の薬剤結晶は、前記金属層に覆われている薬剤結晶と、前記金属層に覆われていない薬剤結晶と、を含むバルーンカテーテル。 - 前記薬剤結晶の少なくとも一部は、長尺な結晶形態型の薬剤結晶であり、
前記長尺な結晶形態型の薬剤結晶は、前記金属層に覆われている薬剤結晶と、前記金属層に覆われていない薬剤結晶と、を含む請求項1に記載のバルーンカテーテル。 - 生体管腔内に挿入可能なバルーンカテーテルであって、
長尺なカテーテル本体と、
前記カテーテル本体の遠位側に設けられて径方向へ拡張可能なバルーンと、
前記バルーンの外表面に配置されて複数の薬剤結晶および添加剤を含むコート層と、
前記バルーンの外表面に蒸着されずに前記コート層の外表面に蒸着された金属層と、を有するバルーンカテーテル。 - 前記金属層の材料は、金、白金、クロム、亜鉛、ニッケル、銀、銅からなる群から選択される少なくとも1つを含有する請求項1~3のいずれか1項に記載のバルーンカテーテル。
- 前記金属層は、前記コート層の外表面を部分的に覆っている請求項1~4のいずれか1項に記載のバルーンカテーテル。
- 前記薬剤は、ラパマイシン、パクリタキセル、ドセタキセルおよびエベロリムスからなる群から選択される少なくとも1つを含有する請求項1~5のいずれか1項に記載のバルーンカテーテル。
- バルーンの外表面に薬剤を含むコート層が形成されたバルーンカテーテルの製造方法であって、
前記バルーンの外表面に複数の薬剤結晶を含むコート層を形成するステップと、
前記コート層の外表面に金属を蒸着して、前記複数の薬剤結晶が金属層に覆われている薬剤結晶と前記金属層に覆われていない薬剤結晶とを含むように前記金属層を形成するステップと、を有するバルーンカテーテルの製造方法。 - 前記金属層の金属は、金、白金、クロム、亜鉛、ニッケル、銀、銅からなる群から選択される少なくとも1つを含有する請求項7に記載のバルーンカテーテルの製造方法。
- 前記金属層を形成するステップにおいて、前記コート層の外表面に部分的に前記金属層を形成する請求項7または8に記載のバルーンカテーテルの製造方法。
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