JP6832339B2 - バルーンカテーテル及びその製造方法並びに処置方法 - Google Patents
バルーンカテーテル及びその製造方法並びに処置方法 Download PDFInfo
- Publication number
- JP6832339B2 JP6832339B2 JP2018507395A JP2018507395A JP6832339B2 JP 6832339 B2 JP6832339 B2 JP 6832339B2 JP 2018507395 A JP2018507395 A JP 2018507395A JP 2018507395 A JP2018507395 A JP 2018507395A JP 6832339 B2 JP6832339 B2 JP 6832339B2
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- balloon
- crystal
- blade
- elongated body
- catheter
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- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M2025/1043—Balloon catheters with special features or adapted for special applications
- A61M2025/105—Balloon catheters with special features or adapted for special applications having a balloon suitable for drug delivery, e.g. by using holes for delivery, drug coating or membranes
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Description
前記バルーンの表面は、傾倒状態となっている複数の前記長尺体が長軸方向いずれかの位置で重なり合って結合し一体化した結晶結合体を有し、
前記結晶結合体は、前記バルーンが拡張した際に、前記長尺体が結合した結合部に亀裂が形成される。
前記バルーンの表面にそれぞれ独立した長軸を有する前記長尺体を形成するステップと、
前記バルーンに径方向に突出する羽根部を形成するステップと、
前記バルーンに形成された羽根部を周方向に沿って寝かせるステップと、を有し、
前記バルーンに羽根部を形成するステップ、または前記バルーンの羽根部を寝かせるステップのいずれかにおいて、前記バルーンを変形させるために作用させる力及び熱によって、前記バルーンの表面でそれぞれ独立した前記長尺体を、傾倒させながら隣接する前記長尺体と一体化させ、複数の前記長尺体が長軸方向いずれかの位置で重なりあって結合した結晶結合体を形成する。
前記バルーンの表面に複数の前記長尺体が長軸方向いずれかの位置で重なりあって結合した結晶結合体を形成するステップと、
前記バルーンに径方向に突出する羽根部を形成するステップと、
前記バルーンに形成された羽根部を周方向に沿って寝かせるステップと、を有し、
前記バルーンに羽根部を形成するステップ、または前記バルーンの羽根部を寝かせるステップのいずれかにおいて、前記バルーンを変形させるために作用させる力及び熱によって、前記結晶結合体を前記バルーンの表面に対して傾倒させる。
11 カテーテルシャフト
12 バルーン
13 ハブ
20 外管
21 内管
22 拡張ルーメン
23 ガイドワイヤルーメン
24 開口部
30 コート層
31 バルーン表面
32 基層
33 長尺体
33a 基端
33b 固定側長尺体
33c 分離側長尺体
40 羽根部
40a 羽根内側部
40b 羽根外側部
40c 根元部
41 周面部
41a 対向面部
41b 外周構成面部
50 バルーンコーティング装置
60 回転機構部
70 支持台
80 移動機構部
90 塗布機構部
94 ディスペンシングチューブ
100 バルーン折り畳み装置
Claims (7)
- カテーテルシャフトの先端部にバルーンを有し、長軸方向に延在する水不溶性薬剤の結晶である長尺体が前記バルーンの表面に設けられているバルーンカテーテルであって、
前記バルーンの表面は、傾倒状態となっている複数の前記長尺体が長軸方向いずれかの位置で重なり合って結合し一体化した結晶結合体を有し、
前記結晶結合体は、前記バルーンが拡張した際に、前記長尺体が結合した結合部に亀裂が形成されるバルーンカテーテル。 - 前記結晶結合体を形成する傾倒状態の前記長尺体は、前記バルーンの表面に対してなす角度が30度以下である請求項1記載のバルーンカテーテル。
- 前記水不溶性薬剤は、ラパマイシン、パクリタキセル、ドセタキセル、またはエベロリムスである請求項1または2に記載のバルーンカテーテル。
- 前記結晶結合体は、前記バルーンが拡張した際に、前記長尺体が結合した結合部に亀裂が形成された際に、前記結晶結合体を構成する前記長尺体が分離し、独立状態となる請求項1〜3のいずれか1項に記載のバルーンカテーテル。
- 分離した前記長尺体は、前記バルーンの表面に対して立設状態である請求項4に記載のバルーンカテーテル。
- 長軸方向に延在する水不溶性薬剤の結晶である長尺体がバルーンの表面に設けられているバルーンカテーテルの製造方法において、
前記バルーンの表面にそれぞれ独立した長軸を有する前記長尺体を形成するステップと、
前記バルーンに径方向に突出する羽根部を形成するステップと、
前記バルーンに形成された羽根部を周方向に沿って寝かせるステップと、を有し、
前記バルーンに羽根部を形成するステップ、または前記バルーンの羽根部を寝かせるステップのいずれかにおいて、前記バルーンを変形させるために作用させる力及び熱によって、前記バルーンの表面でそれぞれ独立した前記長尺体を、傾倒させながら隣接する前記長尺体と一体化させ、複数の前記長尺体が長軸方向いずれかの位置で重なりあって結合した結晶結合体を形成するバルーンカテーテルの製造方法。 - 長軸方向に延在する水不溶性薬剤の結晶である長尺体がバルーンの表面に設けられているバルーンカテーテルの製造方法において、
前記バルーンの表面に複数の前記長尺体が長軸方向いずれかの位置で重なりあって結合した結晶結合体を形成するステップと、
前記バルーンに径方向に突出する羽根部を形成するステップと、
前記バルーンに形成された羽根部を周方向に沿って寝かせるステップと、を有し、
前記バルーンに羽根部を形成するステップ、または前記バルーンの羽根部を寝かせるステップのいずれかにおいて、前記バルーンを変形させるために作用させる力及び熱によって、前記結晶結合体を前記バルーンの表面に対して傾倒させるバルーンカテーテルの製造方法。
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WO2011008393A2 (en) * | 2009-07-17 | 2011-01-20 | Boston Scientific Scimed, Inc. | Nucleation of drug delivery balloons to provide improved crystal size and density |
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