JP6702862B2 - オリゴヌクレオチド−リガンドコンジュゲートおよびそれらの調製方法 - Google Patents

オリゴヌクレオチド−リガンドコンジュゲートおよびそれらの調製方法 Download PDF

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JP6702862B2
JP6702862B2 JP2016525825A JP2016525825A JP6702862B2 JP 6702862 B2 JP6702862 B2 JP 6702862B2 JP 2016525825 A JP2016525825 A JP 2016525825A JP 2016525825 A JP2016525825 A JP 2016525825A JP 6702862 B2 JP6702862 B2 JP 6702862B2
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compound
mmol
nucleotide sequence
oligonucleotide
ligand
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JP2016529230A (ja
JP2016529230A5 (https=
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マノハラン，ムシア
ケイ ナイール，ジャヤプラカシュ
ケイ ナイール，ジャヤプラカシュ
カンダサミィ，パチャムス
マツダ，シゲオ
ヴィー ケリン，アレクサンダー
ヴィー ケリン，アレクサンダー
ジャヤラマン，ムスサミィ
ジー ラジーフ，カランソタッチル
ジー ラジーフ，カランソタッチル
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Alnylam Pharmaceuticals Inc
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Alnylam Pharmaceuticals Inc
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    • C—CHEMISTRY; METALLURGY
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111—General methods applicable to biologically active non-coding nucleic acids
    • C—CHEMISTRY; METALLURGY
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
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    • C12N2330/00—Production
    • C12N2330/30—Production chemically synthesised

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2016525825A 2013-07-11 2014-07-11 オリゴヌクレオチド−リガンドコンジュゲートおよびそれらの調製方法 Active JP6702862B2 (ja)

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JP2020081749A JP7296916B2 (ja) 2013-07-11 2020-05-07 オリゴヌクレオチド－リガンドコンジュゲートおよびそれらの調製方法
JP2023060071A JP7676460B2 (ja) 2013-07-11 2023-04-03 オリゴヌクレオチド－リガンドコンジュゲートおよびそれらの調製方法
JP2025075070A JP2025107295A (ja) 2013-07-11 2025-04-30 オリゴヌクレオチド－リガンドコンジュゲートおよびそれらの調製方法

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US201361845279P 2013-07-11 2013-07-11
US61/845,279 2013-07-11
PCT/US2014/046425 WO2015006740A2 (en) 2013-07-11 2014-07-11 Oligonucleotide-ligand conjugates and process for their preparation

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JP2016529230A JP2016529230A (ja) 2016-09-23
JP2016529230A5 JP2016529230A5 (https=) 2017-08-24
JP6702862B2 true JP6702862B2 (ja) 2020-06-03

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JP2020081749A Active JP7296916B2 (ja) 2013-07-11 2020-05-07 オリゴヌクレオチド－リガンドコンジュゲートおよびそれらの調製方法
JP2023060071A Active JP7676460B2 (ja) 2013-07-11 2023-04-03 オリゴヌクレオチド－リガンドコンジュゲートおよびそれらの調製方法
JP2025075070A Pending JP2025107295A (ja) 2013-07-11 2025-04-30 オリゴヌクレオチド－リガンドコンジュゲートおよびそれらの調製方法

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JP2023060071A Active JP7676460B2 (ja) 2013-07-11 2023-04-03 オリゴヌクレオチド－リガンドコンジュゲートおよびそれらの調製方法
JP2025075070A Pending JP2025107295A (ja) 2013-07-11 2025-04-30 オリゴヌクレオチド－リガンドコンジュゲートおよびそれらの調製方法

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US (3) US10808246B2 (https=)
EP (3) EP3019200B1 (https=)
JP (4) JP6702862B2 (https=)
AU (4) AU2014287002A1 (https=)
CA (2) CA3177846A1 (https=)
DK (1) DK3019200T3 (https=)
WO (1) WO2015006740A2 (https=)

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